Association of carotid intima media thickness with atherogenic index of plasma, apo B/apo A-I ratio and paraoxonase activity in patients with non-alcoholic fatty liver disease.

Abstract:

BACKGROUND:NAFLD patients have higher risk of atherosclerosis cardiovascular disease (ASCVD). apo B/apoA-I ratio and atherogenic index of plasma (AIP) have been suggested as biomarker for ASCVD. METHODS:apo A-I, apoB, aryl esterase (ARE) and paraoxonase (PON) activities and carotid intima media thickness (cIMT) were determined in 49 NAFLD patients and 33 controls. RESULTS:Plasma levels of apo A-I, adiponectin, ARE and PON activities decreased in NAFLD patients, while apo B, AIP and apoB/apo A-I ratio level were higher in NAFLD patients compared to controls. Furthermore, cIMT showed a positive association with AIP, apo B/apo A-I ratio and AIP + (apo B/apo A-I) in NAFLD patients. Strikingly, AIP + (apo B/apo A-I) showed a good ability to discriminating increased cIMT in NAFLD patients. CONCLUSIONS:The result showed that AIP and apo B/apo A-I associated with cIMT in NAFLD patients; however, more study are needed to prove this concept.

journal_name

Arch Physiol Biochem

authors

Fadaei R,Meshkani R,Poustchi H,Fallah S,Moradi N,Panahi G,Merat S,Golmohammadi T

doi

10.1080/13813455.2018.1429475

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

19-24

issue

1

eissn

1381-3455

issn

1744-4160

journal_volume

125

pub_type

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