Abstract:
:Diabetic nephropathy (DN) is one of the devastating complications in diabetes mellitus (DM). Glucagon-like peptide-1 (GLP-1) is one of the incretins secreted from L cells in the intestine. Crocin (a carotenoid component of saffron) has antioxidants properties. We investigated the renal effects of Exendin-4 as a GLP-1 agonist and Crocin in DN. Thirty male rats were divided into five groups: control, type II DM, type II DM + Exendin-4, type II DM + Crocin and type II DM + Exendine-4 + Crocin. At the end of the experimental period, systolic and diastolic blood pressures were measured, and GFR was calculated. Blood and urine samples were collected for biochemical analysis. Tissue samples were collected from the kidney for histological examination and biochemical measurements of protein expression. Treatment with GLP-1 agonist or Crocin caused a significant improvement in renal function. Better results were achieved with simultaneous administration of both drugs with inhibition of notch signalling pathway and the related proteins.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Amin SN,El-Gamal EM,Rashed LA,Kamar SS,Haroun MAdoi
10.1080/13813455.2020.1846203subject
Has Abstractpub_date
2020-12-07 00:00:00pages
1-11eissn
1381-3455issn
1744-4160pub_type
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