Epigenetic silencing of ADAMTS5 is associated with increased invasiveness and poor survival in patients with colorectal cancer.

abstract：:Tissue sections of frozen biopsy specimens obtained from normal and hyperplastic human lymphoid tissues as well as 40 cases of non-Hodgkin's lymphomas were analysed in immunofluorescence tests (using red TRITC and green FITC double-labeling). A panel of antisera including well-characterized conventional reagents to im...

journal_title：Journal of cancer research and clinical oncology

authors： Janossy G,Thomas JA,Pizzolo G

更新日期：1981-01-01 00:00:00

abstract：:According to a "two-hit" model, dominantly inherited predisposition to cancer entails a germline mutation, while tumorigenesis requires a second, somatic, mutation. Non-hereditary cancer of the same type requires the same two hits, but both are somatic. The original tumor used in this model, retinoblastoma, involves m...

journal_title：Journal of cancer research and clinical oncology

authors： Knudson AG

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:The oncogenic roles of sphingosine kinase 1 (SphK1) in various cancers, including thyroid cancer, have been well demonstrated. However, the microRNAs (miRNAs) associated with the oncogenic roles of SphK1 remain largely unknown. METHODS:Global gene and miRNA expression in TPC1-Vector and TPC1-SphK1 cells was an...

journal_title：Journal of cancer research and clinical oncology

authors： Liang W,Xie Z,Cui W,Guo Y,Xu L,Wu J,Guan H

更新日期：2017-04-01 00:00:00

abstract：:Nosocomial infections caused by COVID-19 will result in the immediate closure of the infected medical facility due to the highly contagious nature of COVID-19, further worsening medical shortages. We performed a Delphi consulting study to develop a risk model based on the experience of recently resumed activities in m...

journal_title：Journal of cancer research and clinical oncology

authors： Tang Z,Sun B,Xu B

更新日期：2020-07-01 00:00:00

abstract：:Preoperative cytologic examinations were performed on bronchial material from 92 patients with postsurgical (pathologic) stage I (American Joint Committee) adenocarcinoma of the lung. All patients were followed up for at least 5 years or until death; thus, cases of adenocarcinoma metastatic to the lungs were virtually...

journal_title：Journal of cancer research and clinical oncology

authors： Bjornsson J,Goellner JR,Williams DE,Scheiber MV

更新日期：1986-01-01 00:00:00

abstract：:In the supernatant of melanoma cell culture SK mel 25 three indolic compounds - 5-hydroxy-6-methoxyindole, 5-hydroxy-6-methoxyindolyl-2-carboxylic, and 6-hydroxy-5-methoxyindolyl-2-carboxylic acids - have been identified. The supernatants were extracted with ethyl acetate, derivatized, and analyzed by gas chromatograp...

journal_title：Journal of cancer research and clinical oncology

authors： Pavel S,Muskiet FA,de Ley L,The TH,van der Slik W

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:Promising new therapies for neoplasia include tyrosine kinase receptor antagonists. Tyrosine kinase oncogenes present an appealing anti-tumor drug target since they play an integral role in a variety of cellular responses including cell proliferation and differentiation. We previously demonstrated a high rate o...

journal_title：Journal of cancer research and clinical oncology

authors： Henley JD,Cummings OW,Loehrer PJ Sr

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:The molecular mechanisms underlying the development of intestinal metaplasia (IM) of the human stomach have yet to be clarified in detail. Besides ectopic expression of intestinal transcription factors, Cdx1 and Cdx2, little information is available regarding other regulatory factors. Hence, we here analyzed So...

journal_title：Journal of cancer research and clinical oncology

authors： Tsukamoto T,Inada K,Tanaka H,Mizoshita T,Mihara M,Ushijima T,Yamamura Y,Nakamura S,Tatematsu M

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:The high incidence of biliary tract carcinoma in patients with anomalous pancreaticobiliary ductal junction (APBDJ) implicates that a compositional alteration in bile may contribute to the genesis of this cancer. Lysophosphatidylcholine (LPC) is generated in the bile of these patients. Given the role of cycloox...

journal_title：Journal of cancer research and clinical oncology

authors： Gwak GY,Yoon JH,Lee SH,Lee SM,Lee HS,Gores GJ

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:In the present study an antigen-mimetic peptide of the anti-JL1 leukemia-specific monoclonal antibody (mAb) was identified and characterized. METHODS:From combinatorial peptide phage display libraries displaying the random linear heptapeptides and dodecapeptides, we selected clones with affinity to anti-JL1 mA...

journal_title：Journal of cancer research and clinical oncology

authors： Chung J,Park S,Kim D,Rhim J,Kim I,Choi I,Yi K,Ryu S,Suh P,Chung D,Bae Y,Shin Y,Park S

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:To investigate the levels for some specified microRNAs in human's peripheral blood so as to determine whether they can serve as biomarkers for metastatic non-small-cell lung cancer. METHODS:Use a quantitative stem-loop RT-PCR method to examine the serum levels for certain microRNAs including has-miR-125a-5p, h...

journal_title：Journal of cancer research and clinical oncology

authors： Lin Q,Mao W,Shu Y,Lin F,Liu S,Shen H,Gao W,Li S,Shen D

更新日期：2012-01-01 00:00:00

abstract：:Carboplatin and interferon beta (IFN beta) were tested alone and in combination for their antiproliferative activity on the human melanoma cell line SK-MEL 28 in vitro. Cells were incubated for 4 days in the presence of carboplatin (0.1 mM and 0.1 microM) and interferon beta (5 pM and 5 nM) and cell growth inhibition ...

journal_title：Journal of cancer research and clinical oncology

authors： Hübner B,Eckert K,Garbe C,Maurer HR

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Previous studies showed poorer survival in T4 disease with residual lesion. To evaluate the efficacy and toxicity of a boost dose for T4 nasopharyngeal carcinoma (NPC), patients with a residual primary lesion after intensity-modulated radiotherapy (IMRT). METHODS:398 T4 NPC patients with residual primary le...

journal_title：Journal of cancer research and clinical oncology

authors： Fei Z,Xu T,Qiu X,Li M,Chen T,Li L,Huang C,Chen C

更新日期：2021-01-03 00:00:00

abstract：PURPOSE:Solute carrier organic anion transporter family member 4A1 (SLCO4A1) is involved in the transport of various compounds, including sugars, bile salts, organic acids, metal ions, amine compounds, and estrogen. SLCO4A1 is highly expressed in several cancers and a gender bias has been observed in colorectal cancer ...

journal_title：Journal of cancer research and clinical oncology

authors： Ban MJ,Ji SH,Lee CK,Bae SB,Kim HJ,Ahn TS,Lee MS,Baek MJ,Jeong D

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Serum thyrotropin (TSH) is a well-established growth factor for thyroid nodules and suppression of TSH concentrations by administering exogenous thyroxine may interfere with the growth of established nodules as well as the formation of new thyroid nodules. The aim of this study was to investigate whether serum ...

journal_title：Journal of cancer research and clinical oncology

authors： Polyzos SA,Kita M,Efstathiadou Z,Poulakos P,Slavakis A,Sofianou D,Flaris N,Leontsini M,Kourtis A,Avramidis A

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:The spread of malignant lymph nodes due to malignancies of the head and neck is systematically observed. However, sentinel lymph nodes in the cervical region, such as in the axillary or supraclavicular regions, are not described. Therefore, precise preoperative lymph node screening of all neck compartments is r...

journal_title：Journal of cancer research and clinical oncology

authors： Hohlweg-Majert B,Metzger MC,Voss PJ,Hölzle F,Wolff KD,Schulze D

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:Molecular mechanisms of response to hypomethylating agents in patients with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) still remain largely unknown. Therefore, the effects of 5-Azacytidine (Aza) on clonal architecture and DNA methylation were investigated in this study. METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Gawlitza AL,Speith J,Rinke J,Sajzew R,Müller EK,Schäfer V,Hochhaus A,Ernst T

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:To investigate the pattern and level of cyclooxygenase-2 (COX-2) expression in a series of high grade primary and recurrent glioblastoma multiforme (GBM) and correlation with time to recurrence and patients' survival following therapy. The relationship between COX-2 and epidermal growth factor receptor (EGFR) i...

journal_title：Journal of cancer research and clinical oncology

authors： Sminia P,Stoter TR,van der Valk P,Elkhuizen PH,Tadema TM,Kuipers GK,Vandertop WP,Lafleur MV,Slotman BJ

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To discover new molecular targets for cancer therapy and diagnosis, we surveyed signal transducers and activators of transcription 3 (Stat3)-regulated genes, because constitutive activation of Stat3 is associated with a wide variety of human malignancies. METHODS:We investigated the Stat3-regulated genes in 29...

journal_title：Journal of cancer research and clinical oncology

authors： Tomida M,Ohtake H,Yokota T,Kobayashi Y,Kurosumi M

更新日期：2008-05-01 00:00:00

abstract：AIMS:With three consecutive tetratricopeptide repeat (TPR) motifs at its C-terminus essential for neuronal migration, and a p23 domain at its N-terminus, DYX1C1 was the first gene proposed to have a role in developmental dyslexia. In this study, we attempted to identify the potential interaction of DYX1C1 and heat shoc...

journal_title：Journal of cancer research and clinical oncology

authors： Chen Y,Zhao M,Wang S,Chen J,Wang Y,Cao Q,Zhou W,Liu J,Xu Z,Tong G,Li J

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Hypersensitivity reactions (HSRs) to chemotherapy is an ongoing issue in cancer treatments. Strategies to induce tolerance and maximize chemotherapy efficacy include desensitization protocols. The precise impact of these protocols, however, in the long-term treatments remains unclear. We aim to compare overall ...

journal_title：Journal of cancer research and clinical oncology

authors： Altwerger G,Florsheim EB,Menderes G,Black J,Schwab C,Gressel GM,Nelson WK,Carusillo N,Passante T,Huang G,Litkouhi B,Azodi M,Silasi DA,Santin A,Schwartz PE,Ratner ES

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:We studied the antitumor activity of 2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one (Phx), which was synthesized by the reactions of 2-amino-5-methylphenol with bovine hemoglobin, on human B cell lymphoblastoid cell lines, P3HR-1 and Raji derived from African Burkitt's lymphoma, and the human T...

journal_title：Journal of cancer research and clinical oncology

authors： Koshibu-Koizumi J,Akazawa M,Iwamoto T,Takasaki M,Mizuno F,Kobayashi R,Abe A,Tomoda A,Hamatake M,Ishida R

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:Proliferation activity has long been known to be one of the strongest prognostic factors in many different cancers. Nevertheless, microscopic evaluation of mitotic figures remains time-consuming and, furthermore, is relatively subjective. As the expression of cytoskeleton-associated protein 2 (CKAP2) is closely...

journal_title：Journal of cancer research and clinical oncology

authors： Kim HS,Choi YB,Lee JH,Park SY,Kim HK,Koh JS,Yi SY,Kim KT,Hong KU,Park J,Bae CD,Hong KM

更新日期：2012-01-01 00:00:00

abstract：:Gastric and intestinal phenotypic cell markers are widely expressed in gastric carcinomas, irrespective of their histological type. In the present study, the relations between the phenotypic marker expression of the tumour, histological findings, expression of cell adhesion molecules, and the chromosomal changes in ga...

journal_title：Journal of cancer research and clinical oncology

authors： Morohara K,Tajima Y,Nakao K,Nishino N,Aoki S,Kato M,Sakamoto M,Yamazaki K,Kaetsu T,Suzuki S,Tsunoda A,Tachikawa T,Kusano M

更新日期：2006-06-01 00:00:00

abstract：INTRODUCTION:Aberrant expression of RNA-binding motif protein 3 (RBM3) has been suggested as a prognostic biomarker in several malignancies. MATERIALS AND METHODS:This study was performed to analyse the prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers (NSCLCs). Therefore, we t...

journal_title：Journal of cancer research and clinical oncology

authors： Melling N,Bachmann K,Hofmann B,El Gammal AT,Reeh M,Mann O,Moebius C,Blessmann M,Izbicki JR,Grupp K

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:To study the surgical outcomes of patients with a second primary lung cancer after the extrapulmonary malignancy. MATERIALS AND METHODS:Patients who underwent surgical resection for lung cancers between January 2005 and December 2014 were reviewed. Clinical data, imaging characteristics of tumors, surgical a...

journal_title：Journal of cancer research and clinical oncology

authors： Ko KH,Huang HK,Chen YI,Chang H,Tsai WC,Huang TW

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:The incidence and mortality of gastric and colorectal cancers are among the highest malignant tumors in China. The aim of this study is to investigate whether variations of the human oxoguanine glycosylase 1 (hOGG1) gene are related to the risk of gastric and colorectal cancers in the Chinese population. METHO...

journal_title：Journal of cancer research and clinical oncology

authors： Liu X,Xiao N,Guo W,Wu Y,Cai Z,He Q,Zhang L,Chen X,Sun C,Wang J,Zhu C,Jin H,Wang Y

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:To evaluate the role of radioembolization and systemic chemotherapy as a combined modality therapy for unresectable colorectal liver metastases. PATIENTS AND METHODS:Prospective database of a major yttrium-90 microsphere radioembolization treatment center in Sydney, Australia, that included 140 patients with u...

journal_title：Journal of cancer research and clinical oncology

authors： Chua TC,Bester L,Saxena A,Morris DL

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:Genomic stability is maintained by error-free DNA replication, repair, and recombination. To determine if repair genes contribute to genomic instability, we used a newly established cell line RCC-AJR (from clear-cell renal cell carcinoma) to examine hMSH2 (a mismatch-repair gene) and the gene encoding DNA beta ...

journal_title：Journal of cancer research and clinical oncology

authors： Chen HC,Bhattacharyya N,Wang L,Recupero AJ,Klein EA,Harter ML,Banerjee S

更新日期：2000-04-01 00:00:00

abstract：:Extracts from mistletoe (Viscum album L.) are assumed to exert an antineoplastic activity through their toxicity at high doses or by immunomodulation by nanogram quantities of a lectin. They are used as an unconventional therapy modality in the management of a wide range of cancer diseases, although no anticancer pote...

journal_title：Journal of cancer research and clinical oncology

authors： Kunze E,Schulz H,Gabius HJ

更新日期：1998-01-01 00:00:00