Abstract:
BACKGROUND:The aim of our study was to assess two tumor markers, carbohydrate antigen 724 (CA724) and neuron-specific enolase (NSE), in 20 healthy individuals. Then, we determined their average intra- and inter-individual biological variations (CVI and CVG ). METHODS:Blood samples were taken at weekly intervals for five weeks from 20 healthy subjects through a detailed questionnaire and physical examination. These samples were stored at -80°C and analyzed in a single run in duplicate. We calculated the biological variations, the reference change value (RCV), and the index of individuality (II) for the two tumor markers. RESULTS:The intra-individual and inter-individual biological variations were 50.3% and 103.4% for CA724, and 10.1% and 12.0% for NSE, respectively. The II values for CA724 and NSE were 0.48 and 0.85, respectively. CONCLUSION:We determined the biological variations and indices of individuality for CA724 and NSE among 20 healthy subjects. These results will improve clinical applications of the markers.
journal_name
J Clin Lab Analjournal_title
Journal of clinical laboratory analysisauthors
Wang S,Zhao M,Mu R,Zhang X,Yun K,Shang Hdoi
10.1002/jcla.22327subject
Has Abstractpub_date
2018-05-01 00:00:00pages
e22327issue
4eissn
0887-8013issn
1098-2825journal_volume
32pub_type
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journal_title:Journal of clinical laboratory analysis
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journal_title:Journal of clinical laboratory analysis
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