Abstract:
BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common malignant neoplasms worldwide. The p53 gene is frequently mutated in some histological subtypes of HCC. The role of p53 mutations and polymorphic variant of codon 72 in the prognosis of disease is still unclear. The p53 tumor suppressor gene Arg72Pro polymorphism has been associated with HCC. However, results were inconsistent. This meta-analysis was performed to estimate the association between p53 Arg72Pro polymorphism and HCC or HCC infected by HBV/HCV. METHODS:Electronic search of PubMed was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and pooled odds ratio (OR) with 95 % confidence interval (CI) was used to assess the association. RESULTS:Ten published studies, including 1,371 HCC cases and 2,517 controls were identified. The overall results suggested that the variant genotypes were associated with the HCC risk (Pro/Pro vs. Pro/Arg + Arg/Arg: OR 1.355, 95 % CI 1.041-1.764, p = 0.024). In the stratified analysis, individuals with the Pro/Pro in the recessive model had increased risk of HCC (OR 1.927, 95 % CI 1.127-3.297, p = 0.017) in Caucasian. A symmetric funnel plot, the Begg's test, was suggestive of the lack of publication bias. There was no association between the p53 codon 72 polymorphism and HBV/HCV-positive HCC. CONCLUSION:This meta-analysis suggests that p53 condon 72 Pro/Progenotypes are associated with increased risk of HCC in Caucasian. To validate this association, further studies with larger participants worldwide are needed to examine the associations between this polymorphism and HCC.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Jia S,Tang W,Luo Ydoi
10.1007/s12072-012-9389-9subject
Has Abstractpub_date
2013-06-01 00:00:00pages
669-75issue
2eissn
1936-0533issn
1936-0541pii
10.1007/s12072-012-9389-9journal_volume
7pub_type
杂志文章abstract:PURPOSE:To analyze the prognostic factors for the patients with lung metastases from hepatocellular carcinoma (HCC). METHODS AND MATERIALS:One hundred and five patients with lung metastases from HCC were analyzed retrospectively. We analyzed the impact factors, including the gender, age, liver function, serum AFP and ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9052-7
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:Despite improvements in immunosuppressive therapy, acute cellular rejection (ACR) remains an important cause of graft loss in patients undergoing liver transplantation. Recently, associations between cytokine gene polymorphisms in recipients and the occurrence of ACR have been reported. However, most studies di...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9443-2
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND AND AIMS:The liver plays a key role in the storage, metabolism and homeostasis of fat-soluble vitamins. We investigated the relation of Vitamin(Vit)A/D/E serum levels with severity of liver disease and portal hypertension (PHT). METHODS:VitA/D/E serum levels were assessed in 234 patients with advanced chron...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-020-10112-3
更新日期:2020-12-01 00:00:00
abstract::The prognosis of advanced hepatocellular carcinoma (HCC) remains poor. For patients with advanced HCC, the multikinase inhibitor sorafenib is recommended as the current standard of care. In contrast, hepatic arterial infusion chemotherapy (HAIC) is one of the recommended treatments in Japan. However, in Japan, the use...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9515-3
更新日期:2014-09-01 00:00:00
abstract::Hepatitis due to hepatitis B virus reactivation after cytotoxic or immunosuppressive therapy is a serious cause of liver-related morbidity and mortality. With the characterization of the underlying pathogenesis, much progress in the management of this important clinical problem has been made in the past 2 decades. By ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9056-3
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:Interferon-induced graft dysfunction (IGD) is a poorly defined, unrecognized, but potentially serious condition for patients receiving antiviral drugs after liver transplantation for hepatitis C. METHODS:We evaluated the characteristics of 80 patients who received pegylated interferon-based antiviral treatment...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9496-2
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Recently, Sofosbuvir was launched in India at affordable cost. We conducted a real-life study to determine the efficacy and safety of Sofosbuvir plus Ribavirin, with and without peginterferon-alfa 2a, in patients with chronic hepatitis C (CHC) genotype 3, the commonest genotype in South Asia. METHO...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-017-9794-1
更新日期:2017-05-01 00:00:00
abstract::Patients (85%) with hepatocellular adenoma (HCA) are women taking oral contraceptives. They can be divided into four subgroups according to their genotype/phenotype features. (1) Hepatocyte nuclear factor 1alpha (HNF1alpha) biallelic somatic mutations are observed in 35% of the HCA cases. It occurs in almost all cases...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9075-0
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Coronavirus disease 2019 (COVID-19) pandemic is ongoing. Except for lung injury, it is possible that COVID-19 patients develop liver injury. Thus, we conducted a systematic review and meta-analysis to explore the incidence, risk factors, and prognosis of abnormal liver biochemical tests in COVID-19 ...
journal_title:Hepatology international
pub_type: 杂志文章,meta分析
doi:10.1007/s12072-020-10074-6
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:The relationship between chronic hepatitis B virus (HBV) infection and fatty liver in patients remains unclear. Although high-fat diets-induced hepatic steatosis was proved to reduce HBV replication in transgenic mice, the interplay between HBV and fatty liver in immunocompetent mouse model is yet to be eluci...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-018-9877-7
更新日期:2018-09-01 00:00:00
abstract::Patients with chronic hepatitis C virus (HCV) infection experience a range of symptoms including depression, fatigue and neurocognitive deficits, impairing quality of life. Depression, in particular, may be reactive to increased psychosocial stress, and the physical symptoms of advanced HCV or associated comorbidities...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-018-9879-5
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:Either combination treatment or monotherapy using agents with a high genetic barrier are recommended for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB). The aim of this study was to compare effect of naïve HBeAg-negative CHB patients with either de novo combination of lamivudine (LAM) and adef...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9243-x
更新日期:2011-06-01 00:00:00
abstract::The bone marrow contains stem cells that have the potential to differentiate into a variety of organ-specific mature cells, including the liver and the pancreas. Recently, the origin of hepatic progenitors and hepatocytes was identified to be the bone marrow. However, evidence that describes which cells, among all bon...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-007-9031-4
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:Transcriptional silencing of tumor suppressor genes associated with DNA hypermethylation has been known as a hallmark of human cancer. In this study, we revealed that a local anesthetic, procaine (PCA), possessed growth-inhibitory and demethylating effect on human hepatoma cells in vitro and in vivo. METHODS:T...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-007-9014-5
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:To evaluate the recent topics of Ballloon-occluded retrograde trasnvenous obliteration(B-RTO). METHOD:We overviewed the recent scientific papers regarding B-RTO. RESULT:B-RTO is a treatment method for occluding varices retrogradely using a sclerosing agent under balloon occlusion of a major draining vein. It ...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-017-9813-2
更新日期:2018-02-01 00:00:00
abstract::The term nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of increasingly harmful conditions ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) to liver fibrosis and end-stage cirrhosis. NAFLD is the currently most common form of chronic liver disease in both adults and ch...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-019-10001-4
更新日期:2020-01-01 00:00:00
abstract::Along with the obesity epidemic, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased exponentially. The histological disease spectrum of NAFLD ranges from bland fatty liver (hepatic steatosis), to the concomitant presence of inflammation and ballooning which defines nonalcoholic steatohepatitis (N...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-015-9689-y
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND AND AIM:There is an increased awareness of de novo hepatitis B virus (HBV) infection (DNH) in hepatitis B surface antigen (HBsAg)-negative recipients receiving hepatitis B core antibody (HBcAb)-positive liver organ. Whether hepatitis B surface antibody (HBsAb) has positive result on preventing the occurrence...
journal_title:Hepatology international
pub_type: 杂志文章,meta分析
doi:10.1007/s12072-020-10021-5
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:The diagnostic potential of hepatic stellate cells (HSCs) and γδT cells for patients with hepatocellular carcinoma (HCC) and their synergistic contributions to the prognosis of these patients have not yet been investigated. The aim of this study was to elucidate the prognostic value of these cells in HCC. METH...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09969-w
更新日期:2019-09-01 00:00:00
abstract::Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease characterized by progressive destruction of small intrahepatic bile ducts. If left untreated, PBC may eventually result in end-stage liver disease. For better management of PBC and optimal allocation of med...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-017-9819-9
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is a progressive disease associated with rapid clinical worsening and high mortality. Early prediction of mortality and intervention can improve patient outcomes. We aimed to develop a dynamic prognostic model and compare it with the existing models. METHODS:A ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-017-9816-z
更新日期:2017-09-01 00:00:00
abstract::To address the relationship between hepatitis B virus (HBV) endemicity and HBV-related liver diseases in Mexico. Research literature reporting on HBsAg and antibody to hepatitis B core antigen (anti-HBc) prevalence in Mexican study groups were searched in NLM Gateway, PubMed, IMBIOMED, and others. Weighted mean preval...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9115-9
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is associated with a high mortality rate in the absence of liver transplantation. There is limited data on predictors of survival in ACLF in children. Therefore, we prospectively studied the predictors of outcome of ACLF in children. METHODS:A prospective evalu...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9217-z
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Sorafenib significantly improves survival in patients with advanced hepatocellular carcinoma (HCC). This phase IV study assessed sorafenib efficacy/safety in Taiwanese patients with advanced HCC and Child-Pugh A status. METHODS:All patients received 400 mg sorafenib BID. Safety, efficacy, sorafenib pharmaco...
journal_title:Hepatology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12072-016-9774-x
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Clevudine 30 mg showed potent antiviral activity with a marked post-treatment antiviral effect. However, long-term treatment with clevudine monotherapy induced resistance and myopathy in some cases. The objective of this study is to evaluate the preliminary efficacy and safety of the combination of clevudine 20...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-014-9537-5
更新日期:2014-05-25 00:00:00
abstract::Immunomodulatory cell therapy as a complement to standard pharmacotherapy represents a novel approach to solid organ allograft acceptance. This methodology may allow for a reduced dose of immunosuppressive drug to be administered and thus attenuate the severe side effects associated with long-term immunosuppression su...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9509-1
更新日期:2014-04-01 00:00:00
abstract::Cirrhotic cardiomyopathy is a recently recognized condition in cirrhosis consisting of systolic incompetence under condition of stress, diastolic dysfunction related to altered diastolic relaxation, and electrophysiological abnormalities in the absence of any known cardiac disease. It can be diagnosed by using a combi...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9109-7
更新日期:2009-03-01 00:00:00
abstract::Hepatitis B virus (HBV) reactivation with hepatic decompensation leading to acute on chronic liver failure is not uncommon. It is associated with high mortality of up to 30-70%. Prognostic factors for mortality include high bilirubin level, more prolonged prothrombin time, low platelet count and presence of pre-existi...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-014-9569-x
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Compositional changes of the gut microbiota are known to occur in patients with nonalcoholic fatty liver disease (NAFLD); however, the changes did not corroborate between the studies. We evaluated the gut microbiota between NAFLD and non-NAFLD participants, excluding the influence of obesity and sex in this ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09987-8
更新日期:2019-11-01 00:00:00
abstract::Substantial advancements in the field of primary biliary cirrhosis (PBC) research have broadened our understanding of this enigmatic disease. Genome-wide studies have identified several new candidate genes involved in the immunoregulatory process, particularly those responsible for antigen presentation and lymphocyte ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9362-7
更新日期:2013-03-01 00:00:00