Abstract:
:The prognosis of advanced hepatocellular carcinoma (HCC) remains poor. For patients with advanced HCC, the multikinase inhibitor sorafenib is recommended as the current standard of care. In contrast, hepatic arterial infusion chemotherapy (HAIC) is one of the recommended treatments in Japan. However, in Japan, the use of sorafenib versus hepatic arterial infusion chemotherapy for first-line treatment remains unclear, because there have been no randomized controlled trials comparing HAIC with sorafenib. HAIC can substantially prolong survival in patients with complete and partial response, while non-responders may be suitable candidates for sorafenib therapy. Nonetheless, HAIC non-responders with deteriorated liver function currently have no treatment options. We have shown the efficacy of an alternative therapy, the iron chelator deferoxamine, for advanced HCC patients with deteriorated liver function. Iron chelators may have future therapeutic possibilities in this patient population.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Yamasaki T,Saeki I,Sakaida Idoi
10.1007/s12072-013-9515-3subject
Has Abstractpub_date
2014-09-01 00:00:00pages
492-8eissn
1936-0533issn
1936-0541pii
10.1007/s12072-013-9515-3journal_volume
8 Suppl 2pub_type
杂志文章abstract::Patients with chronic hepatitis C virus (HCV) infection experience a range of symptoms including depression, fatigue and neurocognitive deficits, impairing quality of life. Depression, in particular, may be reactive to increased psychosocial stress, and the physical symptoms of advanced HCV or associated comorbidities...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-018-9879-5
更新日期:2018-07-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a common malignant tumor with high lethality, and the hepatitis B virus (HBV) is a chief cause. HBV can accelerate HCC via multiple mechanisms. First, HBV induces immune reactions that lead to repeated hepatic inflammation, fibrosis and a deficient immune microenvironment. Subsequentl...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-016-9779-5
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Status 1A patients are prioritized over end-stage liver disease (ESLD) for liver transplantation (LT). ESLD patients with high MELD may have higher waitlist mortality than Status 1A patients, and may require LT more urgently. METHODS:Using United Network for Organ Sharing registry data, we retrospe...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-016-9735-4
更新日期:2016-09-01 00:00:00
abstract::Patients (85%) with hepatocellular adenoma (HCA) are women taking oral contraceptives. They can be divided into four subgroups according to their genotype/phenotype features. (1) Hepatocyte nuclear factor 1alpha (HNF1alpha) biallelic somatic mutations are observed in 35% of the HCA cases. It occurs in almost all cases...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9075-0
更新日期:2008-09-01 00:00:00
abstract::In patients with chronic hepatitis B (CHB), liver fibrosis assessment is essential not only for determining prognosis but also for identifying patients who should receive treatment. Liver biopsy is limited by its invasiveness and sampling error. To explore effective non-invasive methods for liver fibrosis assessment, ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9439-y
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:Interferon-induced graft dysfunction (IGD) is a poorly defined, unrecognized, but potentially serious condition for patients receiving antiviral drugs after liver transplantation for hepatitis C. METHODS:We evaluated the characteristics of 80 patients who received pegylated interferon-based antiviral treatment...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9496-2
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:Cholecystectomy is routinely performed at most transplant centers during living donor liver transplantation (LDLT). This study was performed to evaluate the feasibility of liver graft procurement with donor gallbladder preservation in LDLT. METHODS:Eighty-nine LDLTs (from June 2006 to Dec 2012) were retrospe...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9628-y
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND AND AIMS:The progression of HBsAg-positive chronic hepatitis is insidious and unpredictable. Identification of factors leading to either a benign or more serious clinical outcome may assist in decision making for antiviral therapy. METHODS:From 1989 to 1998, 130 untreated patients with chronic hepatitis wer...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9651-z
更新日期:2015-10-01 00:00:00
abstract::The presence of hepatic encephalopathy (HE) within 4 weeks is part of the criteria for defining acute-on-chronic liver failure (ACLF). The pathophysiology of HE is complex, and hyperammonemia and cerebral hemodynamic dysfunction appear to be central in the pathogenesis of encephalopathy. Recent data also suggest that ...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-015-9626-0
更新日期:2015-10-01 00:00:00
abstract::Portal hypertension develops as a result of increased intrahepatic vascular resistance often caused by chronic liver disease that leads to structural distortion by fibrosis, microvascular thrombosis, dysfunction of liver sinusoidal endothelial cells (LSECs), and hepatic stellate cell (HSC) activation. While the basic ...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-017-9826-x
更新日期:2018-02-01 00:00:00
abstract:AIMS:Relationships of renal function and liver disease are described in acute and chronic liver failure. The aim of the study is to investigate which relationship, if any, is present between severity of non-alcoholic fatty liver disease (NAFLD), assessed by bright liver score (BLS) versus mild-moderate renal insufficie...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9254-2
更新日期:2011-09-01 00:00:00
abstract::Chronic hepatitis B virus (HBV) infection is endemic in the Asian-Pacific region, and reactivation of HBV post-cancer chemotherapy has become an emerging clinical challenge. Patients with detectable serum HBV DNA before chemotherapy and those receiving intensive chemotherapy are particularly at a risk of HBV reactivat...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9279-6
更新日期:2013-06-01 00:00:00
abstract::Hepatitis C virus (HCV) treatment in HIV/HCV co-infected individuals has renewed relevance given the ongoing opioid crisis and rise of new HIV and HCV infections associated with injection drug use. Patients co-infected with HIV and HCV demonstrate increased rates of hepatic fibrosis, progression to liver failure, and ...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-018-9896-4
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND/AIMS:[corrected] The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. METHODS:The patients with liver tumor or chronic hepatitis i...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9223-1
更新日期:2010-10-08 00:00:00
abstract::Reactive oxygen and nitrogen species (ROS and RNS) are produced by metabolism of normal cells. However, in liver diseases, redox is increased thereby damaging the hepatic tissue; the capability of ethanol to increase both ROS/RNS and peroxidation of lipids, DNA, and proteins was demonstrated in a variety of systems, c...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-009-9158-6
更新日期:2009-12-01 00:00:00
abstract:GOALS:The aim of our study is to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis in patients with type 1 diabetes (T1D) using simple noninvasive scores. BACKGROUND:There is paucity of data on the prevalence of NAFLD in T1D. Moreover, T1D could be a risk factor for advanc...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-017-9840-z
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:The diagnostic potential of hepatic stellate cells (HSCs) and γδT cells for patients with hepatocellular carcinoma (HCC) and their synergistic contributions to the prognosis of these patients have not yet been investigated. The aim of this study was to elucidate the prognostic value of these cells in HCC. METH...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09969-w
更新日期:2019-09-01 00:00:00
abstract::The cancer stem cell (CSC) hypothesis has been disproved in many cancers. CSCs may exist in blood cancer, while many epithelial cancers may not have CSCs but tumor-initiating cells (TICs). Several independent studies have provided strong evidence for existence of CSCs in brain, skin, and colon cancers (Mani et al. in ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-016-9777-7
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Possible serologic activity after hepatitis B surface antigen (HBsAg) seroclearance documented by conventional assays in chronic hepatitis B (CHB) has not been thoroughly investigated. METHODS:We determined the levels of serum hepatitis B virus (HBV) DNA, hepatitis B core-related antigen (HBcrAg), and linea...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9354-7
更新日期:2012-03-13 00:00:00
abstract:PURPOSE:To analyze the prognostic factors for the patients with lung metastases from hepatocellular carcinoma (HCC). METHODS AND MATERIALS:One hundred and five patients with lung metastases from HCC were analyzed retrospectively. We analyzed the impact factors, including the gender, age, liver function, serum AFP and ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9052-7
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Compositional changes of the gut microbiota are known to occur in patients with nonalcoholic fatty liver disease (NAFLD); however, the changes did not corroborate between the studies. We evaluated the gut microbiota between NAFLD and non-NAFLD participants, excluding the influence of obesity and sex in this ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09987-8
更新日期:2019-11-01 00:00:00
abstract::Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease, characterized by multiple strictures and dilatations of the intra- and extrahepatic bile ducts, leading to progressive liver fibrosis, in 10-15% cholangiocarcinoma, and ultimately end-stage liver disease. The pathogenesis is poorly understood, b...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-020-10118-x
更新日期:2020-12-30 00:00:00
abstract::Liver transplantation is a definitive therapy for patients with end-stage liver disease and cirrhosis, with improvement in survival and quality of life. Patients are carefully screened and selected for this modality of treatment to achieve maximum survival benefit. For example, a patient with hepatocellular carcinoma ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-016-9770-1
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND AIMS:A discrepancy in virological and biochemical responses may occur throughout interferon-based therapy for hepatitis C virus (HCV). We aimed to explore the risk, associated factors, potential mechanisms, and impact on the treatment outcome of the discrepancy. SUBJECTS AND METHODS:Consecutive 496, chr...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9388-x
更新日期:2013-03-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is currently one of the leading forms of chronic liver disease, and its rising frequency worldwide has reached epidemic proportions. NAFLD, particularly its progressive variant NASH (non-alcoholic steatohepatitis), can lead to advanced fibrosis, cirrhosis, and HCC. The pathoph...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-018-9854-1
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND AND OBJECT:The risk of occult HBV infection (OBI) in children whose mothers are HBV carriers has received more widespread attention, but there were few reports to focus on the children with HBsAg-positive parents. In this study, we aimed to investigate the prevalence of OBI in immunized children with HBsAg-p...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-020-10055-9
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND AND AIM:There is an increased awareness of de novo hepatitis B virus (HBV) infection (DNH) in hepatitis B surface antigen (HBsAg)-negative recipients receiving hepatitis B core antibody (HBcAb)-positive liver organ. Whether hepatitis B surface antibody (HBsAb) has positive result on preventing the occurrence...
journal_title:Hepatology international
pub_type: 杂志文章,meta分析
doi:10.1007/s12072-020-10021-5
更新日期:2020-03-01 00:00:00
abstract::Cirrhotic cardiomyopathy is a recently recognized condition in cirrhosis consisting of systolic incompetence under condition of stress, diastolic dysfunction related to altered diastolic relaxation, and electrophysiological abnormalities in the absence of any known cardiac disease. It can be diagnosed by using a combi...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9109-7
更新日期:2009-03-01 00:00:00
abstract:PURPOSE/BACKGROUND:Severe alcoholic hepatitis (AH) is a life-threatening liver disease with a potential of 30-40 % mortality at 1 month. While steroids remain to be a first line therapy, they provide only about 50 % survival benefit. The aim of the study was to evaluate the efficacy of glucocorticoids plus S-adenosylme...
journal_title:Hepatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s12072-016-9751-4
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:There is much controversy surrounding the natural history of hepatitis C virus (HCV) infection. AIMS:The aim of this review was to review the natural history of HCV infection. METHODS:Published English literature was searched via pubmed and then reviewed. RESULTS:Approximately, 75-85% of HCV-infected pers...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9355-6
更新日期:2012-10-01 00:00:00