Abstract:
:Chronic hepatitis B virus (HBV) infection is endemic in the Asian-Pacific region, and reactivation of HBV post-cancer chemotherapy has become an emerging clinical challenge. Patients with detectable serum HBV DNA before chemotherapy and those receiving intensive chemotherapy are particularly at a risk of HBV reactivation. Most patients with HBV reactivation are positive for hepatitis B surface antigen (HBsAg) and are, therefore, easily identified by recommended serological screening before chemotherapy. However, a small, but significant proportion of subjects who have apparently recovered from HBV infection as reflected by HBsAg negativity and hepatitis B core antibody positivity in HBV endemic areas may also experience reactivation when host immunity is severely compromised by cancer chemotherapy. Serum alanine aminotransferase, HBsAg, and/or HBV DNA should be monitored closely in these subjects and antiviral therapy should be administered immediately when any evidence of HBV reactivation is detected during chemotherapy. The prophylactic use of nucleos(t)ide analogs before chemotherapy and its continuation until reconstitution of host immunity remain the mainstay of effective prevention of hepatitis B reactivation in this special clinical entity.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Liu CJ,Chen PJ,Chen DS,Kao JHdoi
10.1007/s12072-011-9279-6subject
Has Abstractpub_date
2013-06-01 00:00:00pages
316-26issue
2eissn
1936-0533issn
1936-0541pii
10.1007/s12072-011-9279-6journal_volume
7pub_type
杂志文章abstract::Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease, characterized by multiple strictures and dilatations of the intra- and extrahepatic bile ducts, leading to progressive liver fibrosis, in 10-15% cholangiocarcinoma, and ultimately end-stage liver disease. The pathogenesis is poorly understood, b...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-020-10118-x
更新日期:2020-12-30 00:00:00
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journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-017-9813-2
更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s12072-020-10108-z
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journal_title:Hepatology international
pub_type: 社论
doi:10.1007/s12072-017-9793-2
更新日期:2017-05-01 00:00:00
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journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-007-9032-3
更新日期:2008-03-01 00:00:00
abstract::Spontaneous bacterial peritonitis (SBP) is a common cause of morbidity and mortality in patients with advanced cirrhosis and portal hypertension. While gram-negative rods and Enterococcus species are the common offending organisms, Salmonella has also been recognized as a rare and atypical offending organism. Atypical...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9087-9
更新日期:2008-09-01 00:00:00
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journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9439-y
更新日期:2013-06-01 00:00:00
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journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9243-x
更新日期:2011-06-01 00:00:00
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journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09969-w
更新日期:2019-09-01 00:00:00
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journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9378-z
更新日期:2013-03-01 00:00:00
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journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-015-9701-6
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Compositional changes of the gut microbiota are known to occur in patients with nonalcoholic fatty liver disease (NAFLD); however, the changes did not corroborate between the studies. We evaluated the gut microbiota between NAFLD and non-NAFLD participants, excluding the influence of obesity and sex in this ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09987-8
更新日期:2019-11-01 00:00:00
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journal_title:Hepatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s12072-016-9751-4
更新日期:2016-11-01 00:00:00
abstract::The term nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of increasingly harmful conditions ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) to liver fibrosis and end-stage cirrhosis. NAFLD is the currently most common form of chronic liver disease in both adults and ch...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-019-10001-4
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/PURPOSE:In Japan, there is a growing population of patients with chronic hepatitis C virus (HCV) infection who failed a direct-acting antiviral (DAA)-based regimen. In this Phase 3 study, we evaluated sofosbuvir-velpatasvir plus ribavirin in Japanese patients with genotype 1 or 2 HCV infection who previously...
journal_title:Hepatology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12072-018-9878-6
更新日期:2018-07-01 00:00:00
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journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9109-7
更新日期:2009-03-01 00:00:00
abstract::Duodenal varices are a rare complication in patients with portal hypertension. Bleeding from duodenal varices often results in a severe prognosis. Diagnosis of the disease is usually based on findings obtained by endoscopy or angiography. However, it occasionally fails to detect the lesion and demonstrate its porto-sy...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9191-5
更新日期:2010-07-24 00:00:00
abstract:BACKGROUND/AIMS:[corrected] The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. METHODS:The patients with liver tumor or chronic hepatitis i...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9223-1
更新日期:2010-10-08 00:00:00
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journal_title:Hepatology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12072-016-9774-x
更新日期:2017-03-01 00:00:00
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journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9179-1
更新日期:2010-04-07 00:00:00
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journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-007-9031-4
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Controversy exists on whether tenofovir disoproxil fumarate (TDF) is superior to entecavir (ETV) in lowering the risk of hepatocellular carcinoma (HCC) development. This meta-analysis was performed to clarify this issue with critical clinical and methodological considerations. METHODS:PubMed, EMBASE, and Co...
journal_title:Hepatology international
pub_type: 杂志文章,meta分析
doi:10.1007/s12072-019-10005-0
更新日期:2020-01-01 00:00:00
abstract::Substantial advancements in the field of primary biliary cirrhosis (PBC) research have broadened our understanding of this enigmatic disease. Genome-wide studies have identified several new candidate genes involved in the immunoregulatory process, particularly those responsible for antigen presentation and lymphocyte ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9362-7
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Possible serologic activity after hepatitis B surface antigen (HBsAg) seroclearance documented by conventional assays in chronic hepatitis B (CHB) has not been thoroughly investigated. METHODS:We determined the levels of serum hepatitis B virus (HBV) DNA, hepatitis B core-related antigen (HBcrAg), and linea...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9354-7
更新日期:2012-03-13 00:00:00
abstract:BACKGROUND AND AIMS:A discrepancy in virological and biochemical responses may occur throughout interferon-based therapy for hepatitis C virus (HCV). We aimed to explore the risk, associated factors, potential mechanisms, and impact on the treatment outcome of the discrepancy. SUBJECTS AND METHODS:Consecutive 496, chr...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9388-x
更新日期:2013-03-01 00:00:00
abstract::Hepatitis C virus (HCV) treatment in HIV/HCV co-infected individuals has renewed relevance given the ongoing opioid crisis and rise of new HIV and HCV infections associated with injection drug use. Patients co-infected with HIV and HCV demonstrate increased rates of hepatic fibrosis, progression to liver failure, and ...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-018-9896-4
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND AND AIMS:The progression of HBsAg-positive chronic hepatitis is insidious and unpredictable. Identification of factors leading to either a benign or more serious clinical outcome may assist in decision making for antiviral therapy. METHODS:From 1989 to 1998, 130 untreated patients with chronic hepatitis wer...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9651-z
更新日期:2015-10-01 00:00:00
abstract::Portal hypertension develops as a result of increased intrahepatic vascular resistance often caused by chronic liver disease that leads to structural distortion by fibrosis, microvascular thrombosis, dysfunction of liver sinusoidal endothelial cells (LSECs), and hepatic stellate cell (HSC) activation. While the basic ...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-017-9826-x
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Early prediction of lamivudine (LAM) response by individualized monitoring of serum HBV DNA like roadmap concept, and investigation of the outcome after LAM discontinuation in renal transplant recipients (RTRs) with chronic hepatitis B (CHB). METHODS:We conducted a study on 19 RTRs with HBV infection receiv...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9295-6
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND AIMS:The liver plays a key role in the storage, metabolism and homeostasis of fat-soluble vitamins. We investigated the relation of Vitamin(Vit)A/D/E serum levels with severity of liver disease and portal hypertension (PHT). METHODS:VitA/D/E serum levels were assessed in 234 patients with advanced chron...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-020-10112-3
更新日期:2020-12-01 00:00:00