Abstract：
:The term nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of increasingly harmful conditions ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) to liver fibrosis and end-stage cirrhosis. NAFLD is the currently most common form of chronic liver disease in both adults and children worldwide. As NAFLD evolves as a global pandemic alongside the still growing prevalence of metabolic syndrome, obesity, and diabetes, it is inevitable to develop effective counterstrategies. Over the last decades, great effort has been dedicated to the understanding of the pathogenesis of NAFLD. This includes the development of an array of models for NAFLD, ranging from advanced in vitro (primary cells, 3D cultures, biochip, spheroids, organoids) to in vivo rodent models (particularly in mice). Based on these approaches novel therapies have been proposed and subsequently evaluated for patients with advanced forms of NAFLD, in particular those with NASH and liver fibrosis or cirrhosis. In this review, we delineate the current understanding of disease pathophysiology and depict how novel therapeutic strategies aim to exploit these different mechanisms to ameliorate, treat, or stop progression of NASH. We also discuss obstacles and chances along the way from basic models to promising clinical treatment options.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Reimer KC,Wree A,Roderburg C,Tacke Fdoi
10.1007/s12072-019-10001-4subject
Has Abstractpub_date
2020-01-01 00:00:00pages
8-23issue
1eissn
1936-0533issn
1936-0541pii
10.1007/s12072-019-10001-4journal_volume
14pub_type
杂志文章,评审abstract：PURPOSE:Ethanol binge augments liver injury after chronic ethanol consumption in humans, but the mechanism behind the enhanced liver injury by ethanol binge is not known. In this study we used a clinically relevant rat model in which liver injury is amplified by binge after chronic ethanol treatment and investigated th...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-014-9546-4
更新日期：2014-09-01 00:00:00
abstract：:The prognosis of advanced hepatocellular carcinoma (HCC) remains poor. For patients with advanced HCC, the multikinase inhibitor sorafenib is recommended as the current standard of care. In contrast, hepatic arterial infusion chemotherapy (HAIC) is one of the recommended treatments in Japan. However, in Japan, the use...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-013-9515-3
更新日期：2014-09-01 00:00:00
abstract：:More than 170 million people worldwide are infected with hepatitis C virus (HCV). A characteristic of this virus is a high tendency toward chronic infection. Several factors affect the viral outcome after infection. Among them, HCV-specific CD4 T cells are thought to play a crucial role in controlling viremia. Cumulat...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9321-8
更新日期：2012-01-01 00:00:00
abstract：:An ultrasound (US) examination is a common noninvasive technique widely applied for diagnosis of a variety of diseases. Based on the rapid development of US equipment, many US images have been accumulated and are now available and ready for the preparation of a database for the development of computer-aided US diagnos...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-019-09937-4
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Sorafenib significantly improves survival in patients with advanced hepatocellular carcinoma (HCC). This phase IV study assessed sorafenib efficacy/safety in Taiwanese patients with advanced HCC and Child-Pugh A status. METHODS:All patients received 400 mg sorafenib BID. Safety, efficacy, sorafenib pharmaco...
journal_title：Hepatology international
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s12072-016-9774-x
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:The relationship between chronic hepatitis B virus (HBV) infection and fatty liver in patients remains unclear. Although high-fat diets-induced hepatic steatosis was proved to reduce HBV replication in transgenic mice, the interplay between HBV and fatty liver in immunocompetent mouse model is yet to be eluci...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-018-9877-7
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND AND AIM:There is an increased awareness of de novo hepatitis B virus (HBV) infection (DNH) in hepatitis B surface antigen (HBsAg)-negative recipients receiving hepatitis B core antibody (HBcAb)-positive liver organ. Whether hepatitis B surface antibody (HBsAb) has positive result on preventing the occurrence...
journal_title：Hepatology international
pub_type： 杂志文章,meta分析
doi：10.1007/s12072-020-10021-5
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:All previous studies reported the benefit of antibiotic prophylaxis in cirrhotic patients with either a mixture of nonvariceal and variceal bleeding or variceal bleeding alone. Reports on sole peptic ulcers bleeding are lacking. We aimed to assess the effect of antibiotic prophylaxis in cirrhotic patients with ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-012-9378-z
更新日期：2013-03-01 00:00:00
abstract：PURPOSE:The diagnostic potential of hepatic stellate cells (HSCs) and γδT cells for patients with hepatocellular carcinoma (HCC) and their synergistic contributions to the prognosis of these patients have not yet been investigated. The aim of this study was to elucidate the prognostic value of these cells in HCC. METH...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-019-09969-w
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:There have been reports that radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) is as equally effective as surgical resection for the treatment of hepatocellular carcinoma (HCC). This study aimed to evaluate recurrence rate and risk factor of recurrence after RFA combined with TA...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9290-y
更新日期：2012-04-01 00:00:00
abstract：:Portal hypertension develops as a result of increased intrahepatic vascular resistance often caused by chronic liver disease that leads to structural distortion by fibrosis, microvascular thrombosis, dysfunction of liver sinusoidal endothelial cells (LSECs), and hepatic stellate cell (HSC) activation. While the basic ...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-017-9826-x
更新日期：2018-02-01 00:00:00
abstract：:Substantial advancements in the field of primary biliary cirrhosis (PBC) research have broadened our understanding of this enigmatic disease. Genome-wide studies have identified several new candidate genes involved in the immunoregulatory process, particularly those responsible for antigen presentation and lymphocyte ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-012-9362-7
更新日期：2013-03-01 00:00:00
abstract：:Since their original identification, our understanding of the role of hepatic stellate cells in both health and disease continues to grow. Numerous studies have delineated the role of stellate cell activation in contributing to the pool of myofibroblasts responsible for liver fibrosis, and these have resulted in the d...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-016-9758-x
更新日期：2016-11-01 00:00:00
abstract：:The bone marrow contains stem cells that have the potential to differentiate into a variety of organ-specific mature cells, including the liver and the pancreas. Recently, the origin of hepatic progenitors and hepatocytes was identified to be the bone marrow. However, evidence that describes which cells, among all bon...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-007-9031-4
更新日期：2008-03-01 00:00:00
abstract：PURPOSE/BACKGROUND:Severe alcoholic hepatitis (AH) is a life-threatening liver disease with a potential of 30-40 % mortality at 1 month. While steroids remain to be a first line therapy, they provide only about 50 % survival benefit. The aim of the study was to evaluate the efficacy of glucocorticoids plus S-adenosylme...
journal_title：Hepatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s12072-016-9751-4
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND AND AIMS:Ultrasonography is the most frequently used modality in surveillance for HCC among patients with chronic hepatitis C. However, the optimal surveillance interval is still controversial and the usefulness of supplementary tumor marker determination has not been confirmed. METHODS:A total of 243 cases...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-009-9145-y
更新日期：2009-12-01 00:00:00
abstract：:Hepatitis C virus (HCV) treatment in HIV/HCV co-infected individuals has renewed relevance given the ongoing opioid crisis and rise of new HIV and HCV infections associated with injection drug use. Patients co-infected with HIV and HCV demonstrate increased rates of hepatic fibrosis, progression to liver failure, and ...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-018-9896-4
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND AND AIMS:The progression of HBsAg-positive chronic hepatitis is insidious and unpredictable. Identification of factors leading to either a benign or more serious clinical outcome may assist in decision making for antiviral therapy. METHODS:From 1989 to 1998, 130 untreated patients with chronic hepatitis wer...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-015-9651-z
更新日期：2015-10-01 00:00:00
abstract：:Hepatitis due to hepatitis B virus reactivation after cytotoxic or immunosuppressive therapy is a serious cause of liver-related morbidity and mortality. With the characterization of the underlying pathogenesis, much progress in the management of this important clinical problem has been made in the past 2 decades. By ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-008-9056-3
更新日期：2008-06-01 00:00:00
abstract：PURPOSE:To analyze the prognostic factors for the patients with lung metastases from hepatocellular carcinoma (HCC). METHODS AND MATERIALS:One hundred and five patients with lung metastases from HCC were analyzed retrospectively. We analyzed the impact factors, including the gender, age, liver function, serum AFP and ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-008-9052-7
更新日期：2008-06-01 00:00:00
abstract：:In a country such as Japan with the average age of patients with chronic hepatitis C treated with antivirals sometimes well above 60 years, the standard combination therapy is not well tolerated. In this randomized, prospective, controlled trial, we investigated the efficacy of 24-week peginterferon α monotherapy for ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-009-9134-1
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Possible serologic activity after hepatitis B surface antigen (HBsAg) seroclearance documented by conventional assays in chronic hepatitis B (CHB) has not been thoroughly investigated. METHODS:We determined the levels of serum hepatitis B virus (HBV) DNA, hepatitis B core-related antigen (HBcrAg), and linea...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-012-9354-7
更新日期：2012-03-13 00:00:00
abstract：BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is associated with a high mortality rate in the absence of liver transplantation. There is limited data on predictors of survival in ACLF in children. Therefore, we prospectively studied the predictors of outcome of ACLF in children. METHODS:A prospective evalu...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-010-9217-z
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND AND AIMS:The peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand, piglitazone, enhances the degradation of branched-chain amino acids (BCAAs) in adipose tissue. However, it remains unknown whether pioglitazone influences the plasma amino acids (AA) profile in patients with nonalcoholic steatohepatit...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-012-9395-y
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:To compare the efficacy of entecavir (ETV) monotherapy up to 4 years in nucleos(t)ide analog (NA)-experienced and -naïve subjects. METHODS:One hundred sixty NA-experienced and 282 naïve chronic hepatitis B patients who were treated with ETV were enrolled. Of the 160 NA-experienced patients, 49 had prior lamivu...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-013-9440-5
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Initial presentation of hepatocellular carcinoma (HCC) at an advanced stage in patients under a regular surveillance program is a devastating problem. AIMS:We assessed the prevalence and factors associated with this surveillance failure. METHODS:A total of 304 HCC patients who received regular surveillance...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-013-9462-z
更新日期：2013-10-01 00:00:00
abstract：:Patients (85%) with hepatocellular adenoma (HCA) are women taking oral contraceptives. They can be divided into four subgroups according to their genotype/phenotype features. (1) Hepatocyte nuclear factor 1alpha (HNF1alpha) biallelic somatic mutations are observed in 35% of the HCA cases. It occurs in almost all cases...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-008-9075-0
更新日期：2008-09-01 00:00:00
abstract：:Along with the obesity epidemic, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased exponentially. The histological disease spectrum of NAFLD ranges from bland fatty liver (hepatic steatosis), to the concomitant presence of inflammation and ballooning which defines nonalcoholic steatohepatitis (N...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-015-9689-y
更新日期：2016-05-01 00:00:00
abstract：PURPOSE:To evaluate the recent topics of Ballloon-occluded retrograde trasnvenous obliteration(B-RTO). METHOD:We overviewed the recent scientific papers regarding B-RTO. RESULT:B-RTO is a treatment method for occluding varices retrogradely using a sclerosing agent under balloon occlusion of a major draining vein. It ...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-017-9813-2
更新日期：2018-02-01 00:00:00
abstract：:Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease characterized by progressive destruction of small intrahepatic bile ducts. If left untreated, PBC may eventually result in end-stage liver disease. For better management of PBC and optimal allocation of med...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-017-9819-9
更新日期：2017-09-01 00:00:00
