CSH guidelines for the diagnosis and treatment of drug-induced liver injury.

abstract：:NAFLD is a spectrum of liver disease starting with fatty liver at one end of the spectrum and cirrhosis or liver cancer at the other end. Worldwide, NAFLD has become one of the most common liver diseases and it has also become one of the leading indications for liver transplantation. Our understanding of the NAFLD epi...

journal_title：Hepatology international

authors： Alukal JJ,Thuluvath PJ

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Although arterial stiffness has been reported to be associated with nonalcoholic fatty liver disease (NAFLD), previous studies have relied only on noninvasive assessments for the diagnosis of NAFLD. This study attempted to investigate the association of arterial stiffness with the histological severity of NA...

journal_title：Hepatology international

authors： Kim HL,Koo BK,Joo SK,Kim W

更新日期：2020-12-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is currently one of the leading forms of chronic liver disease, and its rising frequency worldwide has reached epidemic proportions. NAFLD, particularly its progressive variant NASH (non-alcoholic steatohepatitis), can lead to advanced fibrosis, cirrhosis, and HCC. The pathoph...

journal_title：Hepatology international

authors： Kovalic AJ,Satapathy SK,Chalasani N

更新日期：2018-03-01 00:00:00

abstract：:Alcoholic liver disease (ALD) is a leading cause of liver-related morbidity and mortality worldwide. ALD encompasses a spectrum of disorders including asymptomatic steatosis, steatohepatitis, fibrosis, cirrhosis and its related complications, and the acute-on-chronic state of alcoholic hepatitis. While multidisciplina...

journal_title：Hepatology international

authors： Arsene D,Farooq O,Bataller R

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND AIM:There is an increased awareness of de novo hepatitis B virus (HBV) infection (DNH) in hepatitis B surface antigen (HBsAg)-negative recipients receiving hepatitis B core antibody (HBcAb)-positive liver organ. Whether hepatitis B surface antibody (HBsAb) has positive result on preventing the occurrence...

journal_title：Hepatology international

authors： Yang Y,Huang A,Zhao Y

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:Hepatitis B viral markers may be useful for predicting outcomes such as liver-related deaths or development of hepatocellular carcinoma. We determined the frequency of these markers in different clinical stages of chronic hepatitis B infection. METHODS:We compared baseline hepatitis B viral markers in 317 pati...

journal_title：Hepatology international

authors： Tong MJ,Hsu L,Hsien C,Kao JH,Durazo FA,Saab S,Blatt LM

更新日期：2010-04-07 00:00:00

abstract：BACKGROUND AND AIMS:Coagulopathic bleeding risk prediction is challenging in decompensated cirrhosis (DC) by conventional assays. Viscoelastic tests (VETs) are likely to be more useful for assessing coagulation status in these patients. We investigated whether the VET (Sonoclot) parameters with fibrinogen could predict...

journal_title：Hepatology international

authors： Bihari C,Patil A,Shasthry SM,Baweja S,Kumar G,Sarin SK

更新日期：2020-07-01 00:00:00

abstract：:Solitary necrotic nodules of the liver occur rarely. Although these nodules are usually benign, they are surgically removed in most cases because they cannot be differentiated from malignant lesions. To date, the natural history of solitary fibrous nodules remains unclear. We present the case of an incidentally detect...

journal_title：Hepatology international

authors： Choi CS,Cho EY,Jeong JS,Im CJ,Yang BJ,Kim HC

更新日期：2010-07-29 00:00:00

abstract：:Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease, characterized by multiple strictures and dilatations of the intra- and extrahepatic bile ducts, leading to progressive liver fibrosis, in 10-15% cholangiocarcinoma, and ultimately end-stage liver disease. The pathogenesis is poorly understood, b...

journal_title：Hepatology international

authors： Prokopič M,Beuers U

更新日期：2020-12-30 00:00:00

abstract：:Since their original identification, our understanding of the role of hepatic stellate cells in both health and disease continues to grow. Numerous studies have delineated the role of stellate cell activation in contributing to the pool of myofibroblasts responsible for liver fibrosis, and these have resulted in the d...

journal_title：Hepatology international

authors： Bansal MB

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is associated with a high mortality rate in the absence of liver transplantation. There is limited data on predictors of survival in ACLF in children. Therefore, we prospectively studied the predictors of outcome of ACLF in children. METHODS:A prospective evalu...

journal_title：Hepatology international

authors： Lal J,Thapa BR,Rawal P,Ratho RK,Singh K

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common malignant neoplasms worldwide. The p53 gene is frequently mutated in some histological subtypes of HCC. The role of p53 mutations and polymorphic variant of codon 72 in the prognosis of disease is still unclear. The p53 tumor suppressor gene Arg72Pro p...

journal_title：Hepatology international

authors： Jia S,Tang W,Luo Y

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND AIM:Relationships between circulating microRNA-122 (miR-122) and histological features of nonalcoholic fatty liver disease (NAFLD) are unclear. METHODS:The impact of serum miR-122 levels for histological features and hepatocellular carcinoma (HCC) was investigated in 305 Japanese patients with histologi...

journal_title：Hepatology international

authors： Akuta N,Kawamura Y,Suzuki F,Saitoh S,Arase Y,Kunimoto H,Sorin Y,Fujiyama S,Sezaki H,Hosaka T,Kobayashi M,Suzuki Y,Kobayashi M,Ikeda K,Kumada H

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND AIM:Acute kidney injury (AKI), as defined by the Acute Kidney Injury Network, has been widely investigated in decompensated liver cirrhosis patients. AKI is frequently progressive and independently associated with mortality in these patients. However, in the Asia-Pacific region, the majority of cases of ...

journal_title：Hepatology international

authors： Huang Z,Lin C,Fang J,Wang N,Zhou R,Pan C

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The progression of HBsAg-positive chronic hepatitis is insidious and unpredictable. Identification of factors leading to either a benign or more serious clinical outcome may assist in decision making for antiviral therapy. METHODS:From 1989 to 1998, 130 untreated patients with chronic hepatitis wer...

journal_title：Hepatology international

authors： Tong MJ,Huynh TT,Siripongsakun S,Chang PW,Tong LT,Ha YP,Mena EA,Weissman MF

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To evaluate the recent topics of Ballloon-occluded retrograde trasnvenous obliteration(B-RTO). METHOD:We overviewed the recent scientific papers regarding B-RTO. RESULT:B-RTO is a treatment method for occluding varices retrogradely using a sclerosing agent under balloon occlusion of a major draining vein. It ...

journal_title：Hepatology international

authors： Hirota S,Kobayashi K,Kako Y,Takaki H,Yamakado K

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:Ethanol binge augments liver injury after chronic ethanol consumption in humans, but the mechanism behind the enhanced liver injury by ethanol binge is not known. In this study we used a clinically relevant rat model in which liver injury is amplified by binge after chronic ethanol treatment and investigated th...

journal_title：Hepatology international

authors： Aroor AR,Restrepo RJ,Kharbanda KK,Shukla SD

更新日期：2014-09-01 00:00:00

abstract：:Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease characterized by progressive destruction of small intrahepatic bile ducts. If left untreated, PBC may eventually result in end-stage liver disease. For better management of PBC and optimal allocation of med...

journal_title：Hepatology international

authors： Chen S,Duan W,You H,Jia J

更新日期：2017-09-01 00:00:00

abstract：PURPOSE/BACKGROUND:Severe alcoholic hepatitis (AH) is a life-threatening liver disease with a potential of 30-40 % mortality at 1 month. While steroids remain to be a first line therapy, they provide only about 50 % survival benefit. The aim of the study was to evaluate the efficacy of glucocorticoids plus S-adenosylme...

journal_title：Hepatology international

authors： Tkachenko P,Maevskaya M,Pavlov A,Komkova I,Pavlov C,Ivashkin V

更新日期：2016-11-01 00:00:00

abstract：:Cirrhotic cardiomyopathy is a recently recognized condition in cirrhosis consisting of systolic incompetence under condition of stress, diastolic dysfunction related to altered diastolic relaxation, and electrophysiological abnormalities in the absence of any known cardiac disease. It can be diagnosed by using a combi...

journal_title：Hepatology international

authors： Wong F

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND AIMS:The peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand, piglitazone, enhances the degradation of branched-chain amino acids (BCAAs) in adipose tissue. However, it remains unknown whether pioglitazone influences the plasma amino acids (AA) profile in patients with nonalcoholic steatohepatit...

journal_title：Hepatology international

authors： Kakazu E,Kondo Y,Ninomiya M,Kimura O,Nagasaki F,Ueno Y,Shimosegawa T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:The life cycle of hepatitis C virus (HCV) is tightly associated with host lipoprotein metabolic pathways. Apolipoprotein is present on the outer surface of lipoprotein particles and plays an important role in lipoprotein metabolism. We aimed to elucidate the influence of chronic HCV infection on serum apolip...

journal_title：Hepatology international

authors： Seki N,Sugita T,Aida Y,Itagaki M,Ishiguro H,Sutoh S,Abe H,Tsubota A,Matsushima M,Aizawa Y

更新日期：2014-10-01 00:00:00

abstract：:Reactive oxygen and nitrogen species (ROS and RNS) are produced by metabolism of normal cells. However, in liver diseases, redox is increased thereby damaging the hepatic tissue; the capability of ethanol to increase both ROS/RNS and peroxidation of lipids, DNA, and proteins was demonstrated in a variety of systems, c...

journal_title：Hepatology international

authors： Muriel P

更新日期：2009-12-01 00:00:00

abstract：:Spontaneous bacterial peritonitis (SBP) is a common cause of morbidity and mortality in patients with advanced cirrhosis and portal hypertension. While gram-negative rods and Enterococcus species are the common offending organisms, Salmonella has also been recognized as a rare and atypical offending organism. Atypical...

journal_title：Hepatology international

authors： Rajekar H,Wai CT,Lee KH,Wong SY,Tan KC

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party to develop a consensus cost-effectiveness model for treatment of Hepatitis B in Asia Pacific countries in March 2010. METHODS:The working party consisted of expert hepatologists, virologists and epidemiolog...

journal_title：Hepatology international

authors： Dan YY,Wong JB,Hamid SS,Han KH,Jia JD,Liu CJ,Piratvisuth T,Lok AS,Lim SG

更新日期：2014-07-01 00:00:00

abstract：GOALS:The aim of our study is to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis in patients with type 1 diabetes (T1D) using simple noninvasive scores. BACKGROUND:There is paucity of data on the prevalence of NAFLD in T1D. Moreover, T1D could be a risk factor for advanc...

journal_title：Hepatology international

authors： Singh A,Le P,Lopez R,Alkhouri N

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is a progressive disease associated with rapid clinical worsening and high mortality. Early prediction of mortality and intervention can improve patient outcomes. We aimed to develop a dynamic prognostic model and compare it with the existing models. METHODS:A ...

journal_title：Hepatology international

authors： Choudhury A,Jindal A,Maiwall R,Sharma MK,Sharma BC,Pamecha V,Mahtab M,Rahman S,Chawla YK,Taneja S,Tan SS,Devarbhavi H,Duan Z,Yu C,Ning Q,Jia JD,Amarapurkar D,Eapen CE,Goel A,Hamid SS,Butt AS,Jafri W,Kim DJ,G

更新日期：2017-09-01 00:00:00

abstract：:Portal hypertension develops as a result of increased intrahepatic vascular resistance often caused by chronic liver disease that leads to structural distortion by fibrosis, microvascular thrombosis, dysfunction of liver sinusoidal endothelial cells (LSECs), and hepatic stellate cell (HSC) activation. While the basic ...

journal_title：Hepatology international

authors： McConnell M,Iwakiri Y

更新日期：2018-02-01 00:00:00

abstract：:In patients with chronic hepatitis B (CHB), liver fibrosis assessment is essential not only for determining prognosis but also for identifying patients who should receive treatment. Liver biopsy is limited by its invasiveness and sampling error. To explore effective non-invasive methods for liver fibrosis assessment, ...

journal_title：Hepatology international

authors： Chen YP,Peng J,Hou JL

更新日期：2013-06-01 00:00:00

abstract：:Actinomycotic hepatic abscess was diagnosed in a 46-year-old male driver from Ukraine presenting with the symptoms of malaise, loss of appetite, upper right quadrant pain, weight loss, and night sweats which had been present for last 2 months. Computed tomography (CT) of the abdomen revealed a hypodense mass in the le...

journal_title：Hepatology international

authors： Tiftikci A,Vardareli EN,Kaban K,Peker O,Akansel S,Tozun N

更新日期：2008-03-01 00:00:00