Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury.

abstract：BACKGROUND/AIMS:[corrected] The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. METHODS:The patients with liver tumor or chronic hepatitis i...

journal_title：Hepatology international

authors： Kuo YH,Lu SN,Hung CH,Kee KM,Chen CH,Hu TH,Lee CM,Changchien CS,Wang JH

更新日期：2010-10-08 00:00:00

abstract：PURPOSE:Interferon-induced graft dysfunction (IGD) is a poorly defined, unrecognized, but potentially serious condition for patients receiving antiviral drugs after liver transplantation for hepatitis C. METHODS:We evaluated the characteristics of 80 patients who received pegylated interferon-based antiviral treatment...

journal_title：Hepatology international

authors： Ikegami T,Wang H,Yoshizumi T,Toshima T,Aishima S,Fukuhara T,Furusyo N,Kotoh K,Shimoda S,Shirabe K,Maehara Y

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is a progressive disease associated with rapid clinical worsening and high mortality. Early prediction of mortality and intervention can improve patient outcomes. We aimed to develop a dynamic prognostic model and compare it with the existing models. METHODS:A ...

journal_title：Hepatology international

authors： Choudhury A,Jindal A,Maiwall R,Sharma MK,Sharma BC,Pamecha V,Mahtab M,Rahman S,Chawla YK,Taneja S,Tan SS,Devarbhavi H,Duan Z,Yu C,Ning Q,Jia JD,Amarapurkar D,Eapen CE,Goel A,Hamid SS,Butt AS,Jafri W,Kim DJ,G

更新日期：2017-09-01 00:00:00

abstract：:In patients with chronic hepatitis B (CHB), liver fibrosis assessment is essential not only for determining prognosis but also for identifying patients who should receive treatment. Liver biopsy is limited by its invasiveness and sampling error. To explore effective non-invasive methods for liver fibrosis assessment, ...

journal_title：Hepatology international

authors： Chen YP,Peng J,Hou JL

更新日期：2013-06-01 00:00:00

abstract：:Patients (85%) with hepatocellular adenoma (HCA) are women taking oral contraceptives. They can be divided into four subgroups according to their genotype/phenotype features. (1) Hepatocyte nuclear factor 1alpha (HNF1alpha) biallelic somatic mutations are observed in 35% of the HCA cases. It occurs in almost all cases...

journal_title：Hepatology international

authors： Bioulac-Sage P,Laumonier H,Laurent C,Zucman-Rossi J,Balabaud C

更新日期：2008-09-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is endemic in the Asian-Pacific region, and reactivation of HBV post-cancer chemotherapy has become an emerging clinical challenge. Patients with detectable serum HBV DNA before chemotherapy and those receiving intensive chemotherapy are particularly at a risk of HBV reactivat...

journal_title：Hepatology international

authors： Liu CJ,Chen PJ,Chen DS,Kao JH

更新日期：2013-06-01 00:00:00

abstract：:The bone marrow contains stem cells that have the potential to differentiate into a variety of organ-specific mature cells, including the liver and the pancreas. Recently, the origin of hepatic progenitors and hepatocytes was identified to be the bone marrow. However, evidence that describes which cells, among all bon...

journal_title：Hepatology international

authors： Bae SH,Choi JY,Yoon SK,Oh IH,Yoon KH,Park ST,Kim GD,Oh SH,Petersen BE

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Variceal bleeding is a major complication of portal hypertension, which is associated with significant mortality. Moreover, patients surviving a variceal bleeding episode have very high risk of rebleeding, which is associated with mortality as high as that of the first bleed. Because of this, prevention of b...

journal_title：Hepatology international

authors： Baiges A,Hernández-Gea V,Bosch J

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Although arterial stiffness has been reported to be associated with nonalcoholic fatty liver disease (NAFLD), previous studies have relied only on noninvasive assessments for the diagnosis of NAFLD. This study attempted to investigate the association of arterial stiffness with the histological severity of NA...

journal_title：Hepatology international

authors： Kim HL,Koo BK,Joo SK,Kim W

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function. METHODS:Liver biopsy was performed for 30 patients with hepatitis B cirrhosis to test the content of hydroxyproline in hepatic tissue, judge the degree of cirrh...

journal_title：Hepatology international

authors： Wang W,Li J,Pan R,A S,Liao C

更新日期：2015-10-01 00:00:00

abstract：:Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease characterized by progressive destruction of small intrahepatic bile ducts. If left untreated, PBC may eventually result in end-stage liver disease. For better management of PBC and optimal allocation of med...

journal_title：Hepatology international

authors： Chen S,Duan W,You H,Jia J

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The association of obstructive sleep apnea (OSA) with nonalcoholic fatty liver disease (NAFLD) has only been studied in selected subgroups such as the morbidly obese. We aimed to determine the prevalence and effect of OSA on NAFLD and vice versa in unselected patients attending the outpatient department. ME...

journal_title：Hepatology international

authors： Agrawal S,Duseja A,Aggarwal A,Das A,Mehta M,Dhiman RK,Chawla Y

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Sorafenib significantly improves survival in patients with advanced hepatocellular carcinoma (HCC). This phase IV study assessed sorafenib efficacy/safety in Taiwanese patients with advanced HCC and Child-Pugh A status. METHODS:All patients received 400 mg sorafenib BID. Safety, efficacy, sorafenib pharmaco...

journal_title：Hepatology international

authors： Lin SM,Lu SN,Chen PT,Jeng LB,Chen SC,Hu CT,Yang SS,Le Berre MA,Liu X,Mitchell DY,Prins K,Grevel J,Peña CA,Meinhardt G

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Although clinical and experimental studies have demonstrated a correlation between obstructive jaundice and the development of sepsis, the mechanism has not been fully elucidated. PURPOSE:The aim of this study was to investigate the influence of biliary obstruction on bacterial translocation as a possible s...

journal_title：Hepatology international

authors： Abdeldayem H,Ghoneim E,Refaei AA,Abou-Gabal A

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Compositional changes of the gut microbiota are known to occur in patients with nonalcoholic fatty liver disease (NAFLD); however, the changes did not corroborate between the studies. We evaluated the gut microbiota between NAFLD and non-NAFLD participants, excluding the influence of obesity and sex in this ...

journal_title：Hepatology international

authors： Iino C,Endo T,Mikami K,Hasegawa T,Kimura M,Sawada N,Nakaji S,Fukuda S

更新日期：2019-11-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden and cure is rarely achieved by current antiviral therapies. Therefore, there is an urgent need for new therapeutic options. Immune modulation with the goal to restore dysfunctional HBV-specific immunity is an interesting target for new therapeut...

journal_title：Hepatology international

authors： Lang J,Neumann-Haefelin C,Thimme R

更新日期：2019-03-01 00:00:00

abstract：:An ultrasound (US) examination is a common noninvasive technique widely applied for diagnosis of a variety of diseases. Based on the rapid development of US equipment, many US images have been accumulated and are now available and ready for the preparation of a database for the development of computer-aided US diagnos...

journal_title：Hepatology international

authors： Nishida N,Yamakawa M,Shiina T,Kudo M

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND AIM:Acute kidney injury (AKI), as defined by the Acute Kidney Injury Network, has been widely investigated in decompensated liver cirrhosis patients. AKI is frequently progressive and independently associated with mortality in these patients. However, in the Asia-Pacific region, the majority of cases of ...

journal_title：Hepatology international

authors： Huang Z,Lin C,Fang J,Wang N,Zhou R,Pan C

更新日期：2015-07-01 00:00:00

abstract：:Patients with chronic hepatitis C virus (HCV) infection experience a range of symptoms including depression, fatigue and neurocognitive deficits, impairing quality of life. Depression, in particular, may be reactive to increased psychosocial stress, and the physical symptoms of advanced HCV or associated comorbidities...

journal_title：Hepatology international

authors： Yeoh SW,Holmes ACN,Saling MM,Everall IP,Nicoll AJ

更新日期：2018-07-01 00:00:00

abstract：:The term nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of increasingly harmful conditions ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) to liver fibrosis and end-stage cirrhosis. NAFLD is the currently most common form of chronic liver disease in both adults and ch...

journal_title：Hepatology international

authors： Reimer KC,Wree A,Roderburg C,Tacke F

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:To compare the efficacy of entecavir (ETV) monotherapy up to 4 years in nucleos(t)ide analog (NA)-experienced and -naïve subjects. METHODS:One hundred sixty NA-experienced and 282 naïve chronic hepatitis B patients who were treated with ETV were enrolled. Of the 160 NA-experienced patients, 49 had prior lamivu...

journal_title：Hepatology international

authors： Chen CH,Hu TH,Hung CH,Lu SN,Wang JH,Chang MH,Changchien CS,Lee CM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Early prediction of lamivudine (LAM) response by individualized monitoring of serum HBV DNA like roadmap concept, and investigation of the outcome after LAM discontinuation in renal transplant recipients (RTRs) with chronic hepatitis B (CHB). METHODS:We conducted a study on 19 RTRs with HBV infection receiv...

journal_title：Hepatology international

authors： Hu TH,Tsai MC,Chen YT,Chien YS,Hung CH,Chen TC,Tseng PL,Chang KC,Yen YH

更新日期：2012-04-01 00:00:00

abstract：AIMS:Relationships of renal function and liver disease are described in acute and chronic liver failure. The aim of the study is to investigate which relationship, if any, is present between severity of non-alcoholic fatty liver disease (NAFLD), assessed by bright liver score (BLS) versus mild-moderate renal insufficie...

journal_title：Hepatology international

authors： Catalano D,Trovato GM,Martines GF,Pirri C,Trovato FM

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party to develop a consensus cost-effectiveness model for treatment of Hepatitis B in Asia Pacific countries in March 2010. METHODS:The working party consisted of expert hepatologists, virologists and epidemiolog...

journal_title：Hepatology international

authors： Dan YY,Wong JB,Hamid SS,Han KH,Jia JD,Liu CJ,Piratvisuth T,Lok AS,Lim SG

更新日期：2014-07-01 00:00:00

abstract：:Cirrhotic cardiomyopathy is a recently recognized condition in cirrhosis consisting of systolic incompetence under condition of stress, diastolic dysfunction related to altered diastolic relaxation, and electrophysiological abnormalities in the absence of any known cardiac disease. It can be diagnosed by using a combi...

journal_title：Hepatology international

authors： Wong F

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To assess the accuracy of a formula derived from 159 living liver donors to estimate the liver size of a normal subject: standard liver weight (g) = 218 + body weight (kg) × 12.3 + 51 (if male). Standard liver volume (SLV) is attained by a conversion factor of 1.19 mL/g. METHODS:The total liver volume (TLV) of...

journal_title：Hepatology international

authors： Chan SC,Lo CM,Chok KS,Sharr WW,Cheung TT,Tsang SH,Chan AC,Fan ST

更新日期：2011-03-26 00:00:00

abstract：PURPOSE:Microvascular invasion of hepatocellular carcinoma (HCC) is considered a poor prognostic factor of liver resection (LR) and liver transplantation (LT), but its significance for lesions within the up-to-7 criteria is unclear. This study investigated the survival benefit of primary LT against LR for HCC with micr...

journal_title：Hepatology international

authors： Chan SC,Fan ST,Chok KS,Cheung TT,Chan AC,Fung JY,Poon RT,Lo CM

更新日期：2011-10-21 00:00:00

abstract：PURPOSE:To analyze the prognostic factors for the patients with lung metastases from hepatocellular carcinoma (HCC). METHODS AND MATERIALS:One hundred and five patients with lung metastases from HCC were analyzed retrospectively. We analyzed the impact factors, including the gender, age, liver function, serum AFP and ...

journal_title：Hepatology international

authors： Zhang SM,Zeng ZC,Tang ZY,Sun J,Cheng JM,Liu R,Wang P,Zhang BH

更新日期：2008-06-01 00:00:00

abstract：:More than 170 million people worldwide are infected with hepatitis C virus (HCV). A characteristic of this virus is a high tendency toward chronic infection. Several factors affect the viral outcome after infection. Among them, HCV-specific CD4 T cells are thought to play a crucial role in controlling viremia. Cumulat...

journal_title：Hepatology international

authors： Sugimoto K,Shiraki K

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Either combination treatment or monotherapy using agents with a high genetic barrier are recommended for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB). The aim of this study was to compare effect of naïve HBeAg-negative CHB patients with either de novo combination of lamivudine (LAM) and adef...

journal_title：Hepatology international

authors： Wang LC,Chen EQ,Cao J,Liu L,Zheng L,Li DJ,Xu L,Lei XZ,Liu C,Tang H

更新日期：2011-06-01 00:00:00