Abstract:
BACKGROUND:The association of obstructive sleep apnea (OSA) with nonalcoholic fatty liver disease (NAFLD) has only been studied in selected subgroups such as the morbidly obese. We aimed to determine the prevalence and effect of OSA on NAFLD and vice versa in unselected patients attending the outpatient department. METHODS:OSA was diagnosed by polysomnography, done in patients having symptoms of OSA, in patients with NAFLD attending the liver clinic. Polysomnography-proven patients with OSA attending the chest clinic were evaluated for NAFLD by ultrasonography. Anthropometry, liver function tests, metabolic syndrome evaluation and transient elastography were performed in all patients. RESULTS:Three (3%; 95% CI 1.03-8.45%) out of 100 patients with NAFLD (mean age 41 ± 11 years) had symptomatic OSA. Of 23 patients with OSA (mean age 46 ± 12 years,), 3 (13%) had mild, 5 (22%) moderate and 15 (65%) severe OSA. Twenty-one (91.3%; 95% CI 73.2-97.6%) patients with OSA had NAFLD, while raised hepatic transaminase levels were seen in seven (30.4%; 95% CI 15.6-50.9%). Body mass index (OR 1.21, 95% CI 1.02-1.44) and male gender (OR 4.79, 95% CI 1.12-20.48) were significant independent predictors of OSA in NAFLD. The apnea-hypopnea index (OR 1.084, 95% CI 1.002-1.172), a marker of OSA severity, was the only significant independent predictor of significant fibrosis in patients with NAFLD. CONCLUSIONS:Prevalence of symptomatic OSA in patients with NAFLD is low and is predicted by male gender and obesity. Prevalence of NAFLD in patients with OSA is very high. Significant hepatic fibrosis in patients with NAFLD is predicted by OSA independent of obesity and metabolic syndrome.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Agrawal S,Duseja A,Aggarwal A,Das A,Mehta M,Dhiman RK,Chawla Ydoi
10.1007/s12072-015-9615-3subject
Has Abstractpub_date
2015-04-01 00:00:00pages
283-91issue
2eissn
1936-0533issn
1936-0541journal_volume
9pub_type
杂志文章abstract:BACKGROUND AND AIMS:The progression of HBsAg-positive chronic hepatitis is insidious and unpredictable. Identification of factors leading to either a benign or more serious clinical outcome may assist in decision making for antiviral therapy. METHODS:From 1989 to 1998, 130 untreated patients with chronic hepatitis wer...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9651-z
更新日期:2015-10-01 00:00:00
abstract::Solitary necrotic nodules of the liver occur rarely. Although these nodules are usually benign, they are surgically removed in most cases because they cannot be differentiated from malignant lesions. To date, the natural history of solitary fibrous nodules remains unclear. We present the case of an incidentally detect...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9199-x
更新日期:2010-07-29 00:00:00
abstract:BACKGROUND AND AIMS:Coagulopathic bleeding risk prediction is challenging in decompensated cirrhosis (DC) by conventional assays. Viscoelastic tests (VETs) are likely to be more useful for assessing coagulation status in these patients. We investigated whether the VET (Sonoclot) parameters with fibrinogen could predict...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-020-10036-y
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:Case reports and small case series have reported a high rate of complications associated with chest tube placement for hepatic hydrothorax. We describe the in-hospital and 3-month outcomes of patients who have had this procedure. METHODS:A retrospective medical record review was performed of all patients admit...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-009-9136-z
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Status 1A patients are prioritized over end-stage liver disease (ESLD) for liver transplantation (LT). ESLD patients with high MELD may have higher waitlist mortality than Status 1A patients, and may require LT more urgently. METHODS:Using United Network for Organ Sharing registry data, we retrospe...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-016-9735-4
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:Microvascular invasion of hepatocellular carcinoma (HCC) is considered a poor prognostic factor of liver resection (LR) and liver transplantation (LT), but its significance for lesions within the up-to-7 criteria is unclear. This study investigated the survival benefit of primary LT against LR for HCC with micr...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9318-3
更新日期:2011-10-21 00:00:00
abstract:BACKGROUND AND AIMS:T cell-mediated immune injury plays a critical role in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Given the high short-term mortality and crucial role of T cells in the disease progression, it is necessary to investigate the dynamics of T cell clones dur...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-10008-x
更新日期:2020-01-01 00:00:00
abstract:PURPOSE/BACKGROUND:Severe alcoholic hepatitis (AH) is a life-threatening liver disease with a potential of 30-40 % mortality at 1 month. While steroids remain to be a first line therapy, they provide only about 50 % survival benefit. The aim of the study was to evaluate the efficacy of glucocorticoids plus S-adenosylme...
journal_title:Hepatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s12072-016-9751-4
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Although clinical and experimental studies have demonstrated a correlation between obstructive jaundice and the development of sepsis, the mechanism has not been fully elucidated. PURPOSE:The aim of this study was to investigate the influence of biliary obstruction on bacterial translocation as a possible s...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-007-9018-1
更新日期:2007-12-01 00:00:00
abstract::Chronic hepatitis B virus (HBV) infection is a major global health burden and cure is rarely achieved by current antiviral therapies. Therefore, there is an urgent need for new therapeutic options. Immune modulation with the goal to restore dysfunctional HBV-specific immunity is an interesting target for new therapeut...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-018-9912-8
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function. METHODS:Liver biopsy was performed for 30 patients with hepatitis B cirrhosis to test the content of hydroxyproline in hepatic tissue, judge the degree of cirrh...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9648-7
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:To evaluate the recent topics of Ballloon-occluded retrograde trasnvenous obliteration(B-RTO). METHOD:We overviewed the recent scientific papers regarding B-RTO. RESULT:B-RTO is a treatment method for occluding varices retrogradely using a sclerosing agent under balloon occlusion of a major draining vein. It ...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-017-9813-2
更新日期:2018-02-01 00:00:00
abstract::In a country such as Japan with the average age of patients with chronic hepatitis C treated with antivirals sometimes well above 60 years, the standard combination therapy is not well tolerated. In this randomized, prospective, controlled trial, we investigated the efficacy of 24-week peginterferon α monotherapy for ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-009-9134-1
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:There have been reports that radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) is as equally effective as surgical resection for the treatment of hepatocellular carcinoma (HCC). This study aimed to evaluate recurrence rate and risk factor of recurrence after RFA combined with TA...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9290-y
更新日期:2012-04-01 00:00:00
abstract:AIMS:Relationships of renal function and liver disease are described in acute and chronic liver failure. The aim of the study is to investigate which relationship, if any, is present between severity of non-alcoholic fatty liver disease (NAFLD), assessed by bright liver score (BLS) versus mild-moderate renal insufficie...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9254-2
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Initial presentation of hepatocellular carcinoma (HCC) at an advanced stage in patients under a regular surveillance program is a devastating problem. AIMS:We assessed the prevalence and factors associated with this surveillance failure. METHODS:A total of 304 HCC patients who received regular surveillance...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9462-z
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND AND OBJECT:The risk of occult HBV infection (OBI) in children whose mothers are HBV carriers has received more widespread attention, but there were few reports to focus on the children with HBsAg-positive parents. In this study, we aimed to investigate the prevalence of OBI in immunized children with HBsAg-p...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-020-10055-9
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:Transcriptional silencing of tumor suppressor genes associated with DNA hypermethylation has been known as a hallmark of human cancer. In this study, we revealed that a local anesthetic, procaine (PCA), possessed growth-inhibitory and demethylating effect on human hepatoma cells in vitro and in vivo. METHODS:T...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-007-9014-5
更新日期:2007-09-01 00:00:00
abstract::The prognosis of advanced hepatocellular carcinoma (HCC) remains poor. For patients with advanced HCC, the multikinase inhibitor sorafenib is recommended as the current standard of care. In contrast, hepatic arterial infusion chemotherapy (HAIC) is one of the recommended treatments in Japan. However, in Japan, the use...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9515-3
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Hepatitis C (HCV) is the predominant cause of chronic liver disease in the USA and is increasingly recognized as a common cause of liver disease in China. Studies of HCV patients in the US found major gaps in knowledge but little is known about HCV knowledge among patients in China. METHODS:We conducted a s...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-014-9559-z
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:L-Asparaginase is a bacterial enzyme used in the treatment of acute lymphoblastic leukemia. In the ongoing U.S. Drug-Induced Liver Injury Network (DILIN) prospective study, standard and pegylated asparaginase were the most frequent cause of liver injury with jaundice among anti-cancer agents (8 of 40: 20%). ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09971-2
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND AND AIM:Acute kidney injury (AKI), as defined by the Acute Kidney Injury Network, has been widely investigated in decompensated liver cirrhosis patients. AKI is frequently progressive and independently associated with mortality in these patients. However, in the Asia-Pacific region, the majority of cases of ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9636-y
更新日期:2015-07-01 00:00:00
abstract::Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI i...
journal_title:Hepatology international
pub_type: 社论
doi:10.1007/s12072-017-9793-2
更新日期:2017-05-01 00:00:00
abstract::More than 170 million people worldwide are infected with hepatitis C virus (HCV). A characteristic of this virus is a high tendency toward chronic infection. Several factors affect the viral outcome after infection. Among them, HCV-specific CD4 T cells are thought to play a crucial role in controlling viremia. Cumulat...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9321-8
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Early prediction of lamivudine (LAM) response by individualized monitoring of serum HBV DNA like roadmap concept, and investigation of the outcome after LAM discontinuation in renal transplant recipients (RTRs) with chronic hepatitis B (CHB). METHODS:We conducted a study on 19 RTRs with HBV infection receiv...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9295-6
更新日期:2012-04-01 00:00:00
abstract::Reactive oxygen and nitrogen species (ROS and RNS) are produced by metabolism of normal cells. However, in liver diseases, redox is increased thereby damaging the hepatic tissue; the capability of ethanol to increase both ROS/RNS and peroxidation of lipids, DNA, and proteins was demonstrated in a variety of systems, c...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-009-9158-6
更新日期:2009-12-01 00:00:00
abstract::The presence of hepatic encephalopathy (HE) within 4 weeks is part of the criteria for defining acute-on-chronic liver failure (ACLF). The pathophysiology of HE is complex, and hyperammonemia and cerebral hemodynamic dysfunction appear to be central in the pathogenesis of encephalopathy. Recent data also suggest that ...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-015-9626-0
更新日期:2015-10-01 00:00:00
abstract::Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease characterized by progressive destruction of small intrahepatic bile ducts. If left untreated, PBC may eventually result in end-stage liver disease. For better management of PBC and optimal allocation of med...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-017-9819-9
更新日期:2017-09-01 00:00:00
abstract::Cirrhotic cardiomyopathy is a recently recognized condition in cirrhosis consisting of systolic incompetence under condition of stress, diastolic dysfunction related to altered diastolic relaxation, and electrophysiological abnormalities in the absence of any known cardiac disease. It can be diagnosed by using a combi...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9109-7
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Controversy exists on whether tenofovir disoproxil fumarate (TDF) is superior to entecavir (ETV) in lowering the risk of hepatocellular carcinoma (HCC) development. This meta-analysis was performed to clarify this issue with critical clinical and methodological considerations. METHODS:PubMed, EMBASE, and Co...
journal_title:Hepatology international
pub_type: 杂志文章,meta分析
doi:10.1007/s12072-019-10005-0
更新日期:2020-01-01 00:00:00