Abstract:
:An ultrasound (US) examination is a common noninvasive technique widely applied for diagnosis of a variety of diseases. Based on the rapid development of US equipment, many US images have been accumulated and are now available and ready for the preparation of a database for the development of computer-aided US diagnosis with deep learning technology. On the contrary, because of the unique characteristics of the US image, there could be some issues that need to be resolved for the establishment of computer-aided diagnosis (CAD) system in this field. For example, compared to the other modalities, the quality of a US image is, currently, highly operator dependent; the conditions of examination should also directly affect the quality of US images. So far, these factors have hampered the application of deep learning-based technology in the field of US diagnosis. However, the development of CAD and US technologies will contribute to an increase in diagnostic quality, facilitate the development of remote medicine, and reduce the costs in the national health care through the early diagnosis of diseases. From this point of view, it may have a large enough potential to induce a paradigm shift in the field of US imaging and diagnosis of liver diseases.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Nishida N,Yamakawa M,Shiina T,Kudo Mdoi
10.1007/s12072-019-09937-4subject
Has Abstractpub_date
2019-07-01 00:00:00pages
416-421issue
4eissn
1936-0533issn
1936-0541pii
10.1007/s12072-019-09937-4journal_volume
13pub_type
杂志文章,评审abstract:BACKGROUND AND AIMS:The progression of HBsAg-positive chronic hepatitis is insidious and unpredictable. Identification of factors leading to either a benign or more serious clinical outcome may assist in decision making for antiviral therapy. METHODS:From 1989 to 1998, 130 untreated patients with chronic hepatitis wer...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9651-z
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:Transcriptional silencing of tumor suppressor genes associated with DNA hypermethylation has been known as a hallmark of human cancer. In this study, we revealed that a local anesthetic, procaine (PCA), possessed growth-inhibitory and demethylating effect on human hepatoma cells in vitro and in vivo. METHODS:T...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-007-9014-5
更新日期:2007-09-01 00:00:00
abstract::Spontaneous bacterial peritonitis (SBP) is a common cause of morbidity and mortality in patients with advanced cirrhosis and portal hypertension. While gram-negative rods and Enterococcus species are the common offending organisms, Salmonella has also been recognized as a rare and atypical offending organism. Atypical...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9087-9
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:There is much controversy surrounding the natural history of hepatitis C virus (HCV) infection. AIMS:The aim of this review was to review the natural history of HCV infection. METHODS:Published English literature was searched via pubmed and then reviewed. RESULTS:Approximately, 75-85% of HCV-infected pers...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9355-6
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND AND AIMS:A discrepancy in virological and biochemical responses may occur throughout interferon-based therapy for hepatitis C virus (HCV). We aimed to explore the risk, associated factors, potential mechanisms, and impact on the treatment outcome of the discrepancy. SUBJECTS AND METHODS:Consecutive 496, chr...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9388-x
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:To compare the efficacy of entecavir (ETV) monotherapy up to 4 years in nucleos(t)ide analog (NA)-experienced and -naïve subjects. METHODS:One hundred sixty NA-experienced and 282 naïve chronic hepatitis B patients who were treated with ETV were enrolled. Of the 160 NA-experienced patients, 49 had prior lamivu...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9440-5
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:Interferon-induced graft dysfunction (IGD) is a poorly defined, unrecognized, but potentially serious condition for patients receiving antiviral drugs after liver transplantation for hepatitis C. METHODS:We evaluated the characteristics of 80 patients who received pegylated interferon-based antiviral treatment...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9496-2
更新日期:2014-04-01 00:00:00
abstract:AIM:Tamibarotene is a synthetic retinoid expected to inhibit tumor-cell proliferation and to induce apoptosis by selective interaction with retinoic acid receptor α/β. We conducted an open-label phase I/II study to determine the maximum tolerated dose (MTD) and recommended dose (RD), and to evaluate the pharmacokinetic...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9459-7
更新日期:2014-01-01 00:00:00
abstract::Solitary necrotic nodules of the liver occur rarely. Although these nodules are usually benign, they are surgically removed in most cases because they cannot be differentiated from malignant lesions. To date, the natural history of solitary fibrous nodules remains unclear. We present the case of an incidentally detect...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9199-x
更新日期:2010-07-29 00:00:00
abstract:BACKGROUND:The association of obstructive sleep apnea (OSA) with nonalcoholic fatty liver disease (NAFLD) has only been studied in selected subgroups such as the morbidly obese. We aimed to determine the prevalence and effect of OSA on NAFLD and vice versa in unselected patients attending the outpatient department. ME...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9615-3
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND AND AIMS:The peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand, piglitazone, enhances the degradation of branched-chain amino acids (BCAAs) in adipose tissue. However, it remains unknown whether pioglitazone influences the plasma amino acids (AA) profile in patients with nonalcoholic steatohepatit...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9395-y
更新日期:2013-06-01 00:00:00
abstract::Liver transplantation is a definitive therapy for patients with end-stage liver disease and cirrhosis, with improvement in survival and quality of life. Patients are carefully screened and selected for this modality of treatment to achieve maximum survival benefit. For example, a patient with hepatocellular carcinoma ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-016-9770-1
更新日期:2017-01-01 00:00:00
abstract::To address the relationship between hepatitis B virus (HBV) endemicity and HBV-related liver diseases in Mexico. Research literature reporting on HBsAg and antibody to hepatitis B core antigen (anti-HBc) prevalence in Mexican study groups were searched in NLM Gateway, PubMed, IMBIOMED, and others. Weighted mean preval...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9115-9
更新日期:2009-06-01 00:00:00
abstract::NAFLD is a spectrum of liver disease starting with fatty liver at one end of the spectrum and cirrhosis or liver cancer at the other end. Worldwide, NAFLD has become one of the most common liver diseases and it has also become one of the leading indications for liver transplantation. Our understanding of the NAFLD epi...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-019-09970-3
更新日期:2019-09-01 00:00:00
abstract::In patients with chronic hepatitis B (CHB), liver fibrosis assessment is essential not only for determining prognosis but also for identifying patients who should receive treatment. Liver biopsy is limited by its invasiveness and sampling error. To explore effective non-invasive methods for liver fibrosis assessment, ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9439-y
更新日期:2013-06-01 00:00:00
abstract::Hepatitis due to hepatitis B virus reactivation after cytotoxic or immunosuppressive therapy is a serious cause of liver-related morbidity and mortality. With the characterization of the underlying pathogenesis, much progress in the management of this important clinical problem has been made in the past 2 decades. By ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9056-3
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Status 1A patients are prioritized over end-stage liver disease (ESLD) for liver transplantation (LT). ESLD patients with high MELD may have higher waitlist mortality than Status 1A patients, and may require LT more urgently. METHODS:Using United Network for Organ Sharing registry data, we retrospe...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-016-9735-4
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Cytokines have been reported to be involved in the cirrhosis and hepatic encephalopathy (HE). Many aspects on the correlation between minimal HE (MHE) and cytokine levels were still unclear. METHODS:Two hundred eighty-nine HBV-infected cirrhotic patients were grouped: non MHE (n = 156), MHE (n...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9610-8
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:Despite improvements in immunosuppressive therapy, acute cellular rejection (ACR) remains an important cause of graft loss in patients undergoing liver transplantation. Recently, associations between cytokine gene polymorphisms in recipients and the occurrence of ACR have been reported. However, most studies di...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9443-2
更新日期:2013-07-01 00:00:00
abstract::Portal hypertension develops as a result of increased intrahepatic vascular resistance often caused by chronic liver disease that leads to structural distortion by fibrosis, microvascular thrombosis, dysfunction of liver sinusoidal endothelial cells (LSECs), and hepatic stellate cell (HSC) activation. While the basic ...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-017-9826-x
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Recently, Sofosbuvir was launched in India at affordable cost. We conducted a real-life study to determine the efficacy and safety of Sofosbuvir plus Ribavirin, with and without peginterferon-alfa 2a, in patients with chronic hepatitis C (CHC) genotype 3, the commonest genotype in South Asia. METHO...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-017-9794-1
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:The life cycle of hepatitis C virus (HCV) is tightly associated with host lipoprotein metabolic pathways. Apolipoprotein is present on the outer surface of lipoprotein particles and plays an important role in lipoprotein metabolism. We aimed to elucidate the influence of chronic HCV infection on serum apolip...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-014-9572-2
更新日期:2014-10-01 00:00:00
abstract::Immunomodulatory cell therapy as a complement to standard pharmacotherapy represents a novel approach to solid organ allograft acceptance. This methodology may allow for a reduced dose of immunosuppressive drug to be administered and thus attenuate the severe side effects associated with long-term immunosuppression su...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9509-1
更新日期:2014-04-01 00:00:00
abstract::The prognosis of advanced hepatocellular carcinoma (HCC) remains poor. For patients with advanced HCC, the multikinase inhibitor sorafenib is recommended as the current standard of care. In contrast, hepatic arterial infusion chemotherapy (HAIC) is one of the recommended treatments in Japan. However, in Japan, the use...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9515-3
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND/PURPOSE:Gut microbiota has been associated with liver cirrhosis and, possibly, hepatic encephalopathy. However, only a few studies have examined the link between mucosa-associated microbiota (MAM) and minimal hepatic encephalopathy (MHE). Our aim was to investigate this relationship. METHODS:Twenty-four pat...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09963-2
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Sorafenib significantly improves survival in patients with advanced hepatocellular carcinoma (HCC). This phase IV study assessed sorafenib efficacy/safety in Taiwanese patients with advanced HCC and Child-Pugh A status. METHODS:All patients received 400 mg sorafenib BID. Safety, efficacy, sorafenib pharmaco...
journal_title:Hepatology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12072-016-9774-x
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Coagulopathic bleeding risk prediction is challenging in decompensated cirrhosis (DC) by conventional assays. Viscoelastic tests (VETs) are likely to be more useful for assessing coagulation status in these patients. We investigated whether the VET (Sonoclot) parameters with fibrinogen could predict...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-020-10036-y
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND AND AIM:Acute kidney injury (AKI), as defined by the Acute Kidney Injury Network, has been widely investigated in decompensated liver cirrhosis patients. AKI is frequently progressive and independently associated with mortality in these patients. However, in the Asia-Pacific region, the majority of cases of ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9636-y
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:We investigated whether the combined presence and evolution of hepatitis B virus (HBV) mutant strains in the hepatitis B e antigen (HBeAg)-positive status can predict clinical outcomes after HBeAg seroconversion. METHODS:One hundred and eighty-six patients with spontaneous HBeAg seroconversion were enrolled in...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9381-4
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:Case reports and small case series have reported a high rate of complications associated with chest tube placement for hepatic hydrothorax. We describe the in-hospital and 3-month outcomes of patients who have had this procedure. METHODS:A retrospective medical record review was performed of all patients admit...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-009-9136-z
更新日期:2009-12-01 00:00:00