Abstract：
:Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease characterized by progressive destruction of small intrahepatic bile ducts. If left untreated, PBC may eventually result in end-stage liver disease. For better management of PBC and optimal allocation of medical resources, it is pivotal to accurately estimate the prognosis of patients with PBC. This article will briefly review the models that predict long-term outcome of PBC patients, with special focus on the applicability, strengths and limitations of the widely used models reported from 1983 to 2016. Among many, the Mayo score has been extensively validated and considered as the classic prognostic model for untreated PBC patients, whereas the well-validated Paris I and Paris II criteria are mainly used in ursodeoxycholic acid (UDCA)-treated patients with advanced PBC (stage III-IV) and early PBC (stege I-II), respectively. Based on multicenter studies with large sample sizes, the recently reported GLOBE score and UK-PBC score seem to be superior to previous models and can be applied in patients with different stages of PBC who are already on UDCA therapy, but further external validation may be justified.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Chen S,Duan W,You H,Jia Jdoi
10.1007/s12072-017-9819-9subject
Has Abstractpub_date
2017-09-01 00:00:00pages
412-418issue
5eissn
1936-0533issn
1936-0541pii
10.1007/s12072-017-9819-9journal_volume
11pub_type
杂志文章,评审abstract：:An ultrasound (US) examination is a common noninvasive technique widely applied for diagnosis of a variety of diseases. Based on the rapid development of US equipment, many US images have been accumulated and are now available and ready for the preparation of a database for the development of computer-aided US diagnos...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-019-09937-4
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND AND AIMS:The peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand, piglitazone, enhances the degradation of branched-chain amino acids (BCAAs) in adipose tissue. However, it remains unknown whether pioglitazone influences the plasma amino acids (AA) profile in patients with nonalcoholic steatohepatit...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-012-9395-y
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:Interferon-induced graft dysfunction (IGD) is a poorly defined, unrecognized, but potentially serious condition for patients receiving antiviral drugs after liver transplantation for hepatitis C. METHODS:We evaluated the characteristics of 80 patients who received pegylated interferon-based antiviral treatment...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-013-9496-2
更新日期：2014-04-01 00:00:00
abstract：PURPOSE:To assess the accuracy of a formula derived from 159 living liver donors to estimate the liver size of a normal subject: standard liver weight (g) = 218 + body weight (kg) × 12.3 + 51 (if male). Standard liver volume (SLV) is attained by a conversion factor of 1.19 mL/g. METHODS:The total liver volume (TLV) of...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9264-0
更新日期：2011-03-26 00:00:00
abstract：OBJECTIVE:The relationship between chronic hepatitis B virus (HBV) infection and fatty liver in patients remains unclear. Although high-fat diets-induced hepatic steatosis was proved to reduce HBV replication in transgenic mice, the interplay between HBV and fatty liver in immunocompetent mouse model is yet to be eluci...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-018-9877-7
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND AND AIM:There is an increased awareness of de novo hepatitis B virus (HBV) infection (DNH) in hepatitis B surface antigen (HBsAg)-negative recipients receiving hepatitis B core antibody (HBcAb)-positive liver organ. Whether hepatitis B surface antibody (HBsAb) has positive result on preventing the occurrence...
journal_title：Hepatology international
pub_type： 杂志文章,meta分析
doi：10.1007/s12072-020-10021-5
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:All previous studies reported the benefit of antibiotic prophylaxis in cirrhotic patients with either a mixture of nonvariceal and variceal bleeding or variceal bleeding alone. Reports on sole peptic ulcers bleeding are lacking. We aimed to assess the effect of antibiotic prophylaxis in cirrhotic patients with ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-012-9378-z
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND AND AIMS:Coronavirus disease 2019 (COVID-19) pandemic is ongoing. Except for lung injury, it is possible that COVID-19 patients develop liver injury. Thus, we conducted a systematic review and meta-analysis to explore the incidence, risk factors, and prognosis of abnormal liver biochemical tests in COVID-19 ...
journal_title：Hepatology international
pub_type： 杂志文章,meta分析
doi：10.1007/s12072-020-10074-6
更新日期：2020-09-01 00:00:00
abstract：:The presence of hepatic encephalopathy (HE) within 4 weeks is part of the criteria for defining acute-on-chronic liver failure (ACLF). The pathophysiology of HE is complex, and hyperammonemia and cerebral hemodynamic dysfunction appear to be central in the pathogenesis of encephalopathy. Recent data also suggest that ...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-015-9626-0
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND AND AIM:Relationships between circulating microRNA-122 (miR-122) and histological features of nonalcoholic fatty liver disease (NAFLD) are unclear. METHODS:The impact of serum miR-122 levels for histological features and hepatocellular carcinoma (HCC) was investigated in 305 Japanese patients with histologi...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-016-9729-2
更新日期：2016-07-01 00:00:00
abstract：:Chronic hepatitis B virus (HBV) infection is endemic in the Asian-Pacific region, and reactivation of HBV post-cancer chemotherapy has become an emerging clinical challenge. Patients with detectable serum HBV DNA before chemotherapy and those receiving intensive chemotherapy are particularly at a risk of HBV reactivat...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9279-6
更新日期：2013-06-01 00:00:00
abstract：:Cirrhotic cardiomyopathy is a recently recognized condition in cirrhosis consisting of systolic incompetence under condition of stress, diastolic dysfunction related to altered diastolic relaxation, and electrophysiological abnormalities in the absence of any known cardiac disease. It can be diagnosed by using a combi...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-008-9109-7
更新日期：2009-03-01 00:00:00
abstract：AIM:Tamibarotene is a synthetic retinoid expected to inhibit tumor-cell proliferation and to induce apoptosis by selective interaction with retinoic acid receptor α/β. We conducted an open-label phase I/II study to determine the maximum tolerated dose (MTD) and recommended dose (RD), and to evaluate the pharmacokinetic...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-013-9459-7
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:The association of obstructive sleep apnea (OSA) with nonalcoholic fatty liver disease (NAFLD) has only been studied in selected subgroups such as the morbidly obese. We aimed to determine the prevalence and effect of OSA on NAFLD and vice versa in unselected patients attending the outpatient department. ME...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-015-9615-3
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is associated with a high mortality rate in the absence of liver transplantation. There is limited data on predictors of survival in ACLF in children. Therefore, we prospectively studied the predictors of outcome of ACLF in children. METHODS:A prospective evalu...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-010-9217-z
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:The aim of our study was to explore how C1QTNF1-AS1 regulated miR-221-3p/SOCS3 axis in human hepatocellular carcinoma (HCC). METHODS:Differentially expressed lncRNAs and genes were examined via RNA-seq. GO analysis and KEGG pathway enrichment analysis were carried out based on the function of dys-regulated ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-019-09944-5
更新日期：2019-05-01 00:00:00
abstract：:Portal hypertension develops as a result of increased intrahepatic vascular resistance often caused by chronic liver disease that leads to structural distortion by fibrosis, microvascular thrombosis, dysfunction of liver sinusoidal endothelial cells (LSECs), and hepatic stellate cell (HSC) activation. While the basic ...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-017-9826-x
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:Type II mixed cryoglobulinemia (MC) is a systemic vasculitis usually associated with hepatitis C virus (HCV). The present trial was performed to investigate the efficacy of therapy with pegylated interferon alfa-2a (PEG-IFN alfa-2a) plus ribavirin in patients with HCV-related MC vasculitis and evaluate the fa...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9303-x
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:Transcriptional silencing of tumor suppressor genes associated with DNA hypermethylation has been known as a hallmark of human cancer. In this study, we revealed that a local anesthetic, procaine (PCA), possessed growth-inhibitory and demethylating effect on human hepatoma cells in vitro and in vivo. METHODS:T...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-007-9014-5
更新日期：2007-09-01 00:00:00
abstract：:Spontaneous bacterial peritonitis (SBP) is a common cause of morbidity and mortality in patients with advanced cirrhosis and portal hypertension. While gram-negative rods and Enterococcus species are the common offending organisms, Salmonella has also been recognized as a rare and atypical offending organism. Atypical...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-008-9087-9
更新日期：2008-09-01 00:00:00
abstract：:NAFLD is a spectrum of liver disease starting with fatty liver at one end of the spectrum and cirrhosis or liver cancer at the other end. Worldwide, NAFLD has become one of the most common liver diseases and it has also become one of the leading indications for liver transplantation. Our understanding of the NAFLD epi...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-019-09970-3
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Although clinical and experimental studies have demonstrated a correlation between obstructive jaundice and the development of sepsis, the mechanism has not been fully elucidated. PURPOSE:The aim of this study was to investigate the influence of biliary obstruction on bacterial translocation as a possible s...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-007-9018-1
更新日期：2007-12-01 00:00:00
abstract：:Solitary necrotic nodules of the liver occur rarely. Although these nodules are usually benign, they are surgically removed in most cases because they cannot be differentiated from malignant lesions. To date, the natural history of solitary fibrous nodules remains unclear. We present the case of an incidentally detect...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-010-9199-x
更新日期：2010-07-29 00:00:00
abstract：:Background and aims The aims of this study were to evaluate a preventive effect on collateral venous circulation of long-term administration of propranolol in intrahepatic portal hypertensive rats. Methods Eighty-six Sprague-Dawley rats were allocated to two models of hepatic fibrosis, bile duct-ligated (BDL) induced ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-008-9070-5
更新日期：2008-12-01 00:00:00
abstract：:Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous ...
journal_title：Hepatology international
pub_type： 杂志文章,实务指引
doi：10.1007/s12072-015-9675-4
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Status 1A patients are prioritized over end-stage liver disease (ESLD) for liver transplantation (LT). ESLD patients with high MELD may have higher waitlist mortality than Status 1A patients, and may require LT more urgently. METHODS:Using United Network for Organ Sharing registry data, we retrospe...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-016-9735-4
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND AND AIMS:T cell-mediated immune injury plays a critical role in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Given the high short-term mortality and crucial role of T cells in the disease progression, it is necessary to investigate the dynamics of T cell clones dur...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-019-10008-x
更新日期：2020-01-01 00:00:00
abstract：:In patients with chronic hepatitis B (CHB), liver fibrosis assessment is essential not only for determining prognosis but also for identifying patients who should receive treatment. Liver biopsy is limited by its invasiveness and sampling error. To explore effective non-invasive methods for liver fibrosis assessment, ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-013-9439-y
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:To evaluate the sequence variations in the enhancer II (EnhII)/basal core promotor (BCP)/precore (PC) and X genes of hepatitis B virus (HBV) in Thai patients with hepatocellular carcinoma (HCC) by conducting a cross-sectional case-control study. METHODS:As much as 60 patients with HCC and 60 patients without H...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-010-9197-z
更新日期：2010-07-31 00:00:00
abstract：BACKGROUND:Initial presentation of hepatocellular carcinoma (HCC) at an advanced stage in patients under a regular surveillance program is a devastating problem. AIMS:We assessed the prevalence and factors associated with this surveillance failure. METHODS:A total of 304 HCC patients who received regular surveillance...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-013-9462-z
更新日期：2013-10-01 00:00:00
