Abstract：
:Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease characterized by progressive destruction of small intrahepatic bile ducts. If left untreated, PBC may eventually result in end-stage liver disease. For better management of PBC and optimal allocation of medical resources, it is pivotal to accurately estimate the prognosis of patients with PBC. This article will briefly review the models that predict long-term outcome of PBC patients, with special focus on the applicability, strengths and limitations of the widely used models reported from 1983 to 2016. Among many, the Mayo score has been extensively validated and considered as the classic prognostic model for untreated PBC patients, whereas the well-validated Paris I and Paris II criteria are mainly used in ursodeoxycholic acid (UDCA)-treated patients with advanced PBC (stage III-IV) and early PBC (stege I-II), respectively. Based on multicenter studies with large sample sizes, the recently reported GLOBE score and UK-PBC score seem to be superior to previous models and can be applied in patients with different stages of PBC who are already on UDCA therapy, but further external validation may be justified.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Chen S,Duan W,You H,Jia Jdoi
10.1007/s12072-017-9819-9subject
Has Abstractpub_date
2017-09-01 00:00:00pages
412-418issue
5eissn
1936-0533issn
1936-0541pii
10.1007/s12072-017-9819-9journal_volume
11pub_type
杂志文章,评审abstract：BACKGROUND:Variceal bleeding is a major complication of portal hypertension, which is associated with significant mortality. Moreover, patients surviving a variceal bleeding episode have very high risk of rebleeding, which is associated with mortality as high as that of the first bleed. Because of this, prevention of b...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-017-9833-y
更新日期：2018-02-01 00:00:00
abstract：:Along with the obesity epidemic, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased exponentially. The histological disease spectrum of NAFLD ranges from bland fatty liver (hepatic steatosis), to the concomitant presence of inflammation and ballooning which defines nonalcoholic steatohepatitis (N...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-015-9689-y
更新日期：2016-05-01 00:00:00
abstract：PURPOSE:Interferon-induced graft dysfunction (IGD) is a poorly defined, unrecognized, but potentially serious condition for patients receiving antiviral drugs after liver transplantation for hepatitis C. METHODS:We evaluated the characteristics of 80 patients who received pegylated interferon-based antiviral treatment...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-013-9496-2
更新日期：2014-04-01 00:00:00
abstract：PURPOSE:To evaluate the recent topics of Ballloon-occluded retrograde trasnvenous obliteration(B-RTO). METHOD:We overviewed the recent scientific papers regarding B-RTO. RESULT:B-RTO is a treatment method for occluding varices retrogradely using a sclerosing agent under balloon occlusion of a major draining vein. It ...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-017-9813-2
更新日期：2018-02-01 00:00:00
abstract：:The bone marrow contains stem cells that have the potential to differentiate into a variety of organ-specific mature cells, including the liver and the pancreas. Recently, the origin of hepatic progenitors and hepatocytes was identified to be the bone marrow. However, evidence that describes which cells, among all bon...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-007-9031-4
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:Microvascular invasion of hepatocellular carcinoma (HCC) is considered a poor prognostic factor of liver resection (LR) and liver transplantation (LT), but its significance for lesions within the up-to-7 criteria is unclear. This study investigated the survival benefit of primary LT against LR for HCC with micr...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9318-3
更新日期：2011-10-21 00:00:00
abstract：BACKGROUND AND AIM:Acute kidney injury (AKI), as defined by the Acute Kidney Injury Network, has been widely investigated in decompensated liver cirrhosis patients. AKI is frequently progressive and independently associated with mortality in these patients. However, in the Asia-Pacific region, the majority of cases of ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-015-9636-y
更新日期：2015-07-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is a common malignant tumor with high lethality, and the hepatitis B virus (HBV) is a chief cause. HBV can accelerate HCC via multiple mechanisms. First, HBV induces immune reactions that lead to repeated hepatic inflammation, fibrosis and a deficient immune microenvironment. Subsequentl...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-016-9779-5
更新日期：2017-03-01 00:00:00
abstract：:Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease, characterized by multiple strictures and dilatations of the intra- and extrahepatic bile ducts, leading to progressive liver fibrosis, in 10-15% cholangiocarcinoma, and ultimately end-stage liver disease. The pathogenesis is poorly understood, b...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-020-10118-x
更新日期：2020-12-30 00:00:00
abstract：AIM:Tamibarotene is a synthetic retinoid expected to inhibit tumor-cell proliferation and to induce apoptosis by selective interaction with retinoic acid receptor α/β. We conducted an open-label phase I/II study to determine the maximum tolerated dose (MTD) and recommended dose (RD), and to evaluate the pharmacokinetic...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-013-9459-7
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party to develop a consensus cost-effectiveness model for treatment of Hepatitis B in Asia Pacific countries in March 2010. METHODS:The working party consisted of expert hepatologists, virologists and epidemiolog...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-014-9549-1
更新日期：2014-07-01 00:00:00
abstract：PURPOSE:To elucidate the efficiency of contrast-enhanced ultrasonography alone and in combination with other noninvasive models for grading hepatic fibrosis. METHODS:This prospective study included 74 patients with four grades (F1-F4) of chronic liver disease (17, 20, 18, and 19 patients, respectively). Diagnostic per...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-012-9370-7
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND AND AIMS:T cell-mediated immune injury plays a critical role in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Given the high short-term mortality and crucial role of T cells in the disease progression, it is necessary to investigate the dynamics of T cell clones dur...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-019-10008-x
更新日期：2020-01-01 00:00:00
abstract：:The presence of hepatic encephalopathy (HE) within 4 weeks is part of the criteria for defining acute-on-chronic liver failure (ACLF). The pathophysiology of HE is complex, and hyperammonemia and cerebral hemodynamic dysfunction appear to be central in the pathogenesis of encephalopathy. Recent data also suggest that ...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-015-9626-0
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:The life cycle of hepatitis C virus (HCV) is tightly associated with host lipoprotein metabolic pathways. Apolipoprotein is present on the outer surface of lipoprotein particles and plays an important role in lipoprotein metabolism. We aimed to elucidate the influence of chronic HCV infection on serum apolip...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-014-9572-2
更新日期：2014-10-01 00:00:00
abstract：:More than 170 million people worldwide are infected with hepatitis C virus (HCV). A characteristic of this virus is a high tendency toward chronic infection. Several factors affect the viral outcome after infection. Among them, HCV-specific CD4 T cells are thought to play a crucial role in controlling viremia. Cumulat...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9321-8
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:Ethanol binge augments liver injury after chronic ethanol consumption in humans, but the mechanism behind the enhanced liver injury by ethanol binge is not known. In this study we used a clinically relevant rat model in which liver injury is amplified by binge after chronic ethanol treatment and investigated th...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-014-9546-4
更新日期：2014-09-01 00:00:00
abstract：:Hepatitis C virus (HCV) treatment in HIV/HCV co-infected individuals has renewed relevance given the ongoing opioid crisis and rise of new HIV and HCV infections associated with injection drug use. Patients co-infected with HIV and HCV demonstrate increased rates of hepatic fibrosis, progression to liver failure, and ...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-018-9896-4
更新日期：2018-11-01 00:00:00
abstract：PURPOSE:Clevudine 30 mg showed potent antiviral activity with a marked post-treatment antiviral effect. However, long-term treatment with clevudine monotherapy induced resistance and myopathy in some cases. The objective of this study is to evaluate the preliminary efficacy and safety of the combination of clevudine 20...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-014-9537-5
更新日期：2014-05-25 00:00:00
abstract：:Portal hypertension develops as a result of increased intrahepatic vascular resistance often caused by chronic liver disease that leads to structural distortion by fibrosis, microvascular thrombosis, dysfunction of liver sinusoidal endothelial cells (LSECs), and hepatic stellate cell (HSC) activation. While the basic ...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-017-9826-x
更新日期：2018-02-01 00:00:00
abstract：:The term nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of increasingly harmful conditions ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) to liver fibrosis and end-stage cirrhosis. NAFLD is the currently most common form of chronic liver disease in both adults and ch...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-019-10001-4
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Hepatitis C (HCV) is the predominant cause of chronic liver disease in the USA and is increasingly recognized as a common cause of liver disease in China. Studies of HCV patients in the US found major gaps in knowledge but little is known about HCV knowledge among patients in China. METHODS:We conducted a s...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-014-9559-z
更新日期：2015-01-01 00:00:00
abstract：:Cirrhotic cardiomyopathy is a recently recognized condition in cirrhosis consisting of systolic incompetence under condition of stress, diastolic dysfunction related to altered diastolic relaxation, and electrophysiological abnormalities in the absence of any known cardiac disease. It can be diagnosed by using a combi...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-008-9109-7
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Although arterial stiffness has been reported to be associated with nonalcoholic fatty liver disease (NAFLD), previous studies have relied only on noninvasive assessments for the diagnosis of NAFLD. This study attempted to investigate the association of arterial stiffness with the histological severity of NA...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-020-10108-z
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:The association of obstructive sleep apnea (OSA) with nonalcoholic fatty liver disease (NAFLD) has only been studied in selected subgroups such as the morbidly obese. We aimed to determine the prevalence and effect of OSA on NAFLD and vice versa in unselected patients attending the outpatient department. ME...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-015-9615-3
更新日期：2015-04-01 00:00:00
abstract：:Background and aims The aims of this study were to evaluate a preventive effect on collateral venous circulation of long-term administration of propranolol in intrahepatic portal hypertensive rats. Methods Eighty-six Sprague-Dawley rats were allocated to two models of hepatic fibrosis, bile duct-ligated (BDL) induced ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-008-9070-5
更新日期：2008-12-01 00:00:00
abstract：:Liver transplantation is a definitive therapy for patients with end-stage liver disease and cirrhosis, with improvement in survival and quality of life. Patients are carefully screened and selected for this modality of treatment to achieve maximum survival benefit. For example, a patient with hepatocellular carcinoma ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-016-9770-1
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Possible serologic activity after hepatitis B surface antigen (HBsAg) seroclearance documented by conventional assays in chronic hepatitis B (CHB) has not been thoroughly investigated. METHODS:We determined the levels of serum hepatitis B virus (HBV) DNA, hepatitis B core-related antigen (HBcrAg), and linea...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-012-9354-7
更新日期：2012-03-13 00:00:00
abstract：:An ultrasound (US) examination is a common noninvasive technique widely applied for diagnosis of a variety of diseases. Based on the rapid development of US equipment, many US images have been accumulated and are now available and ready for the preparation of a database for the development of computer-aided US diagnos...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-019-09937-4
更新日期：2019-07-01 00:00:00
abstract：:Hepatitis due to hepatitis B virus reactivation after cytotoxic or immunosuppressive therapy is a serious cause of liver-related morbidity and mortality. With the characterization of the underlying pathogenesis, much progress in the management of this important clinical problem has been made in the past 2 decades. By ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-008-9056-3
更新日期：2008-06-01 00:00:00
