A brief review on prognostic models of primary biliary cholangitis.


:Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease characterized by progressive destruction of small intrahepatic bile ducts. If left untreated, PBC may eventually result in end-stage liver disease. For better management of PBC and optimal allocation of medical resources, it is pivotal to accurately estimate the prognosis of patients with PBC. This article will briefly review the models that predict long-term outcome of PBC patients, with special focus on the applicability, strengths and limitations of the widely used models reported from 1983 to 2016. Among many, the Mayo score has been extensively validated and considered as the classic prognostic model for untreated PBC patients, whereas the well-validated Paris I and Paris II criteria are mainly used in ursodeoxycholic acid (UDCA)-treated patients with advanced PBC (stage III-IV) and early PBC (stege I-II), respectively. Based on multicenter studies with large sample sizes, the recently reported GLOBE score and UK-PBC score seem to be superior to previous models and can be applied in patients with different stages of PBC who are already on UDCA therapy, but further external validation may be justified.


Hepatol Int


Hepatology international


Chen S,Duan W,You H,Jia J




Has Abstract


2017-09-01 00:00:00














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    journal_title:Hepatology international

    pub_type: 杂志文章,评审


    authors: Eslam M,George J

    更新日期:2016-05-01 00:00:00

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    journal_title:Hepatology international

    pub_type: 杂志文章,meta分析,评审


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    更新日期:2018-07-01 00:00:00

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    pub_type: 社论,实务指引


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    authors: Kovalic AJ,Satapathy SK,Chalasani N

    更新日期:2018-03-01 00:00:00

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    更新日期:2013-06-01 00:00:00

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    更新日期:2013-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Roman S,Panduro A,Aguilar-Gutierrez Y,Maldonado M,Vazquez-Vandyck M,Martinez-Lopez E,Ruiz-Madrigal B,Hernandez-Nazara Z

    更新日期:2009-06-01 00:00:00

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    pub_type: 杂志文章


    authors: El Khayat HR,Fouad YM,Ahmad EA,El Amin H,Ismael F,Rizk A

    更新日期:2012-06-01 00:00:00

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    abstract:AIM:Tamibarotene is a synthetic retinoid expected to inhibit tumor-cell proliferation and to induce apoptosis by selective interaction with retinoic acid receptor α/β. We conducted an open-label phase I/II study to determine the maximum tolerated dose (MTD) and recommended dose (RD), and to evaluate the pharmacokinetic...

    journal_title:Hepatology international

    pub_type: 杂志文章


    authors: Kanai F,Obi S,Fujiyama S,Shiina S,Tamai H,Mochizuki H,Koike Y,Imamura J,Yamaguchi T,Saida I,Yokosuka O,Omata M

    更新日期:2014-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Tong MJ,Huynh TT,Siripongsakun S,Chang PW,Tong LT,Ha YP,Mena EA,Weissman MF

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    authors: Kuo YH,Lu SN,Hung CH,Kee KM,Chen CH,Hu TH,Lee CM,Changchien CS,Wang JH

    更新日期:2010-10-08 00:00:00

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    authors: Tada M,Imazeki F,Fukai K,Sakamoto A,Arai M,Mikata R,Tokuhisa T,Yokosuka O

    更新日期:2007-09-01 00:00:00

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    authors: Yamasaki T,Saeki I,Sakaida I

    更新日期:2014-09-01 00:00:00

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    authors: Wong F

    更新日期:2009-03-01 00:00:00

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    journal_title:Hepatology international

    pub_type: 杂志文章


    authors: Sinn DH,Yi J,Choi MS,Choi D,Gwak GY,Paik YH,Lee JH,Koh KC,Paik SW,Yoo BC

    更新日期:2013-10-01 00:00:00

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    abstract:BACKGROUND/PURPOSE:In Japan, there is a growing population of patients with chronic hepatitis C virus (HCV) infection who failed a direct-acting antiviral (DAA)-based regimen. In this Phase 3 study, we evaluated sofosbuvir-velpatasvir plus ribavirin in Japanese patients with genotype 1 or 2 HCV infection who previously...

    journal_title:Hepatology international

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Izumi N,Takehara T,Chayama K,Yatsuhashi H,Takaguchi K,Ide T,Kurosaki M,Ueno Y,Toyoda H,Kakizaki S,Tanaka Y,Kawakami Y,Enomoto H,Ikeda F,Jiang D,De-Oertel S,McNabb BL,Camus G,Stamm LM,Brainard DM,McHutchison JG,M

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    journal_title:Hepatology international

    pub_type: 杂志文章


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    更新日期:2017-03-01 00:00:00

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    journal_title:Hepatology international

    pub_type: 杂志文章


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    journal_title:Hepatology international

    pub_type: 杂志文章,评审


    authors: McConnell M,Iwakiri Y

    更新日期:2018-02-01 00:00:00

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    journal_title:Hepatology international

    pub_type: 杂志文章,评审


    authors: Lee GH

    更新日期:2015-10-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2014-10-01 00:00:00

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    journal_title:Hepatology international

    pub_type: 杂志文章


    authors: Sidhu SS,Malhi NS,Goyal O,Singh R,Dutta U,Grover R,Sidhu JS,Nanda V,Saluja H,Bansal A,Singh G,Sehgal A,Kishore H,Sidhu S

    更新日期:2017-05-01 00:00:00

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    journal_title:Hepatology international

    pub_type: 杂志文章


    authors: Bihari C,Patil A,Shasthry SM,Baweja S,Kumar G,Sarin SK

    更新日期:2020-07-01 00:00:00

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    journal_title:Hepatology international

    pub_type: 杂志文章


    authors: Yang SC,Wu KL,Wang JH,Lee CH,Kuo YH,Tai WC,Chen CH,Chiou SS,Lu SN,Hu TH,Changchien CS,Chuah SK

    更新日期:2013-03-01 00:00:00

  • Prognostic analysis of pulmonary metastases from hepatocellular carcinoma.

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    journal_title:Hepatology international

    pub_type: 杂志文章


    authors: Zhang SM,Zeng ZC,Tang ZY,Sun J,Cheng JM,Liu R,Wang P,Zhang BH

    更新日期:2008-06-01 00:00:00

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    journal_title:Hepatology international

    pub_type: 杂志文章


    authors: Chan SC,Lo CM,Chok KS,Sharr WW,Cheung TT,Tsang SH,Chan AC,Fan ST

    更新日期:2011-03-26 00:00:00

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    journal_title:Hepatology international

    pub_type: 杂志文章,评审


    authors: Lang J,Neumann-Haefelin C,Thimme R

    更新日期:2019-03-01 00:00:00