Hemodynamic effects of the early and long-term administration of propranolol in rats with intrahepatic portal hypertension.

abstract：:Substantial advancements in the field of primary biliary cirrhosis (PBC) research have broadened our understanding of this enigmatic disease. Genome-wide studies have identified several new candidate genes involved in the immunoregulatory process, particularly those responsible for antigen presentation and lymphocyte ...

journal_title：Hepatology international

authors： Trivedi PJ,Cullen S

更新日期：2013-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a common malignant tumor with high lethality, and the hepatitis B virus (HBV) is a chief cause. HBV can accelerate HCC via multiple mechanisms. First, HBV induces immune reactions that lead to repeated hepatic inflammation, fibrosis and a deficient immune microenvironment. Subsequentl...

journal_title：Hepatology international

authors： Wang M,Xi D,Ning Q

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:The diagnostic potential of hepatic stellate cells (HSCs) and γδT cells for patients with hepatocellular carcinoma (HCC) and their synergistic contributions to the prognosis of these patients have not yet been investigated. The aim of this study was to elucidate the prognostic value of these cells in HCC. METH...

journal_title：Hepatology international

authors： Zhou BY,Gong JH,Cai XY,Wang JX,Luo F,Jiang N,Gong JP,Du CY,Liao R

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:The relationship between chronic hepatitis B virus (HBV) infection and fatty liver in patients remains unclear. Although high-fat diets-induced hepatic steatosis was proved to reduce HBV replication in transgenic mice, the interplay between HBV and fatty liver in immunocompetent mouse model is yet to be eluci...

journal_title：Hepatology international

authors： Hu D,Wang H,Wang H,Wang Y,Wan X,Yan W,Luo X,Ning Q

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Ultrasonography is the most frequently used modality in surveillance for HCC among patients with chronic hepatitis C. However, the optimal surveillance interval is still controversial and the usefulness of supplementary tumor marker determination has not been confirmed. METHODS:A total of 243 cases...

journal_title：Hepatology international

authors： Sato T,Tateishi R,Yoshida H,Ohki T,Masuzaki R,Imamura J,Goto T,Kanai F,Obi S,Kato N,Shiina S,Kawabe T,Omata M

更新日期：2009-12-01 00:00:00

abstract：:Hepatitis B virus (HBV) reactivation with hepatic decompensation leading to acute on chronic liver failure is not uncommon. It is associated with high mortality of up to 30-70%. Prognostic factors for mortality include high bilirubin level, more prolonged prothrombin time, low platelet count and presence of pre-existi...

journal_title：Hepatology international

authors： Yuen MF

更新日期：2015-07-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden and cure is rarely achieved by current antiviral therapies. Therefore, there is an urgent need for new therapeutic options. Immune modulation with the goal to restore dysfunctional HBV-specific immunity is an interesting target for new therapeut...

journal_title：Hepatology international

authors： Lang J,Neumann-Haefelin C,Thimme R

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Early prediction of lamivudine (LAM) response by individualized monitoring of serum HBV DNA like roadmap concept, and investigation of the outcome after LAM discontinuation in renal transplant recipients (RTRs) with chronic hepatitis B (CHB). METHODS:We conducted a study on 19 RTRs with HBV infection receiv...

journal_title：Hepatology international

authors： Hu TH,Tsai MC,Chen YT,Chien YS,Hung CH,Chen TC,Tseng PL,Chang KC,Yen YH

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Recently, Sofosbuvir was launched in India at affordable cost. We conducted a real-life study to determine the efficacy and safety of Sofosbuvir plus Ribavirin, with and without peginterferon-alfa 2a, in patients with chronic hepatitis C (CHC) genotype 3, the commonest genotype in South Asia. METHO...

journal_title：Hepatology international

authors： Sidhu SS,Malhi NS,Goyal O,Singh R,Dutta U,Grover R,Sidhu JS,Nanda V,Saluja H,Bansal A,Singh G,Sehgal A,Kishore H,Sidhu S

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:L-Asparaginase is a bacterial enzyme used in the treatment of acute lymphoblastic leukemia. In the ongoing U.S. Drug-Induced Liver Injury Network (DILIN) prospective study, standard and pegylated asparaginase were the most frequent cause of liver injury with jaundice among anti-cancer agents (8 of 40: 20%). ...

journal_title：Hepatology international

authors： Kamal N,Koh C,Samala N,Fontana RJ,Stolz A,Durazo F,Hayashi PH,Phillips E,Wang T,Hoofnagle JH,Drug-Induced Liver Injury Network.

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:Ethanol binge augments liver injury after chronic ethanol consumption in humans, but the mechanism behind the enhanced liver injury by ethanol binge is not known. In this study we used a clinically relevant rat model in which liver injury is amplified by binge after chronic ethanol treatment and investigated th...

journal_title：Hepatology international

authors： Aroor AR,Restrepo RJ,Kharbanda KK,Shukla SD

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Type II mixed cryoglobulinemia (MC) is a systemic vasculitis usually associated with hepatitis C virus (HCV). The present trial was performed to investigate the efficacy of therapy with pegylated interferon alfa-2a (PEG-IFN alfa-2a) plus ribavirin in patients with HCV-related MC vasculitis and evaluate the fa...

journal_title：Hepatology international

authors： El Khayat HR,Fouad YM,Ahmad EA,El Amin H,Ismael F,Rizk A

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Possible serologic activity after hepatitis B surface antigen (HBsAg) seroclearance documented by conventional assays in chronic hepatitis B (CHB) has not been thoroughly investigated. METHODS:We determined the levels of serum hepatitis B virus (HBV) DNA, hepatitis B core-related antigen (HBcrAg), and linea...

journal_title：Hepatology international

authors： Seto WK,Tanaka Y,Wong DK,Lai CL,Shinkai N,Yuen JC,Tong T,Fung J,Hung IF,Yuen MF

更新日期：2012-03-13 00:00:00

abstract：:To address the relationship between hepatitis B virus (HBV) endemicity and HBV-related liver diseases in Mexico. Research literature reporting on HBsAg and antibody to hepatitis B core antigen (anti-HBc) prevalence in Mexican study groups were searched in NLM Gateway, PubMed, IMBIOMED, and others. Weighted mean preval...

journal_title：Hepatology international

authors： Roman S,Panduro A,Aguilar-Gutierrez Y,Maldonado M,Vazquez-Vandyck M,Martinez-Lopez E,Ruiz-Madrigal B,Hernandez-Nazara Z

更新日期：2009-06-01 00:00:00

abstract：:The term nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of increasingly harmful conditions ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) to liver fibrosis and end-stage cirrhosis. NAFLD is the currently most common form of chronic liver disease in both adults and ch...

journal_title：Hepatology international

authors： Reimer KC,Wree A,Roderburg C,Tacke F

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Despite improvements in immunosuppressive therapy, acute cellular rejection (ACR) remains an important cause of graft loss in patients undergoing liver transplantation. Recently, associations between cytokine gene polymorphisms in recipients and the occurrence of ACR have been reported. However, most studies di...

journal_title：Hepatology international

authors： Kamei H,Masuda S,Nakamura T,Ishigami M,Fujimoto Y,Ogura Y,Oike F,Takada Y,Hamajima N

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:Either combination treatment or monotherapy using agents with a high genetic barrier are recommended for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB). The aim of this study was to compare effect of naïve HBeAg-negative CHB patients with either de novo combination of lamivudine (LAM) and adef...

journal_title：Hepatology international

authors： Wang LC,Chen EQ,Cao J,Liu L,Zheng L,Li DJ,Xu L,Lei XZ,Liu C,Tang H

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:We investigated whether the combined presence and evolution of hepatitis B virus (HBV) mutant strains in the hepatitis B e antigen (HBeAg)-positive status can predict clinical outcomes after HBeAg seroconversion. METHODS:One hundred and eighty-six patients with spontaneous HBeAg seroconversion were enrolled in...

journal_title：Hepatology international

authors： Chen CH,Lee CM,Wang JH,Hu TH,Hung CH,Changchien CS,Lu SN

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:To evaluate the recent topics of Ballloon-occluded retrograde trasnvenous obliteration(B-RTO). METHOD:We overviewed the recent scientific papers regarding B-RTO. RESULT:B-RTO is a treatment method for occluding varices retrogradely using a sclerosing agent under balloon occlusion of a major draining vein. It ...

journal_title：Hepatology international

authors： Hirota S,Kobayashi K,Kako Y,Takaki H,Yamakado K

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The association of obstructive sleep apnea (OSA) with nonalcoholic fatty liver disease (NAFLD) has only been studied in selected subgroups such as the morbidly obese. We aimed to determine the prevalence and effect of OSA on NAFLD and vice versa in unselected patients attending the outpatient department. ME...

journal_title：Hepatology international

authors： Agrawal S,Duseja A,Aggarwal A,Das A,Mehta M,Dhiman RK,Chawla Y

更新日期：2015-04-01 00:00:00

abstract：:Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI i...

journal_title：Hepatology international

authors： Yu YC,Mao YM,Chen CW,Chen JJ,Chen J,Cong WM,Ding Y,Duan ZP,Fu QC,Guo XY,Hu P,Hu XQ,Jia JD,Lai RT,Li DL,Liu YX,Lu LG,Ma SW,Ma X,Nan YM,Ren H,Shen T,Wang H,Wang JY,Wang TL,Wang XJ,Wei L,Xie Q,Xie W,

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is associated with a high mortality rate in the absence of liver transplantation. There is limited data on predictors of survival in ACLF in children. Therefore, we prospectively studied the predictors of outcome of ACLF in children. METHODS:A prospective evalu...

journal_title：Hepatology international

authors： Lal J,Thapa BR,Rawal P,Ratho RK,Singh K

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:Lamivudine treatment of chronic hepatitis B (CHB) is associated with frequent resistance and loss of clinical benefit. We present outcomes of lamivudine-refractory Japanese patients treated with entecavir for 3 years. METHODS:Eighty-two patients refractory to lamivudine therapy received entecavir 0.5 or 1 mg d...

journal_title：Hepatology international

authors： Karino Y,Toyota J,Kumada H,Katano Y,Izumi N,Kobashi H,Sata M,Moriyama M,Imazeki F,Kage M,Ishikawa H,Masaki N,Seriu T,Omata M

更新日期：2010-02-06 00:00:00

abstract：BACKGROUND AND AIMS:Coronavirus disease 2019 (COVID-19) pandemic is ongoing. Except for lung injury, it is possible that COVID-19 patients develop liver injury. Thus, we conducted a systematic review and meta-analysis to explore the incidence, risk factors, and prognosis of abnormal liver biochemical tests in COVID-19 ...

journal_title：Hepatology international

authors： Wu Y,Li H,Guo X,Yoshida EM,Mendez-Sanchez N,Levi Sandri GB,Teschke R,Romeiro FG,Shukla A,Qi X

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:Interferon-induced graft dysfunction (IGD) is a poorly defined, unrecognized, but potentially serious condition for patients receiving antiviral drugs after liver transplantation for hepatitis C. METHODS:We evaluated the characteristics of 80 patients who received pegylated interferon-based antiviral treatment...

journal_title：Hepatology international

authors： Ikegami T,Wang H,Yoshizumi T,Toshima T,Aishima S,Fukuhara T,Furusyo N,Kotoh K,Shimoda S,Shirabe K,Maehara Y

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Initial presentation of hepatocellular carcinoma (HCC) at an advanced stage in patients under a regular surveillance program is a devastating problem. AIMS:We assessed the prevalence and factors associated with this surveillance failure. METHODS:A total of 304 HCC patients who received regular surveillance...

journal_title：Hepatology international

authors： Sinn DH,Yi J,Choi MS,Choi D,Gwak GY,Paik YH,Lee JH,Koh KC,Paik SW,Yoo BC

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:To compare the efficacy of entecavir (ETV) monotherapy up to 4 years in nucleos(t)ide analog (NA)-experienced and -naïve subjects. METHODS:One hundred sixty NA-experienced and 282 naïve chronic hepatitis B patients who were treated with ETV were enrolled. Of the 160 NA-experienced patients, 49 had prior lamivu...

journal_title：Hepatology international

authors： Chen CH,Hu TH,Hung CH,Lu SN,Wang JH,Chang MH,Changchien CS,Lee CM

更新日期：2013-07-01 00:00:00

abstract：:Patients (85%) with hepatocellular adenoma (HCA) are women taking oral contraceptives. They can be divided into four subgroups according to their genotype/phenotype features. (1) Hepatocyte nuclear factor 1alpha (HNF1alpha) biallelic somatic mutations are observed in 35% of the HCA cases. It occurs in almost all cases...

journal_title：Hepatology international

authors： Bioulac-Sage P,Laumonier H,Laurent C,Zucman-Rossi J,Balabaud C

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND AND AIM:There is an increased awareness of de novo hepatitis B virus (HBV) infection (DNH) in hepatitis B surface antigen (HBsAg)-negative recipients receiving hepatitis B core antibody (HBcAb)-positive liver organ. Whether hepatitis B surface antibody (HBsAb) has positive result on preventing the occurrence...

journal_title：Hepatology international

authors： Yang Y,Huang A,Zhao Y

更新日期：2020-03-01 00:00:00

abstract：:An ultrasound (US) examination is a common noninvasive technique widely applied for diagnosis of a variety of diseases. Based on the rapid development of US equipment, many US images have been accumulated and are now available and ready for the preparation of a database for the development of computer-aided US diagnos...

journal_title：Hepatology international

authors： Nishida N,Yamakawa M,Shiina T,Kudo M

更新日期：2019-07-01 00:00:00