Abstract：
:Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous APASL guidelines for management of HBV infection were published in 2012. The objective of this manuscript is to update the recommendations for the optimal management of chronic HBV infection. The 2015 guidelines were developed by a panel of Asian experts chosen by the APASL. The clinical practice guidelines are based on evidence from existing publications or, if evidence was unavailable, on the experts' personal experience and opinion after deliberations. Manuscripts and abstracts of important meetings published through January 2015 have been evaluated. This guideline covers the full spectrum of care of patients infected with hepatitis B, including new terminology, natural history, screening, vaccination, counseling, diagnosis, assessment of the stage of liver disease, the indications, timing, choice and duration of single or combination of antiviral drugs, screening for HCC, management in special situations like childhood, pregnancy, coinfections, renal impairment and pre- and post-liver transplant, and policy guidelines. However, areas of uncertainty still exist, and clinicians, patients, and public health authorities must therefore continue to make choices on the basis of the evolving evidence. The final clinical practice guidelines and recommendations are presented here, along with the relevant background information.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Sarin SK,Kumar M,Lau GK,Abbas Z,Chan HL,Chen CJ,Chen DS,Chen HL,Chen PJ,Chien RN,Dokmeci AK,Gane E,Hou JL,Jafri W,Jia J,Kim JH,Lai CL,Lee HC,Lim SG,Liu CJ,Locarnini S,Al Mahtab M,Mohamed R,Omata M,Park J,doi
10.1007/s12072-015-9675-4subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1-98issue
1eissn
1936-0533issn
1936-0541pii
10.1007/s12072-015-9675-4journal_volume
10pub_type
杂志文章,实务指引abstract：:The presence of hepatic encephalopathy (HE) within 4 weeks is part of the criteria for defining acute-on-chronic liver failure (ACLF). The pathophysiology of HE is complex, and hyperammonemia and cerebral hemodynamic dysfunction appear to be central in the pathogenesis of encephalopathy. Recent data also suggest that ...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-015-9626-0
更新日期：2015-10-01 00:00:00
abstract：GOALS:The aim of our study is to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis in patients with type 1 diabetes (T1D) using simple noninvasive scores. BACKGROUND:There is paucity of data on the prevalence of NAFLD in T1D. Moreover, T1D could be a risk factor for advanc...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-017-9840-z
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND AND AIM:Cirrhosis is a controversial determinant of mortality in HBV-related acute-on-chronic liver failure (HBV-ACLF). The present study aimed to explore the effects of cirrhosis and the associated risk factors, especially its complications, on the outcome of HBV-ACLF. METHODS:A prospective-retrospective c...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-019-09992-x
更新日期：2019-11-01 00:00:00
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journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-020-10108-z
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:The life cycle of hepatitis C virus (HCV) is tightly associated with host lipoprotein metabolic pathways. Apolipoprotein is present on the outer surface of lipoprotein particles and plays an important role in lipoprotein metabolism. We aimed to elucidate the influence of chronic HCV infection on serum apolip...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-014-9572-2
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:To evaluate the sequence variations in the enhancer II (EnhII)/basal core promotor (BCP)/precore (PC) and X genes of hepatitis B virus (HBV) in Thai patients with hepatocellular carcinoma (HCC) by conducting a cross-sectional case-control study. METHODS:As much as 60 patients with HCC and 60 patients without H...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-010-9197-z
更新日期：2010-07-31 00:00:00
abstract：:Substantial advancements in the field of primary biliary cirrhosis (PBC) research have broadened our understanding of this enigmatic disease. Genome-wide studies have identified several new candidate genes involved in the immunoregulatory process, particularly those responsible for antigen presentation and lymphocyte ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-012-9362-7
更新日期：2013-03-01 00:00:00
abstract：:Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease, characterized by multiple strictures and dilatations of the intra- and extrahepatic bile ducts, leading to progressive liver fibrosis, in 10-15% cholangiocarcinoma, and ultimately end-stage liver disease. The pathogenesis is poorly understood, b...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-020-10118-x
更新日期：2020-12-30 00:00:00
abstract：BACKGROUND:L-Asparaginase is a bacterial enzyme used in the treatment of acute lymphoblastic leukemia. In the ongoing U.S. Drug-Induced Liver Injury Network (DILIN) prospective study, standard and pegylated asparaginase were the most frequent cause of liver injury with jaundice among anti-cancer agents (8 of 40: 20%). ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-019-09971-2
更新日期：2019-09-01 00:00:00
abstract：:Liver transplantation is a definitive therapy for patients with end-stage liver disease and cirrhosis, with improvement in survival and quality of life. Patients are carefully screened and selected for this modality of treatment to achieve maximum survival benefit. For example, a patient with hepatocellular carcinoma ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-016-9770-1
更新日期：2017-01-01 00:00:00
abstract：:Hepatitis due to hepatitis B virus reactivation after cytotoxic or immunosuppressive therapy is a serious cause of liver-related morbidity and mortality. With the characterization of the underlying pathogenesis, much progress in the management of this important clinical problem has been made in the past 2 decades. By ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-008-9056-3
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is a progressive disease associated with rapid clinical worsening and high mortality. Early prediction of mortality and intervention can improve patient outcomes. We aimed to develop a dynamic prognostic model and compare it with the existing models. METHODS:A ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-017-9816-z
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Initial presentation of hepatocellular carcinoma (HCC) at an advanced stage in patients under a regular surveillance program is a devastating problem. AIMS:We assessed the prevalence and factors associated with this surveillance failure. METHODS:A total of 304 HCC patients who received regular surveillance...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-013-9462-z
更新日期：2013-10-01 00:00:00
abstract：:Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI i...
journal_title：Hepatology international
pub_type： 社论
doi：10.1007/s12072-017-9793-2
更新日期：2017-05-01 00:00:00
abstract：PURPOSE:To evaluate the recent topics of Ballloon-occluded retrograde trasnvenous obliteration(B-RTO). METHOD:We overviewed the recent scientific papers regarding B-RTO. RESULT:B-RTO is a treatment method for occluding varices retrogradely using a sclerosing agent under balloon occlusion of a major draining vein. It ...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-017-9813-2
更新日期：2018-02-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is a common malignant tumor with high lethality, and the hepatitis B virus (HBV) is a chief cause. HBV can accelerate HCC via multiple mechanisms. First, HBV induces immune reactions that lead to repeated hepatic inflammation, fibrosis and a deficient immune microenvironment. Subsequentl...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-016-9779-5
更新日期：2017-03-01 00:00:00
abstract：PURPOSE:Hepatitis B viral markers may be useful for predicting outcomes such as liver-related deaths or development of hepatocellular carcinoma. We determined the frequency of these markers in different clinical stages of chronic hepatitis B infection. METHODS:We compared baseline hepatitis B viral markers in 317 pati...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-010-9179-1
更新日期：2010-04-07 00:00:00
abstract：:The term nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of increasingly harmful conditions ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) to liver fibrosis and end-stage cirrhosis. NAFLD is the currently most common form of chronic liver disease in both adults and ch...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-019-10001-4
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Although clinical and experimental studies have demonstrated a correlation between obstructive jaundice and the development of sepsis, the mechanism has not been fully elucidated. PURPOSE:The aim of this study was to investigate the influence of biliary obstruction on bacterial translocation as a possible s...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-007-9018-1
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Variceal bleeding is a major complication of portal hypertension, which is associated with significant mortality. Moreover, patients surviving a variceal bleeding episode have very high risk of rebleeding, which is associated with mortality as high as that of the first bleed. Because of this, prevention of b...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-017-9833-y
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND AND AIMS:The peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand, piglitazone, enhances the degradation of branched-chain amino acids (BCAAs) in adipose tissue. However, it remains unknown whether pioglitazone influences the plasma amino acids (AA) profile in patients with nonalcoholic steatohepatit...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-012-9395-y
更新日期：2013-06-01 00:00:00
abstract：:Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease characterized by progressive destruction of small intrahepatic bile ducts. If left untreated, PBC may eventually result in end-stage liver disease. For better management of PBC and optimal allocation of med...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-017-9819-9
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:To elucidate the efficiency of contrast-enhanced ultrasonography alone and in combination with other noninvasive models for grading hepatic fibrosis. METHODS:This prospective study included 74 patients with four grades (F1-F4) of chronic liver disease (17, 20, 18, and 19 patients, respectively). Diagnostic per...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-012-9370-7
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:Ethanol binge augments liver injury after chronic ethanol consumption in humans, but the mechanism behind the enhanced liver injury by ethanol binge is not known. In this study we used a clinically relevant rat model in which liver injury is amplified by binge after chronic ethanol treatment and investigated th...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-014-9546-4
更新日期：2014-09-01 00:00:00
abstract：PURPOSE:Either combination treatment or monotherapy using agents with a high genetic barrier are recommended for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB). The aim of this study was to compare effect of naïve HBeAg-negative CHB patients with either de novo combination of lamivudine (LAM) and adef...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-010-9243-x
更新日期：2011-06-01 00:00:00
abstract：:In a country such as Japan with the average age of patients with chronic hepatitis C treated with antivirals sometimes well above 60 years, the standard combination therapy is not well tolerated. In this randomized, prospective, controlled trial, we investigated the efficacy of 24-week peginterferon α monotherapy for ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-009-9134-1
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to investigate the association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function. METHODS:Liver biopsy was performed for 30 patients with hepatitis B cirrhosis to test the content of hydroxyproline in hepatic tissue, judge the degree of cirrh...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-015-9648-7
更新日期：2015-10-01 00:00:00
abstract：:More than 170 million people worldwide are infected with hepatitis C virus (HCV). A characteristic of this virus is a high tendency toward chronic infection. Several factors affect the viral outcome after infection. Among them, HCV-specific CD4 T cells are thought to play a crucial role in controlling viremia. Cumulat...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9321-8
更新日期：2012-01-01 00:00:00
abstract：AIMS:Relationships of renal function and liver disease are described in acute and chronic liver failure. The aim of the study is to investigate which relationship, if any, is present between severity of non-alcoholic fatty liver disease (NAFLD), assessed by bright liver score (BLS) versus mild-moderate renal insufficie...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9254-2
更新日期：2011-09-01 00:00:00
abstract：:Hepatitis C virus (HCV) treatment in HIV/HCV co-infected individuals has renewed relevance given the ongoing opioid crisis and rise of new HIV and HCV infections associated with injection drug use. Patients co-infected with HIV and HCV demonstrate increased rates of hepatic fibrosis, progression to liver failure, and ...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-018-9896-4
更新日期：2018-11-01 00:00:00
