Virus-induced hepatocellular carcinoma with special emphasis on HBV.

Abstract:

:Hepatocellular carcinoma (HCC) is a common malignant tumor with high lethality, and the hepatitis B virus (HBV) is a chief cause. HBV can accelerate HCC via multiple mechanisms. First, HBV induces immune reactions that lead to repeated hepatic inflammation, fibrosis and a deficient immune microenvironment. Subsequently, HBV can modify host genes near the insertion point through DNA integration to cause host cell genome instability and to generate carcinogenic fusion proteins. Additionally, HBV expresses diverse active proteins, especially HBx and HBs, which have a range of transactivation functions such as regulation of apoptosis, interference with intracellular signaling pathways, and alteration of epigenetics. Currently, primary prevention measures for HBV-induced HCC focus on vaccination and antiviral treatment. Here, we report the epidemiology, the molecular mechanism and the progress in therapeutic strategies for controlling HBV-induced HCC.

journal_name

Hepatol Int

journal_title

Hepatology international

authors

Wang M,Xi D,Ning Q

doi

10.1007/s12072-016-9779-5

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

171-180

issue

2

eissn

1936-0533

issn

1936-0541

pii

10.1007/s12072-016-9779-5

journal_volume

11

pub_type

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