Abstract:
:Hepatocellular carcinoma (HCC) is a common malignant tumor with high lethality, and the hepatitis B virus (HBV) is a chief cause. HBV can accelerate HCC via multiple mechanisms. First, HBV induces immune reactions that lead to repeated hepatic inflammation, fibrosis and a deficient immune microenvironment. Subsequently, HBV can modify host genes near the insertion point through DNA integration to cause host cell genome instability and to generate carcinogenic fusion proteins. Additionally, HBV expresses diverse active proteins, especially HBx and HBs, which have a range of transactivation functions such as regulation of apoptosis, interference with intracellular signaling pathways, and alteration of epigenetics. Currently, primary prevention measures for HBV-induced HCC focus on vaccination and antiviral treatment. Here, we report the epidemiology, the molecular mechanism and the progress in therapeutic strategies for controlling HBV-induced HCC.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Wang M,Xi D,Ning Qdoi
10.1007/s12072-016-9779-5subject
Has Abstractpub_date
2017-03-01 00:00:00pages
171-180issue
2eissn
1936-0533issn
1936-0541pii
10.1007/s12072-016-9779-5journal_volume
11pub_type
杂志文章,评审abstract:BACKGROUND AND AIMS:Status 1A patients are prioritized over end-stage liver disease (ESLD) for liver transplantation (LT). ESLD patients with high MELD may have higher waitlist mortality than Status 1A patients, and may require LT more urgently. METHODS:Using United Network for Organ Sharing registry data, we retrospe...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-016-9735-4
更新日期:2016-09-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is currently one of the leading forms of chronic liver disease, and its rising frequency worldwide has reached epidemic proportions. NAFLD, particularly its progressive variant NASH (non-alcoholic steatohepatitis), can lead to advanced fibrosis, cirrhosis, and HCC. The pathoph...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-018-9854-1
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party to develop a consensus cost-effectiveness model for treatment of Hepatitis B in Asia Pacific countries in March 2010. METHODS:The working party consisted of expert hepatologists, virologists and epidemiolog...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-014-9549-1
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:L-Asparaginase is a bacterial enzyme used in the treatment of acute lymphoblastic leukemia. In the ongoing U.S. Drug-Induced Liver Injury Network (DILIN) prospective study, standard and pegylated asparaginase were the most frequent cause of liver injury with jaundice among anti-cancer agents (8 of 40: 20%). ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09971-2
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND AND AIMS:The peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand, piglitazone, enhances the degradation of branched-chain amino acids (BCAAs) in adipose tissue. However, it remains unknown whether pioglitazone influences the plasma amino acids (AA) profile in patients with nonalcoholic steatohepatit...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9395-y
更新日期:2013-06-01 00:00:00
abstract::An ultrasound (US) examination is a common noninvasive technique widely applied for diagnosis of a variety of diseases. Based on the rapid development of US equipment, many US images have been accumulated and are now available and ready for the preparation of a database for the development of computer-aided US diagnos...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-019-09937-4
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:Type II mixed cryoglobulinemia (MC) is a systemic vasculitis usually associated with hepatitis C virus (HCV). The present trial was performed to investigate the efficacy of therapy with pegylated interferon alfa-2a (PEG-IFN alfa-2a) plus ribavirin in patients with HCV-related MC vasculitis and evaluate the fa...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9303-x
更新日期:2012-06-01 00:00:00
abstract::The cancer stem cell (CSC) hypothesis has been disproved in many cancers. CSCs may exist in blood cancer, while many epithelial cancers may not have CSCs but tumor-initiating cells (TICs). Several independent studies have provided strong evidence for existence of CSCs in brain, skin, and colon cancers (Mani et al. in ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-016-9777-7
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Clevudine 30 mg showed potent antiviral activity with a marked post-treatment antiviral effect. However, long-term treatment with clevudine monotherapy induced resistance and myopathy in some cases. The objective of this study is to evaluate the preliminary efficacy and safety of the combination of clevudine 20...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-014-9537-5
更新日期:2014-05-25 00:00:00
abstract::Substantial advancements in the field of primary biliary cirrhosis (PBC) research have broadened our understanding of this enigmatic disease. Genome-wide studies have identified several new candidate genes involved in the immunoregulatory process, particularly those responsible for antigen presentation and lymphocyte ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9362-7
更新日期:2013-03-01 00:00:00
abstract::The Chinese Society of Hepatology developed the current guidelines for the Management of Ascites and Its Related Complications in Cirrhosis based on the published evidences and the panelists' consensus. The guidelines provided recommendations for the diagnosis and management of cirrhotic ascites emphasizing a step-wis...
journal_title:Hepatology international
pub_type: 社论,实务指引
doi:10.1007/s12072-018-09923-2
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To assess the accuracy of a formula derived from 159 living liver donors to estimate the liver size of a normal subject: standard liver weight (g) = 218 + body weight (kg) × 12.3 + 51 (if male). Standard liver volume (SLV) is attained by a conversion factor of 1.19 mL/g. METHODS:The total liver volume (TLV) of...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9264-0
更新日期:2011-03-26 00:00:00
abstract:BACKGROUND AND AIM:Relationships between circulating microRNA-122 (miR-122) and histological features of nonalcoholic fatty liver disease (NAFLD) are unclear. METHODS:The impact of serum miR-122 levels for histological features and hepatocellular carcinoma (HCC) was investigated in 305 Japanese patients with histologi...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-016-9729-2
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:Interferon-induced graft dysfunction (IGD) is a poorly defined, unrecognized, but potentially serious condition for patients receiving antiviral drugs after liver transplantation for hepatitis C. METHODS:We evaluated the characteristics of 80 patients who received pegylated interferon-based antiviral treatment...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9496-2
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:Case reports and small case series have reported a high rate of complications associated with chest tube placement for hepatic hydrothorax. We describe the in-hospital and 3-month outcomes of patients who have had this procedure. METHODS:A retrospective medical record review was performed of all patients admit...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-009-9136-z
更新日期:2009-12-01 00:00:00
abstract::NAFLD is a spectrum of liver disease starting with fatty liver at one end of the spectrum and cirrhosis or liver cancer at the other end. Worldwide, NAFLD has become one of the most common liver diseases and it has also become one of the leading indications for liver transplantation. Our understanding of the NAFLD epi...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-019-09970-3
更新日期:2019-09-01 00:00:00
abstract::Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI i...
journal_title:Hepatology international
pub_type: 社论
doi:10.1007/s12072-017-9793-2
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND AND AIMS:To estimate the impact of viral hepatitis B status on outcomes of intrahepatic cholangiocarcinoma. METHODS:We searched Pubmed and Embase for original articles that evaluated the impact of hepatitis B virus infection on outcomes of intrahepatic cholangiocarcinoma. The present study was conducted to ...
journal_title:Hepatology international
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12072-018-9881-y
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND/PURPOSE:Gut microbiota has been associated with liver cirrhosis and, possibly, hepatic encephalopathy. However, only a few studies have examined the link between mucosa-associated microbiota (MAM) and minimal hepatic encephalopathy (MHE). Our aim was to investigate this relationship. METHODS:Twenty-four pat...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09963-2
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:Cholecystectomy is routinely performed at most transplant centers during living donor liver transplantation (LDLT). This study was performed to evaluate the feasibility of liver graft procurement with donor gallbladder preservation in LDLT. METHODS:Eighty-nine LDLTs (from June 2006 to Dec 2012) were retrospe...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9628-y
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Sorafenib significantly improves survival in patients with advanced hepatocellular carcinoma (HCC). This phase IV study assessed sorafenib efficacy/safety in Taiwanese patients with advanced HCC and Child-Pugh A status. METHODS:All patients received 400 mg sorafenib BID. Safety, efficacy, sorafenib pharmaco...
journal_title:Hepatology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12072-016-9774-x
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND/AIMS:[corrected] The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. METHODS:The patients with liver tumor or chronic hepatitis i...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9223-1
更新日期:2010-10-08 00:00:00
abstract::Portal hypertension develops as a result of increased intrahepatic vascular resistance often caused by chronic liver disease that leads to structural distortion by fibrosis, microvascular thrombosis, dysfunction of liver sinusoidal endothelial cells (LSECs), and hepatic stellate cell (HSC) activation. While the basic ...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-017-9826-x
更新日期:2018-02-01 00:00:00
abstract::Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous ...
journal_title:Hepatology international
pub_type: 杂志文章,实务指引
doi:10.1007/s12072-015-9675-4
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Controversy exists on whether tenofovir disoproxil fumarate (TDF) is superior to entecavir (ETV) in lowering the risk of hepatocellular carcinoma (HCC) development. This meta-analysis was performed to clarify this issue with critical clinical and methodological considerations. METHODS:PubMed, EMBASE, and Co...
journal_title:Hepatology international
pub_type: 杂志文章,meta分析
doi:10.1007/s12072-019-10005-0
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common malignant neoplasms worldwide. The p53 gene is frequently mutated in some histological subtypes of HCC. The role of p53 mutations and polymorphic variant of codon 72 in the prognosis of disease is still unclear. The p53 tumor suppressor gene Arg72Pro p...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9389-9
更新日期:2013-06-01 00:00:00
abstract::To address the relationship between hepatitis B virus (HBV) endemicity and HBV-related liver diseases in Mexico. Research literature reporting on HBsAg and antibody to hepatitis B core antigen (anti-HBc) prevalence in Mexican study groups were searched in NLM Gateway, PubMed, IMBIOMED, and others. Weighted mean preval...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-008-9115-9
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:To evaluate the sequence variations in the enhancer II (EnhII)/basal core promotor (BCP)/precore (PC) and X genes of hepatitis B virus (HBV) in Thai patients with hepatocellular carcinoma (HCC) by conducting a cross-sectional case-control study. METHODS:As much as 60 patients with HCC and 60 patients without H...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9197-z
更新日期:2010-07-31 00:00:00
abstract:BACKGROUND:Initial presentation of hepatocellular carcinoma (HCC) at an advanced stage in patients under a regular surveillance program is a devastating problem. AIMS:We assessed the prevalence and factors associated with this surveillance failure. METHODS:A total of 304 HCC patients who received regular surveillance...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9462-z
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND AND OBJECT:The risk of occult HBV infection (OBI) in children whose mothers are HBV carriers has received more widespread attention, but there were few reports to focus on the children with HBsAg-positive parents. In this study, we aimed to investigate the prevalence of OBI in immunized children with HBsAg-p...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-020-10055-9
更新日期:2020-07-01 00:00:00