当前位置： SCI文献检索 > Hepatology International期刊下所有文献 > Cirrhotic cardiomyopathy.

Cirrhotic cardiomyopathy.

Abstract：

:Cirrhotic cardiomyopathy is a recently recognized condition in cirrhosis consisting of systolic incompetence under condition of stress, diastolic dysfunction related to altered diastolic relaxation, and electrophysiological abnormalities in the absence of any known cardiac disease. It can be diagnosed by using a combination of electrocardiograph, 2-dimensional echocardiography, and various serum markers such as brain natriuretic factor. The underlying pathogenetic mechanisms include abnormalities in the beta-adrenergic signaling pathway, altered cardiomyocyte membrane fluidity, increased myocardial fibrosis, cardiomyocyte hypertrophy, and ion channel defects. Various compounds for which levels are elevated in cirrhosis such as nitric oxide and carbon monoxide can also exert a negative inotropic effect on the myocardium, whereas excess sodium and volume retention can lead to myocardial hypertrophy. Various toxins can also aggravate the ion channel defects, thereby widening the QRS complex causing prolonged QT intervals. Clinically, systolic incompetence is most evident when cirrhotic patients are placed under stress, whether physical or pharmacological, or when the extent of peripheral arterial vasodilatation demands an increased cardiac output as in the case of bacterial infections. Acute volume overload such as immediately after insertion of a transjugular intrahepatic portosystemic shunt or after liver transplantation can also tip these cirrhotic patients into cardiac failure. Treatment of cirrhotic cardiomyopathy is unsatisfactory. There is some evidence that beta-blockade may help some cirrhotic patients with baseline prolonged QT interval. Long-term aldosterone antagonism may help reduce myocardial hypertrophy. Future studies should include further elucidation of pathogenetic mechanisms so as to develop effective treatment strategies.

journal_name

Hepatol Int

journal_title

Hepatology international

authors

Wong F

doi

10.1007/s12072-008-9109-7

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

294-304

issue

1

eissn

1936-0533

issn

1936-0541

journal_volume

3

pub_type

杂志文章

相关文献

Hepatology International文献大全
  • A brief review on prognostic models of primary biliary cholangitis.

    abstract：:Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease characterized by progressive destruction of small intrahepatic bile ducts. If left untreated, PBC may eventually result in end-stage liver disease. For better management of PBC and optimal allocation of med...

    journal_title：Hepatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s12072-017-9819-9

    authors： Chen S,Duan W,You H,Jia J

    更新日期：2017-09-01 00:00:00

  • Live donor liver transplantation for alcoholic hepatitis.

    abstract：:Liver transplantation is a definitive therapy for patients with end-stage liver disease and cirrhosis, with improvement in survival and quality of life. Patients are carefully screened and selected for this modality of treatment to achieve maximum survival benefit. For example, a patient with hepatocellular carcinoma ...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-016-9770-1

    authors： Singal AK,Kamath PS

    更新日期：2017-01-01 00:00:00

  • Liver stiffness measurement in the risk assessment of hepatocellular carcinoma for patients with chronic hepatitis.

    abstract：BACKGROUND/AIMS:[corrected] The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. METHODS:The patients with liver tumor or chronic hepatitis i...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-010-9223-1

    authors： Kuo YH,Lu SN,Hung CH,Kee KM,Chen CH,Hu TH,Lee CM,Changchien CS,Wang JH

    更新日期：2010-10-08 00:00:00

  • Association of arterial stiffness with the histological severity of nonalcoholic fatty liver disease.

    abstract：BACKGROUND:Although arterial stiffness has been reported to be associated with nonalcoholic fatty liver disease (NAFLD), previous studies have relied only on noninvasive assessments for the diagnosis of NAFLD. This study attempted to investigate the association of arterial stiffness with the histological severity of NA...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-020-10108-z

    authors： Kim HL,Koo BK,Joo SK,Kim W

    更新日期：2020-12-01 00:00:00

  • Pharmacologic prevention of variceal bleeding and rebleeding.

    abstract：BACKGROUND:Variceal bleeding is a major complication of portal hypertension, which is associated with significant mortality. Moreover, patients surviving a variceal bleeding episode have very high risk of rebleeding, which is associated with mortality as high as that of the first bleed. Because of this, prevention of b...

    journal_title：Hepatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s12072-017-9833-y

    authors： Baiges A,Hernández-Gea V,Bosch J

    更新日期：2018-02-01 00:00:00

  • Hepatocellular adenoma: what is new in 2008.

    abstract：:Patients (85%) with hepatocellular adenoma (HCA) are women taking oral contraceptives. They can be divided into four subgroups according to their genotype/phenotype features. (1) Hepatocyte nuclear factor 1alpha (HNF1alpha) biallelic somatic mutations are observed in 35% of the HCA cases. It occurs in almost all cases...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-008-9075-0

    authors： Bioulac-Sage P,Laumonier H,Laurent C,Zucman-Rossi J,Balabaud C

    更新日期：2008-09-01 00:00:00

  • Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.

    abstract：:Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous ...

    journal_title：Hepatology international

    pub_type： 杂志文章,实务指引

    doi：10.1007/s12072-015-9675-4

    authors： Sarin SK,Kumar M,Lau GK,Abbas Z,Chan HL,Chen CJ,Chen DS,Chen HL,Chen PJ,Chien RN,Dokmeci AK,Gane E,Hou JL,Jafri W,Jia J,Kim JH,Lai CL,Lee HC,Lim SG,Liu CJ,Locarnini S,Al Mahtab M,Mohamed R,Omata M,Park J,

    更新日期：2016-01-01 00:00:00

  • Role of free radicals in liver diseases.

    abstract：:Reactive oxygen and nitrogen species (ROS and RNS) are produced by metabolism of normal cells. However, in liver diseases, redox is increased thereby damaging the hepatic tissue; the capability of ethanol to increase both ROS/RNS and peroxidation of lipids, DNA, and proteins was demonstrated in a variety of systems, c...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-009-9158-6

    authors： Muriel P

    更新日期：2009-12-01 00:00:00

  • Survival advantage of primary liver transplantation for hepatocellular carcinoma within the up-to-7 criteria with microvascular invasion.

    abstract：PURPOSE:Microvascular invasion of hepatocellular carcinoma (HCC) is considered a poor prognostic factor of liver resection (LR) and liver transplantation (LT), but its significance for lesions within the up-to-7 criteria is unclear. This study investigated the survival benefit of primary LT against LR for HCC with micr...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-011-9318-3

    authors： Chan SC,Fan ST,Chok KS,Cheung TT,Chan AC,Fung JY,Poon RT,Lo CM

    更新日期：2011-10-21 00:00:00

  • A comparison of 4-year entecavir efficacy in nucleos(t)ide analog-naïve and -experienced adult Taiwanese chronic hepatitis B patients.

    abstract：PURPOSE:To compare the efficacy of entecavir (ETV) monotherapy up to 4 years in nucleos(t)ide analog (NA)-experienced and -naïve subjects. METHODS:One hundred sixty NA-experienced and 282 naïve chronic hepatitis B patients who were treated with ETV were enrolled. Of the 160 NA-experienced patients, 49 had prior lamivu...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-013-9440-5

    authors： Chen CH,Hu TH,Hung CH,Lu SN,Wang JH,Chang MH,Changchien CS,Lee CM

    更新日期：2013-07-01 00:00:00

  • A changing paradigm: management and treatment of the HCV/HIV-co-infected patient.

    abstract：:Hepatitis C virus (HCV) treatment in HIV/HCV co-infected individuals has renewed relevance given the ongoing opioid crisis and rise of new HIV and HCV infections associated with injection drug use. Patients co-infected with HIV and HCV demonstrate increased rates of hepatic fibrosis, progression to liver failure, and ...

    journal_title：Hepatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s12072-018-9896-4

    authors： Abutaleb A,Sherman KE

    更新日期：2018-11-01 00:00:00

  • Hepatitis B reactivation after chemotherapy: two decades of clinical research.

    abstract：:Hepatitis due to hepatitis B virus reactivation after cytotoxic or immunosuppressive therapy is a serious cause of liver-related morbidity and mortality. With the characterization of the underlying pathogenesis, much progress in the management of this important clinical problem has been made in the past 2 decades. By ...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-008-9056-3

    authors： Lau GK

    更新日期：2008-06-01 00:00:00

  • Chinese guidelines on the management of ascites and its related complications in cirrhosis.

    abstract：:The Chinese Society of Hepatology developed the current guidelines for the Management of Ascites and Its Related Complications in Cirrhosis based on the published evidences and the panelists' consensus. The guidelines provided recommendations for the diagnosis and management of cirrhotic ascites emphasizing a step-wis...

    journal_title：Hepatology international

    pub_type： 社论,实务指引

    doi：10.1007/s12072-018-09923-2

    authors： Chinese Society of Hepatology, Chinese Medical Association.,Xu X,Duan Z,Ding H,Li W,Jia J,Wei L,Linghu E,Zhuang H

    更新日期：2019-01-01 00:00:00

  • Obstructive jaundice promotes intestinal-barrier dysfunction and bacterial translocation: experimental study.

    abstract：BACKGROUND:Although clinical and experimental studies have demonstrated a correlation between obstructive jaundice and the development of sepsis, the mechanism has not been fully elucidated. PURPOSE:The aim of this study was to investigate the influence of biliary obstruction on bacterial translocation as a possible s...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-007-9018-1

    authors： Abdeldayem H,Ghoneim E,Refaei AA,Abou-Gabal A

    更新日期：2007-12-01 00:00:00

  • Significant decrease in Faecalibacterium among gut microbiota in nonalcoholic fatty liver disease: a large BMI- and sex-matched population study.

    abstract：BACKGROUND:Compositional changes of the gut microbiota are known to occur in patients with nonalcoholic fatty liver disease (NAFLD); however, the changes did not corroborate between the studies. We evaluated the gut microbiota between NAFLD and non-NAFLD participants, excluding the influence of obesity and sex in this ...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-019-09987-8

    authors： Iino C,Endo T,Mikami K,Hasegawa T,Kimura M,Sawada N,Nakaji S,Fukuda S

    更新日期：2019-11-01 00:00:00

  • De novo combination of lamivudine and adefovir versus entecavir monotherapy for the treatment of naïve HBeAg-negative chronic hepatitis B patients.

    abstract：PURPOSE:Either combination treatment or monotherapy using agents with a high genetic barrier are recommended for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB). The aim of this study was to compare effect of naïve HBeAg-negative CHB patients with either de novo combination of lamivudine (LAM) and adef...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-010-9243-x

    authors： Wang LC,Chen EQ,Cao J,Liu L,Zheng L,Li DJ,Xu L,Lei XZ,Liu C,Tang H

    更新日期：2011-06-01 00:00:00

  • Hepatic encephalopathy in acute-on-chronic liver failure.

    abstract：:The presence of hepatic encephalopathy (HE) within 4 weeks is part of the criteria for defining acute-on-chronic liver failure (ACLF). The pathophysiology of HE is complex, and hyperammonemia and cerebral hemodynamic dysfunction appear to be central in the pathogenesis of encephalopathy. Recent data also suggest that ...

    journal_title：Hepatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s12072-015-9626-0

    authors： Lee GH

    更新日期：2015-10-01 00:00:00

  • MSC-based therapies in solid organ transplantation.

    abstract：:Immunomodulatory cell therapy as a complement to standard pharmacotherapy represents a novel approach to solid organ allograft acceptance. This methodology may allow for a reduced dose of immunosuppressive drug to be administered and thus attenuate the severe side effects associated with long-term immunosuppression su...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-013-9509-1

    authors： Benseler V,Obermajer N,Johnson CL,Soeder Y,Dahlke MD,Popp FC

    更新日期：2014-04-01 00:00:00

  • Balloon-occluded retrograde transvenous obliteration of varices: focusing on the portal hemodynamics and the recent techniques.

    abstract：PURPOSE:To evaluate the recent topics of Ballloon-occluded retrograde trasnvenous obliteration(B-RTO). METHOD:We overviewed the recent scientific papers regarding B-RTO. RESULT:B-RTO is a treatment method for occluding varices retrogradely using a sclerosing agent under balloon occlusion of a major draining vein. It ...

    journal_title：Hepatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s12072-017-9813-2

    authors： Hirota S,Kobayashi K,Kako Y,Takaki H,Yamakado K

    更新日期：2018-02-01 00:00:00

  • The utility of noninvasive scores in assessing the prevalence of nonalcoholic fatty liver disease and advanced fibrosis in type 1 diabetic patients.

    abstract：GOALS:The aim of our study is to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis in patients with type 1 diabetes (T1D) using simple noninvasive scores. BACKGROUND:There is paucity of data on the prevalence of NAFLD in T1D. Moreover, T1D could be a risk factor for advanc...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-017-9840-z

    authors： Singh A,Le P,Lopez R,Alkhouri N

    更新日期：2018-01-01 00:00:00

  • Procaine inhibits the proliferation and DNA methylation in human hepatoma cells.

    abstract：PURPOSE:Transcriptional silencing of tumor suppressor genes associated with DNA hypermethylation has been known as a hallmark of human cancer. In this study, we revealed that a local anesthetic, procaine (PCA), possessed growth-inhibitory and demethylating effect on human hepatoma cells in vitro and in vivo. METHODS:T...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-007-9014-5

    authors： Tada M,Imazeki F,Fukai K,Sakamoto A,Arai M,Mikata R,Tokuhisa T,Yokosuka O

    更新日期：2007-09-01 00:00:00

  • End-stage liver disease patients with MELD >40 have higher waitlist mortality compared to Status 1A patients.

    abstract：BACKGROUND AND AIMS:Status 1A patients are prioritized over end-stage liver disease (ESLD) for liver transplantation (LT). ESLD patients with high MELD may have higher waitlist mortality than Status 1A patients, and may require LT more urgently. METHODS:Using United Network for Organ Sharing registry data, we retrospe...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-016-9735-4

    authors： Ahn J,Bhuket T,Mosadeghi S,Frenette C,Liu B,Wong RJ

    更新日期：2016-09-01 00:00:00

  • Non-alcoholic hepatic steatosis attenuates hepatitis B virus replication in an HBV-immunocompetent mouse model.

    abstract：OBJECTIVE:The relationship between chronic hepatitis B virus (HBV) infection and fatty liver in patients remains unclear. Although high-fat diets-induced hepatic steatosis was proved to reduce HBV replication in transgenic mice, the interplay between HBV and fatty liver in immunocompetent mouse model is yet to be eluci...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-018-9877-7

    authors： Hu D,Wang H,Wang H,Wang Y,Wan X,Yan W,Luo X,Ning Q

    更新日期：2018-09-01 00:00:00

  • Hepatitis B virus reactivation in patients receiving cancer chemotherapy: natural history, pathogenesis, and management.

    abstract：:Chronic hepatitis B virus (HBV) infection is endemic in the Asian-Pacific region, and reactivation of HBV post-cancer chemotherapy has become an emerging clinical challenge. Patients with detectable serum HBV DNA before chemotherapy and those receiving intensive chemotherapy are particularly at a risk of HBV reactivat...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-011-9279-6

    authors： Liu CJ,Chen PJ,Chen DS,Kao JH

    更新日期：2013-06-01 00:00:00

  • HATT: a phase IV, single-arm, open-label study of sorafenib in Taiwanese patients with advanced hepatocellular carcinoma.

    abstract：BACKGROUND:Sorafenib significantly improves survival in patients with advanced hepatocellular carcinoma (HCC). This phase IV study assessed sorafenib efficacy/safety in Taiwanese patients with advanced HCC and Child-Pugh A status. METHODS:All patients received 400 mg sorafenib BID. Safety, efficacy, sorafenib pharmaco...

    journal_title：Hepatology international

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s12072-016-9774-x

    authors： Lin SM,Lu SN,Chen PT,Jeng LB,Chen SC,Hu CT,Yang SS,Le Berre MA,Liu X,Mitchell DY,Prins K,Grevel J,Peña CA,Meinhardt G

    更新日期：2017-03-01 00:00:00

  • Non-invasive assessment of liver fibrosis in patients with chronic hepatitis B.

    abstract：:In patients with chronic hepatitis B (CHB), liver fibrosis assessment is essential not only for determining prognosis but also for identifying patients who should receive treatment. Liver biopsy is limited by its invasiveness and sampling error. To explore effective non-invasive methods for liver fibrosis assessment, ...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-013-9439-y

    authors： Chen YP,Peng J,Hou JL

    更新日期：2013-06-01 00:00:00

  • Tenofovir versus entecavir in lowering the risk of hepatocellular carcinoma development in patients with chronic hepatitis B: a critical systematic review and meta-analysis.

    abstract：BACKGROUND:Controversy exists on whether tenofovir disoproxil fumarate (TDF) is superior to entecavir (ETV) in lowering the risk of hepatocellular carcinoma (HCC) development. This meta-analysis was performed to clarify this issue with critical clinical and methodological considerations. METHODS:PubMed, EMBASE, and Co...

    journal_title：Hepatology international

    pub_type： 杂志文章,meta分析

    doi：10.1007/s12072-019-10005-0

    authors： Li M,Lv T,Wu S,Wei W,Wu X,Ou X,Ma H,Chow SC,Kong Y,You H,Jia J

    更新日期：2020-01-01 00:00:00

  • Reversal of NASH fibrosis with pharmacotherapy.

    abstract：:NAFLD is a spectrum of liver disease starting with fatty liver at one end of the spectrum and cirrhosis or liver cancer at the other end. Worldwide, NAFLD has become one of the most common liver diseases and it has also become one of the leading indications for liver transplantation. Our understanding of the NAFLD epi...

    journal_title：Hepatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s12072-019-09970-3

    authors： Alukal JJ,Thuluvath PJ

    更新日期：2019-09-01 00:00:00

  • Virus-induced hepatocellular carcinoma with special emphasis on HBV.

    abstract：:Hepatocellular carcinoma (HCC) is a common malignant tumor with high lethality, and the hepatitis B virus (HBV) is a chief cause. HBV can accelerate HCC via multiple mechanisms. First, HBV induces immune reactions that lead to repeated hepatic inflammation, fibrosis and a deficient immune microenvironment. Subsequentl...

    journal_title：Hepatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s12072-016-9779-5

    authors： Wang M,Xi D,Ning Q

    更新日期：2017-03-01 00:00:00

  • Hepatitis C virus (genotype 4)-associated mixed cryoglobulinemia vasculitis: effects of antiviral treatment.

    abstract：OBJECTIVE:Type II mixed cryoglobulinemia (MC) is a systemic vasculitis usually associated with hepatitis C virus (HCV). The present trial was performed to investigate the efficacy of therapy with pegylated interferon alfa-2a (PEG-IFN alfa-2a) plus ribavirin in patients with HCV-related MC vasculitis and evaluate the fa...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-011-9303-x

    authors： El Khayat HR,Fouad YM,Ahmad EA,El Amin H,Ismael F,Rizk A

    更新日期：2012-06-01 00:00:00