Abstract:
:Non-alcoholic fatty liver disease (NAFLD) is currently one of the leading forms of chronic liver disease, and its rising frequency worldwide has reached epidemic proportions. NAFLD, particularly its progressive variant NASH (non-alcoholic steatohepatitis), can lead to advanced fibrosis, cirrhosis, and HCC. The pathophysiologic mechanisms that contribute to the development and progression of NAFLD and NASH are complex, and as such myriad therapies are under investigation targeting different pathophysiological mechanisms. Incretin-based therapies, including GLP-1RAs and DPP-4 inhibitors and the inhibition of ASK1 pathway have provided two such novel mechanisms in the management of this disease, and will remain focus of this review.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Kovalic AJ,Satapathy SK,Chalasani Ndoi
10.1007/s12072-018-9854-1subject
Has Abstractpub_date
2018-03-01 00:00:00pages
97-106issue
2eissn
1936-0533issn
1936-0541pii
10.1007/s12072-018-9854-1journal_volume
12pub_type
杂志文章,评审abstract::Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI i...
journal_title:Hepatology international
pub_type: 社论
doi:10.1007/s12072-017-9793-2
更新日期:2017-05-01 00:00:00
abstract::Liver transplantation is a definitive therapy for patients with end-stage liver disease and cirrhosis, with improvement in survival and quality of life. Patients are carefully screened and selected for this modality of treatment to achieve maximum survival benefit. For example, a patient with hepatocellular carcinoma ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-016-9770-1
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND AIM:Acute kidney injury (AKI), as defined by the Acute Kidney Injury Network, has been widely investigated in decompensated liver cirrhosis patients. AKI is frequently progressive and independently associated with mortality in these patients. However, in the Asia-Pacific region, the majority of cases of ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9636-y
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Ultrasonography is the most frequently used modality in surveillance for HCC among patients with chronic hepatitis C. However, the optimal surveillance interval is still controversial and the usefulness of supplementary tumor marker determination has not been confirmed. METHODS:A total of 243 cases...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-009-9145-y
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:Case reports and small case series have reported a high rate of complications associated with chest tube placement for hepatic hydrothorax. We describe the in-hospital and 3-month outcomes of patients who have had this procedure. METHODS:A retrospective medical record review was performed of all patients admit...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-009-9136-z
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:There have been reports that radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) is as equally effective as surgical resection for the treatment of hepatocellular carcinoma (HCC). This study aimed to evaluate recurrence rate and risk factor of recurrence after RFA combined with TA...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9290-y
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:To evaluate the sequence variations in the enhancer II (EnhII)/basal core promotor (BCP)/precore (PC) and X genes of hepatitis B virus (HBV) in Thai patients with hepatocellular carcinoma (HCC) by conducting a cross-sectional case-control study. METHODS:As much as 60 patients with HCC and 60 patients without H...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9197-z
更新日期:2010-07-31 00:00:00
abstract::Actinomycotic hepatic abscess was diagnosed in a 46-year-old male driver from Ukraine presenting with the symptoms of malaise, loss of appetite, upper right quadrant pain, weight loss, and night sweats which had been present for last 2 months. Computed tomography (CT) of the abdomen revealed a hypodense mass in the le...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-007-9032-3
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND AND AIM:Cirrhosis is a controversial determinant of mortality in HBV-related acute-on-chronic liver failure (HBV-ACLF). The present study aimed to explore the effects of cirrhosis and the associated risk factors, especially its complications, on the outcome of HBV-ACLF. METHODS:A prospective-retrospective c...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09992-x
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:The diagnostic potential of hepatic stellate cells (HSCs) and γδT cells for patients with hepatocellular carcinoma (HCC) and their synergistic contributions to the prognosis of these patients have not yet been investigated. The aim of this study was to elucidate the prognostic value of these cells in HCC. METH...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09969-w
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Cytokines have been reported to be involved in the cirrhosis and hepatic encephalopathy (HE). Many aspects on the correlation between minimal HE (MHE) and cytokine levels were still unclear. METHODS:Two hundred eighty-nine HBV-infected cirrhotic patients were grouped: non MHE (n = 156), MHE (n...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9610-8
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:Lamivudine treatment of chronic hepatitis B (CHB) is associated with frequent resistance and loss of clinical benefit. We present outcomes of lamivudine-refractory Japanese patients treated with entecavir for 3 years. METHODS:Eighty-two patients refractory to lamivudine therapy received entecavir 0.5 or 1 mg d...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-009-9162-x
更新日期:2010-02-06 00:00:00
abstract:PURPOSE:To elucidate the efficiency of contrast-enhanced ultrasonography alone and in combination with other noninvasive models for grading hepatic fibrosis. METHODS:This prospective study included 74 patients with four grades (F1-F4) of chronic liver disease (17, 20, 18, and 19 patients, respectively). Diagnostic per...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9370-7
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:The life cycle of hepatitis C virus (HCV) is tightly associated with host lipoprotein metabolic pathways. Apolipoprotein is present on the outer surface of lipoprotein particles and plays an important role in lipoprotein metabolism. We aimed to elucidate the influence of chronic HCV infection on serum apolip...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-014-9572-2
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND AND AIMS:T cell-mediated immune injury plays a critical role in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Given the high short-term mortality and crucial role of T cells in the disease progression, it is necessary to investigate the dynamics of T cell clones dur...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-10008-x
更新日期:2020-01-01 00:00:00
abstract::Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease, characterized by multiple strictures and dilatations of the intra- and extrahepatic bile ducts, leading to progressive liver fibrosis, in 10-15% cholangiocarcinoma, and ultimately end-stage liver disease. The pathogenesis is poorly understood, b...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-020-10118-x
更新日期:2020-12-30 00:00:00
abstract:BACKGROUND AND AIMS:Coagulopathic bleeding risk prediction is challenging in decompensated cirrhosis (DC) by conventional assays. Viscoelastic tests (VETs) are likely to be more useful for assessing coagulation status in these patients. We investigated whether the VET (Sonoclot) parameters with fibrinogen could predict...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-020-10036-y
更新日期:2020-07-01 00:00:00
abstract::Along with the obesity epidemic, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased exponentially. The histological disease spectrum of NAFLD ranges from bland fatty liver (hepatic steatosis), to the concomitant presence of inflammation and ballooning which defines nonalcoholic steatohepatitis (N...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-015-9689-y
更新日期:2016-05-01 00:00:00
abstract::Solitary necrotic nodules of the liver occur rarely. Although these nodules are usually benign, they are surgically removed in most cases because they cannot be differentiated from malignant lesions. To date, the natural history of solitary fibrous nodules remains unclear. We present the case of an incidentally detect...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9199-x
更新日期:2010-07-29 00:00:00
abstract::The cancer stem cell (CSC) hypothesis has been disproved in many cancers. CSCs may exist in blood cancer, while many epithelial cancers may not have CSCs but tumor-initiating cells (TICs). Several independent studies have provided strong evidence for existence of CSCs in brain, skin, and colon cancers (Mani et al. in ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-016-9777-7
更新日期:2017-03-01 00:00:00
abstract::The prognosis of advanced hepatocellular carcinoma (HCC) remains poor. For patients with advanced HCC, the multikinase inhibitor sorafenib is recommended as the current standard of care. In contrast, hepatic arterial infusion chemotherapy (HAIC) is one of the recommended treatments in Japan. However, in Japan, the use...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9515-3
更新日期:2014-09-01 00:00:00
abstract::Immunomodulatory cell therapy as a complement to standard pharmacotherapy represents a novel approach to solid organ allograft acceptance. This methodology may allow for a reduced dose of immunosuppressive drug to be administered and thus attenuate the severe side effects associated with long-term immunosuppression su...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9509-1
更新日期:2014-04-01 00:00:00
abstract:PURPOSE/BACKGROUND:Severe alcoholic hepatitis (AH) is a life-threatening liver disease with a potential of 30-40 % mortality at 1 month. While steroids remain to be a first line therapy, they provide only about 50 % survival benefit. The aim of the study was to evaluate the efficacy of glucocorticoids plus S-adenosylme...
journal_title:Hepatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s12072-016-9751-4
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Variceal bleeding is a major complication of portal hypertension, which is associated with significant mortality. Moreover, patients surviving a variceal bleeding episode have very high risk of rebleeding, which is associated with mortality as high as that of the first bleed. Because of this, prevention of b...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-017-9833-y
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:L-Asparaginase is a bacterial enzyme used in the treatment of acute lymphoblastic leukemia. In the ongoing U.S. Drug-Induced Liver Injury Network (DILIN) prospective study, standard and pegylated asparaginase were the most frequent cause of liver injury with jaundice among anti-cancer agents (8 of 40: 20%). ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09971-2
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND AND AIMS:The liver plays a key role in the storage, metabolism and homeostasis of fat-soluble vitamins. We investigated the relation of Vitamin(Vit)A/D/E serum levels with severity of liver disease and portal hypertension (PHT). METHODS:VitA/D/E serum levels were assessed in 234 patients with advanced chron...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-020-10112-3
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND/AIMS:[corrected] The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. METHODS:The patients with liver tumor or chronic hepatitis i...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9223-1
更新日期:2010-10-08 00:00:00
abstract::Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous ...
journal_title:Hepatology international
pub_type: 杂志文章,实务指引
doi:10.1007/s12072-015-9675-4
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is associated with a high mortality rate in the absence of liver transplantation. There is limited data on predictors of survival in ACLF in children. Therefore, we prospectively studied the predictors of outcome of ACLF in children. METHODS:A prospective evalu...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9217-z
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:The association of obstructive sleep apnea (OSA) with nonalcoholic fatty liver disease (NAFLD) has only been studied in selected subgroups such as the morbidly obese. We aimed to determine the prevalence and effect of OSA on NAFLD and vice versa in unselected patients attending the outpatient department. ME...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9615-3
更新日期:2015-04-01 00:00:00