Hepatic stellate cells: fibrogenic, regenerative or both? Heterogeneity and context are key.

abstract：BACKGROUND:The life cycle of hepatitis C virus (HCV) is tightly associated with host lipoprotein metabolic pathways. Apolipoprotein is present on the outer surface of lipoprotein particles and plays an important role in lipoprotein metabolism. We aimed to elucidate the influence of chronic HCV infection on serum apolip...

journal_title：Hepatology international

authors： Seki N,Sugita T,Aida Y,Itagaki M,Ishiguro H,Sutoh S,Abe H,Tsubota A,Matsushima M,Aizawa Y

更新日期：2014-10-01 00:00:00

abstract：:More than 170 million people worldwide are infected with hepatitis C virus (HCV). A characteristic of this virus is a high tendency toward chronic infection. Several factors affect the viral outcome after infection. Among them, HCV-specific CD4 T cells are thought to play a crucial role in controlling viremia. Cumulat...

journal_title：Hepatology international

authors： Sugimoto K,Shiraki K

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Despite improvements in immunosuppressive therapy, acute cellular rejection (ACR) remains an important cause of graft loss in patients undergoing liver transplantation. Recently, associations between cytokine gene polymorphisms in recipients and the occurrence of ACR have been reported. However, most studies di...

journal_title：Hepatology international

authors： Kamei H,Masuda S,Nakamura T,Ishigami M,Fujimoto Y,Ogura Y,Oike F,Takada Y,Hamajima N

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:The diagnostic potential of hepatic stellate cells (HSCs) and γδT cells for patients with hepatocellular carcinoma (HCC) and their synergistic contributions to the prognosis of these patients have not yet been investigated. The aim of this study was to elucidate the prognostic value of these cells in HCC. METH...

journal_title：Hepatology international

authors： Zhou BY,Gong JH,Cai XY,Wang JX,Luo F,Jiang N,Gong JP,Du CY,Liao R

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Variceal bleeding is a major complication of portal hypertension, which is associated with significant mortality. Moreover, patients surviving a variceal bleeding episode have very high risk of rebleeding, which is associated with mortality as high as that of the first bleed. Because of this, prevention of b...

journal_title：Hepatology international

authors： Baiges A,Hernández-Gea V,Bosch J

更新日期：2018-02-01 00:00:00

abstract：:Patients with chronic hepatitis C virus (HCV) infection experience a range of symptoms including depression, fatigue and neurocognitive deficits, impairing quality of life. Depression, in particular, may be reactive to increased psychosocial stress, and the physical symptoms of advanced HCV or associated comorbidities...

journal_title：Hepatology international

authors： Yeoh SW,Holmes ACN,Saling MM,Everall IP,Nicoll AJ

更新日期：2018-07-01 00:00:00

abstract：:In patients with chronic hepatitis B (CHB), liver fibrosis assessment is essential not only for determining prognosis but also for identifying patients who should receive treatment. Liver biopsy is limited by its invasiveness and sampling error. To explore effective non-invasive methods for liver fibrosis assessment, ...

journal_title：Hepatology international

authors： Chen YP,Peng J,Hou JL

更新日期：2013-06-01 00:00:00

abstract：:Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease characterized by progressive destruction of small intrahepatic bile ducts. If left untreated, PBC may eventually result in end-stage liver disease. For better management of PBC and optimal allocation of med...

journal_title：Hepatology international

authors： Chen S,Duan W,You H,Jia J

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Lamivudine treatment of chronic hepatitis B (CHB) is associated with frequent resistance and loss of clinical benefit. We present outcomes of lamivudine-refractory Japanese patients treated with entecavir for 3 years. METHODS:Eighty-two patients refractory to lamivudine therapy received entecavir 0.5 or 1 mg d...

journal_title：Hepatology international

authors： Karino Y,Toyota J,Kumada H,Katano Y,Izumi N,Kobashi H,Sata M,Moriyama M,Imazeki F,Kage M,Ishikawa H,Masaki N,Seriu T,Omata M

更新日期：2010-02-06 00:00:00

abstract：BACKGROUND:Possible serologic activity after hepatitis B surface antigen (HBsAg) seroclearance documented by conventional assays in chronic hepatitis B (CHB) has not been thoroughly investigated. METHODS:We determined the levels of serum hepatitis B virus (HBV) DNA, hepatitis B core-related antigen (HBcrAg), and linea...

journal_title：Hepatology international

authors： Seto WK,Tanaka Y,Wong DK,Lai CL,Shinkai N,Yuen JC,Tong T,Fung J,Hung IF,Yuen MF

更新日期：2012-03-13 00:00:00

abstract：BACKGROUND:Although arterial stiffness has been reported to be associated with nonalcoholic fatty liver disease (NAFLD), previous studies have relied only on noninvasive assessments for the diagnosis of NAFLD. This study attempted to investigate the association of arterial stiffness with the histological severity of NA...

journal_title：Hepatology international

authors： Kim HL,Koo BK,Joo SK,Kim W

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Compositional changes of the gut microbiota are known to occur in patients with nonalcoholic fatty liver disease (NAFLD); however, the changes did not corroborate between the studies. We evaluated the gut microbiota between NAFLD and non-NAFLD participants, excluding the influence of obesity and sex in this ...

journal_title：Hepatology international

authors： Iino C,Endo T,Mikami K,Hasegawa T,Kimura M,Sawada N,Nakaji S,Fukuda S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Ultrasonography is the most frequently used modality in surveillance for HCC among patients with chronic hepatitis C. However, the optimal surveillance interval is still controversial and the usefulness of supplementary tumor marker determination has not been confirmed. METHODS:A total of 243 cases...

journal_title：Hepatology international

authors： Sato T,Tateishi R,Yoshida H,Ohki T,Masuzaki R,Imamura J,Goto T,Kanai F,Obi S,Kato N,Shiina S,Kawabe T,Omata M

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND AIMS:The peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand, piglitazone, enhances the degradation of branched-chain amino acids (BCAAs) in adipose tissue. However, it remains unknown whether pioglitazone influences the plasma amino acids (AA) profile in patients with nonalcoholic steatohepatit...

journal_title：Hepatology international

authors： Kakazu E,Kondo Y,Ninomiya M,Kimura O,Nagasaki F,Ueno Y,Shimosegawa T

更新日期：2013-06-01 00:00:00

abstract：GOALS:The aim of our study is to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis in patients with type 1 diabetes (T1D) using simple noninvasive scores. BACKGROUND:There is paucity of data on the prevalence of NAFLD in T1D. Moreover, T1D could be a risk factor for advanc...

journal_title：Hepatology international

authors： Singh A,Le P,Lopez R,Alkhouri N

更新日期：2018-01-01 00:00:00

abstract：:Reactive oxygen and nitrogen species (ROS and RNS) are produced by metabolism of normal cells. However, in liver diseases, redox is increased thereby damaging the hepatic tissue; the capability of ethanol to increase both ROS/RNS and peroxidation of lipids, DNA, and proteins was demonstrated in a variety of systems, c...

journal_title：Hepatology international

authors： Muriel P

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND AIMS:T cell-mediated immune injury plays a critical role in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Given the high short-term mortality and crucial role of T cells in the disease progression, it is necessary to investigate the dynamics of T cell clones dur...

journal_title：Hepatology international

authors： Shen G,Sun S,Huang J,Deng H,Xu Y,Wang Z,Tang X,Gong X

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Coagulopathic bleeding risk prediction is challenging in decompensated cirrhosis (DC) by conventional assays. Viscoelastic tests (VETs) are likely to be more useful for assessing coagulation status in these patients. We investigated whether the VET (Sonoclot) parameters with fibrinogen could predict...

journal_title：Hepatology international

authors： Bihari C,Patil A,Shasthry SM,Baweja S,Kumar G,Sarin SK

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:There is much controversy surrounding the natural history of hepatitis C virus (HCV) infection. AIMS:The aim of this review was to review the natural history of HCV infection. METHODS:Published English literature was searched via pubmed and then reviewed. RESULTS:Approximately, 75-85% of HCV-infected pers...

journal_title：Hepatology international

authors： Sarin SK,Kumar M

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND/AIMS:[corrected] The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. METHODS:The patients with liver tumor or chronic hepatitis i...

journal_title：Hepatology international

authors： Kuo YH,Lu SN,Hung CH,Kee KM,Chen CH,Hu TH,Lee CM,Changchien CS,Wang JH

更新日期：2010-10-08 00:00:00

abstract：:Alcoholic liver disease (ALD) is a leading cause of liver-related morbidity and mortality worldwide. ALD encompasses a spectrum of disorders including asymptomatic steatosis, steatohepatitis, fibrosis, cirrhosis and its related complications, and the acute-on-chronic state of alcoholic hepatitis. While multidisciplina...

journal_title：Hepatology international

authors： Arsene D,Farooq O,Bataller R

更新日期：2016-07-01 00:00:00

abstract：:Immunomodulatory cell therapy as a complement to standard pharmacotherapy represents a novel approach to solid organ allograft acceptance. This methodology may allow for a reduced dose of immunosuppressive drug to be administered and thus attenuate the severe side effects associated with long-term immunosuppression su...

journal_title：Hepatology international

authors： Benseler V,Obermajer N,Johnson CL,Soeder Y,Dahlke MD,Popp FC

更新日期：2014-04-01 00:00:00

abstract：:Background and aims The aims of this study were to evaluate a preventive effect on collateral venous circulation of long-term administration of propranolol in intrahepatic portal hypertensive rats. Methods Eighty-six Sprague-Dawley rats were allocated to two models of hepatic fibrosis, bile duct-ligated (BDL) induced ...

journal_title：Hepatology international

authors： Fizanne L,Régenet N,Wang J,Oberti F,Moal F,Roux J,Gallois Y,Michalak S,Calès P

更新日期：2008-12-01 00:00:00

abstract：:The cancer stem cell (CSC) hypothesis has been disproved in many cancers. CSCs may exist in blood cancer, while many epithelial cancers may not have CSCs but tumor-initiating cells (TICs). Several independent studies have provided strong evidence for existence of CSCs in brain, skin, and colon cancers (Mani et al. in ...

journal_title：Hepatology international

authors： Machida K

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Interferon-induced graft dysfunction (IGD) is a poorly defined, unrecognized, but potentially serious condition for patients receiving antiviral drugs after liver transplantation for hepatitis C. METHODS:We evaluated the characteristics of 80 patients who received pegylated interferon-based antiviral treatment...

journal_title：Hepatology international

authors： Ikegami T,Wang H,Yoshizumi T,Toshima T,Aishima S,Fukuhara T,Furusyo N,Kotoh K,Shimoda S,Shirabe K,Maehara Y

更新日期：2014-04-01 00:00:00

abstract：:In a country such as Japan with the average age of patients with chronic hepatitis C treated with antivirals sometimes well above 60 years, the standard combination therapy is not well tolerated. In this randomized, prospective, controlled trial, we investigated the efficacy of 24-week peginterferon α monotherapy for ...

journal_title：Hepatology international

authors： Iwasaki Y,Shiratori Y,Hige S,Nishiguchi S,Takagi H,Onji M,Yoshida H,Izumi N,Kohgo Y,Yamamoto K,Sato N,Shibuya A,Saito H,Sata M,Suzuki K,Kaneko S,Moriyama M,Omata M

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND/PURPOSE:In Japan, there is a growing population of patients with chronic hepatitis C virus (HCV) infection who failed a direct-acting antiviral (DAA)-based regimen. In this Phase 3 study, we evaluated sofosbuvir-velpatasvir plus ribavirin in Japanese patients with genotype 1 or 2 HCV infection who previously...

journal_title：Hepatology international

authors： Izumi N,Takehara T,Chayama K,Yatsuhashi H,Takaguchi K,Ide T,Kurosaki M,Ueno Y,Toyoda H,Kakizaki S,Tanaka Y,Kawakami Y,Enomoto H,Ikeda F,Jiang D,De-Oertel S,McNabb BL,Camus G,Stamm LM,Brainard DM,McHutchison JG,M

更新日期：2018-07-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is endemic in the Asian-Pacific region, and reactivation of HBV post-cancer chemotherapy has become an emerging clinical challenge. Patients with detectable serum HBV DNA before chemotherapy and those receiving intensive chemotherapy are particularly at a risk of HBV reactivat...

journal_title：Hepatology international

authors： Liu CJ,Chen PJ,Chen DS,Kao JH

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND/PURPOSE:Gut microbiota has been associated with liver cirrhosis and, possibly, hepatic encephalopathy. However, only a few studies have examined the link between mucosa-associated microbiota (MAM) and minimal hepatic encephalopathy (MHE). Our aim was to investigate this relationship. METHODS:Twenty-four pat...

journal_title：Hepatology international

authors： Haraguchi M,Miuma S,Masumoto H,Ichikawa T,Kanda Y,Sasaki R,Fukushima M,Miyaaki H,Taura N,Nakao K

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Recently, Sofosbuvir was launched in India at affordable cost. We conducted a real-life study to determine the efficacy and safety of Sofosbuvir plus Ribavirin, with and without peginterferon-alfa 2a, in patients with chronic hepatitis C (CHC) genotype 3, the commonest genotype in South Asia. METHO...

journal_title：Hepatology international

authors： Sidhu SS,Malhi NS,Goyal O,Singh R,Dutta U,Grover R,Sidhu JS,Nanda V,Saluja H,Bansal A,Singh G,Sehgal A,Kishore H,Sidhu S

更新日期：2017-05-01 00:00:00