Abstract:
:Actinomycotic hepatic abscess was diagnosed in a 46-year-old male driver from Ukraine presenting with the symptoms of malaise, loss of appetite, upper right quadrant pain, weight loss, and night sweats which had been present for last 2 months. Computed tomography (CT) of the abdomen revealed a hypodense mass in the left liver lobe which was suspected as hepatocellular carcinoma. Histopathological examination of the CT guided biopsy specimen yielded a diagnosis of actinomycotic abscess of the liver. Treatment with intravenous penicillin for 6 weeks followed by a course of oral penicillin for 14 weeks resulted in complete cure as evidenced by clinical improvement and radiological disappearance of the lesion.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Tiftikci A,Vardareli EN,Kaban K,Peker O,Akansel S,Tozun Ndoi
10.1007/s12072-007-9032-3subject
Has Abstractpub_date
2008-03-01 00:00:00pages
133-5issue
1eissn
1936-0533issn
1936-0541journal_volume
2pub_type
杂志文章abstract:BACKGROUND:Sorafenib significantly improves survival in patients with advanced hepatocellular carcinoma (HCC). This phase IV study assessed sorafenib efficacy/safety in Taiwanese patients with advanced HCC and Child-Pugh A status. METHODS:All patients received 400 mg sorafenib BID. Safety, efficacy, sorafenib pharmaco...
journal_title:Hepatology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12072-016-9774-x
更新日期:2017-03-01 00:00:00
abstract::The bone marrow contains stem cells that have the potential to differentiate into a variety of organ-specific mature cells, including the liver and the pancreas. Recently, the origin of hepatic progenitors and hepatocytes was identified to be the bone marrow. However, evidence that describes which cells, among all bon...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-007-9031-4
更新日期:2008-03-01 00:00:00
abstract:PURPOSE/BACKGROUND:Severe alcoholic hepatitis (AH) is a life-threatening liver disease with a potential of 30-40 % mortality at 1 month. While steroids remain to be a first line therapy, they provide only about 50 % survival benefit. The aim of the study was to evaluate the efficacy of glucocorticoids plus S-adenosylme...
journal_title:Hepatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s12072-016-9751-4
更新日期:2016-11-01 00:00:00
abstract:PURPOSE:Clevudine 30 mg showed potent antiviral activity with a marked post-treatment antiviral effect. However, long-term treatment with clevudine monotherapy induced resistance and myopathy in some cases. The objective of this study is to evaluate the preliminary efficacy and safety of the combination of clevudine 20...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-014-9537-5
更新日期:2014-05-25 00:00:00
abstract:BACKGROUND:Early prediction of lamivudine (LAM) response by individualized monitoring of serum HBV DNA like roadmap concept, and investigation of the outcome after LAM discontinuation in renal transplant recipients (RTRs) with chronic hepatitis B (CHB). METHODS:We conducted a study on 19 RTRs with HBV infection receiv...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9295-6
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Possible serologic activity after hepatitis B surface antigen (HBsAg) seroclearance documented by conventional assays in chronic hepatitis B (CHB) has not been thoroughly investigated. METHODS:We determined the levels of serum hepatitis B virus (HBV) DNA, hepatitis B core-related antigen (HBcrAg), and linea...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9354-7
更新日期:2012-03-13 00:00:00
abstract::The cancer stem cell (CSC) hypothesis has been disproved in many cancers. CSCs may exist in blood cancer, while many epithelial cancers may not have CSCs but tumor-initiating cells (TICs). Several independent studies have provided strong evidence for existence of CSCs in brain, skin, and colon cancers (Mani et al. in ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-016-9777-7
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Compositional changes of the gut microbiota are known to occur in patients with nonalcoholic fatty liver disease (NAFLD); however, the changes did not corroborate between the studies. We evaluated the gut microbiota between NAFLD and non-NAFLD participants, excluding the influence of obesity and sex in this ...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09987-8
更新日期:2019-11-01 00:00:00
abstract::Reactive oxygen and nitrogen species (ROS and RNS) are produced by metabolism of normal cells. However, in liver diseases, redox is increased thereby damaging the hepatic tissue; the capability of ethanol to increase both ROS/RNS and peroxidation of lipids, DNA, and proteins was demonstrated in a variety of systems, c...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-009-9158-6
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Ultrasonography is the most frequently used modality in surveillance for HCC among patients with chronic hepatitis C. However, the optimal surveillance interval is still controversial and the usefulness of supplementary tumor marker determination has not been confirmed. METHODS:A total of 243 cases...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-009-9145-y
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Initial presentation of hepatocellular carcinoma (HCC) at an advanced stage in patients under a regular surveillance program is a devastating problem. AIMS:We assessed the prevalence and factors associated with this surveillance failure. METHODS:A total of 304 HCC patients who received regular surveillance...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9462-z
更新日期:2013-10-01 00:00:00
abstract::The presence of hepatic encephalopathy (HE) within 4 weeks is part of the criteria for defining acute-on-chronic liver failure (ACLF). The pathophysiology of HE is complex, and hyperammonemia and cerebral hemodynamic dysfunction appear to be central in the pathogenesis of encephalopathy. Recent data also suggest that ...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-015-9626-0
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND AND AIM:Relationships between circulating microRNA-122 (miR-122) and histological features of nonalcoholic fatty liver disease (NAFLD) are unclear. METHODS:The impact of serum miR-122 levels for histological features and hepatocellular carcinoma (HCC) was investigated in 305 Japanese patients with histologi...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-016-9729-2
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:There is much controversy surrounding the natural history of hepatitis C virus (HCV) infection. AIMS:The aim of this review was to review the natural history of HCV infection. METHODS:Published English literature was searched via pubmed and then reviewed. RESULTS:Approximately, 75-85% of HCV-infected pers...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-012-9355-6
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:Despite improvements in immunosuppressive therapy, acute cellular rejection (ACR) remains an important cause of graft loss in patients undergoing liver transplantation. Recently, associations between cytokine gene polymorphisms in recipients and the occurrence of ACR have been reported. However, most studies di...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-013-9443-2
更新日期:2013-07-01 00:00:00
abstract::Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease, characterized by multiple strictures and dilatations of the intra- and extrahepatic bile ducts, leading to progressive liver fibrosis, in 10-15% cholangiocarcinoma, and ultimately end-stage liver disease. The pathogenesis is poorly understood, b...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-020-10118-x
更新日期:2020-12-30 00:00:00
abstract:GOALS:The aim of our study is to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis in patients with type 1 diabetes (T1D) using simple noninvasive scores. BACKGROUND:There is paucity of data on the prevalence of NAFLD in T1D. Moreover, T1D could be a risk factor for advanc...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-017-9840-z
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:There have been reports that radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) is as equally effective as surgical resection for the treatment of hepatocellular carcinoma (HCC). This study aimed to evaluate recurrence rate and risk factor of recurrence after RFA combined with TA...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9290-y
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND/PURPOSE:In Japan, there is a growing population of patients with chronic hepatitis C virus (HCV) infection who failed a direct-acting antiviral (DAA)-based regimen. In this Phase 3 study, we evaluated sofosbuvir-velpatasvir plus ribavirin in Japanese patients with genotype 1 or 2 HCV infection who previously...
journal_title:Hepatology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12072-018-9878-6
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Type II mixed cryoglobulinemia (MC) is a systemic vasculitis usually associated with hepatitis C virus (HCV). The present trial was performed to investigate the efficacy of therapy with pegylated interferon alfa-2a (PEG-IFN alfa-2a) plus ribavirin in patients with HCV-related MC vasculitis and evaluate the fa...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9303-x
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND AND AIM:Cirrhosis is a controversial determinant of mortality in HBV-related acute-on-chronic liver failure (HBV-ACLF). The present study aimed to explore the effects of cirrhosis and the associated risk factors, especially its complications, on the outcome of HBV-ACLF. METHODS:A prospective-retrospective c...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-09992-x
更新日期:2019-11-01 00:00:00
abstract::Chronic hepatitis B virus (HBV) infection is a major global health burden and cure is rarely achieved by current antiviral therapies. Therefore, there is an urgent need for new therapeutic options. Immune modulation with the goal to restore dysfunctional HBV-specific immunity is an interesting target for new therapeut...
journal_title:Hepatology international
pub_type: 杂志文章,评审
doi:10.1007/s12072-018-9912-8
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND AND AIMS:T cell-mediated immune injury plays a critical role in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Given the high short-term mortality and crucial role of T cells in the disease progression, it is necessary to investigate the dynamics of T cell clones dur...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-019-10008-x
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Although clinical and experimental studies have demonstrated a correlation between obstructive jaundice and the development of sepsis, the mechanism has not been fully elucidated. PURPOSE:The aim of this study was to investigate the influence of biliary obstruction on bacterial translocation as a possible s...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-007-9018-1
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Cytokines have been reported to be involved in the cirrhosis and hepatic encephalopathy (HE). Many aspects on the correlation between minimal HE (MHE) and cytokine levels were still unclear. METHODS:Two hundred eighty-nine HBV-infected cirrhotic patients were grouped: non MHE (n = 156), MHE (n...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9610-8
更新日期:2015-04-01 00:00:00
abstract:AIMS:Relationships of renal function and liver disease are described in acute and chronic liver failure. The aim of the study is to investigate which relationship, if any, is present between severity of non-alcoholic fatty liver disease (NAFLD), assessed by bright liver score (BLS) versus mild-moderate renal insufficie...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-011-9254-2
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function. METHODS:Liver biopsy was performed for 30 patients with hepatitis B cirrhosis to test the content of hydroxyproline in hepatic tissue, judge the degree of cirrh...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-015-9648-7
更新日期:2015-10-01 00:00:00
abstract::Solitary necrotic nodules of the liver occur rarely. Although these nodules are usually benign, they are surgically removed in most cases because they cannot be differentiated from malignant lesions. To date, the natural history of solitary fibrous nodules remains unclear. We present the case of an incidentally detect...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9199-x
更新日期:2010-07-29 00:00:00
abstract:OBJECTIVE:The relationship between chronic hepatitis B virus (HBV) infection and fatty liver in patients remains unclear. Although high-fat diets-induced hepatic steatosis was proved to reduce HBV replication in transgenic mice, the interplay between HBV and fatty liver in immunocompetent mouse model is yet to be eluci...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-018-9877-7
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND/AIMS:[corrected] The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. METHODS:The patients with liver tumor or chronic hepatitis i...
journal_title:Hepatology international
pub_type: 杂志文章
doi:10.1007/s12072-010-9223-1
更新日期:2010-10-08 00:00:00