Existence of cancer stem cells in hepatocellular carcinoma: myth or reality?

abstract：AIMS:Relationships of renal function and liver disease are described in acute and chronic liver failure. The aim of the study is to investigate which relationship, if any, is present between severity of non-alcoholic fatty liver disease (NAFLD), assessed by bright liver score (BLS) versus mild-moderate renal insufficie...

journal_title：Hepatology international

authors： Catalano D,Trovato GM,Martines GF,Pirri C,Trovato FM

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND AND OBJECT:The risk of occult HBV infection (OBI) in children whose mothers are HBV carriers has received more widespread attention, but there were few reports to focus on the children with HBsAg-positive parents. In this study, we aimed to investigate the prevalence of OBI in immunized children with HBsAg-p...

journal_title：Hepatology international

authors： Zhuge S,Ge C,Yang Y,Cui Y,Yue X,Zhang Z,Xu H,Huang A,Zhao Y

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:Despite improvements in immunosuppressive therapy, acute cellular rejection (ACR) remains an important cause of graft loss in patients undergoing liver transplantation. Recently, associations between cytokine gene polymorphisms in recipients and the occurrence of ACR have been reported. However, most studies di...

journal_title：Hepatology international

authors： Kamei H,Masuda S,Nakamura T,Ishigami M,Fujimoto Y,Ogura Y,Oike F,Takada Y,Hamajima N

更新日期：2013-07-01 00:00:00

abstract：:Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease characterized by progressive destruction of small intrahepatic bile ducts. If left untreated, PBC may eventually result in end-stage liver disease. For better management of PBC and optimal allocation of med...

journal_title：Hepatology international

authors： Chen S,Duan W,You H,Jia J

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The liver plays a key role in the storage, metabolism and homeostasis of fat-soluble vitamins. We investigated the relation of Vitamin(Vit)A/D/E serum levels with severity of liver disease and portal hypertension (PHT). METHODS:VitA/D/E serum levels were assessed in 234 patients with advanced chron...

journal_title：Hepatology international

authors： Simbrunner B,Semmler G,Stadlmann A,Scheiner B,Schwabl P,Paternostro R,Bucsics T,Bauer D,Eigenbauer E,Pinter M,Stättermayer AF,Quehenberger P,Marculescu R,Trauner M,Mandorfer M,Reiberger T

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:There is much controversy surrounding the natural history of hepatitis C virus (HCV) infection. AIMS:The aim of this review was to review the natural history of HCV infection. METHODS:Published English literature was searched via pubmed and then reviewed. RESULTS:Approximately, 75-85% of HCV-infected pers...

journal_title：Hepatology international

authors： Sarin SK,Kumar M

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:The relationship between chronic hepatitis B virus (HBV) infection and fatty liver in patients remains unclear. Although high-fat diets-induced hepatic steatosis was proved to reduce HBV replication in transgenic mice, the interplay between HBV and fatty liver in immunocompetent mouse model is yet to be eluci...

journal_title：Hepatology international

authors： Hu D,Wang H,Wang H,Wang Y,Wan X,Yan W,Luo X,Ning Q

更新日期：2018-09-01 00:00:00

abstract：:Hepatitis B virus (HBV) reactivation with hepatic decompensation leading to acute on chronic liver failure is not uncommon. It is associated with high mortality of up to 30-70%. Prognostic factors for mortality include high bilirubin level, more prolonged prothrombin time, low platelet count and presence of pre-existi...

journal_title：Hepatology international

authors： Yuen MF

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand, piglitazone, enhances the degradation of branched-chain amino acids (BCAAs) in adipose tissue. However, it remains unknown whether pioglitazone influences the plasma amino acids (AA) profile in patients with nonalcoholic steatohepatit...

journal_title：Hepatology international

authors： Kakazu E,Kondo Y,Ninomiya M,Kimura O,Nagasaki F,Ueno Y,Shimosegawa T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Status 1A patients are prioritized over end-stage liver disease (ESLD) for liver transplantation (LT). ESLD patients with high MELD may have higher waitlist mortality than Status 1A patients, and may require LT more urgently. METHODS:Using United Network for Organ Sharing registry data, we retrospe...

journal_title：Hepatology international

authors： Ahn J,Bhuket T,Mosadeghi S,Frenette C,Liu B,Wong RJ

更新日期：2016-09-01 00:00:00

abstract：:Immunomodulatory cell therapy as a complement to standard pharmacotherapy represents a novel approach to solid organ allograft acceptance. This methodology may allow for a reduced dose of immunosuppressive drug to be administered and thus attenuate the severe side effects associated with long-term immunosuppression su...

journal_title：Hepatology international

authors： Benseler V,Obermajer N,Johnson CL,Soeder Y,Dahlke MD,Popp FC

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Cytokines have been reported to be involved in the cirrhosis and hepatic encephalopathy (HE). Many aspects on the correlation between minimal HE (MHE) and cytokine levels were still unclear. METHODS:Two hundred eighty-nine HBV-infected cirrhotic patients were grouped: non MHE (n = 156), MHE (n...

journal_title：Hepatology international

authors： Li W,Li N,Wang R,Li Q,Wu H

更新日期：2015-04-01 00:00:00

abstract：:Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous ...

journal_title：Hepatology international

authors： Sarin SK,Kumar M,Lau GK,Abbas Z,Chan HL,Chen CJ,Chen DS,Chen HL,Chen PJ,Chien RN,Dokmeci AK,Gane E,Hou JL,Jafri W,Jia J,Kim JH,Lai CL,Lee HC,Lim SG,Liu CJ,Locarnini S,Al Mahtab M,Mohamed R,Omata M,Park J,

更新日期：2016-01-01 00:00:00

abstract：:More than 170 million people worldwide are infected with hepatitis C virus (HCV). A characteristic of this virus is a high tendency toward chronic infection. Several factors affect the viral outcome after infection. Among them, HCV-specific CD4 T cells are thought to play a crucial role in controlling viremia. Cumulat...

journal_title：Hepatology international

authors： Sugimoto K,Shiraki K

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:To assess the accuracy of a formula derived from 159 living liver donors to estimate the liver size of a normal subject: standard liver weight (g) = 218 + body weight (kg) × 12.3 + 51 (if male). Standard liver volume (SLV) is attained by a conversion factor of 1.19 mL/g. METHODS:The total liver volume (TLV) of...

journal_title：Hepatology international

authors： Chan SC,Lo CM,Chok KS,Sharr WW,Cheung TT,Tsang SH,Chan AC,Fan ST

更新日期：2011-03-26 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a common malignant tumor with high lethality, and the hepatitis B virus (HBV) is a chief cause. HBV can accelerate HCC via multiple mechanisms. First, HBV induces immune reactions that lead to repeated hepatic inflammation, fibrosis and a deficient immune microenvironment. Subsequentl...

journal_title：Hepatology international

authors： Wang M,Xi D,Ning Q

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Case reports and small case series have reported a high rate of complications associated with chest tube placement for hepatic hydrothorax. We describe the in-hospital and 3-month outcomes of patients who have had this procedure. METHODS:A retrospective medical record review was performed of all patients admit...

journal_title：Hepatology international

authors： Orman ES,Lok AS

更新日期：2009-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) treatment in HIV/HCV co-infected individuals has renewed relevance given the ongoing opioid crisis and rise of new HIV and HCV infections associated with injection drug use. Patients co-infected with HIV and HCV demonstrate increased rates of hepatic fibrosis, progression to liver failure, and ...

journal_title：Hepatology international

authors： Abutaleb A,Sherman KE

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Compositional changes of the gut microbiota are known to occur in patients with nonalcoholic fatty liver disease (NAFLD); however, the changes did not corroborate between the studies. We evaluated the gut microbiota between NAFLD and non-NAFLD participants, excluding the influence of obesity and sex in this ...

journal_title：Hepatology international

authors： Iino C,Endo T,Mikami K,Hasegawa T,Kimura M,Sawada N,Nakaji S,Fukuda S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:L-Asparaginase is a bacterial enzyme used in the treatment of acute lymphoblastic leukemia. In the ongoing U.S. Drug-Induced Liver Injury Network (DILIN) prospective study, standard and pegylated asparaginase were the most frequent cause of liver injury with jaundice among anti-cancer agents (8 of 40: 20%). ...

journal_title：Hepatology international

authors： Kamal N,Koh C,Samala N,Fontana RJ,Stolz A,Durazo F,Hayashi PH,Phillips E,Wang T,Hoofnagle JH,Drug-Induced Liver Injury Network.

更新日期：2019-09-01 00:00:00

abstract：:Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI i...

journal_title：Hepatology international

authors： Yu YC,Mao YM,Chen CW,Chen JJ,Chen J,Cong WM,Ding Y,Duan ZP,Fu QC,Guo XY,Hu P,Hu XQ,Jia JD,Lai RT,Li DL,Liu YX,Lu LG,Ma SW,Ma X,Nan YM,Ren H,Shen T,Wang H,Wang JY,Wang TL,Wang XJ,Wei L,Xie Q,Xie W,

更新日期：2017-05-01 00:00:00

abstract：:In patients with chronic hepatitis B (CHB), liver fibrosis assessment is essential not only for determining prognosis but also for identifying patients who should receive treatment. Liver biopsy is limited by its invasiveness and sampling error. To explore effective non-invasive methods for liver fibrosis assessment, ...

journal_title：Hepatology international

authors： Chen YP,Peng J,Hou JL

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Initial presentation of hepatocellular carcinoma (HCC) at an advanced stage in patients under a regular surveillance program is a devastating problem. AIMS:We assessed the prevalence and factors associated with this surveillance failure. METHODS:A total of 304 HCC patients who received regular surveillance...

journal_title：Hepatology international

authors： Sinn DH,Yi J,Choi MS,Choi D,Gwak GY,Paik YH,Lee JH,Koh KC,Paik SW,Yoo BC

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Variceal bleeding is a major complication of portal hypertension, which is associated with significant mortality. Moreover, patients surviving a variceal bleeding episode have very high risk of rebleeding, which is associated with mortality as high as that of the first bleed. Because of this, prevention of b...

journal_title：Hepatology international

authors： Baiges A,Hernández-Gea V,Bosch J

更新日期：2018-02-01 00:00:00

abstract：:Liver transplantation is a definitive therapy for patients with end-stage liver disease and cirrhosis, with improvement in survival and quality of life. Patients are carefully screened and selected for this modality of treatment to achieve maximum survival benefit. For example, a patient with hepatocellular carcinoma ...

journal_title：Hepatology international

authors： Singal AK,Kamath PS

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Lamivudine treatment of chronic hepatitis B (CHB) is associated with frequent resistance and loss of clinical benefit. We present outcomes of lamivudine-refractory Japanese patients treated with entecavir for 3 years. METHODS:Eighty-two patients refractory to lamivudine therapy received entecavir 0.5 or 1 mg d...

journal_title：Hepatology international

authors： Karino Y,Toyota J,Kumada H,Katano Y,Izumi N,Kobashi H,Sata M,Moriyama M,Imazeki F,Kage M,Ishikawa H,Masaki N,Seriu T,Omata M

更新日期：2010-02-06 00:00:00

abstract：BACKGROUND AND AIMS:A discrepancy in virological and biochemical responses may occur throughout interferon-based therapy for hepatitis C virus (HCV). We aimed to explore the risk, associated factors, potential mechanisms, and impact on the treatment outcome of the discrepancy. SUBJECTS AND METHODS:Consecutive 496, chr...

journal_title：Hepatology international

authors： Chen CH,Huang JF,Huang CF,Yeh ML,Yang JF,Hsieh MY,Hou NJ,Lin ZY,Chen SC,Hsieh MY,Wang LY,Chuang WL,Dai CY,Yu ML

更新日期：2013-03-01 00:00:00

abstract：:Patients with chronic hepatitis C virus (HCV) infection experience a range of symptoms including depression, fatigue and neurocognitive deficits, impairing quality of life. Depression, in particular, may be reactive to increased psychosocial stress, and the physical symptoms of advanced HCV or associated comorbidities...

journal_title：Hepatology international

authors： Yeoh SW,Holmes ACN,Saling MM,Everall IP,Nicoll AJ

更新日期：2018-07-01 00:00:00

abstract：:Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease, characterized by multiple strictures and dilatations of the intra- and extrahepatic bile ducts, leading to progressive liver fibrosis, in 10-15% cholangiocarcinoma, and ultimately end-stage liver disease. The pathogenesis is poorly understood, b...

journal_title：Hepatology international

authors： Prokopič M,Beuers U

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND AND AIMS:To estimate the impact of viral hepatitis B status on outcomes of intrahepatic cholangiocarcinoma. METHODS:We searched Pubmed and Embase for original articles that evaluated the impact of hepatitis B virus infection on outcomes of intrahepatic cholangiocarcinoma. The present study was conducted to ...

journal_title：Hepatology international

authors： Jeong S,Luo G,Wang ZH,Sha M,Chen L,Xia Q

更新日期：2018-07-01 00:00:00