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Recurrence rates and factors for recurrence after radiofrequency ablation combined with transarterial chemoembolization for hepatocellular carcinoma: a retrospective cohort study.

Abstract：

PURPOSE:There have been reports that radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) is as equally effective as surgical resection for the treatment of hepatocellular carcinoma (HCC). This study aimed to evaluate recurrence rate and risk factor of recurrence after RFA combined with TACE for early stage HCC. METHODS:We reviewed the medical records of the patients who were diagnosed with early stage HCC between March 2006 and August 2008 at Korea University Medical Center and treated with RFA combined with TACE for curative intent (n = 65). RESULTS:Recurrence rate was 40% (26 cases) and the time to recurrence was 14.9 months. Cumulative recurrence rate at 1 year was 20% (13 cases) and at 2 years was 33.8% (22 cases). Significant variables for recurrence were: (1) RFA repeated more than one session at initial therapy (P < 0.001) and (2) size of main lesion ≥2 cm (P = 0.047). CONCLUSIONS:The recurrence rate of combination therapy was considerably high. Regardless of the therapy used, careful post-RFA follow-up is needed, especially if additional treatment is required after the first session or if the main lesion is ≥2 cm at the time of RFA.

journal_name

Hepatol Int

journal_title

Hepatology international

authors

Kim JH,Yim HJ,Lee KG,Kim SY,Jung ES,Jung YK,Kim JH,Seo YS,Yeon JE,Lee HS,Um SH,Byun KS,Ryu HS

doi

10.1007/s12072-011-9290-y

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

505-10

issue

2

eissn

1936-0533

issn

1936-0541

pii

10.1007/s12072-011-9290-y

journal_volume

6

pub_type

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