Tenofovir versus entecavir in lowering the risk of hepatocellular carcinoma development in patients with chronic hepatitis B: a critical systematic review and meta-analysis.

abstract：BACKGROUND/PURPOSE:Gut microbiota has been associated with liver cirrhosis and, possibly, hepatic encephalopathy. However, only a few studies have examined the link between mucosa-associated microbiota (MAM) and minimal hepatic encephalopathy (MHE). Our aim was to investigate this relationship. METHODS:Twenty-four pat...

journal_title：Hepatology international

authors： Haraguchi M,Miuma S,Masumoto H,Ichikawa T,Kanda Y,Sasaki R,Fukushima M,Miyaaki H,Taura N,Nakao K

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Ethanol binge augments liver injury after chronic ethanol consumption in humans, but the mechanism behind the enhanced liver injury by ethanol binge is not known. In this study we used a clinically relevant rat model in which liver injury is amplified by binge after chronic ethanol treatment and investigated th...

journal_title：Hepatology international

authors： Aroor AR,Restrepo RJ,Kharbanda KK,Shukla SD

更新日期：2014-09-01 00:00:00

abstract：:An ultrasound (US) examination is a common noninvasive technique widely applied for diagnosis of a variety of diseases. Based on the rapid development of US equipment, many US images have been accumulated and are now available and ready for the preparation of a database for the development of computer-aided US diagnos...

journal_title：Hepatology international

authors： Nishida N,Yamakawa M,Shiina T,Kudo M

更新日期：2019-07-01 00:00:00

abstract：:Patients with chronic hepatitis C virus (HCV) infection experience a range of symptoms including depression, fatigue and neurocognitive deficits, impairing quality of life. Depression, in particular, may be reactive to increased psychosocial stress, and the physical symptoms of advanced HCV or associated comorbidities...

journal_title：Hepatology international

authors： Yeoh SW,Holmes ACN,Saling MM,Everall IP,Nicoll AJ

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand, piglitazone, enhances the degradation of branched-chain amino acids (BCAAs) in adipose tissue. However, it remains unknown whether pioglitazone influences the plasma amino acids (AA) profile in patients with nonalcoholic steatohepatit...

journal_title：Hepatology international

authors： Kakazu E,Kondo Y,Ninomiya M,Kimura O,Nagasaki F,Ueno Y,Shimosegawa T

更新日期：2013-06-01 00:00:00

abstract：:Cirrhotic cardiomyopathy is a recently recognized condition in cirrhosis consisting of systolic incompetence under condition of stress, diastolic dysfunction related to altered diastolic relaxation, and electrophysiological abnormalities in the absence of any known cardiac disease. It can be diagnosed by using a combi...

journal_title：Hepatology international

authors： Wong F

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND/AIMS:[corrected] The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. METHODS:The patients with liver tumor or chronic hepatitis i...

journal_title：Hepatology international

authors： Kuo YH,Lu SN,Hung CH,Kee KM,Chen CH,Hu TH,Lee CM,Changchien CS,Wang JH

更新日期：2010-10-08 00:00:00

abstract：:The presence of hepatic encephalopathy (HE) within 4 weeks is part of the criteria for defining acute-on-chronic liver failure (ACLF). The pathophysiology of HE is complex, and hyperammonemia and cerebral hemodynamic dysfunction appear to be central in the pathogenesis of encephalopathy. Recent data also suggest that ...

journal_title：Hepatology international

authors： Lee GH

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Cholecystectomy is routinely performed at most transplant centers during living donor liver transplantation (LDLT). This study was performed to evaluate the feasibility of liver graft procurement with donor gallbladder preservation in LDLT. METHODS:Eighty-nine LDLTs (from June 2006 to Dec 2012) were retrospe...

journal_title：Hepatology international

authors： Dong JH,Ye S,Duan WD,Ji WB,Liang YR

更新日期：2015-10-01 00:00:00

abstract：:The bone marrow contains stem cells that have the potential to differentiate into a variety of organ-specific mature cells, including the liver and the pancreas. Recently, the origin of hepatic progenitors and hepatocytes was identified to be the bone marrow. However, evidence that describes which cells, among all bon...

journal_title：Hepatology international

authors： Bae SH,Choi JY,Yoon SK,Oh IH,Yoon KH,Park ST,Kim GD,Oh SH,Petersen BE

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Coagulopathic bleeding risk prediction is challenging in decompensated cirrhosis (DC) by conventional assays. Viscoelastic tests (VETs) are likely to be more useful for assessing coagulation status in these patients. We investigated whether the VET (Sonoclot) parameters with fibrinogen could predict...

journal_title：Hepatology international

authors： Bihari C,Patil A,Shasthry SM,Baweja S,Kumar G,Sarin SK

更新日期：2020-07-01 00:00:00

abstract：:More than 170 million people worldwide are infected with hepatitis C virus (HCV). A characteristic of this virus is a high tendency toward chronic infection. Several factors affect the viral outcome after infection. Among them, HCV-specific CD4 T cells are thought to play a crucial role in controlling viremia. Cumulat...

journal_title：Hepatology international

authors： Sugimoto K,Shiraki K

更新日期：2012-01-01 00:00:00

abstract：:Alcoholic liver disease (ALD) is a leading cause of liver-related morbidity and mortality worldwide. ALD encompasses a spectrum of disorders including asymptomatic steatosis, steatohepatitis, fibrosis, cirrhosis and its related complications, and the acute-on-chronic state of alcoholic hepatitis. While multidisciplina...

journal_title：Hepatology international

authors： Arsene D,Farooq O,Bataller R

更新日期：2016-07-01 00:00:00

abstract：:In a country such as Japan with the average age of patients with chronic hepatitis C treated with antivirals sometimes well above 60 years, the standard combination therapy is not well tolerated. In this randomized, prospective, controlled trial, we investigated the efficacy of 24-week peginterferon α monotherapy for ...

journal_title：Hepatology international

authors： Iwasaki Y,Shiratori Y,Hige S,Nishiguchi S,Takagi H,Onji M,Yoshida H,Izumi N,Kohgo Y,Yamamoto K,Sato N,Shibuya A,Saito H,Sata M,Suzuki K,Kaneko S,Moriyama M,Omata M

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Case reports and small case series have reported a high rate of complications associated with chest tube placement for hepatic hydrothorax. We describe the in-hospital and 3-month outcomes of patients who have had this procedure. METHODS:A retrospective medical record review was performed of all patients admit...

journal_title：Hepatology international

authors： Orman ES,Lok AS

更新日期：2009-12-01 00:00:00

abstract：:Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous ...

journal_title：Hepatology international

authors： Sarin SK,Kumar M,Lau GK,Abbas Z,Chan HL,Chen CJ,Chen DS,Chen HL,Chen PJ,Chien RN,Dokmeci AK,Gane E,Hou JL,Jafri W,Jia J,Kim JH,Lai CL,Lee HC,Lim SG,Liu CJ,Locarnini S,Al Mahtab M,Mohamed R,Omata M,Park J,

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Ultrasonography is the most frequently used modality in surveillance for HCC among patients with chronic hepatitis C. However, the optimal surveillance interval is still controversial and the usefulness of supplementary tumor marker determination has not been confirmed. METHODS:A total of 243 cases...

journal_title：Hepatology international

authors： Sato T,Tateishi R,Yoshida H,Ohki T,Masuzaki R,Imamura J,Goto T,Kanai F,Obi S,Kato N,Shiina S,Kawabe T,Omata M

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The association of obstructive sleep apnea (OSA) with nonalcoholic fatty liver disease (NAFLD) has only been studied in selected subgroups such as the morbidly obese. We aimed to determine the prevalence and effect of OSA on NAFLD and vice versa in unselected patients attending the outpatient department. ME...

journal_title：Hepatology international

authors： Agrawal S,Duseja A,Aggarwal A,Das A,Mehta M,Dhiman RK,Chawla Y

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND AIM:Cirrhosis is a controversial determinant of mortality in HBV-related acute-on-chronic liver failure (HBV-ACLF). The present study aimed to explore the effects of cirrhosis and the associated risk factors, especially its complications, on the outcome of HBV-ACLF. METHODS:A prospective-retrospective c...

journal_title：Hepatology international

authors： Chen T,Yang Z,Choudhury AK,Al Mahtab M,Li J,Chen Y,Tan SS,Han T,Hu J,Hamid SS,Huei LG,Ghazinian H,Nan Y,Chawla YK,Yuen MF,Devarbhavi H,Shukla A,Abbas Z,Sahu M,Dokmeci AK,Lesmana LA,Lesmana CRA,Xin S,Duan Z,

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Compositional changes of the gut microbiota are known to occur in patients with nonalcoholic fatty liver disease (NAFLD); however, the changes did not corroborate between the studies. We evaluated the gut microbiota between NAFLD and non-NAFLD participants, excluding the influence of obesity and sex in this ...

journal_title：Hepatology international

authors： Iino C,Endo T,Mikami K,Hasegawa T,Kimura M,Sawada N,Nakaji S,Fukuda S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND AIMS:T cell-mediated immune injury plays a critical role in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Given the high short-term mortality and crucial role of T cells in the disease progression, it is necessary to investigate the dynamics of T cell clones dur...

journal_title：Hepatology international

authors： Shen G,Sun S,Huang J,Deng H,Xu Y,Wang Z,Tang X,Gong X

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND AIM:Acute kidney injury (AKI), as defined by the Acute Kidney Injury Network, has been widely investigated in decompensated liver cirrhosis patients. AKI is frequently progressive and independently associated with mortality in these patients. However, in the Asia-Pacific region, the majority of cases of ...

journal_title：Hepatology international

authors： Huang Z,Lin C,Fang J,Wang N,Zhou R,Pan C

更新日期：2015-07-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden and cure is rarely achieved by current antiviral therapies. Therefore, there is an urgent need for new therapeutic options. Immune modulation with the goal to restore dysfunctional HBV-specific immunity is an interesting target for new therapeut...

journal_title：Hepatology international

authors： Lang J,Neumann-Haefelin C,Thimme R

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:To evaluate the sequence variations in the enhancer II (EnhII)/basal core promotor (BCP)/precore (PC) and X genes of hepatitis B virus (HBV) in Thai patients with hepatocellular carcinoma (HCC) by conducting a cross-sectional case-control study. METHODS:As much as 60 patients with HCC and 60 patients without H...

journal_title：Hepatology international

authors： Tangkijvanich P,Sa-Nguanmoo P,Mahachai V,Theamboonlers A,Poovorawan Y

更新日期：2010-07-31 00:00:00

abstract：:The Chinese Society of Hepatology developed the current guidelines for the Management of Ascites and Its Related Complications in Cirrhosis based on the published evidences and the panelists' consensus. The guidelines provided recommendations for the diagnosis and management of cirrhotic ascites emphasizing a step-wis...

journal_title：Hepatology international

authors： Chinese Society of Hepatology, Chinese Medical Association.,Xu X,Duan Z,Ding H,Li W,Jia J,Wei L,Linghu E,Zhuang H

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common malignant neoplasms worldwide. The p53 gene is frequently mutated in some histological subtypes of HCC. The role of p53 mutations and polymorphic variant of codon 72 in the prognosis of disease is still unclear. The p53 tumor suppressor gene Arg72Pro p...

journal_title：Hepatology international

authors： Jia S,Tang W,Luo Y

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND AIM:Relationships between circulating microRNA-122 (miR-122) and histological features of nonalcoholic fatty liver disease (NAFLD) are unclear. METHODS:The impact of serum miR-122 levels for histological features and hepatocellular carcinoma (HCC) was investigated in 305 Japanese patients with histologi...

journal_title：Hepatology international

authors： Akuta N,Kawamura Y,Suzuki F,Saitoh S,Arase Y,Kunimoto H,Sorin Y,Fujiyama S,Sezaki H,Hosaka T,Kobayashi M,Suzuki Y,Kobayashi M,Ikeda K,Kumada H

更新日期：2016-07-01 00:00:00

abstract：AIM:Tamibarotene is a synthetic retinoid expected to inhibit tumor-cell proliferation and to induce apoptosis by selective interaction with retinoic acid receptor α/β. We conducted an open-label phase I/II study to determine the maximum tolerated dose (MTD) and recommended dose (RD), and to evaluate the pharmacokinetic...

journal_title：Hepatology international

authors： Kanai F,Obi S,Fujiyama S,Shiina S,Tamai H,Mochizuki H,Koike Y,Imamura J,Yamaguchi T,Saida I,Yokosuka O,Omata M

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:We investigated whether the combined presence and evolution of hepatitis B virus (HBV) mutant strains in the hepatitis B e antigen (HBeAg)-positive status can predict clinical outcomes after HBeAg seroconversion. METHODS:One hundred and eighty-six patients with spontaneous HBeAg seroconversion were enrolled in...

journal_title：Hepatology international

authors： Chen CH,Lee CM,Wang JH,Hu TH,Hung CH,Changchien CS,Lu SN

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is associated with a high mortality rate in the absence of liver transplantation. There is limited data on predictors of survival in ACLF in children. Therefore, we prospectively studied the predictors of outcome of ACLF in children. METHODS:A prospective evalu...

journal_title：Hepatology international

authors： Lal J,Thapa BR,Rawal P,Ratho RK,Singh K

更新日期：2011-06-01 00:00:00