Abstract：
BACKGROUND AND AIMS:Recently, Sofosbuvir was launched in India at affordable cost. We conducted a real-life study to determine the efficacy and safety of Sofosbuvir plus Ribavirin, with and without peginterferon-alfa 2a, in patients with chronic hepatitis C (CHC) genotype 3, the commonest genotype in South Asia. METHODS:This study included data of CHC patients from 11 sites in northern India between March 2015 and December 2015 (n = 1203). Patients with CHC genotype 3 (n = 931), who were treated with either Sofosbuvir 400 mg plus weight-based Ribavirin, daily ×24 weeks (n = 432) (dual therapy), or Peginterferon-α2a 180 mcg weekly, Sofosbuvir 400 mg plus weight-based Ribavirin, daily ×12 weeks (n = 499) (triple therapy) were included for analysis. Primary outcome was the proportion of patients achieving sustained viral response at 12 weeks post-therapy. RESULTS:The overall SVR rates were 91 and 92% in the dual and triple therapy arms, respectively. The SVR rates in treatment experienced were 67 and 74% versus 93 and 96% in naïve patients, on the dual and triple therapy arms, respectively. The SVR rates of cirrhotics were 73 and 75% on the dual and triple treatment arms, respectively. The SVR rates were low in the experienced cirrhotic patients: 44% (dual therapy) and 58% (triple therapy). Common adverse events were fatigue, headache, and myalgia. CONCLUSION:Both dual and triple therapy regimes resulted in SVR rates of >95% in CHC genotype 3 who were naive non-cirrhotics. However, the SVR rates were low in treatment-experienced cirrhotics.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Sidhu SS,Malhi NS,Goyal O,Singh R,Dutta U,Grover R,Sidhu JS,Nanda V,Saluja H,Bansal A,Singh G,Sehgal A,Kishore H,Sidhu Sdoi
10.1007/s12072-017-9794-1subject
Has Abstractpub_date
2017-05-01 00:00:00pages
277-285issue
3eissn
1936-0533issn
1936-0541pii
10.1007/s12072-017-9794-1journal_volume
11pub_type
杂志文章abstract：PURPOSE:Interferon-induced graft dysfunction (IGD) is a poorly defined, unrecognized, but potentially serious condition for patients receiving antiviral drugs after liver transplantation for hepatitis C. METHODS:We evaluated the characteristics of 80 patients who received pegylated interferon-based antiviral treatment...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-013-9496-2
更新日期：2014-04-01 00:00:00
abstract：PURPOSE:To analyze the prognostic factors for the patients with lung metastases from hepatocellular carcinoma (HCC). METHODS AND MATERIALS:One hundred and five patients with lung metastases from HCC were analyzed retrospectively. We analyzed the impact factors, including the gender, age, liver function, serum AFP and ...
journal_title：Hepatology international
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pub_type： 杂志文章
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journal_title：Hepatology international
pub_type： 杂志文章
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abstract：:Alcoholic liver disease (ALD) is a leading cause of liver-related morbidity and mortality worldwide. ALD encompasses a spectrum of disorders including asymptomatic steatosis, steatohepatitis, fibrosis, cirrhosis and its related complications, and the acute-on-chronic state of alcoholic hepatitis. While multidisciplina...
journal_title：Hepatology international
pub_type： 杂志文章,评审
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abstract：BACKGROUND/AIMS:[corrected] The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. METHODS:The patients with liver tumor or chronic hepatitis i...
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pub_type： 杂志文章,评审
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更新日期：2014-01-01 00:00:00
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更新日期：2010-04-07 00:00:00
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journal_title：Hepatology international
pub_type： 杂志文章,多中心研究
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更新日期：2016-11-01 00:00:00
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journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-007-9018-1
更新日期：2007-12-01 00:00:00
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journal_title：Hepatology international
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更新日期：2013-06-01 00:00:00
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journal_title：Hepatology international
pub_type： 杂志文章,评审
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更新日期：2012-10-01 00:00:00
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更新日期：2015-10-01 00:00:00
