当前位置： SCI文献检索 > Hepatology International期刊下所有文献 > MSC-based therapies in solid organ transplantation.

MSC-based therapies in solid organ transplantation.

Abstract：

:Immunomodulatory cell therapy as a complement to standard pharmacotherapy represents a novel approach to solid organ allograft acceptance. This methodology may allow for a reduced dose of immunosuppressive drug to be administered and thus attenuate the severe side effects associated with long-term immunosuppression such as drug-related impairment of renal function, increased risk from opportunistic infections and malignancies. Mesenchymal stem cells (MSCs) have been shown to possess both immune modulatory and regenerative properties in vitro and in preclinical models. Encouraging results have been reported from studies examining the safety and efficacy of MSCs as a treatment for acute graft-versus-host disease. MSCs represent a promising candidate cell therapy to supplement immunosuppression in recipients of solid organs, and initial reports on the clinical use of MSCs in kidney transplantation have been recently published (Tan et al. in J Am Med Assoc 307:1169-1177, 2012; Reinders et al. in Stem Cells Transl Med 2:107-111, 2013; Perico et al. in Transpl Int 26:867-878, 2013; Perico et al. in Clin J Am Soc Nephrol 6:412-422, 2011). An area of even greater interest might be the application of MSCs in clinical liver transplantation as graft survival is closely associated with overall patient survival. Here, we present preclinical findings and discuss their possible impact on clinical liver transplantation. Then we discuss clinical studies designed to investigate how MSCs may be distributed and act in solid organ transplantation.

journal_name

Hepatol Int

journal_title

Hepatology international

authors

Benseler V,Obermajer N,Johnson CL,Soeder Y,Dahlke MD,Popp FC

doi

10.1007/s12072-013-9509-1

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

179-84

issue

2

eissn

1936-0533

issn

1936-0541

pii

10.1007/s12072-013-9509-1

journal_volume

8

pub_type

杂志文章

相关文献

Hepatology International文献大全
  • Obstructive jaundice promotes intestinal-barrier dysfunction and bacterial translocation: experimental study.

    abstract：BACKGROUND:Although clinical and experimental studies have demonstrated a correlation between obstructive jaundice and the development of sepsis, the mechanism has not been fully elucidated. PURPOSE:The aim of this study was to investigate the influence of biliary obstruction on bacterial translocation as a possible s...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-007-9018-1

    authors： Abdeldayem H,Ghoneim E,Refaei AA,Abou-Gabal A

    更新日期：2007-12-01 00:00:00

  • Asparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis.

    abstract：BACKGROUND:L-Asparaginase is a bacterial enzyme used in the treatment of acute lymphoblastic leukemia. In the ongoing U.S. Drug-Induced Liver Injury Network (DILIN) prospective study, standard and pegylated asparaginase were the most frequent cause of liver injury with jaundice among anti-cancer agents (8 of 40: 20%). ...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-019-09971-2

    authors： Kamal N,Koh C,Samala N,Fontana RJ,Stolz A,Durazo F,Hayashi PH,Phillips E,Wang T,Hoofnagle JH,Drug-Induced Liver Injury Network.

    更新日期：2019-09-01 00:00:00

  • Sofosbuvir-velpatasvir plus ribavirin in Japanese patients with genotype 1 or 2 hepatitis C who failed direct-acting antivirals.

    abstract：BACKGROUND/PURPOSE:In Japan, there is a growing population of patients with chronic hepatitis C virus (HCV) infection who failed a direct-acting antiviral (DAA)-based regimen. In this Phase 3 study, we evaluated sofosbuvir-velpatasvir plus ribavirin in Japanese patients with genotype 1 or 2 HCV infection who previously...

    journal_title：Hepatology international

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s12072-018-9878-6

    authors： Izumi N,Takehara T,Chayama K,Yatsuhashi H,Takaguchi K,Ide T,Kurosaki M,Ueno Y,Toyoda H,Kakizaki S,Tanaka Y,Kawakami Y,Enomoto H,Ikeda F,Jiang D,De-Oertel S,McNabb BL,Camus G,Stamm LM,Brainard DM,McHutchison JG,M

    更新日期：2018-07-01 00:00:00

  • Actinomycotic hepatic abscess.

    abstract：:Actinomycotic hepatic abscess was diagnosed in a 46-year-old male driver from Ukraine presenting with the symptoms of malaise, loss of appetite, upper right quadrant pain, weight loss, and night sweats which had been present for last 2 months. Computed tomography (CT) of the abdomen revealed a hypodense mass in the le...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-007-9032-3

    authors： Tiftikci A,Vardareli EN,Kaban K,Peker O,Akansel S,Tozun N

    更新日期：2008-03-01 00:00:00

  • Treatment of chronic hepatitis C genotype 3 with Sofosbuvir-based therpy: a real-life study.

    abstract：BACKGROUND AND AIMS:Recently, Sofosbuvir was launched in India at affordable cost. We conducted a real-life study to determine the efficacy and safety of Sofosbuvir plus Ribavirin, with and without peginterferon-alfa 2a, in patients with chronic hepatitis C (CHC) genotype 3, the commonest genotype in South Asia. METHO...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-017-9794-1

    authors： Sidhu SS,Malhi NS,Goyal O,Singh R,Dutta U,Grover R,Sidhu JS,Nanda V,Saluja H,Bansal A,Singh G,Sehgal A,Kishore H,Sidhu S

    更新日期：2017-05-01 00:00:00

  • A low steady HBsAg seroprevalence is associated with a low incidence of HBV-related liver cirrhosis and hepatocellular carcinoma in Mexico: a systematic review.

    abstract：:To address the relationship between hepatitis B virus (HBV) endemicity and HBV-related liver diseases in Mexico. Research literature reporting on HBsAg and antibody to hepatitis B core antigen (anti-HBc) prevalence in Mexican study groups were searched in NLM Gateway, PubMed, IMBIOMED, and others. Weighted mean preval...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-008-9115-9

    authors： Roman S,Panduro A,Aguilar-Gutierrez Y,Maldonado M,Vazquez-Vandyck M,Martinez-Lopez E,Ruiz-Madrigal B,Hernandez-Nazara Z

    更新日期：2009-06-01 00:00:00

  • Incidence and risk factors for surveillance failure in patients with regular hepatocellular carcinoma surveillance.

    abstract：BACKGROUND:Initial presentation of hepatocellular carcinoma (HCC) at an advanced stage in patients under a regular surveillance program is a devastating problem. AIMS:We assessed the prevalence and factors associated with this surveillance failure. METHODS:A total of 304 HCC patients who received regular surveillance...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-013-9462-z

    authors： Sinn DH,Yi J,Choi MS,Choi D,Gwak GY,Paik YH,Lee JH,Koh KC,Paik SW,Yoo BC

    更新日期：2013-10-01 00:00:00

  • Impact of viral hepatitis B status on outcomes of intrahepatic cholangiocarcinoma: a meta-analysis.

    abstract：BACKGROUND AND AIMS:To estimate the impact of viral hepatitis B status on outcomes of intrahepatic cholangiocarcinoma. METHODS:We searched Pubmed and Embase for original articles that evaluated the impact of hepatitis B virus infection on outcomes of intrahepatic cholangiocarcinoma. The present study was conducted to ...

    journal_title：Hepatology international

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s12072-018-9881-y

    authors： Jeong S,Luo G,Wang ZH,Sha M,Chen L,Xia Q

    更新日期：2018-07-01 00:00:00

  • Natural history of HCV infection.

    abstract：BACKGROUND:There is much controversy surrounding the natural history of hepatitis C virus (HCV) infection. AIMS:The aim of this review was to review the natural history of HCV infection. METHODS:Published English literature was searched via pubmed and then reviewed. RESULTS:Approximately, 75-85% of HCV-infected pers...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-012-9355-6

    authors： Sarin SK,Kumar M

    更新日期：2012-10-01 00:00:00

  • De novo combination of lamivudine and adefovir versus entecavir monotherapy for the treatment of naïve HBeAg-negative chronic hepatitis B patients.

    abstract：PURPOSE:Either combination treatment or monotherapy using agents with a high genetic barrier are recommended for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB). The aim of this study was to compare effect of naïve HBeAg-negative CHB patients with either de novo combination of lamivudine (LAM) and adef...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-010-9243-x

    authors： Wang LC,Chen EQ,Cao J,Liu L,Zheng L,Li DJ,Xu L,Lei XZ,Liu C,Tang H

    更新日期：2011-06-01 00:00:00

  • Impact of circulating miR-122 for histological features and hepatocellular carcinoma of nonalcoholic fatty liver disease in Japan.

    abstract：BACKGROUND AND AIM:Relationships between circulating microRNA-122 (miR-122) and histological features of nonalcoholic fatty liver disease (NAFLD) are unclear. METHODS:The impact of serum miR-122 levels for histological features and hepatocellular carcinoma (HCC) was investigated in 305 Japanese patients with histologi...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-016-9729-2

    authors： Akuta N,Kawamura Y,Suzuki F,Saitoh S,Arase Y,Kunimoto H,Sorin Y,Fujiyama S,Sezaki H,Hosaka T,Kobayashi M,Suzuki Y,Kobayashi M,Ikeda K,Kumada H

    更新日期：2016-07-01 00:00:00

  • Recurrence rates and factors for recurrence after radiofrequency ablation combined with transarterial chemoembolization for hepatocellular carcinoma: a retrospective cohort study.

    abstract：PURPOSE:There have been reports that radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) is as equally effective as surgical resection for the treatment of hepatocellular carcinoma (HCC). This study aimed to evaluate recurrence rate and risk factor of recurrence after RFA combined with TA...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-011-9290-y

    authors： Kim JH,Yim HJ,Lee KG,Kim SY,Jung ES,Jung YK,Kim JH,Seo YS,Yeon JE,Lee HS,Um SH,Byun KS,Ryu HS

    更新日期：2012-04-01 00:00:00

  • Genetic and epigenetic mechanisms of NASH.

    abstract：:Along with the obesity epidemic, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased exponentially. The histological disease spectrum of NAFLD ranges from bland fatty liver (hepatic steatosis), to the concomitant presence of inflammation and ballooning which defines nonalcoholic steatohepatitis (N...

    journal_title：Hepatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s12072-015-9689-y

    authors： Eslam M,George J

    更新日期：2016-05-01 00:00:00

  • Cytokine gene polymorphisms in acute cellular rejection following living donor liver transplantation: analysis of 155 donor-recipient pairs.

    abstract：PURPOSE:Despite improvements in immunosuppressive therapy, acute cellular rejection (ACR) remains an important cause of graft loss in patients undergoing liver transplantation. Recently, associations between cytokine gene polymorphisms in recipients and the occurrence of ACR have been reported. However, most studies di...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-013-9443-2

    authors： Kamei H,Masuda S,Nakamura T,Ishigami M,Fujimoto Y,Ogura Y,Oike F,Takada Y,Hamajima N

    更新日期：2013-07-01 00:00:00

  • Hepatic encephalopathy in acute-on-chronic liver failure.

    abstract：:The presence of hepatic encephalopathy (HE) within 4 weeks is part of the criteria for defining acute-on-chronic liver failure (ACLF). The pathophysiology of HE is complex, and hyperammonemia and cerebral hemodynamic dysfunction appear to be central in the pathogenesis of encephalopathy. Recent data also suggest that ...

    journal_title：Hepatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s12072-015-9626-0

    authors： Lee GH

    更新日期：2015-10-01 00:00:00

  • Predictors of outcome in acute-on-chronic liver failure in children.

    abstract：BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is associated with a high mortality rate in the absence of liver transplantation. There is limited data on predictors of survival in ACLF in children. Therefore, we prospectively studied the predictors of outcome of ACLF in children. METHODS:A prospective evalu...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-010-9217-z

    authors： Lal J,Thapa BR,Rawal P,Ratho RK,Singh K

    更新日期：2011-06-01 00:00:00

  • Hepatocellular adenoma: what is new in 2008.

    abstract：:Patients (85%) with hepatocellular adenoma (HCA) are women taking oral contraceptives. They can be divided into four subgroups according to their genotype/phenotype features. (1) Hepatocyte nuclear factor 1alpha (HNF1alpha) biallelic somatic mutations are observed in 35% of the HCA cases. It occurs in almost all cases...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-008-9075-0

    authors： Bioulac-Sage P,Laumonier H,Laurent C,Zucman-Rossi J,Balabaud C

    更新日期：2008-09-01 00:00:00

  • Viscoelastic test-based bleeding risk score reliably predicts coagulopathic bleeding in decompensated cirrhosis and ACLF patients.

    abstract：BACKGROUND AND AIMS:Coagulopathic bleeding risk prediction is challenging in decompensated cirrhosis (DC) by conventional assays. Viscoelastic tests (VETs) are likely to be more useful for assessing coagulation status in these patients. We investigated whether the VET (Sonoclot) parameters with fibrinogen could predict...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-020-10036-y

    authors： Bihari C,Patil A,Shasthry SM,Baweja S,Kumar G,Sarin SK

    更新日期：2020-07-01 00:00:00

  • Anti-viral therapy in hepatitis B virus reactivation with acute-on-chronic liver failure.

    abstract：:Hepatitis B virus (HBV) reactivation with hepatic decompensation leading to acute on chronic liver failure is not uncommon. It is associated with high mortality of up to 30-70%. Prognostic factors for mortality include high bilirubin level, more prolonged prothrombin time, low platelet count and presence of pre-existi...

    journal_title：Hepatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s12072-014-9569-x

    authors： Yuen MF

    更新日期：2015-07-01 00:00:00

  • A changing paradigm: management and treatment of the HCV/HIV-co-infected patient.

    abstract：:Hepatitis C virus (HCV) treatment in HIV/HCV co-infected individuals has renewed relevance given the ongoing opioid crisis and rise of new HIV and HCV infections associated with injection drug use. Patients co-infected with HIV and HCV demonstrate increased rates of hepatic fibrosis, progression to liver failure, and ...

    journal_title：Hepatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s12072-018-9896-4

    authors： Abutaleb A,Sherman KE

    更新日期：2018-11-01 00:00:00

  • The therapeutic response of antiviral therapy in HBsAg-positive renal transplant recipients and a long-term follow-up.

    abstract：BACKGROUND:Early prediction of lamivudine (LAM) response by individualized monitoring of serum HBV DNA like roadmap concept, and investigation of the outcome after LAM discontinuation in renal transplant recipients (RTRs) with chronic hepatitis B (CHB). METHODS:We conducted a study on 19 RTRs with HBV infection receiv...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-011-9295-6

    authors： Hu TH,Tsai MC,Chen YT,Chien YS,Hung CH,Chen TC,Tseng PL,Chang KC,Yen YH

    更新日期：2012-04-01 00:00:00

  • p53 codon 72 polymorphism and hepatocellular carcinoma: a meta-analysis.

    abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common malignant neoplasms worldwide. The p53 gene is frequently mutated in some histological subtypes of HCC. The role of p53 mutations and polymorphic variant of codon 72 in the prognosis of disease is still unclear. The p53 tumor suppressor gene Arg72Pro p...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-012-9389-9

    authors： Jia S,Tang W,Luo Y

    更新日期：2013-06-01 00:00:00

  • Existence of cancer stem cells in hepatocellular carcinoma: myth or reality?

    abstract：:The cancer stem cell (CSC) hypothesis has been disproved in many cancers. CSCs may exist in blood cancer, while many epithelial cancers may not have CSCs but tumor-initiating cells (TICs). Several independent studies have provided strong evidence for existence of CSCs in brain, skin, and colon cancers (Mani et al. in ...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-016-9777-7

    authors： Machida K

    更新日期：2017-03-01 00:00:00

  • HATT: a phase IV, single-arm, open-label study of sorafenib in Taiwanese patients with advanced hepatocellular carcinoma.

    abstract：BACKGROUND:Sorafenib significantly improves survival in patients with advanced hepatocellular carcinoma (HCC). This phase IV study assessed sorafenib efficacy/safety in Taiwanese patients with advanced HCC and Child-Pugh A status. METHODS:All patients received 400 mg sorafenib BID. Safety, efficacy, sorafenib pharmaco...

    journal_title：Hepatology international

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s12072-016-9774-x

    authors： Lin SM,Lu SN,Chen PT,Jeng LB,Chen SC,Hu CT,Yang SS,Le Berre MA,Liu X,Mitchell DY,Prins K,Grevel J,Peña CA,Meinhardt G

    更新日期：2017-03-01 00:00:00

  • Virus-induced hepatocellular carcinoma with special emphasis on HBV.

    abstract：:Hepatocellular carcinoma (HCC) is a common malignant tumor with high lethality, and the hepatitis B virus (HBV) is a chief cause. HBV can accelerate HCC via multiple mechanisms. First, HBV induces immune reactions that lead to repeated hepatic inflammation, fibrosis and a deficient immune microenvironment. Subsequentl...

    journal_title：Hepatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s12072-016-9779-5

    authors： Wang M,Xi D,Ning Q

    更新日期：2017-03-01 00:00:00

  • Prognostic analysis of pulmonary metastases from hepatocellular carcinoma.

    abstract：PURPOSE:To analyze the prognostic factors for the patients with lung metastases from hepatocellular carcinoma (HCC). METHODS AND MATERIALS:One hundred and five patients with lung metastases from HCC were analyzed retrospectively. We analyzed the impact factors, including the gender, age, liver function, serum AFP and ...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-008-9052-7

    authors： Zhang SM,Zeng ZC,Tang ZY,Sun J,Cheng JM,Liu R,Wang P,Zhang BH

    更新日期：2008-06-01 00:00:00

  • Effect of hepatitis B surface antibody in patients with core antibody-positive liver transplantation: a systematic review and meta-analysis.

    abstract：BACKGROUND AND AIM:There is an increased awareness of de novo hepatitis B virus (HBV) infection (DNH) in hepatitis B surface antigen (HBsAg)-negative recipients receiving hepatitis B core antibody (HBcAb)-positive liver organ. Whether hepatitis B surface antibody (HBsAb) has positive result on preventing the occurrence...

    journal_title：Hepatology international

    pub_type： 杂志文章,meta分析

    doi：10.1007/s12072-020-10021-5

    authors： Yang Y,Huang A,Zhao Y

    更新日期：2020-03-01 00:00:00

  • The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH).

    abstract：BACKGROUND AND AIMS:The peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand, piglitazone, enhances the degradation of branched-chain amino acids (BCAAs) in adipose tissue. However, it remains unknown whether pioglitazone influences the plasma amino acids (AA) profile in patients with nonalcoholic steatohepatit...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-012-9395-y

    authors： Kakazu E,Kondo Y,Ninomiya M,Kimura O,Nagasaki F,Ueno Y,Shimosegawa T

    更新日期：2013-06-01 00:00:00

  • Immunological cure of HBV infection.

    abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden and cure is rarely achieved by current antiviral therapies. Therefore, there is an urgent need for new therapeutic options. Immune modulation with the goal to restore dysfunctional HBV-specific immunity is an interesting target for new therapeut...

    journal_title：Hepatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s12072-018-9912-8

    authors： Lang J,Neumann-Haefelin C,Thimme R

    更新日期：2019-03-01 00:00:00

  • A comparison of hepatitis B viral markers of patients in different clinical stages of chronic infection.

    abstract：PURPOSE:Hepatitis B viral markers may be useful for predicting outcomes such as liver-related deaths or development of hepatocellular carcinoma. We determined the frequency of these markers in different clinical stages of chronic hepatitis B infection. METHODS:We compared baseline hepatitis B viral markers in 317 pati...

    journal_title：Hepatology international

    pub_type： 杂志文章

    doi：10.1007/s12072-010-9179-1

    authors： Tong MJ,Hsu L,Hsien C,Kao JH,Durazo FA,Saab S,Blatt LM

    更新日期：2010-04-07 00:00:00