Abstract：
:Hepatitis B virus (HBV) reactivation with hepatic decompensation leading to acute on chronic liver failure is not uncommon. It is associated with high mortality of up to 30-70%. Prognostic factors for mortality include high bilirubin level, more prolonged prothrombin time, low platelet count and presence of pre-existing cirrhosis. Several studies addressing the efficacy of different anti-viral therapies, namely lamivudine, entecavir and tenofovir, have been performed. Although the results were not highly consistent, it appeared that use of anti-viral agents was associated with decreasing chance of mortality, subsequent HBV reactivation, disease progression, and with excellent viral suppression. The beneficial effects were most prominently observed in patients with MELD score 20-30. However, even with anti-viral therapy, patients may still have irreversible liver decompensation requiring liver transplantation if other adverse parameters. including pre-existing cirrhosis, bilirubin >20 mg/dL (340 µmol/L), prothrombin time <40%, platelet count <120 × 10(9)/L. were present. Mortality rate in patients with MELD score >30 was >92% even with prompt anti-viral treatment. Liver transplantation should be considered urgently.
journal_name
Hepatol Intjournal_title
Hepatology internationalauthors
Yuen MFdoi
10.1007/s12072-014-9569-xsubject
Has Abstractpub_date
2015-07-01 00:00:00pages
373-7issue
3eissn
1936-0533issn
1936-0541journal_volume
9pub_type
杂志文章,评审abstract：PURPOSE:To assess the accuracy of a formula derived from 159 living liver donors to estimate the liver size of a normal subject: standard liver weight (g) = 218 + body weight (kg) × 12.3 + 51 (if male). Standard liver volume (SLV) is attained by a conversion factor of 1.19 mL/g. METHODS:The total liver volume (TLV) of...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9264-0
更新日期：2011-03-26 00:00:00
abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden and cure is rarely achieved by current antiviral therapies. Therefore, there is an urgent need for new therapeutic options. Immune modulation with the goal to restore dysfunctional HBV-specific immunity is an interesting target for new therapeut...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-018-9912-8
更新日期：2019-03-01 00:00:00
abstract：PURPOSE:To analyze the prognostic factors for the patients with lung metastases from hepatocellular carcinoma (HCC). METHODS AND MATERIALS:One hundred and five patients with lung metastases from HCC were analyzed retrospectively. We analyzed the impact factors, including the gender, age, liver function, serum AFP and ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-008-9052-7
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND AND AIM:Cirrhosis is a controversial determinant of mortality in HBV-related acute-on-chronic liver failure (HBV-ACLF). The present study aimed to explore the effects of cirrhosis and the associated risk factors, especially its complications, on the outcome of HBV-ACLF. METHODS:A prospective-retrospective c...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-019-09992-x
更新日期：2019-11-01 00:00:00
abstract：:More than 170 million people worldwide are infected with hepatitis C virus (HCV). A characteristic of this virus is a high tendency toward chronic infection. Several factors affect the viral outcome after infection. Among them, HCV-specific CD4 T cells are thought to play a crucial role in controlling viremia. Cumulat...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9321-8
更新日期：2012-01-01 00:00:00
abstract：PURPOSE/BACKGROUND:Severe alcoholic hepatitis (AH) is a life-threatening liver disease with a potential of 30-40 % mortality at 1 month. While steroids remain to be a first line therapy, they provide only about 50 % survival benefit. The aim of the study was to evaluate the efficacy of glucocorticoids plus S-adenosylme...
journal_title：Hepatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s12072-016-9751-4
更新日期：2016-11-01 00:00:00
abstract：:Substantial advancements in the field of primary biliary cirrhosis (PBC) research have broadened our understanding of this enigmatic disease. Genome-wide studies have identified several new candidate genes involved in the immunoregulatory process, particularly those responsible for antigen presentation and lymphocyte ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-012-9362-7
更新日期：2013-03-01 00:00:00
abstract：PURPOSE:To evaluate the recent topics of Ballloon-occluded retrograde trasnvenous obliteration(B-RTO). METHOD:We overviewed the recent scientific papers regarding B-RTO. RESULT:B-RTO is a treatment method for occluding varices retrogradely using a sclerosing agent under balloon occlusion of a major draining vein. It ...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-017-9813-2
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Cytokines have been reported to be involved in the cirrhosis and hepatic encephalopathy (HE). Many aspects on the correlation between minimal HE (MHE) and cytokine levels were still unclear. METHODS:Two hundred eighty-nine HBV-infected cirrhotic patients were grouped: non MHE (n = 156), MHE (n...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-015-9610-8
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Sorafenib significantly improves survival in patients with advanced hepatocellular carcinoma (HCC). This phase IV study assessed sorafenib efficacy/safety in Taiwanese patients with advanced HCC and Child-Pugh A status. METHODS:All patients received 400 mg sorafenib BID. Safety, efficacy, sorafenib pharmaco...
journal_title：Hepatology international
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s12072-016-9774-x
更新日期：2017-03-01 00:00:00
abstract：PURPOSE:All previous studies reported the benefit of antibiotic prophylaxis in cirrhotic patients with either a mixture of nonvariceal and variceal bleeding or variceal bleeding alone. Reports on sole peptic ulcers bleeding are lacking. We aimed to assess the effect of antibiotic prophylaxis in cirrhotic patients with ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-012-9378-z
更新日期：2013-03-01 00:00:00
abstract：:Cirrhotic cardiomyopathy is a recently recognized condition in cirrhosis consisting of systolic incompetence under condition of stress, diastolic dysfunction related to altered diastolic relaxation, and electrophysiological abnormalities in the absence of any known cardiac disease. It can be diagnosed by using a combi...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-008-9109-7
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:The diagnostic potential of hepatic stellate cells (HSCs) and γδT cells for patients with hepatocellular carcinoma (HCC) and their synergistic contributions to the prognosis of these patients have not yet been investigated. The aim of this study was to elucidate the prognostic value of these cells in HCC. METH...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-019-09969-w
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:Despite improvements in immunosuppressive therapy, acute cellular rejection (ACR) remains an important cause of graft loss in patients undergoing liver transplantation. Recently, associations between cytokine gene polymorphisms in recipients and the occurrence of ACR have been reported. However, most studies di...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-013-9443-2
更新日期：2013-07-01 00:00:00
abstract：PURPOSE:Ethanol binge augments liver injury after chronic ethanol consumption in humans, but the mechanism behind the enhanced liver injury by ethanol binge is not known. In this study we used a clinically relevant rat model in which liver injury is amplified by binge after chronic ethanol treatment and investigated th...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-014-9546-4
更新日期：2014-09-01 00:00:00
abstract：PURPOSE:Lamivudine treatment of chronic hepatitis B (CHB) is associated with frequent resistance and loss of clinical benefit. We present outcomes of lamivudine-refractory Japanese patients treated with entecavir for 3 years. METHODS:Eighty-two patients refractory to lamivudine therapy received entecavir 0.5 or 1 mg d...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-009-9162-x
更新日期：2010-02-06 00:00:00
abstract：:Chronic hepatitis B virus (HBV) infection is endemic in the Asian-Pacific region, and reactivation of HBV post-cancer chemotherapy has become an emerging clinical challenge. Patients with detectable serum HBV DNA before chemotherapy and those receiving intensive chemotherapy are particularly at a risk of HBV reactivat...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9279-6
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:There have been reports that radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) is as equally effective as surgical resection for the treatment of hepatocellular carcinoma (HCC). This study aimed to evaluate recurrence rate and risk factor of recurrence after RFA combined with TA...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9290-y
更新日期：2012-04-01 00:00:00
abstract：:Liver transplantation is a definitive therapy for patients with end-stage liver disease and cirrhosis, with improvement in survival and quality of life. Patients are carefully screened and selected for this modality of treatment to achieve maximum survival benefit. For example, a patient with hepatocellular carcinoma ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-016-9770-1
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Although arterial stiffness has been reported to be associated with nonalcoholic fatty liver disease (NAFLD), previous studies have relied only on noninvasive assessments for the diagnosis of NAFLD. This study attempted to investigate the association of arterial stiffness with the histological severity of NA...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-020-10108-z
更新日期：2020-12-01 00:00:00
abstract：AIMS:Relationships of renal function and liver disease are described in acute and chronic liver failure. The aim of the study is to investigate which relationship, if any, is present between severity of non-alcoholic fatty liver disease (NAFLD), assessed by bright liver score (BLS) versus mild-moderate renal insufficie...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9254-2
更新日期：2011-09-01 00:00:00
abstract：:Actinomycotic hepatic abscess was diagnosed in a 46-year-old male driver from Ukraine presenting with the symptoms of malaise, loss of appetite, upper right quadrant pain, weight loss, and night sweats which had been present for last 2 months. Computed tomography (CT) of the abdomen revealed a hypodense mass in the le...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-007-9032-3
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Early prediction of lamivudine (LAM) response by individualized monitoring of serum HBV DNA like roadmap concept, and investigation of the outcome after LAM discontinuation in renal transplant recipients (RTRs) with chronic hepatitis B (CHB). METHODS:We conducted a study on 19 RTRs with HBV infection receiv...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-011-9295-6
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:Transcriptional silencing of tumor suppressor genes associated with DNA hypermethylation has been known as a hallmark of human cancer. In this study, we revealed that a local anesthetic, procaine (PCA), possessed growth-inhibitory and demethylating effect on human hepatoma cells in vitro and in vivo. METHODS:T...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-007-9014-5
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:The aim of our study was to explore how C1QTNF1-AS1 regulated miR-221-3p/SOCS3 axis in human hepatocellular carcinoma (HCC). METHODS:Differentially expressed lncRNAs and genes were examined via RNA-seq. GO analysis and KEGG pathway enrichment analysis were carried out based on the function of dys-regulated ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-019-09944-5
更新日期：2019-05-01 00:00:00
abstract：:Hepatitis due to hepatitis B virus reactivation after cytotoxic or immunosuppressive therapy is a serious cause of liver-related morbidity and mortality. With the characterization of the underlying pathogenesis, much progress in the management of this important clinical problem has been made in the past 2 decades. By ...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-008-9056-3
更新日期：2008-06-01 00:00:00
abstract：:An ultrasound (US) examination is a common noninvasive technique widely applied for diagnosis of a variety of diseases. Based on the rapid development of US equipment, many US images have been accumulated and are now available and ready for the preparation of a database for the development of computer-aided US diagnos...
journal_title：Hepatology international
pub_type： 杂志文章,评审
doi：10.1007/s12072-019-09937-4
更新日期：2019-07-01 00:00:00
abstract：:The bone marrow contains stem cells that have the potential to differentiate into a variety of organ-specific mature cells, including the liver and the pancreas. Recently, the origin of hepatic progenitors and hepatocytes was identified to be the bone marrow. However, evidence that describes which cells, among all bon...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-007-9031-4
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party to develop a consensus cost-effectiveness model for treatment of Hepatitis B in Asia Pacific countries in March 2010. METHODS:The working party consisted of expert hepatologists, virologists and epidemiolog...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-014-9549-1
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND/PURPOSE:Gut microbiota has been associated with liver cirrhosis and, possibly, hepatic encephalopathy. However, only a few studies have examined the link between mucosa-associated microbiota (MAM) and minimal hepatic encephalopathy (MHE). Our aim was to investigate this relationship. METHODS:Twenty-four pat...
journal_title：Hepatology international
pub_type： 杂志文章
doi：10.1007/s12072-019-09963-2
更新日期：2019-07-01 00:00:00
