The role of microRNAs in the development and progression of chemical-associated cancers.

abstract：:Antineoplastic drugs cause severe cytotoxicity for normal cells, especially hematopoietic stem cells (HSCs). However, bleomycin (BLM) is glycopeptide antibiotic that is effective on various cancers and has either low or no myelosuppression effects. The aim of the present study was to investigate the effect of BLM on 5...

journal_title：Toxicology and applied pharmacology

authors： Fakhrabadi HG,Rabbani-Chadegani A,Ghadam P,Amiri S

更新日期：2020-06-01 00:00:00

abstract：:Side effects of methotrexate (MTX) especially hepatotoxicity limits clinical applications of this anticancer agent. Carboxypeptidase G2 (CPG2) is administrated for the treatment of elevated plasma concentrations of MTX. In this study, we have investigated the intracellular delivery of CPG2 fused to the transactivator ...

journal_title：Toxicology and applied pharmacology

authors： Sadeghian I,Khalvati B,Ghasemi Y,Hemmati S

更新日期：2018-05-01 00:00:00

abstract：:There is concern that P-glycoprotein mediated efflux contributes to steroid resistance. Therefore, this study examined bidirectional corticosteroid transport and induction capabilities for P-glycoprotein (P-gp) to understand which of the systemic and inhaled corticosteroids interacted with P-gp to the greatest extent....

journal_title：Toxicology and applied pharmacology

authors： Crowe A,Tan AM

更新日期：2012-05-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) can protect the liver from injury produced by a variety of hepatotoxicants when administered prior to or concomitant with the toxicants. This protective action has previously been attributed to DMSO-induced inhibition of bioactivation of the compounds to toxic intermediates. In these studies,...

journal_title：Toxicology and applied pharmacology

authors： Lind RC,Gandolfi AJ

更新日期：1997-01-01 00:00:00

abstract：:Infants exposed to second hand smoke (SHS) experience more problems with wheezing. This study was designed to determine if perinatal SHS exposure increases intrinsic and/or in vivo airway responsiveness to methacholine and whether potential structural/cellular alterations in the airway might explain the change in resp...

journal_title：Toxicology and applied pharmacology

authors： Joad JP,Kott KS,Bric JM,Peake JL,Pinkerton KE

更新日期：2009-02-01 00:00:00

abstract：:The mechanism of action of Cd on Na,K-ATPase was investigated in two "classical" model systems, the shark rectal gland and rabbit kidney outer medulla. In lyophilized plasma membranes from dogfish rectal gland Cd inhibited Na,K-ATPase activity after 30 min of preincubation with an I50 of 1.3 x 10(-5) M. K-Dependent p-...

journal_title：Toxicology and applied pharmacology

authors： Kinne-Saffran E,Hülseweh M,Pfaff C,Kinne RK

更新日期：1993-07-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental pollutant that activates the aryl hydrocarbon receptor (AhR) resulting in altered gene expression. In vivo, in vitro, and ex vivo studies have demonstrated that B cells are directly impaired by TCDD, and are a sensitive target as evidenced by sup...

journal_title：Toxicology and applied pharmacology

authors： Kovalova N,Nault R,Crawford R,Zacharewski TR,Kaminski NE

更新日期：2017-02-01 00:00:00

abstract：:The putative neurotoxicity of the organophosphorus compound triphenyl phosphite (TPP) was examined in Long Evans, adult male rats. Animals were exposed to two 1.0 ml/kg (1184 mg/kg) injections (sc) of TPP spaced 1 week apart and sampled for biochemical and neuropathological examination. At the time of sampling, rats d...

journal_title：Toxicology and applied pharmacology

authors： Veronesi B,Padilla S,Newland D

更新日期：1986-04-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) activate neutrophils to induce degranulation and undergo superoxide production through a mechanism that involves stimulation of phospholipase A(2) (PLA(2)). Since the biochemical processes leading to the PCB-induced activation of this enzyme are unknown, the objective of this study was...

journal_title：Toxicology and applied pharmacology

authors： Olivero J,Ganey PE

更新日期：2000-02-15 00:00:00

abstract：:Earlier studies with etretinate and its metabolite acitretin suggested that area under the concentration-time curve (AUC) is the most suitable pharmacokinetic correlate to etretinate-induced teratogenesis. In an attempt to test this hypothesis with respect to the embryotoxic effects of all-trans-retinoic acid (all-tra...

journal_title：Toxicology and applied pharmacology

authors： Tzimas G,Thiel R,Chahoud I,Nau H

更新日期：1997-04-01 00:00:00

abstract：:Excessive fetal glucocorticoid exposure has been linked to increased susceptibility to hypertension and cardiac diseases in the adult life, a process called fetal programming. The cardiac contribution to the hypertensive phenotype of glucocorticoid-programmed progeny is less known, therefore, we investigated in vitro ...

journal_title：Toxicology and applied pharmacology

authors： Kiguti LRA,Borges CS,Mueller A,Silva KP,Polo CM,Rosa JL,Silva PV,Missassi G,Valencise L,Kempinas WG,Pupo AS

更新日期：2017-11-01 00:00:00

abstract：:Male Wistar rats exposed to a systemic organophosphorus insecticide, phorate [O,O-diethyl S-[(ethylthio) methyl] phosphorothioate] at varying oral doses of 0.046, 0.092 or 0.184mg phorate/kg bw for 14days, exhibited substantial oxidative stress, cellular DNA damage and activation of apoptosis-related p53, caspase 3 an...

journal_title：Toxicology and applied pharmacology

authors： Saquib Q,Attia SM,Siddiqui MA,Aboul-Soud MA,Al-Khedhairy AA,Giesy JP,Musarrat J

更新日期：2012-02-15 00:00:00

abstract：:The dermal sensitizing potencies of four diisocyanates were investigated using the mouse ear-swelling test (MEST) with BALB/cBy mice. Mice were administered topical doses of diisocyanates to the abdomen and were challenged on the ear 4 days later with a nonirritating dose of chemical. The increase in ear thickness at ...

journal_title：Toxicology and applied pharmacology

authors： Thorne PS,Hillebrand JA,Lewis GR,Karol MH

更新日期：1987-01-01 00:00:00

abstract：:After a fire involving a transformer, the State Office Building in Binghamton, New York, was contaminated with soot containing polychlorinated biphenyls, biphenylenes, naphthalenes, dioxins, and dibenzofurans. The toxicity of the soot and its effect on liver morphology after prolonged (subchronic) exposure were determ...

journal_title：Toxicology and applied pharmacology

authors： Turner JN,Collins DN

更新日期：1984-05-01 00:00:00

abstract：:Gallium arsenide (GaAs), indium arsenide (InAs), and aluminium gallium arsenide (AlGaAs) are semiconductor applications. Although the increased use of these materials has raised concerns about occupational exposure to them, there is little information regarding the adverse health effects to workers arising from exposu...

journal_title：Toxicology and applied pharmacology

authors： Tanaka A

更新日期：2004-08-01 00:00:00

abstract：:We investigated the relative contribution of several cardiorespiratory components to acute lethality produced by N-methylcarbamate cholinesterase (ChE) inhibitors physostigmine, 2-sec-butylphenyl methylcarbamate (BPMC), and 2-isopropoxyphenyl methylcarbamate (PHC) in halothane-anesthetized rabbits. Intravenous injecti...

journal_title：Toxicology and applied pharmacology

authors： Futagawa H,Kakinuma Y,Takahashi H

更新日期：2000-05-15 00:00:00

abstract：:Statins are widely used to treat lipid disorders. These drugs are safe and well tolerated; however, in <1% of patients, myopathy and/or rhabdomyolysis can develop. To better understand the mechanism of statin-induced myopathy, we examined the ability of structurally distinct statins to induce apoptosis in an optimized...

journal_title：Toxicology and applied pharmacology

authors： Johnson TE,Zhang X,Bleicher KB,Dysart G,Loughlin AF,Schaefer WH,Umbenhauer DR

更新日期：2004-11-01 00:00:00

abstract：:The ability of brain tissue preparation to generate superoxide from xenobiotic interactions has been investigated. We showed that a significant superoxide production occurred with different molecules known to undergo a single electron reductive pathway of metabolism, both in a homogenate derived from neuronal and glia...

journal_title：Toxicology and applied pharmacology

authors： Ghersi-Egea JF,Livertoux MH,Minn A,Perrin R,Siest G

更新日期：1991-08-01 00:00:00

abstract：:The effect of captopril, an angiotensin-converting enzyme inhibitor, on the progression of chronic renal disease was studied in rats subjected to partial nephrectomy. Following ablation of approximately 70% of their renal mass, rats were divided into three treatment groups: group I received a placebo treatment; group ...

journal_title：Toxicology and applied pharmacology

authors： Hall RL,Wilke WL,Fettman MJ

更新日期：1985-09-30 00:00:00

abstract：:Neuropathy target esterase (NTE) is a membrane-bound protein with high esterase catalytic activity. The physiological function of the protein is not known and the catalytic activity is not essential to health of nerve axons. Nevertheless there is overwhelming evidence that modification of the structure of NTE by coval...

journal_title：Toxicology and applied pharmacology

authors： Johnson MK

更新日期：1990-03-01 00:00:00

abstract：:Valinomycin and cereulide are bacterial toxins with closely similar chemical structure and properties but different toxic effects. Emetic poisoning is induced by cereulide but not by valinomycin. Both are specific potassium ionophores. Such compounds may affect mitochondrial functions. Both compounds cause a potassium...

journal_title：Toxicology and applied pharmacology

authors： Teplova VV,Mikkola R,Tonshin AA,Saris NE,Salkinoja-Salonen MS

更新日期：2006-01-01 00:00:00

abstract：:1-Nitropyrene (1-NP), a constituent of diesel exhaust, is carcinogenic to rats and is a bacterial and mammalian mutagen. Biliary and fecal excretion of 1-NP metabolites are the major routes of excretion in rats, suggesting that hepatic metabolism plays a dominant role in determining the biological fate of 1-NP. The pu...

journal_title：Toxicology and applied pharmacology

authors： Bond JA,Medinsky MA,Dutcher JS

更新日期：1984-09-30 00:00:00

abstract：:Direct additions to culture media of either acetaminophen (APAP) or 7-hydroxy-2-acetylaminofluorene (7-OH-AAF) resulted in abnormal closure of the anterior neuropores of cultured rat embryos in the absence of an exogenous bioactivation system. Concentrations required to produce a 50% incidence of the defect were appro...

journal_title：Toxicology and applied pharmacology

authors： Harris C,Stark KL,Luchtel DL,Juchau MR

更新日期：1989-12-01 00:00:00

abstract：:Diesel exhaust particles (DEPs) cause many adverse health problems, and reports indicate increased risk of breast cancer in men and women through exposure to gasoline and vehicle exhaust. However, DEPs include vast numbers of compounds, and the specific compound(s) responsible for these actions are not clear. We recen...

journal_title：Toxicology and applied pharmacology

authors： Furuta C,Suzuki AK,Watanabe G,Li C,Taneda S,Taya K

更新日期：2008-08-01 00:00:00

abstract：:6-Hydroxy-trans,trans-2,4-hexadienal (CHO-M-OH) is a metabolite of trans,trans-muconaldehyde (muconaldehyde or MUC), a microsomal hematotoxic ring-opened metabolite of benzene. In the present study, the toxicity of CHO-M-OH was examined. In order to assess potential toxic effects of CHO-M-OH on the maturation of eryth...

journal_title：Toxicology and applied pharmacology

authors： Zhang Z,Schafer F,Schoenfeld H,Cooper K,Snyder R,Goldstein BD,Witz G

更新日期：1995-06-01 00:00:00

abstract：:In the metabolism of isosorbide dinitrate (ISDN), fast denitration with the formation of nitrite ions and a mononitrate plays an important role. In contrast, the denitration of isosorbide-5-mononitrate (IS-5-MN) to isosorbide is very slow. Accordingly po administration of high doses of ISDN (92.5 and 236 mg/kg) in con...

journal_title：Toxicology and applied pharmacology

authors： Strein K,Bartsch W,Sponer G,Müller-Beckmann B,Lexa P

更新日期：1984-01-01 00:00:00

abstract：:The purpose of this study was to determine whether exposure to levels of sarin causing no overt clinical signs would cause more subtle, adverse health effects that persisted after the exposure ended. Inhalation exposures of male Fischer 344 rats to 0, 0.2, or 0.4 mg/m(3) of sarin for 1 h/day for 1, 5, or 10 days under...

journal_title：Toxicology and applied pharmacology

authors： Henderson RF,Barr EB,Blackwell WB,Clark CR,Conn CA,Kalra R,March TH,Sopori ML,Tesfaigzi Y,Ménache MG,Mash DC

更新日期：2002-10-15 00:00:00

abstract：:Knowledge of ozone (O3) uptake in rats in integral to efforts to quantitatively extrapolate animal data to man. We have measured percentage O3 uptake in 30 adult Sprague-Dawley rats exposed, nose only, for 1 hr to 0.3, 0.6, or 1.0 ppm O3. Tidal volume and breathing rate measurements, obtained by plethysmography, were ...

journal_title：Toxicology and applied pharmacology

authors： Wiester MJ,Williams TB,King ME,Ménache MG,Miller FJ

更新日期：1987-07-01 00:00:00

abstract：:Improvement of COVID-19 clinical condition was seen in studies where combination of antiretroviral drugs, lopinavir and ritonavir, as well as immunomodulant antimalaric, chloroquine/hydroxychloroquine together with the macrolide-type antibiotic, azithromycin, was used for patient's treatment. Although these drugs are ...

journal_title：Toxicology and applied pharmacology

authors： Baralić K,Jorgovanović D,Živančević K,Antonijević Miljaković E,Antonijević B,Buha Djordjevic A,Ćurčić M,Đukić-Ćosić D

更新日期：2020-11-01 00:00:00

abstract：:This paper reviews the occurrence and properties of cyanobacterial toxins, with reference to the recognition and management of the human health risks which they may present. Mass populations of toxin-producing cyanobacteria in natural and controlled waterbodies include blooms and scums of planktonic species, and mats ...

journal_title：Toxicology and applied pharmacology

authors： Codd GA,Morrison LF,Metcalf JS

更新日期：2005-03-15 00:00:00