Cyanobacterial toxins: risk management for health protection.

abstract：:To further elucidate the mechanism of cadmium inhibition of renal amino acid transport, brush border membrane vesicles were isolated from rabbit renal cortex and the effect of cadmium on the uptake of L-glutamate into the vesicles was investigated. Preincubation of the membranes with CdCl2 decreased sodium-dependent L...

journal_title：Toxicology and applied pharmacology

authors： Kinne RK,Schütz H,Kinne-Saffran E

更新日期：1995-12-01 00:00:00

abstract：:The putative neurotoxicity of the organophosphorus compound triphenyl phosphite (TPP) was examined in Long Evans, adult male rats. Animals were exposed to two 1.0 ml/kg (1184 mg/kg) injections (sc) of TPP spaced 1 week apart and sampled for biochemical and neuropathological examination. At the time of sampling, rats d...

journal_title：Toxicology and applied pharmacology

authors： Veronesi B,Padilla S,Newland D

更新日期：1986-04-01 00:00:00

abstract：:Pulmonary fibrosis is a consequence of severe injury from some toxic agents including high doses of ozone. It is not known, however, whether chronic exposure to low doses of ozone, such as those encountered in polluted ambient atmospheres, could also result in abnormal accumulations of lung collagen. Rats were exposed...

journal_title：Toxicology and applied pharmacology

authors： Wright ES,Kehrer JP,White DM,Smiler KL

更新日期：1988-03-15 00:00:00

abstract：:The effect of T2-toxin on DNA and protein synthesis was investigated, both in vivo and in vitro. For mice which had been submitted to different treatment schedules (single dose, 3-, or 7-day treatment), the rate of DNA and protein biosynthesis was measured in thymus, bone marrow, liver, and spleen cells. T2-toxin inhi...

journal_title：Toxicology and applied pharmacology

authors： Rosenstein Y,Lafarge-Frayssinet C

更新日期：1983-09-15 00:00:00

abstract：:Cigarette smoke has been shown to cause gastric cancer. Overexpression of cyclooxygenase-2 (COX-2) is a common characteristic in gastric malignancy. The present study aimed to explore the correlation between cigarette smoke and COX-2 in the promotion of tumorigenesis in human gastric cancer cells (AGS). We further stu...

journal_title：Toxicology and applied pharmacology

authors： Shin VY,Liu ES,Ye YN,Koo MW,Chu KM,Cho CH

更新日期：2004-02-15 00:00:00

abstract：:Endothelial-mesenchymal transition (EndMT) is a frequent event in endothelial dysfunction, which is associated with pulmonary arterial hypertension (PAH). MiR-181 family members exert diverse effects in multiple biological processes. However, the relationships between miR-181b-5p (miR-181b) and EndMT in PAH are not we...

journal_title：Toxicology and applied pharmacology

authors： Zhao H,Wang Y,Zhang X,Guo Y,Wang X

更新日期：2020-01-01 00:00:00

abstract：:The InnoMed PredTox consortium was formed to evaluate whether conventional preclinical safety assessment can be significantly enhanced by incorporation of molecular profiling ("omics") technologies. In short-term toxicological studies in rats, transcriptomics, proteomics and metabolomics data were collected and analyz...

journal_title：Toxicology and applied pharmacology

authors： Ellinger-Ziegelbauer H,Adler M,Amberg A,Brandenburg A,Callanan JJ,Connor S,Fountoulakis M,Gmuender H,Gruhler A,Hewitt P,Hodson M,Matheis KA,McCarthy D,Raschke M,Riefke B,Schmitt CS,Sieber M,Sposny A,Suter L,Sweatman

更新日期：2011-04-15 00:00:00

abstract：:Eicosanoids released after ozone exposure of a human bronchial epithelial cell line, BEAS-S6, were analyzed by high-pressure liquid chromatography (HPLC) of supernatants from exposed cells prelabeled with [3H]arachidonic acid. BEAS cells released thromboxane B2 (TxB2), prostaglandin E2 (PGE2), leukotriene C4 (LTC4), L...

journal_title：Toxicology and applied pharmacology

authors： McKinnon KP,Madden MC,Noah TL,Devlin RB

更新日期：1993-02-01 00:00:00

abstract：:A primary role of acetylcholinesterase (AChE) is regulation of cholinergic neurotransmission by hydrolysis of synaptic acetylcholine. In the developing nervous system, however, AChE also functions as a morphogenic factor to promote axonal growth. This raises the question of whether organophosphorus pesticides (OPs) th...

journal_title：Toxicology and applied pharmacology

authors： Yang D,Howard A,Bruun D,Ajua-Alemanj M,Pickart C,Lein PJ

更新日期：2008-04-01 00:00:00

abstract：:We have previously shown that ricin, a toxic lectin from the castor bean, increases cardiac output and blood flow to the heart in rabbits in the early stage of its intoxication and causes hemorrhage and necrosis in the heart following a lethal dose. To investigate possible alterations in coronary arteries following ri...

journal_title：Toxicology and applied pharmacology

authors： Zhang L,Hsu CH,Robinson CP

更新日期：1994-11-01 00:00:00

abstract：:A great number of people are suffering from allergic inflammatory disease such as asthma, atopic dermatitis, and sinusitis. Therefore discovery of drugs for the treatment of these diseases is an important subject in human health. Putranjivain A (PJA), member of ellagitannin, is known to possess beneficial effects incl...

journal_title：Toxicology and applied pharmacology

authors： Kim HH,Park SB,Lee S,Kwon TK,Shin TY,Park PH,Lee SH,Kim SH

更新日期：2014-02-01 00:00:00

abstract：:Oxidative glutamate toxicity in HT22 murine hippocampal cells is a model for neuronal death by oxidative stress. We have investigated the role of proteases in HT22 cell oxidative glutamate toxicity. L-glutamate-induced toxicity was characterized by cell and nuclear shrinkage and chromatin condensation, yet occurred in...

journal_title：Toxicology and applied pharmacology

authors： Elphick LM,Hawat M,Toms NJ,Meinander A,Mikhailov A,Eriksson JE,Kass GE

更新日期：2008-10-15 00:00:00

abstract：:In this study, the mouse was used to evaluate paternal germline exposure to the organophosphate methamidophos for its potential to produce adverse effects on spermatozoa and in the offspring. There have been reports that organophosphate exposure can increase abnormal sperm morphology in mice. However, effects transmit...

journal_title：Toxicology and applied pharmacology

authors： Burruel VR,Raabe OG,Overstreet JW,Wilson BW,Wiley LM

更新日期：2000-06-01 00:00:00

abstract：:Bropirimine is an immunomodulator with experimental antiviral and antitumor activities. This pyrimidinone has been found to be embryolethal at doses (200 and 400 mg/kg) that produce only transient maternal toxicity, when administered to pregnant Upj:TUC(SD)spf rats on specific days of gestation. Serum analyses carried...

journal_title：Toxicology and applied pharmacology

authors： Black DL,Marks TA,Branstetter DG,Kirton KT

更新日期：1991-03-15 00:00:00

abstract：:The differential effects of oral and dermal administration of single doses of 100 to 1000 mg/kg S,S,S-tri-n-butyl phosphorotrithioate (DEF) on nonspecific esterases and liver metabolism enzymes were investigated one day following administration. O,O-Diethyl O-(4-nitrophenyl) phosphorothioate (parathion) and tri-o-cres...

journal_title：Toxicology and applied pharmacology

authors： Lapadula DM,Carrington CD,Abou-Donia MB

更新日期：1984-04-01 00:00:00

abstract：:Induction of hepatic UDP-glucuronyltransferase(s) (hUDP-GT(s] activity toward thyroid hormones and the relationship between the activity and the serum thyroid hormones or the thyroid stimulating hormone (TSH) level were examined in male Sprague-Dawley rats after four consecutive ip doses of various hepatic enzyme indu...

journal_title：Toxicology and applied pharmacology

authors： Saito K,Kaneko H,Sato K,Yoshitake A,Yamada H

更新日期：1991-10-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants, some of which may be neurotoxic. In vitro studies from this laboratory indicated that noncoplanar PCBs perturbed intracellular signal transduction mechanisms including Ca2+ homeostasis, receptor-mediated inositol phosphate production, and tran...

journal_title：Toxicology and applied pharmacology

authors： Kodavanti PR,Derr-Yellin EC,Mundy WR,Shafer TJ,Herr DW,Barone S,Choksi NY,MacPhail RC,Tilson HA

更新日期：1998-12-01 00:00:00

abstract：:Methamphetamine (METH) is a drug of abuse which causes neurotoxicity and increased risk of developing neurodegenerative diseases. We previously found that METH induces heme oxygenase (HO)-1 expression in neurons and glial cells, and this offers partial protection against METH toxicity. In this study, we investigated t...

journal_title：Toxicology and applied pharmacology

authors： Huang YN,Wang JY,Lee CT,Lin CH,Lai CC,Wang JY

更新日期：2012-12-01 00:00:00

abstract：:A quantitative method based upon a stochastic model was used to estimate rates of initiation (alteration to express the ATPase-deficient phenotype) and of clonal growth of altered cells in an initiation promotion experiment in the livers of female Wistar rats. Diethylnitrosamine (DEN) was used as the initiating agent ...

journal_title：Toxicology and applied pharmacology

authors： Moolgavkar SH,Luebeck EG,Buchmann A,Bock KW

更新日期：1996-05-01 00:00:00

abstract：:A quantitative assay based on real-time detection polymerase chain reaction (rtdPCR) was applied to analyze basal and metal-induced mRNA levels of two metallothionein (MT) isoforms (Cd-MT and Cu-MT) in organs of the terrestrial gastropod Helix pomatia. The results show that specific Cd-MT mRNA levels increase with Cd ...

journal_title：Toxicology and applied pharmacology

authors： Chabicovsky M,Niederstätter H,Thaler R,Hödl E,Parson W,Rossmanith W,Dallinger R

更新日期：2003-07-01 00:00:00

abstract：:Metabolism of methylene chloride, or dichloromethane (DCM), plays a key role in determining the kinetics and carcinogenicity of the halocarbon. The objectives of this study were: to evaluate and optimize the vial equilibration technique, originally described by Sato and Nakajima (1979a), in order to characterize the h...

journal_title：Toxicology and applied pharmacology

authors： Kim C,Manning RO,Brown RP,Bruckner JV

更新日期：1996-08-01 00:00:00

abstract：:BALB/c mice were sensitized to ovalbumin by systemic injection and then exposed for up to 8 weeks to ovalbumin aerosols in whole body chambers. A pattern of airway inflammation, mucous cell hypertrophy and hyperplasia, and airway remodeling with submucosal fibrosis was observed as lesions evolved over time. Larger con...

journal_title：Toxicology and applied pharmacology

authors： Kenyon NJ,Ward RW,Last JA

更新日期：2003-01-15 00:00:00

abstract：:After a fire involving a transformer, the State Office Building in Binghamton, New York, was contaminated with soot containing polychlorinated biphenyls, biphenylenes, naphthalenes, dioxins, and dibenzofurans. The toxicity of the soot and its effect on liver morphology after prolonged (subchronic) exposure were determ...

journal_title：Toxicology and applied pharmacology

authors： Turner JN,Collins DN

更新日期：1984-05-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is characterized by a disturbed pulmonary redox balance associated with inflammation. To restore this balance, antioxidants are often suggested as therapy for IPF but previous clinical trials with these compounds and their precursors have not been successful in the clinic. The exoge...

journal_title：Toxicology and applied pharmacology

authors： Veith C,Drent M,Bast A,van Schooten FJ,Boots AW

更新日期：2017-12-01 00:00:00

abstract：:To assess the relevance of previously identified axonal atrophy to hexanedione neuropathy, the present study quantitated fiber size in peripheral nerve of rats intoxicated with 2,5-hexanedione (HD) by either oral ingestion (0.4% in drinking water) or ip injection (0.4 g/kg/day). Prior to the appearance of neurobehavio...

journal_title：Toxicology and applied pharmacology

authors： Lehning EJ,Dyer KS,Jortner BS,LoPachin RM

更新日期：1995-11-01 00:00:00

abstract：:Hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD) in premature infants. New BPD is characterized as having alveolar simplification. We reported previously that aryl hydrocarbon receptor (AhR) deficiency increased susceptibility to hyperoxic lung injury in adult mice, and this was associated ...

journal_title：Toxicology and applied pharmacology

authors： Shivanna B,Zhang W,Jiang W,Welty SE,Couroucli XI,Wang L,Moorthy B

更新日期：2013-03-15 00:00:00

abstract：:Following exposure to 2 ppm ozone for 4 hr, two distinct effects on rat lung inflammatory cell oxidant generation were observed. TPA- and opsonized zymosan-stimulated superoxide production by the inflammatory cell population was found to be maximally inhibited 24 hr following ozone exposure. In contrast, luminol-ampli...

journal_title：Toxicology and applied pharmacology

authors： Esterline RL,Bassett DJ,Trush MA

更新日期：1989-06-15 00:00:00

abstract：:In order to assess the effects of long-term exposure to cadmium (Cd) on the renal metabolism of eicosanoids, the urinary excretion of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), prostaglandin E2 (PGE2), prostaglandin F2 alpha (PGF2 alpha), and thromboxane B2 (TXB2) was determined in 37 workers exposed to Cd and...

journal_title：Toxicology and applied pharmacology

authors： Cárdenas A,Ramis I,Hotter G,Roselló J,Gelpí E,Roels H,Bernard A,Lauwerys R

更新日期：1992-10-01 00:00:00

abstract：:A series of naturally occurring cardenolides that exhibit potent anti-transmissible gastroenteritis virus (TGEV) activity in swine testicular (ST) cells has been identified. In an immunofluorescence assay, these cardenolides were found to diminish the expressions of TGEV nucleocapsid and spike protein, which was used ...

journal_title：Toxicology and applied pharmacology

authors： Yang CW,Chang HY,Hsu HY,Lee YZ,Chang HS,Chen IS,Lee SJ

更新日期：2017-10-01 00:00:00

abstract：:Methyl palmitate (MP) has been shown earlier to inhibit Kupffer cells and rat peritoneal macrophages. To evaluate the potential of MP to inhibit the activation of other macrophages, RAW cells (macrophages of alveolar origin) were treated with varying concentrations of MP (0.25, 0.5, 1mM). Assessment of cytotoxicity us...

journal_title：Toxicology and applied pharmacology

authors： El-Demerdash E

更新日期：2011-08-01 00:00:00