Inhibitory effect of Fusarium T2-toxin on lymphoid DNA and protein synthesis.

abstract：UNLABELLED:Acetaminophen (APAP) overdose causes severe hepatotoxicity in animals and humans. However, the mechanisms underlying the gender differences in susceptibility to APAP overdose in mice have not been clarified. In our study, APAP (300mg/kg) caused severe liver injury in male mice but 69-77% lower injury in fema...

journal_title：Toxicology and applied pharmacology

authors： Du K,Williams CD,McGill MR,Jaeschke H

更新日期：2014-11-15 00:00:00

abstract：:In rat hepatocytes and isolated liver mitochondrial fractions, Cyclosporine A (CsA) is often used as a specific inhibitor of mitochondrial Ca(2+) release and as a specific blocker of mitochondrial membrane potential and permeability transition (MPT), which are all processes involved in the inhibition of apoptosis. How...

journal_title：Toxicology and applied pharmacology

authors： Grub S,Persohn E,Trommer WE,Wolf A

更新日期：2000-03-15 00:00:00

abstract：:The radioprotective effect of extracellular melanin, a naturally occurring pigment, isolated from the fungus Gliocephalotrichum simplex was examined in BALB/C mice, and the probable mechanism of action was established. At an effective dose of 50mg/kg body weight, melanin exhibited both prophylactic and mitigative acti...

journal_title：Toxicology and applied pharmacology

authors： Kunwar A,Adhikary B,Jayakumar S,Barik A,Chattopadhyay S,Raghukumar S,Priyadarsini KI

更新日期：2012-10-15 00:00:00

abstract：:Phenobarbital (PB) is an effective growth stimulator of hepatic hyperplastic nodules developed with diethylnitrosamine and 2-acetylaminofluorene plus partial hepatectomy (the Solt-Farber model), but it does not apparently stimulate the growth of preneoplastic lesions produced with aflatoxin B1 (AFB). Some studies have...

journal_title：Toxicology and applied pharmacology

authors： Chen ZY,Eaton DL

更新日期：1991-10-01 00:00:00

abstract：:Free gold nanoparticles easily aggregate when the environment conditions change. Here, gold nanoparticles (AuNPs) with average diameter of 3.7 nm were prepared and then modified with poly(ethylene glycol) (PEG) to improve stability. The gold nanoparticles were first surface-modified with 3-mercaptopropionic acid (MPA)...

journal_title：Toxicology and applied pharmacology

authors： Gu YJ,Cheng J,Lin CC,Lam YW,Cheng SH,Wong WT

更新日期：2009-06-01 00:00:00

abstract：:Sulfur mustard (SM) is a chemical warfare agent that targets skin where it induces large blisters. DNA alkylation is a critical step to explain SM-induced cutaneous symptoms. We determined the kinetics of formation of main SM-DNA adducts and compare it with the development of the SM-induced pathogenesis in skin. SKH-1...

journal_title：Toxicology and applied pharmacology

authors： Batal M,Boudry I,Mouret S,Wartelle J,Emorine S,Bertoni M,Bérard I,Cléry-Barraud C,Douki T

更新日期：2013-12-15 00:00:00

abstract：:To understand the effect of thuringiensin on the lungs tissues, male Sprague-Dawley rats were administrated with thuringiensin by intratracheal instillation at doses 0.8, 1.6 and 3.2 mg/kg of body weight, respectively. The rats were sacrificed 4 h after treatment, and lungs were isolated and examined. Subsequently, an...

journal_title：Toxicology and applied pharmacology

authors： Tsai SF,Yang C,Liu BL,Hwang JS,Ho SP

更新日期：2006-10-15 00:00:00

abstract：:Poly(amidoamine) (PAMAM) dendrimer nanoparticles have been demonstrated to elicit a well defined cytotoxicological response from mammalian cell lines, the response increasing systematically with dendrimer generation and number of surface amino groups. In this work, using generation G4, G5, and G6 dendrimers, this syst...

journal_title：Toxicology and applied pharmacology

authors： Mukherjee SP,Lyng FM,Garcia A,Davoren M,Byrne HJ

更新日期：2010-11-01 00:00:00

abstract：:Propiconazole is a mouse hepatotumorigenic fungicide designed to inhibit CYP51, a key enzyme in the biosynthesis of ergosterol in fungi and is widely used in agriculture to prevent fungal growth. Metabolomic studies in mice revealed that propiconazole increased levels of hepatic cholesterol metabolites and bile acids,...

journal_title：Toxicology and applied pharmacology

authors： Murphy LA,Moore T,Nesnow S

更新日期：2012-04-15 00:00:00

abstract：:Numbers of engineered nanomaterials (ENMs) are steadily increasing. Therefore, alternative testing approaches with reduced costs and high predictivity suitable for high throughput screening and prioritization are urgently needed to ensure a fast and effective development of safe products. In parallel, extensive resear...

journal_title：Toxicology and applied pharmacology

authors： Riebeling C,Wiemann M,Schnekenburger J,Kuhlbusch TA,Wohlleben W,Luch A,Haase A

更新日期：2016-05-15 00:00:00

abstract：:Antineoplastic drugs cause severe cytotoxicity for normal cells, especially hematopoietic stem cells (HSCs). However, bleomycin (BLM) is glycopeptide antibiotic that is effective on various cancers and has either low or no myelosuppression effects. The aim of the present study was to investigate the effect of BLM on 5...

journal_title：Toxicology and applied pharmacology

authors： Fakhrabadi HG,Rabbani-Chadegani A,Ghadam P,Amiri S

更新日期：2020-06-01 00:00:00

abstract：:Single-pass perfusion of mouse livers in situ with the phosphorothioate pesticide parathion resulted in formation of the cholinesterase inhibitor paraoxon (PO), p-nitrophenol (PNP), p-nitrophenyl sulfate (PNPS), and p-nitrophenyl glucuronide (PNPG). Daily pretreatment of mice with phenobarbital (80 mg/kg, ip) for 4 da...

journal_title：Toxicology and applied pharmacology

authors： Sultatos LG

更新日期：1986-10-01 00:00:00

abstract：:Arsenic is a ubiquitous metalloid element present in both inorganic and organic forms in the environment. The liver is considered to be a primary organ of arsenic biotransformation and methylation, as well as the main target of arsenic toxicity. Studies have confirmed that Chang human hepatocytes have an efficient ars...

journal_title：Toxicology and applied pharmacology

authors： Liu D,Xu G,Bai C,Gu Y,Wang D,Li B

更新日期：2021-01-09 00:00:00

abstract：:This study defines a physiologically based kinetic (PBK) model for methyleugenol (ME) in human based on in vitro and in silico derived parameters. With the model obtained, bioactivation and detoxification of methyleugenol (ME) at different doses levels could be investigated. The outcomes of the current model were comp...

journal_title：Toxicology and applied pharmacology

authors： Al-Subeihi AA,Spenkelink B,Punt A,Boersma MG,van Bladeren PJ,Rietjens IM

更新日期：2012-05-01 00:00:00

abstract：:We expressed rat Na(v)1.6 sodium channels in combination with the rat beta(1) and beta(2) auxiliary subunits in Xenopus laevis oocytes and evaluated the effects of the pyrethroid insecticides S-bioallethrin, deltamethrin, and tefluthrin on expressed sodium currents using the two-electrode voltage clamp technique. S-Bi...

journal_title：Toxicology and applied pharmacology

authors： Tan J,Soderlund DM

更新日期：2010-09-15 00:00:00

abstract：:Thymic lymphoma/leukemia is the major cause of death in B6C3F1 mice chronically exposed to 1,3-butadiene (BD). Similar to radiation-induced murine thymic lymphoma, the bone marrow is also a major target organ. Because of the association of murine thymic lymphoma with endogenous type-C murine leukemia retroviruses (MuL...

journal_title：Toxicology and applied pharmacology

authors： Irons RD,Smith CN,Stillman WS,Shah RS,Steinhagen WH,Leiderman LJ

更新日期：1986-09-30 00:00:00

abstract：:The effect of N-benzyl-D-glucamine dithiocarbamate (BGD) on the renal toxicity produced by subacute exposure to cadmium in rats was studied. Rats were injected sc with CdCl2 (1.5 mg Cd/kg) daily for 26 days and thereafter they received 13 injections of BGD (400 mumol/kg) every other day. Urinary protein concentration ...

journal_title：Toxicology and applied pharmacology

authors： Kojima S,Ono H,Kiyozumi M,Honda T,Takadate A

更新日期：1989-03-15 00:00:00

abstract：:Histone deacetylase inhibitors (HDI) have been shown to increase differentiation-related gene expression in several tumor-derived cell lines by hyperacetylating core histones. Effects of HDI on primary cultured cells, however, have hardly been investigated. In the present study, the ability of trichostatin A (TSA), a ...

journal_title：Toxicology and applied pharmacology

authors： Henkens T,Papeleu P,Elaut G,Vinken M,Rogiers V,Vanhaecke T

更新日期：2007-01-01 00:00:00

abstract：:Insulin resistance is a characteristic feature of type 2 diabetes mellitus (T2DM) and is characterized by defects in insulin signaling. Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of the insulin signaling pathways, and its increased activity and expression are implicated in the pathogenesis of ...

journal_title：Toxicology and applied pharmacology

authors： Liu ZQ,Liu T,Chen C,Li MY,Wang ZY,Chen RS,Wei GX,Wang XY,Luo DQ

更新日期：2015-05-15 00:00:00

abstract：:Exposure of mice to cationic rhodamines, Rh 123 and Rh 6G, has been found to be associated with developmental toxicity, while neutral rhodamines (e.g., Rh B) had no such effect. When mouse embryos from dams given ip injections of Rh 123, Rh 6G (15 mg/kg), or Rh B (30 mg/kg) on gestation Day (GD) 10 were examined, Rh 1...

journal_title：Toxicology and applied pharmacology

authors： Ranganathan S,Churchill PF,Hood RD

更新日期：1989-06-01 00:00:00

abstract：:Oxidative stress is involved in hepatic stellate cells (HSCs) activation and extracellular matrix overproduction. We previously reported the promising effects of dioscin against CCl4-induced liver fibrosis, but its effects and mechanisms on BDL- and DMN-induced liver fibrosis remain unknown. The results in the present...

journal_title：Toxicology and applied pharmacology

authors： Gu L,Tao X,Xu Y,Han X,Qi Y,Xu L,Yin L,Peng J

更新日期：2016-02-01 00:00:00

abstract：:Female Golden Syrian hamsters, F-344 rats, Swiss CD-1 mice, and B6C3F1 hybrid mice were exposed 6 hr/day, 5 days/week to carcinogenic levels of vinyl chloride (VC) for 6, 12, 18, or 24 months (rats and hamsters only). Other groups of rodents were held for 6 or 12 months and then exposed for 6 or 12 months. At the end ...

journal_title：Toxicology and applied pharmacology

authors： Drew RT,Boorman GA,Haseman JK,McConnell EE,Busey WM,Moore JA

更新日期：1983-03-30 00:00:00

abstract：:Biodistribution of cocaine in female rats before and after delivery of litters was studied in order to provide an explanation for the observed differences in cocaine-induced toxicity in pregnant and postpartum rats. Cocaine (20 mg/kg, ip) given to female rats at 16 days of gestation or 20 days of gestation did not hav...

journal_title：Toxicology and applied pharmacology

authors： Dwivedi C,Engineer FN,Vaughan SL

更新日期：1993-01-01 00:00:00

abstract：:There is a growing recognition of the need to identify when exposures to specific combinations of chemicals result in toxicological effects of concern. In order to meet this need new tools are required to evaluate the doses of multiple chemicals that occur from the concurrent exposures to multiple sources of the chemi...

journal_title：Toxicology and applied pharmacology

authors： Arnold SF,Price PS,LifeLine Group.

更新日期：2007-09-01 00:00:00

abstract：:Nickel (Ni) carcinogenesis is thought to involve gene chip silencing by epigenetic mechanisms. Serpina3g, a member of the mouse serpin family, was among the most down-regulated genes (32-fold) in response to Ni exposure of mouse cells based on the Affymetrix gene chip. Serpina3g down-regulation was controlled by a hyp...

journal_title：Toxicology and applied pharmacology

authors： Zhao J,Yan Y,Salnikow K,Kluz T,Costa M

更新日期：2004-01-01 00:00:00

abstract：:The inter-relationship of "Thresholds" between chemical mixtures and their respective component single chemicals was studied using three sets of data and two types of analyses. Two in vitro data sets involve cytotoxicity in human keratinocytes from treatment of metals and a metal mixture [Bae, D.S., Gennings, C., Cart...

journal_title：Toxicology and applied pharmacology

authors： Yang RS,Dennison JE

更新日期：2007-09-01 00:00:00

abstract：:Eicosanoids released after ozone exposure of a human bronchial epithelial cell line, BEAS-S6, were analyzed by high-pressure liquid chromatography (HPLC) of supernatants from exposed cells prelabeled with [3H]arachidonic acid. BEAS cells released thromboxane B2 (TxB2), prostaglandin E2 (PGE2), leukotriene C4 (LTC4), L...

journal_title：Toxicology and applied pharmacology

authors： McKinnon KP,Madden MC,Noah TL,Devlin RB

更新日期：1993-02-01 00:00:00

abstract：:Garlic and its active components are known to possess antioxidant and antiinflammatory effects. The present study investigated the effects of garlic oil and its organosulfur compounds on endotoxin-induced intestinal mucosal damage. Wistar rats received by gavage 50 or 200 mg/kg body weight garlic oil (GO), 0.5 mmol/kg...

journal_title：Toxicology and applied pharmacology

authors： Chiang YH,Jen LN,Su HY,Lii CK,Sheen LY,Liu CT

更新日期：2006-05-15 00:00:00

abstract：:Organic UV filters including benzophenone-3 (BP-3) are widely used to protect humans and materials from damage by UV irradiation. Despite the environmental occurrence of BP-3 in the aquatic environment, little is known about its effects and modes of action. In the present study we assess molecular and physiological ef...

journal_title：Toxicology and applied pharmacology

authors： Blüthgen N,Zucchi S,Fent K

更新日期：2012-09-01 00:00:00

abstract：:The embryotoxic and teratogenic potential of inhaled monochlorobenzene (MCB) was evaluated in rats and rabbits. Bred Fischer 344 rats and inseminated New Zealand White rabbits were exposed to 0, 75, 210, or 590 ppm of MCB via inhalation for 6 hr/day during the period of major organogenesis. Exposure to 590 ppm caused ...

journal_title：Toxicology and applied pharmacology

authors： John JA,Hayes WC,Hanley TR Jr,Johnson KA,Gushow TS,Rao KS

更新日期：1984-11-01 00:00:00