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Mechanistic studies of in vitro cytotoxicity of poly(amidoamine) dendrimers in mammalian cells.

Abstract：

:Poly(amidoamine) (PAMAM) dendrimer nanoparticles have been demonstrated to elicit a well defined cytotoxicological response from mammalian cell lines, the response increasing systematically with dendrimer generation and number of surface amino groups. In this work, using generation G4, G5, and G6 dendrimers, this systematic response is furthermore demonstrated for the generation of reactive oxygen species, lysosomal activity, and the onset of apoptosis and levels of DNA damage. The results are consistent with a pathway of localisation of PAMAM dendrimers in the mitochondria leading to ROS production causing oxidative stress, apoptosis and DNA damage. ROS production is co-located in the mitochondria, and both generated levels and timescales are systematically generation dependent (G4

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Mukherjee SP,Lyng FM,Garcia A,Davoren M,Byrne HJ

doi

10.1016/j.taap.2010.08.016

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

259-68

issue

3

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(10)00301-7

journal_volume

248

pub_type

杂志文章

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