当前位置： SCI文献检索 > TOXICOLOGY AND APPLIED PHARMACOLOGY期刊下所有文献 > Polyphyllin I modulates MALAT1/STAT3 signaling to induce apoptosis in gefitinib-resistant non-small cell lung cancer.

Polyphyllin I modulates MALAT1/STAT3 signaling to induce apoptosis in gefitinib-resistant non-small cell lung cancer.

Abstract：

:Non-small cell lung cancer (NSCLC) patients harboring EGFR mutation who initially respond to EGFR-TKI will gradually develop acquired resistance. There is still a challenge to treat EGFR-TKI resistant NSCLC patients. Polyphyllin I (PP I), a steroidal saponin isolated from Paris polyphylla., has been exhibited antitumor activities against various carcinomas. However, its mechanism in treating EGFR-TKI resistant NSCLC has not been well elucidated. In this study, we found that PP I suppressed the cell viability and induced apoptosis of gefitinib-resistant NSCLC cells and xenograft models. These therapeutic efficacies were associated with down-regulated level of MALAT1, leading to inactivation of STAT3 signaling pathway. The cell viability inhibition and apoptosis inducing in gefitinib-resistant NSCLC triggered by PP I were abolished by MALAT1 overexpression, while the cell viability inhibition and apoptosis inducing triggered by PP I were potentiated by MALAT1 knockdown. These findings suggest that, in vitro and in vivo, PP I inhibits the viability and induces apoptosis of gefitinib-resistant NSCLC by down-regulating MALAT1 and inactivating STAT3 signaling pathway. Thus, PPI could serve a promising therapeutic agent for the treatment of gefitinib-resistant NSCLC.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Yang Q,Chen W,Xu Y,Lv X,Zhang M,Jiang H

doi

10.1016/j.taap.2018.07.031

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1-7

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(18)30356-9

journal_volume

356

pub_type

杂志文章

相关文献

TOXICOLOGY AND APPLIED PHARMACOLOGY文献大全
  • Activation of aryl hydrocarbon receptor reduces carbendazim-induced cell death.

    abstract：:Carbendazim inhibits microtubule assembly, thus blocking mitosis and inhibiting cancer cell proliferation. Accordingly, carbendazim is being explored as an anticancer drug. Data show that carbendazim increased mRNA and protein expressions and promoter activity of CYP1A1. In addition, carbendazim activated transcriptio...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2016.06.004

    authors： Wei KL,Chen FY,Lin CY,Gao GL,Kao WY,Yeh CH,Chen CR,Huang HC,Tsai WR,Jong KJ,Li WJ,Su JG

    更新日期：2016-09-01 00:00:00

  • Pretreatment with EDU decreases rat lung cellular responses to ozone.

    abstract：:The phenylurea compound EDU (N-[2-(2-oxo-1-imidazolindinyl)ethyl]-N'-phenylurea) has been shown to protect plants from the damaging effects of ozone exposure. Models of rat lung injury, based on acute exposure to 2 ppm ozone for 3 hr and on exposure to 0.85 ppm ozone for 2 days, were used to determine whether EDU pret...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(89)90089-6

    authors： Bassett DJ,Elbon CL,Reichenbaugh SS,Boswell GA,Stevens TM,McGowan MC,Kerr JS

    更新日期：1989-08-01 00:00:00

  • Renal glutathione depletion and nephrotoxicity of cadmium-metallothionein in rats.

    abstract：:Renal glutathione (GSH) concentrations were reduced approximately 80% at 4 hr after a single injection of buthionine sulfoxime (BSO) (4 mmol/kg body wt) and remained reduced for at least 16 hr in male rats. Following BSO injection, rats were injected with a nephrotoxic dose of cadmium-metallothionein (Cd-MT) (0.3 mg C...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(89)90182-8

    authors： Suzuki CA,Cherian MG

    更新日期：1989-05-01 00:00:00

  • Effect of mitoguazone on polyamine oxidase activity in rat liver.

    abstract：:Mitoguazone is a known inhibitor of polyamine biosynthesis through competitive inhibition of S-adenosylmethionine decarboxylase. A recent renewed interest in mitoguazone as an antineoplastic agent prompted us to investigate the effect of the drug on polyamine catabolism in rat liver, since the organ plays an important...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2004.05.013

    authors： Ferioli ME,Berselli D,Caimi S

    更新日期：2004-12-01 00:00:00

  • Bone marrow toxicity induced by oral benzo[a]pyrene: protection resides at the level of the intestine and liver.

    abstract：:The Ah locus encodes a cytosolic receptor that regulates the induction of certain drug-metabolizing enzymes by polycyclic aromatic hydrocarbons such as benzo[a]pyrene. Some inbred mouse strains such as C57BL/6N have the high-affinity Ah receptor (Ahb/Ahb), others such as DBA/2N, the poor-affinity receptor (Ahd/Ahd). P...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(83)90157-6

    authors： Legraverend C,Harrison DE,Ruscetti FW,Nebert DW

    更新日期：1983-09-30 00:00:00

  • Time-varying conjugation of 7,12-dimethylbenz[a]anthracene metabolites in rainbow trout (Oncorhynchus mykiss).

    abstract：:Sexually immature rainbow trout were dosed via gavage with 7,12-[14C]dimethylbenz[a]anthracene (DMBA) in order to study hepatic metabolite formation over time and at single and multiple doses. beta-Glucuronidase and aryl sulfatase hydrolyses of bile extracts and subsequent high-pressure liquid chromatography analysis ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1993.1129

    authors： Schnitz AR,Squibb KS,O'Connor JM

    更新日期：1993-07-01 00:00:00

  • Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

    abstract：:Methylene chloride (dichloromethane, DCM) is metabolized by two pathways: one dependent on oxidation by mixed function oxidases (MFO) and the other dependent on glutathione S-transferases (GST). A physiologically based pharmacokinetic (PB-PK) model based on knowledge of these pathways was used to describe the metaboli...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(87)90281-x

    authors： Andersen ME,Clewell HJ 3rd,Gargas ML,Smith FA,Reitz RH

    更新日期：1987-02-01 00:00:00

  • Human exposure to bisphenol A by biomonitoring: methods, results and assessment of environmental exposures.

    abstract：:Human exposure to bisphenol A is controversially discussed. This review critically assesses methods for biomonitoring of bisphenol A exposures and reported concentrations of bisphenol A in blood and urine of non-occupationally ("environmentally") exposed humans. From the many methods published to assess bisphenol A co...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2007.12.008

    authors： Dekant W,Völkel W

    更新日期：2008-04-01 00:00:00

  • Maternal-to-zygotic transition as a potential target for niclosamide during early embryogenesis.

    abstract：:Niclosamide is an antihelminthic drug used worldwide for the treatment of tapeworm infections. Recent drug repurposing screens have highlighted the broad bioactivity of niclosamide across diverse mechanisms of action. As a result, niclosamide is being evaluated for a range of alternative drug-repurposing applications,...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2019.114699

    authors： Vliet SMF,Dasgupta S,Sparks NRL,Kirkwood JS,Vollaro A,Hur M,Zur Nieden NI,Volz DC

    更新日期：2019-10-01 00:00:00

  • Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice.

    abstract：:A recent report showed that the unfolded protein response (UPR) signaling was activated in the pathogenesis of carbon tetrachloride (CCl(4))-induced hepatic fibrosis. Phenylbutyric acid (PBA) is a well-known chemical chaperone that inhibits endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signalin...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.11.007

    authors： Wang JQ,Chen X,Zhang C,Tao L,Zhang ZH,Liu XQ,Xu YB,Wang H,Li J,Xu DX

    更新日期：2013-01-15 00:00:00

  • Macrophage uptake of a lipoprotein-sequestered toxicant: a potential route of immunotoxicity.

    abstract：:An experimental system was chosen to investigate the bioactivity of a lipoprotein-sequestered toxicant at the cellular level based on recent studies demonstrating receptor-mediated uptake of lipoproteins by macrophages. Rat peritoneal exudate cell suspensions (PEC) were exposed to DDT and lipoprotein-sequestered DDT, ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(86)90282-6

    authors： Kaminski NE,Wells DS,Dauterman WC,Roberts JF,Guthrie FE

    更新日期：1986-03-15 00:00:00

  • Inhibition of bile-salt-induced hepatocyte apoptosis by the antioxidant lazaroid U83836E.

    abstract：:Intracellular retention of toxic bile salts contributes to hepatocellular injury during cholestasis. We have recently demonstrated that toxic bile salts directly induce apoptosis in hepatocytes. As oxidative stress has been implicated in many models of apoptosis, our aim was to determine if oxidative injury is a criti...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.8031

    authors： Patel T,Gores GJ

    更新日期：1997-01-01 00:00:00

  • Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice.

    abstract：:Nonmelanoma skin cancer is the most common cancer among humans and solar UV radiation, particularly its UVB component (290-320 nm), is its major cause. One way to reduce the occurrence of the cancer is via the use of substances (often antioxidants) termed "photochemopreventive agents". Resveratrol (trans-3,4',5-trihyd...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0041-008x(02)00014-5

    authors： Afaq F,Adhami VM,Ahmad N

    更新日期：2003-01-01 00:00:00

  • Time- and concentration-dependent genomic responses of the rat airway to inhaled nickel subsulfide.

    abstract：OBJECTIVE:To provide insights into the mode of action for Ni3S2 lung carcinogenicity by examining gene expression changes in target cells after inhalation exposure. METHODS:Gene expression changes were determined in micro-dissected lung broncho-alveolar cells from Fischer 344 rats following inhalation of Ni3S2 at 0.0,...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2014.06.007

    authors： Efremenko AY,Campbell JL Jr,Dodd DE,Oller AR,Clewell HJ 3rd

    更新日期：2014-09-15 00:00:00

  • EPAC expression and function in cardiac fibroblasts and myofibroblasts.

    abstract：UNLABELLED:In the heart, cardiac fibroblasts (CF) and cardiac myofibroblasts (CMF) are the main cells responsible for wound healing after cardiac insult. Exchange protein activated by cAMP (EPAC) is a downstream effector of cAMP, and it has been not completely studied on CF. Moreover, in CMF, which are the main cells r...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2013.06.022

    authors： Olmedo I,Muñoz C,Guzmán N,Catalán M,Vivar R,Ayala P,Humeres C,Aránguiz P,García L,Velarde V,Díaz-Araya G

    更新日期：2013-10-15 00:00:00

  • In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni.

    abstract：:Antrodia camphorata (A. camphorata) is a fungus commonly used for treatment of viral hepatitis and cancer in Chinese folk medicine. Extract of A. camphorate is reported to possess anti-inflammatory, antihepatitis B virus and anticancer activities. In this study, we tested the in vivo effects of polysaccharides derived...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2007.10.023

    authors： Cheng PC,Hsu CY,Chen CC,Lee KM

    更新日期：2008-03-01 00:00:00

  • In utero exposure to benzene increases embryonic c-Myb and Pim-1 protein levels in CD-1 mice.

    abstract：:Benzene is a known human leukemogen, but its role as an in utero leukemogen remains controversial. Epidemiological studies have correlated parental exposure to benzene with an increased incidence of childhood leukemias. We hypothesize that in utero exposure to benzene may cause leukemogenesis by affecting the embryoni...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2007.12.014

    authors： Wan J,Winn LM

    更新日期：2008-05-01 00:00:00

  • Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin (deoxynivalenol) in vitro and in vivo.

    abstract：:Interleukin-6 (IL-6) is a central mediator of immunotoxicity that is associated with exposure to the trichothecene vomitoxin (VT). The purpose of this investigation was to test the hypothesis that the inducible cyclooxygenase-2 (COX-2) and its metabolites contribute to VT-induced IL-6 upregulation. VT at 100 to 250 ng...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0041-008x(02)00033-9

    authors： Moon Y,Pestka JJ

    更新日期：2003-03-01 00:00:00

  • Differential ovotoxicity of 4-vinylcyclohexene and its analog, 4-phenylcyclohexene.

    abstract：:Vinylcyclohexene (VCH) is an industrial byproduct that is known to cause the destruction of ovarian follicles in mice. Its analog, 4-phenylcyclohexene (4PC), is a volatile product from latex-backed carpeting. These studies were undertaken to assess the structure-activity relationships of these compounds and the potent...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1993.1073

    authors： Hooser SB,Parola LR,Van Ert MD,Sipes IG

    更新日期：1993-04-01 00:00:00

  • Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approach.

    abstract：:Improvement of COVID-19 clinical condition was seen in studies where combination of antiretroviral drugs, lopinavir and ritonavir, as well as immunomodulant antimalaric, chloroquine/hydroxychloroquine together with the macrolide-type antibiotic, azithromycin, was used for patient's treatment. Although these drugs are ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2020.115237

    authors： Baralić K,Jorgovanović D,Živančević K,Antonijević Miljaković E,Antonijević B,Buha Djordjevic A,Ćurčić M,Đukić-Ćosić D

    更新日期：2020-11-01 00:00:00

  • Metabolic profiling using HPLC allows classification of drugs according to their mechanisms of action in HL-1 cardiomyocytes.

    abstract：:Along with hepatotoxicity, cardiotoxic side effects remain one of the major reasons for drug withdrawals and boxed warnings. Prediction methods for cardiotoxicity are insufficient. High content screening comprising of not only electrophysiological characterization but also cellular molecular alterations are expected t...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2011.02.008

    authors： Strigun A,Wahrheit J,Beckers S,Heinzle E,Noor F

    更新日期：2011-04-15 00:00:00

  • EPR studies of in vivo radical production by 3,3',5,5'-tetrabromobisphenol A (TBBPA) in the Sprague-Dawley rat.

    abstract：:Brominated flame retardants (BFRs) are present in many consumer products ranging from fabrics to plastics and electronics. Wide use of flame retardants can pose an environmental hazard and it is of interest to determine the mechanism of their toxicity. Of all the BFRs, 3,3',5,5'-tetrabromobisphenol A (TBBPA) is produc...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2008.01.035

    authors： Chignell CF,Han SK,Mouithys-Mickalad A,Sik RH,Stadler K,Kadiiska MB

    更新日期：2008-07-01 00:00:00

  • Effects of 2,5-hexanedione on deefferented muscle spindle position sensitivity.

    abstract：:2,5-Hexanedione (HD) produces a neurofilamentous axonpathy in humans and experimental animals. The present study was carried out to determine the time course of the effects of HD on muscle spindle position sensitivity to permit comparisons with similar effects of other toxicants which produce a neurofilamentous axonop...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(90)90235-m

    authors： de Rojas TC,Goldstein BD

    更新日期：1990-04-01 00:00:00

  • Evaluation of the serum catalase and myeloperoxidase activities in chronic arsenic-exposed individuals and concomitant cytogenetic damage.

    abstract：:Chronic arsenic exposure through contaminated drinking water is a major environmental health issue. Chronic arsenic exposure is known to exert its toxic effects by a variety of mechanisms, of which generation of reactive oxygen species (ROS) is one of the most important. A high level of ROS, in turn, leads to DNA dama...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2010.08.013

    authors： Banerjee M,Banerjee N,Ghosh P,Das JK,Basu S,Sarkar AK,States JC,Giri AK

    更新日期：2010-11-15 00:00:00

  • Alterations in biodistribution of cocaine may explain differential toxicity in pregnant and postpartum rats.

    abstract：:Biodistribution of cocaine in female rats before and after delivery of litters was studied in order to provide an explanation for the observed differences in cocaine-induced toxicity in pregnant and postpartum rats. Cocaine (20 mg/kg, ip) given to female rats at 16 days of gestation or 20 days of gestation did not hav...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1993.1018

    authors： Dwivedi C,Engineer FN,Vaughan SL

    更新日期：1993-01-01 00:00:00

  • Morphological alterations and elevations in tumor necrosis factor-alpha, interleukin (IL)-1alpha, and IL-6 in mixed glia cultures following exposure to trimethyltin: modulation by proinflammatory cytokine recombinant proteins and neutralizing antibodies.

    abstract：:Trimethyltin (TMT), is a hippocampal neurotoxicant characterized by neuronal degeneration, astrogliosis, and microglia reactivity with an associated elevation in proinflammatory cytokine mRNA levels. To examine the role of proinflammatory cytokines in the TMT-induced glia response, mixed cortical glia cultures were ex...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.2002.9390

    authors： Harry GJ,Tyler K,d'Hellencourt CL,Tilson HA,Maier WE

    更新日期：2002-05-01 00:00:00

  • Experimental and mathematical modeling methods for the investigation of toxicological interactions.

    abstract：:While procedures have been developed and used for many years to assess risk and determine acceptable exposure levels to individual chemicals, most cases of environmental contamination can result in concurrent or sequential exposure to more than one chemical. Toxicological predictions of such combinations must be based...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2006.07.009

    authors： El-Masri HA

    更新日期：2007-09-01 00:00:00

  • Estrogen down regulates COMT transcription via promoter DNA methylation in human breast cancer cells.

    abstract：:Catechol-O-methyltransferase (COMT) acts as a 'gate-keeper' to prevent DNA damage during estrogen metabolism. Both experimental and epidemiological studies suggest the role of COMT in pathogenesis of human breast cancer (BCa). It was previously reported that inhibition of COMT enzyme activity in estradiol-treated huma...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2019.01.016

    authors： Wu Q,Odwin-Dacosta S,Cao S,Yager JD,Tang WY

    更新日期：2019-03-15 00:00:00

  • The inhibitory effect of CIL-102 on the growth of human astrocytoma cells is mediated by the generation of reactive oxygen species and induction of ERK1/2 MAPK.

    abstract：:CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is the major active agent of the alkaloid derivative of Camptotheca acuminata, with multiple pharmacological activities, including anticancer effects and promotion of apoptosis. The mechanism by which CIL-102 inhibits growth remains poorly understood in hum...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.05.025

    authors： Teng CC,Kuo HC,Cheng HC,Wang TC,Sze CI

    更新日期：2012-08-15 00:00:00

  • Modeling mixtures resulting from concurrent exposures to multiple sources.

    abstract：:There is a growing recognition of the need to identify when exposures to specific combinations of chemicals result in toxicological effects of concern. In order to meet this need new tools are required to evaluate the doses of multiple chemicals that occur from the concurrent exposures to multiple sources of the chemi...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2006.11.032

    authors： Arnold SF,Price PS,LifeLine Group.

    更新日期：2007-09-01 00:00:00