abstract：BACKGROUND:The current COVID-19 pandemic is caused by SARS-CoV-2 which belongs to coronaviridae family. Despite the global prevalence, there are currently no vaccines or drugs. Dietary plant derived exosome-like vesicles are known as edible nanoparticles (ENPs). ENPs are filled with microRNAs (miRNAs), in bioavailable ...

journal_title：Toxicology and applied pharmacology

authors： Kalarikkal SP,Sundaram GM

更新日期：2021-01-28 00:00:00

abstract：:Electrophiles, ubiquitously found in the environment, modify thiol groups of sensor proteins, leading to activation of redox signaling pathways such as the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor E2 related factor 2 (Nrf2) pathway. Nrf2 activation by exposure to single electrophiles has been establi...

journal_title：Toxicology and applied pharmacology

authors： Abiko Y,Aoki H,Kumagai Y

更新日期：2021-01-09 00:00:00

abstract：:Arsenic is a ubiquitous metalloid element present in both inorganic and organic forms in the environment. The liver is considered to be a primary organ of arsenic biotransformation and methylation, as well as the main target of arsenic toxicity. Studies have confirmed that Chang human hepatocytes have an efficient ars...

journal_title：Toxicology and applied pharmacology

authors： Liu D,Xu G,Bai C,Gu Y,Wang D,Li B

更新日期：2021-01-09 00:00:00

abstract：:Tongue cancer is one of the most common oral malignancies. Quisinostat is a histone deacetylase inhibitor with antitumor activity. The aim of this study was to evaluate the effects of quisinostat on the viability of tongue squamous cell carcinoma (TSCC) cells (CAL-27, TCA-8113) in vitro and in vivo. Cell viability, ce...

journal_title：Toxicology and applied pharmacology

authors： Wang X,Liu K,Gong H,Li D,Chu W,Zhao D,Wang X,Xu D

更新日期：2021-01-01 00:00:00

abstract：:Coenzyme Q10 (CoQ10), which is a key cofactor of the electron transport chain in the mitochondria has shown many beneficial effects on liver diseases. However, the mechanisms of CoQ10 protective role on the acetaminophen (APAP)-induced liver injury are elusive and unclear. In this study, we further investigated the Co...

journal_title：Toxicology and applied pharmacology

authors： Zhang P,Chen S,Tang H,Fang W,Chen K,Chen X

更新日期：2021-01-01 00:00:00

abstract：:Polychlorinated biphenyl (PCB)126 and perfluorooctane sulfonic acid (PFOS) are halogenated organic pollutants of high concern. Exposure to these chemicals is ubiquitous, and can lead to potential synergistic adverse effects in individuals exposed to both classes of chemicals. The present study was designed to identify...

journal_title：Toxicology and applied pharmacology

authors： Deng P,Wang C,Wahlang B,Sexton T,Morris AJ,Hennig B

更新日期：2020-12-15 00:00:00

abstract：:Acetaminophen (N-Acetyl-p-Aminophenol or APAP)-induced hepatotoxicity is the most common cause of acute liver failure in the United States and Western Europe. Previous studies have shown that TGFβ1 is elevated during APAP-induced hepatotoxicity and promotes liver injury by reducing liver regeneration while inducing he...

journal_title：Toxicology and applied pharmacology

authors： Frampton G,Reddy P,Jefferson B,Ali M,Khan D,McMillin M

更新日期：2020-12-15 00:00:00

abstract：:Mesaconitine (MA) and hypaconitine (HA) are the main bioactive/toxic alkaloids of Aconitum carmichaelii Debx, and MDR1, BCRP and MRP2 are involved in their efflux in vitro. This study aimed to explore the effects of Mdr1a, Bcrp and Mrp2 on the efficacy/toxicity of MA and HA by using efflux transporter gene knockout mo...

journal_title：Toxicology and applied pharmacology

authors： Li X,Ou X,Luo G,Ou X,Xie Y,Ying M,Qu W,Zuo H,Qi X,Wang Y,Liu Z,Zhu L

更新日期：2020-12-15 00:00:00

abstract：:Arsenic trioxide (ATO) has a long history and it is recognized as both poison and drug for more than two thousand years. Since the establishment of ATO as a frontline therapeutic agent for acute promyelocytic leukemia (APL), the survival of APL patients have been greatly improved and APL is turned from highly fatal to...

journal_title：Toxicology and applied pharmacology

authors： Wang QQ,Hua HY,Naranmandura H,Zhu HH

更新日期：2020-12-15 00:00:00

abstract：:Marijuana or synthetic cannabinoids and alcohol are often used together, with these combinations causing motor impairments that can subsequently lead to motor vehicle accidents. This study investigated the combined use of both synthetic cannabinoids and ethanol and their effect on motor coordination in mice in additio...

journal_title：Toxicology and applied pharmacology

authors： Funada M,Takebayashi-Ohsawa M,Tomiyama KI

更新日期：2020-12-01 00:00:00

abstract：:Nuclear receptors (NRs) are key regulators of human health and constitute a relevant target for medicinal chemistry applications as well as for toxicological risk assessment. Several open databases dedicated to small molecules that modulate NRs exist; however, depending on their final aim (i.e., adverse effect assessm...

journal_title：Toxicology and applied pharmacology

authors： Valsecchi C,Grisoni F,Motta S,Bonati L,Ballabio D

更新日期：2020-11-15 00:00:00

abstract：:Prescribing appropriate Tacrolimus (Tac) dosing is still a challenge for clinicians due to the interindividual variability in dose requirement and the narrow therapeutic index. Our objective is to identify potential factors that affects Tac exposure in Tunisian Kidney patients and to develop and validate a Tac dose re...

journal_title：Toxicology and applied pharmacology

authors： Ben-Fredj N,Hannachi I,Chadli Z,Ben-Romdhane H,A Boughattas N,Ben-Fadhel N,Aouam K

更新日期：2020-11-15 00:00:00

abstract：:Improvement of COVID-19 clinical condition was seen in studies where combination of antiretroviral drugs, lopinavir and ritonavir, as well as immunomodulant antimalaric, chloroquine/hydroxychloroquine together with the macrolide-type antibiotic, azithromycin, was used for patient's treatment. Although these drugs are ...

journal_title：Toxicology and applied pharmacology

authors： Baralić K,Jorgovanović D,Živančević K,Antonijević Miljaković E,Antonijević B,Buha Djordjevic A,Ćurčić M,Đukić-Ćosić D

更新日期：2020-11-01 00:00:00

abstract：:Pyrrolizidine alkaloids (PAs) are a group of hepatic toxicant widely present in plants. Cytochrome P450 (CYP) 3A plays a key role in metabolic activation of PAs to generate electrophilic metabolites, which is the main cause of hepatotoxicity. We have previously demonstrated the sex difference in developmental toxicity...

journal_title：Toxicology and applied pharmacology

authors： Xiang E,Guo Q,Dai YG,Sun XX,Liu J,Fan CP,Wang YQ,Qiu SK,Wang H,Guo Y

更新日期：2020-11-01 00:00:00

abstract：:Energy metabolism and reproduction are closely linked and reciprocally regulated. The detrimental effect of underweight on reproduction complicates the safety evaluation of anti-obesity drugs, making it challenging to distinguish pathological changes mediated through the intended drug-induced weight loss from direct d...

journal_title：Toxicology and applied pharmacology

authors： Bolze F,Williams H,Bhuwania R,Egecioglu E,Bloem E,Paulsson JF,Pedersen MØ,Broadmeadow A,Chesher CJ,Moore EL,Skydsgaard M,Galle PS,Dalgaard M,Wulff BS,Tena-Sempere M,Andersen LW

更新日期：2020-10-01 00:00:00

abstract：:Growing use of carbon nanotubes (CNTs) have garnered concerns regarding their association with adverse health effects. Few studies have probed how CNTs affect a host's susceptibility to pathogens, particularly respiratory viruses. We reported that exposure of lung cells and mice to pristine single-walled CNTs (SWCNTs)...

journal_title：Toxicology and applied pharmacology

authors： Chen H,Humes ST,Rose M,Robinson SE,Loeb JC,Sabaraya IV,Smith LC,Saleh NB,Castleman WL,Lednicky JA,Sabo-Attwood T

更新日期：2020-10-01 00:00:00

abstract：:Acute lung injury is an acute inflammatory disease with high morbidity rate and high mortality rate. However, there is still no effective clinical treatment to date. Our previous studies found that NLRC5 was significantly increased in acute liver injury model induced by LPS to reduce the secretion of IL-6 and TNF-α. N...

journal_title：Toxicology and applied pharmacology

authors： Wang Y,Huang C,Bian E,Lei T,Lv X,Li J

更新日期：2020-09-15 00:00:00

abstract：:We previously demonstrated that cisplatin administration in mice induces muscle atrophy and an increase in the expression of two muscle-specific ubiquitin E3 ligase genes, muscle ring finger protein 1 (MuRF1), and atrophy gene-1 (atrogin-1), in skeletal muscle. Ubiquitination serves as a degradation signal in both the...

journal_title：Toxicology and applied pharmacology

authors： Sakai H,Ikeno Y,Tsukimura Y,Inomata M,Suzuki Y,Kon R,Ikarashi N,Chiba Y,Yamada T,Kamei J

更新日期：2020-09-15 00:00:00

abstract：:Voriconazole is one of the most frequently used antifungal drugs for the initial treatment of invasive aspergillosis, but liver-related adverse events occur frequently and usually lead to drug discontinuation. Moreover, the mechanism of voriconazole-induced hepatotoxicity remains unsettled. A holistic understanding of...

journal_title：Toxicology and applied pharmacology

authors： Wu SL,Cheng CN,Wang CC,Lin SW,Kuo CH

更新日期：2020-09-15 00:00:00

abstract：:Glyphosate (GLY) usage for weed control is extensive. To investigate ovarian impacts of chronic GLY exposure, female C57BL6 mice were orally administered saline as vehicle control (CT) or GLY at 0.25 (G0.25), 0.5 (G0.5), 1.0 (G1.0), 1.5 (G1.5), or 2 (G2.0) mg/kg for five days per wk. for 20 wks. Feed intake increased ...

journal_title：Toxicology and applied pharmacology

authors： Ganesan S,Keating AF

更新日期：2020-09-01 00:00:00

abstract：:Although the development of a therapeutic strategy for glioblastoma multiforme (GBM), the most aggressive type of brain tumor in adults, is in progress, the prognosis is still limited. In this study, we evaluated the anti-glioma effects of darapladib, a selective reversible inhibitor of lipoprotein-associated phosphol...

journal_title：Toxicology and applied pharmacology

authors： Wang YJ,Chang SB,Wang CY,Huang HT,Tzeng SF

更新日期：2020-09-01 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG) is the main bioactive component in tea (Camellia sinensis) catechins, and exhibits potential antitumor activity against colorectal cancer (CRC). However, the underlying mechanisms are largely unclear. We investigated the effects of EGCG on activities of CRC cells and the exact mol...

journal_title：Toxicology and applied pharmacology

authors： Zhang Z,Zhang S,Yang J,Yi P,Xu P,Yi M,Peng W

更新日期：2020-08-15 00:00:00

abstract：:Plasticizers released from microplastic are increasingly viewed with concern. While adverse health effects induced by bisphenol A and its analogues on marine animals are well documented in the literature, the endocrine potential of bisphenolic compounds on human health remains elusive. We applied next generation seque...

journal_title：Toxicology and applied pharmacology

authors： Böckers M,Paul NW,Efferth T

更新日期：2020-07-15 00:00:00

abstract：:The cardiotoxicity caused by doxorubicin and extravasation injury caused by anthracyclines is reduced by the clinically approved bisdioxopiperazine drug dexrazoxane. Dexrazoxane is a rings-closed analog of EDTA and is hydrolyzed in vivo to a form that strongly binds iron. Its protective effects were originally thought...

journal_title：Toxicology and applied pharmacology

authors： Hasinoff BB,Patel D,Wu X

更新日期：2020-07-15 00:00:00

abstract：:Antineoplastic drugs cause severe cytotoxicity for normal cells, especially hematopoietic stem cells (HSCs). However, bleomycin (BLM) is glycopeptide antibiotic that is effective on various cancers and has either low or no myelosuppression effects. The aim of the present study was to investigate the effect of BLM on 5...

journal_title：Toxicology and applied pharmacology

authors： Fakhrabadi HG,Rabbani-Chadegani A,Ghadam P,Amiri S

更新日期：2020-06-01 00:00:00

abstract：:Learning and memory deficits are obvious symptoms that develop over time in patients with poorly controlled diabetes. Hyperactivity of the renin-angiotensin system (RAS) is directly associated with β-cell dysfunction and diabetic complications, including cognitive impairment. Here, we investigated the protective and m...

journal_title：Toxicology and applied pharmacology

authors： Youssef MM,Abd El-Latif HA,El-Yamany MF,Georgy GS

更新日期：2020-05-01 00:00:00

abstract：:During pregnancy, fetal thyroid hormones (THs) are dependent on maternal placental transport and their physiological level is crucial for normal fetal neurodevelopment. Earlier research has shown that Di-(2-ethylhexyl) phthalate (DEHP) disrupts thyroid function and THs homeostasis in pregnant women and fetuses, and af...

journal_title：Toxicology and applied pharmacology

authors： Du ZP,Feng S,Li YL,Li R,Lv J,Ren WQ,Feng QW,Liu P,Wang QN

更新日期：2020-05-01 00:00:00

abstract：:The hypothalamic paraventricular nucleus (PVN) plays crucial roles in central cardiovascular regulation. Increasing evidence in humans and rodents shows that vitamin D intake is important for achieving optimal cardiovascular function. The purpose of this study was to investigate whether calcitriol, an active form of v...

journal_title：Toxicology and applied pharmacology

authors： Xu ML,Yu XJ,Zhao JQ,Du Y,Xia WJ,Su Q,Du MM,Yang Q,Qi J,Li Y,Zhou SW,Zhu GQ,Li HB,Kang YM

更新日期：2020-05-01 00:00:00

abstract：:CAsE-PE cells are an arsenic-transformed, human prostate epithelial line containing oncogenic mutations in KRAS compared to immortalized, normal KRAS parent cells, RWPE-1. We previously reported increased copy number of mutated KRAS in CAsE-PE cells, suggesting gene amplification. Here, KRAS flanking genomic and trans...

journal_title：Toxicology and applied pharmacology

authors： Merrick BA,Phadke DP,Bostrom MA,Shah RR,Wright GM,Wang X,Gordon O,Pelch KE,Auerbach SS,Paules RS,DeVito MJ,Waalkes MP,Tokar EJ

更新日期：2020-04-25 00:00:00

abstract：:Recently, we described a family of non-targeting monomethylauristatin E (MMAE) antibody-drug conjugates (ADCs) whose pharmacokinetics could be tuned through incorporation of a short polyethylene glycol (PEG) moiety of up to twelve units into a drug-linker to render the ADC surface more hydrophilic. That work demonstra...

journal_title：Toxicology and applied pharmacology

authors： Simmons JK,Burke PJ,Cochran JH,Pittman PG,Lyon RP

更新日期：2020-04-01 00:00:00

abstract：:Arsenic, an environmental contaminant in drinking water worldwide is well-established to increase cardiovascular diseases (CVDs) in humans. Of these, thrombotic events represent a major adverse effect associated with arsenic exposure, for which an abundance of epidemiological evidence exists. Platelet aggregation cons...

journal_title：Toxicology and applied pharmacology

authors： Kim K,Shin EK,Chung JH,Lim KM

更新日期：2020-03-15 00:00:00

abstract：:Human-based in silico models are emerging as important tools to study the effects of integrating inward and outward ion channel currents to predict clinical proarrhythmic risk. The aims of this study were 2-fold: 1) Evaluate the capacity of an in silico model to predict QTc interval prolongation in the in vivo anesthe...

journal_title：Toxicology and applied pharmacology

authors： Morissette P,Polak S,Chain A,Zhai J,Imredy JP,Wildey MJ,Travis J,Fitzgerald K,Fanelli P,Passini E,Rodriguez B,Sannajust F,Regan C

更新日期：2020-03-01 00:00:00

abstract：:Pulmonary exposure to multi-walled carbon nanotubes (MWCNT) causes inflammation, fibroproliferation, immunotoxicity, and systemic responses in rodents. However, the search for representative biomarkers of exposure is an ongoing endeavor. Whole blood gene expression profiling is a promising new approach for the identif...

journal_title：Toxicology and applied pharmacology

authors： Khaliullin TO,Yanamala N,Newman MS,Kisin ER,Fatkhutdinova LM,Shvedova AA

更新日期：2020-03-01 00:00:00

abstract：:Gastric cancer ranks as the third leading cause of cancer-related death worldwide. The uncontrolled tumor growth and robust metastasis are key factors to cause the cancer patient death. Mechanistically, aberrant activation of Notch and NF-κB signaling pathways plays pivotal roles in the initiation and metastasis of ga...

journal_title：Toxicology and applied pharmacology

authors： Xiang S,Zhao Z,Zhang T,Zhang B,Meng M,Cao Z,Zhou Q

更新日期：2020-02-01 00:00:00

abstract：:In vitro studies showed that 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) increases P-glycoprotein (P-gp) expression and activity in Caco-2 cells, preventing xenobiotic toxicity. The present study aimed at investigating TX5 effects on P-gp expression/activity using Wistar Han rats: a) in vivo, evaluating ...

journal_title：Toxicology and applied pharmacology

authors： Rocha-Pereira C,Ghanem CI,Silva R,Casanova AG,Duarte-Araújo M,Gonçalves-Monteiro S,Sousa E,Bastos ML,Remião F

更新日期：2020-01-01 00:00:00

abstract：:Endothelial-mesenchymal transition (EndMT) is a frequent event in endothelial dysfunction, which is associated with pulmonary arterial hypertension (PAH). MiR-181 family members exert diverse effects in multiple biological processes. However, the relationships between miR-181b-5p (miR-181b) and EndMT in PAH are not we...

journal_title：Toxicology and applied pharmacology

authors： Zhao H,Wang Y,Zhang X,Guo Y,Wang X

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tiotropium bromide (TB) is a long acting muscarinic receptor antagonist used to manage chronic obstructive pulmonary disease (COPD). Recent meta-analyses suggest an increased risk of cardiovascular events with TB. Ca2+/calmodulin dependent kinase II (CaMKII) and L-type Ca2+ channels regulate Ca2+...

journal_title：Toxicology and applied pharmacology

authors： Cassambai S,Mee CJ,Renshaw D,Hussain A

更新日期：2019-12-01 00:00:00

abstract：:Many studies report that cadmium chloride (CdCl2)-induces oxidative stress is associated with male reproductive damage in the testes. CdCl2 also induces mitochondrial fission by increasing dynamin-related protein 1 (Drp1) expression as well as the mitochondria-dependent apoptosis pathway by extracellular signal-regula...

journal_title：Toxicology and applied pharmacology

authors： Seong JB,Bae YC,Lee HS,Huh JW,Lee SR,Lee HJ,Lee DS

更新日期：2019-12-01 00:00:00

abstract：:High- and low- Se diets received by dams during gestation and lactation are related to insulin resistance in their pups. High-Se diet leads to an increase in serum insulin levels, which does not function properly, and an anabolic process. Low-Se diet is related to very low insulin values and an extreme catabolic energ...

journal_title：Toxicology and applied pharmacology

authors： Ojeda ML,Carreras O,Díaz-Castro J,Murillo ML,Nogales F

更新日期：2019-11-01 00:00:00

abstract：:The use of toxicokinetic (TK) data is becoming more prevalent in the evaluation of food ingredient safety as more TK information is being incorporated in safety data packages. Data demonstrating "1) the extent of absorption, 2) tissue distribution, 3) pathways and rates of metabolism, and 4) rate(s) of elimination" of...

journal_title：Toxicology and applied pharmacology

authors： Kabadi SV,Zang Y,Fisher JW,Smith N,Whiteside C,Aungst J

更新日期：2019-11-01 00:00:00