Time-varying conjugation of 7,12-dimethylbenz[a]anthracene metabolites in rainbow trout (Oncorhynchus mykiss).

Abstract:

:Sexually immature rainbow trout were dosed via gavage with 7,12-[14C]dimethylbenz[a]anthracene (DMBA) in order to study hepatic metabolite formation over time and at single and multiple doses. beta-Glucuronidase and aryl sulfatase hydrolyses of bile extracts and subsequent high-pressure liquid chromatography analysis demonstrated significant levels of sulfate conjugates formed after 12 hr of exposure to a single dose. By 72 hr, glucuronide conjugates had increased and after three doses of [14C]DMBA, glucuronides exceeded the amount of sulfates by almost an order of magnitude. Of the metabolites that could be tentatively identified, the majority were oxidative derivatives of the aromatic rings 3-OH DMBA and 3,4-trans-OHDMBA, the latter of which is mutagenic and a precursor to the proposed ultimate carcinogen of DMBA.

journal_name

Toxicol Appl Pharmacol

authors

Schnitz AR,Squibb KS,O'Connor JM

doi

10.1006/taap.1993.1129

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

58-70

issue

1

eissn

0041-008X

issn

1096-0333

pii

S0041008X83711294

journal_volume

121

pub_type

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