Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approach.

abstract：:Intraperitoneal or intraocular (io) injection of tubulin-binding drugs in goldfish, Carassius auratus L., inhibited axonal regeneration or restoration of functional synapses in optic axons following optic nerve crush. One eye was used to detect effects on regeneration and the other was kept intact to detect effects on...

journal_title：Toxicology and applied pharmacology

authors： Davis RE,Schlumpf BE,Klinger PD

更新日期：1985-09-15 00:00:00

abstract：:Metabonomics is the evaluation of the multiparametric metabolic response of biological systems to pathophysiological stimuli. High-resolution nuclear magnetic resonance (NMR) spectroscopy of biofluids coupled with pattern recognition-based chemometric analysis is an emerging approach to the study of metabonomics and m...

journal_title：Toxicology and applied pharmacology

authors： Slim RM,Robertson DG,Albassam M,Reily MD,Robosky L,Dethloff LA

更新日期：2002-09-01 00:00:00

abstract：:The present study was conducted to clarify the acute effect of tris(2-chloroethyl)phosphate (TRCP), an organophosphate flame-retardant, on spontaneous ambulatory activity (AA) in male ICR mice and to examine the neurochemical mechanism of this effect. Single dose administration of 200 mg/kg i.p. of TRCP increased AA i...

journal_title：Toxicology and applied pharmacology

authors： Umezu T,Yonemoto J,Soma Y,Suzuki T

更新日期：1998-01-01 00:00:00

abstract：:With the purpose of assessing the effect of uranyl nitrate (UN) on the rate of erythropoiesis, 1 mg/kg of the compound was injected iv to adult female Wistar rats. The dosing vehicle was injected into control animals. A single injection of UN induced a transient depression of the rate of red cell volume 59Fe uptake, w...

journal_title：Toxicology and applied pharmacology

authors： Giglio MJ,Brandan N,Leal TL,Bozzini CE

更新日期：1989-06-15 00:00:00

abstract：:Acute lung injury is an acute inflammatory disease with high morbidity rate and high mortality rate. However, there is still no effective clinical treatment to date. Our previous studies found that NLRC5 was significantly increased in acute liver injury model induced by LPS to reduce the secretion of IL-6 and TNF-α. N...

journal_title：Toxicology and applied pharmacology

authors： Wang Y,Huang C,Bian E,Lei T,Lv X,Li J

更新日期：2020-09-15 00:00:00

abstract：:Arsenic is a ubiquitous metalloid element present in both inorganic and organic forms in the environment. The liver is considered to be a primary organ of arsenic biotransformation and methylation, as well as the main target of arsenic toxicity. Studies have confirmed that Chang human hepatocytes have an efficient ars...

journal_title：Toxicology and applied pharmacology

authors： Liu D,Xu G,Bai C,Gu Y,Wang D,Li B

更新日期：2021-01-09 00:00:00

abstract：:Neonatal and adult rats (1, 2, 3, 6, and 12 weeks of age) were given five daily oral doses of di(2-ethylhexyl) phthalate (DEHP) (0, 10, 100, 1000, 2000 mg/kg) and histological changes in the testes were examined 24 hr after the last dose. Relative testis weights were reduced at doses of 1000 mg/kg in 1, 2, 3, and 6-we...

journal_title：Toxicology and applied pharmacology

authors： Dostal LA,Chapin RE,Stefanski SA,Harris MW,Schwetz BA

更新日期：1988-08-01 00:00:00

abstract：:To study the effect of cadmium exposure on maternal and fetal zinc metabolism, rats were exposed to 0, 5, 50, or 100 ppm Cd in the drinking water on Days 6 through 20 of pregnancy. In comparison to controls, fetal and maternal weights were slightly reduced in the 50- and 100-ppm groups, but not the 5-ppm group. Multip...

journal_title：Toxicology and applied pharmacology

authors： Sorell TL,Graziano JH

更新日期：1990-03-01 00:00:00

abstract：:The disposition of polycyclic aromatic hydrocarbons (PAHs) in the respiratory tract of the Beagle dog was measured and presented in two previous papers. In this paper, the data were used to demonstrate that highly lipophilic toxicants, such as PAHs, were diffusion-limited during clearance from the respiratory tract. O...

journal_title：Toxicology and applied pharmacology

authors： Gerde P,Muggenburg BA,Henderson RF

更新日期：1993-08-01 00:00:00

abstract：:The most commonly used chemical mixtures risk assessment methods involve simple notions of additivity and toxicological similarity. Newer methods are emerging in response to the complexities of chemical mixture exposures and effects. Factors based on both science and policy drive decisions regarding whether to conduct...

journal_title：Toxicology and applied pharmacology

authors： Teuschler LK

更新日期：2007-09-01 00:00:00

abstract：:The threshold hemodynamic changes associated with the cardiovascular (CV) toxicity of minoxidil (MNX) in the dog, characterized by subendocardial necrosis, right atrial hemorrhagic lesions, and coronary vascular medial hemorrhage and necrosis, have not been defined. To determine the relationship between serum concentr...

journal_title：Toxicology and applied pharmacology

authors： Mesfin GM,Higgins MJ,Robinson FG,Zhong WZ

更新日期：1996-10-01 00:00:00

abstract：:Baicalin is a major flavonoid compound purified from Scutellariae radix, which has been described as an herb in the Chinese Pharmacopoeia. Previous studies have suggested baicalin possessed extensive anti-inflammatory, anti-cancer, anti-viral properties. However, up to known, there have been no reports of safety and t...

journal_title：Toxicology and applied pharmacology

authors： Cai Y,Ma W,Xiao Y,Wu B,Li X,Liu F,Qiu J,Zhang G

更新日期：2017-10-15 00:00:00

abstract：:Our previous study revealed that 4-aminopyridine (4-AP), a specific blocker of A-type current, could also inhibit inward Na+ currents (I(Na)) with a state-independent mechanism in rat cerebellar granule cells. In the present study, we report an inhibitory effect of 4-AP on voltage-gated and tetrodotoxin (TTX)-sensitiv...

journal_title：Toxicology and applied pharmacology

authors： Lu BX,Liu LY,Liao L,Zhang ZH,Mei YA

更新日期：2005-09-15 00:00:00

abstract：:Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson,...

journal_title：Toxicology and applied pharmacology

authors： Mostafalou S,Abdollahi M

更新日期：2013-04-15 00:00:00

abstract：:The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO(2)-DDE) has been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) treatment. ACC is a rare malignant disorder with poor prognosis, and the current pharmacological therapy o,p'-DDD (mitotane) has limited efficacy and causes severe adverse effects...

journal_title：Toxicology and applied pharmacology

authors： Asp V,Ullerås E,Lindström V,Bergström U,Oskarsson A,Brandt I

更新日期：2010-02-01 00:00:00

abstract：:Motor neuron disease is a devastating neurodegenerative condition, with the majority of sporadic, non-familial cases being of unknown etiology. Several epidemiological studies have suggested that occupational exposure to chemicals may be associated with disease pathogenesis. We report the case of a patient developing ...

journal_title：Toxicology and applied pharmacology

authors： Kanavouras K,Tzatzarakis MN,Mastorodemos V,Plaitakis A,Tsatsakis AM

更新日期：2011-11-01 00:00:00

abstract：:As a part of the serotoninergic dysfunction implicated in neurobiology of depression, evidence has focused on serotonin (5-HT) receptors downstream signaling intermediates including glycogen synthase kinase-3β (GSK-3β), cAMP response element binding protein (CREB) and brain derived neurotrophic factor (BDNF). Our team...

journal_title：Toxicology and applied pharmacology

authors： Abuelezz SA,Hendawy N,Magdy Y

更新日期：2018-02-01 00:00:00

abstract：:Arsenic trioxide (ATO) has a long history and it is recognized as both poison and drug for more than two thousand years. Since the establishment of ATO as a frontline therapeutic agent for acute promyelocytic leukemia (APL), the survival of APL patients have been greatly improved and APL is turned from highly fatal to...

journal_title：Toxicology and applied pharmacology

authors： Wang QQ,Hua HY,Naranmandura H,Zhu HH

更新日期：2020-12-15 00:00:00

abstract：:Organic cations (OCs) constitute a diverse array of compounds of physiological, pharmacological, and toxicological importance. Renal secretion of these compounds, which occurs principally along the proximal portion of the nephron, plays a critical role in regulating the concentration of OCs in the plasma and in cleari...

journal_title：Toxicology and applied pharmacology

authors： Wright SH

更新日期：2005-05-01 00:00:00

abstract：:Defects in tryptophan metabolism on the l-kynurenine pathway (KP) are implicated in a number of human diseases, including chronic kidney disease, brain edema or injury, tuberculosis and malaria - as well as cancer, neurodegenerative and autoimmune disorders. However, it is unclear to what extent detrimental effects of...

journal_title：Toxicology and applied pharmacology

authors： Majewski M,Kasica N,Jakimiuk A,Podlasz P

更新日期：2018-02-15 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) can protect the liver from injury produced by a variety of hepatotoxicants when administered prior to or concomitant with the toxicants. This protective action has previously been attributed to DMSO-induced inhibition of bioactivation of the compounds to toxic intermediates. In these studies,...

journal_title：Toxicology and applied pharmacology

authors： Lind RC,Gandolfi AJ

更新日期：1997-01-01 00:00:00

abstract：:Bobwhite quail were exposed to 2,4-dinitrophenol (DNP) in a respirometer designed to continuously monitor exchange of O2 and CO2, from which metabolic rates (MR) were estimated. After 14-16 days of acclimation to the system (temperature 22 degrees C, light cycle 8L:14D), hens received feed amended with 0, 625, or 1250...

journal_title：Toxicology and applied pharmacology

authors： Dominguez SE,Menkel JL,Fairbrother A,Williams BA,Tanner RW

更新日期：1993-12-01 00:00:00

abstract：:Although insulin and atorvastatin have been shown to exert glycemic control and could improve brain function, the effects of atorvastatin or insulin as well as the combination of atorvastatin plus insulin on brain pathology in diabetes mellitus type 1 (T1DM) are unclear. Therefore, this study investigated the effect o...

journal_title：Toxicology and applied pharmacology

authors： Pratchayasakul W,Thongnak LO,Chattipakorn K,Lungaphin A,Pongchaidecha A,Satjaritanun P,Jaiwongkam T,Kerdphoo S,Chattipakorn SC

更新日期：2018-03-01 00:00:00

abstract：:Acetaminophen (APAP) and 7-hydroxy-2-acetylaminofluorene (7-OH-AAF) each produced a similar incidence of, as well as a qualitatively similar, abnormal closure of the anterior neuropore at similar concentrations when added to the medium of cultured rat embryos. At concentrations producing a 50-65% incidence of abnormal...

journal_title：Toxicology and applied pharmacology

authors： Stark KL,Harris C,Juchau MR

更新日期：1989-03-01 00:00:00

abstract：:Isolated rat lymphocytes in salts-glucose medium (pH 7.2) were incubated with nickel chloride, nickel acetate, nickel sulfate, and a soluble form of nickel subsulfide (0-2 mM) at 37 degrees C for 2 h. The soluble form of nickel subsulfide induced a significant increase in DNA-protein crosslinks (DPXLs) (111%) beginnin...

journal_title：Toxicology and applied pharmacology

authors： Chakrabarti SK,Bai C,Subramanian KS

更新日期：2001-02-01 00:00:00

abstract：:A group of alkyl epoxides was compared for their guinea pig sensitization capacity and reactivities towards a protein-surrogate substrate, n-butylamine. Instead of the previously reported use of a titration method for determination of alkylation rate, proton nuclear magnetic resonance spectrometry (1H NMR) was used. T...

journal_title：Toxicology and applied pharmacology

authors： Betso JE,Carreon RE,Miner VM

更新日期：1991-05-01 00:00:00

abstract：:A previously developed PBPK model for ethylene glycol and glycolic acid was extended to include glyoxylic acid, oxalic acid, and the precipitation of calcium oxalate that is associated with kidney toxicity in rats and humans. The development and evaluation of the PBPK model was based upon previously published pharmaco...

journal_title：Toxicology and applied pharmacology

authors： Corley RA,Saghir SA,Bartels MJ,Hansen SC,Creim J,McMartin KE,Snellings WM

更新日期：2011-02-01 00:00:00

abstract：:The effect of N-benzyl-D-glucamine dithiocarbamate (BGD) on the renal toxicity produced by subacute exposure to cadmium in rats was studied. Rats were injected sc with CdCl2 (1.5 mg Cd/kg) daily for 26 days and thereafter they received 13 injections of BGD (400 mumol/kg) every other day. Urinary protein concentration ...

journal_title：Toxicology and applied pharmacology

authors： Kojima S,Ono H,Kiyozumi M,Honda T,Takadate A

更新日期：1989-03-15 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants and many of their toxic effects, including their immunotoxicities, are mediated by the activation of aryl hydrocarbon receptor (AhR). We previously reported that Aroclor 1254, one of the most widely used PCB mixtures, increased DNA fragmentatio...

journal_title：Toxicology and applied pharmacology

authors： Jeon YJ,Youk ES,Lee SH,Suh J,Na YJ,Kim HM

更新日期：2002-06-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) (50 mg/kg, i.p.) selectively deplete mouse bone marrow (BM) hematopoietic cells through a process that is dependent on CYP1B1. 7,12-dimethylbenz(a)anthracene (DMBA), which forms greater amounts of dihydrodiol-epoxide-DNA adducts in BM, is much more effective in depleting BM cell...

journal_title：Toxicology and applied pharmacology

authors： Galván N,Teske DE,Zhou G,Moorthy B,MacWilliams PS,Czuprynski CJ,Jefcoate CR

更新日期：2005-02-01 00:00:00