The effect of 2,4-dinitrophenol on the metabolic rate of bobwhite quail.

abstract：:The elevation of intracellular Ca2+ in various tissue through oxidative stress induced by menadione has been well documented. Increase of Ca2+ level in platelets results in aggregation of platelets. To test the hypothesis that menadione-induced Ca2+ elevations can play a role in platelet aggregation, we have studied t...

journal_title：Toxicology and applied pharmacology

authors： Kim KA,Lee JY,Park KS,Kim MJ,Chung JH

更新日期：1996-05-01 00:00:00

abstract：:Although the mechanisms responsible for chemically induced oxidative stress are under intense investigation, little is known about the effects of prooxidant chemicals on the expression of drug-metabolizing enzymes. We examined the effects of diquat (0.1 mmol/kg, ip) and ciprofibrate (0.025% w/w, diet), chemicals which...

journal_title：Toxicology and applied pharmacology

authors： Gallagher EP,Buetler TM,Stapleton PL,Wang C,Stahl DL,Eaton DL

更新日期：1995-09-01 00:00:00

abstract：:While the physiologic and molecular effects of capsaicinoids have been extensively studied in various model systems by a variety of administration routes, little is known about the uptake and elimination kinetic profiles in human skin following topical exposure. The present study evaluated the uptake and elimination k...

journal_title：Toxicology and applied pharmacology

authors： Pershing LK,Reilly CA,Corlett JL,Crouch DJ

更新日期：2004-10-01 00:00:00

abstract：:The mechanisms of action of o,p'-DDD on adrenal steroidogenesis were investigated in vitro in rainbow trout (Oncorhynchus mykiss). Acute exposures to o,p'-DDD inhibited ACTH-stimulated cortisol secretion while cell viability decreased significantly only at the highest concentration tested (200 microM o,p'-DDD). Stimul...

journal_title：Toxicology and applied pharmacology

authors： Lacroix M,Hontela A

更新日期：2003-08-01 00:00:00

abstract：:The effect of butylated hydroxytoluene (BHT), which is used widely as an antioxidant, on IgE-dependent allergic responses in vivo and in vitro was investigated. For in vivo study, passive cutaneous anaphylaxis (PCA) was elicited in rats by i.d. injection of anti-DNP IgE and 48 h later by i.v. injection of DNP-HSA. BHT...

journal_title：Toxicology and applied pharmacology

authors： Yamaki K,Taneda S,Yanagisawa R,Inoue K,Takano H,Yoshino S

更新日期：2007-09-01 00:00:00

abstract：:Arsenic is a human carcinogen with exposure associated with cancer of the lung, skin, and bladder. Many potential mechanisms have been implicated as playing a role in the process of arsenical-induced malignancy including the perturbation of signaling pathways and aberrant epigenetic regulation. We initiated studies to...

journal_title：Toxicology and applied pharmacology

authors： Jensen TJ,Wozniak RJ,Eblin KE,Wnek SM,Gandolfi AJ,Futscher BW

更新日期：2009-02-15 00:00:00

abstract：:Metabolism of BHT (2,6-di-tert-butyl-4-methylphenol) is requisite for its pneumotoxic activities. Previous evidence using microsomal preparations from livers and lungs of mice indicated that cytochrome P450-catalyzed hydroxylation of a tertbutyl group to form 6-tert-butyl-2-(hydroxy-tert-butyl)-4-methylphenol (BHTOH) ...

journal_title：Toxicology and applied pharmacology

authors： Bolton JL,Thompson JA,Allentoff AJ,Miley FB,Malkinson AM

更新日期：1993-11-01 00:00:00

abstract：:Calcium channel blockers (CCBs) are important in the management of hypertension and limit restenosis. Although CCB efficacy could derive from decreased blood pressure, other mechanisms independent of CCB activity also can contribute to antiproliferative action. To understand mechanisms of CCB-mediated antiproliferatio...

journal_title：Toxicology and applied pharmacology

authors： Salabei JK,Balakumaran A,Frey JC,Boor PJ,Treinen-Moslen M,Conklin DJ

更新日期：2012-08-01 00:00:00

abstract：:In utero bisphenol A (BPA) exposure affects reproductive function in the first generation (F1) of mice; however, not many studies have examined the reproductive effects of BPA exposure on subsequent generations. In this study, pregnant mice (F0) were orally dosed with vehicle, BPA (0.5, 20, and 50 μg/kg/day) or diethy...

journal_title：Toxicology and applied pharmacology

authors： Ziv-Gal A,Wang W,Zhou C,Flaws JA

更新日期：2015-05-01 00:00:00

abstract：:In this study, the effects of pentavalent dimethylarsinic acid ((CH(3))(2)AsO(OH); DMA(V)) and trivalent dimethylarsinous acid ((CH(3))(2)As(OH); DMA(III)) on synaptic transmission generated by the excitatory Schaffer collateral-CA1 synapse were tested in hippocampal slices of young (14-21 day-old) and adult (2-4 mont...

journal_title：Toxicology and applied pharmacology

authors： Krüger K,Repges H,Hippler J,Hartmann LM,Hirner AV,Straub H,Binding N,Musshoff U

更新日期：2007-11-15 00:00:00

abstract：:The effect of T2-toxin on DNA and protein synthesis was investigated, both in vivo and in vitro. For mice which had been submitted to different treatment schedules (single dose, 3-, or 7-day treatment), the rate of DNA and protein biosynthesis was measured in thymus, bone marrow, liver, and spleen cells. T2-toxin inhi...

journal_title：Toxicology and applied pharmacology

authors： Rosenstein Y,Lafarge-Frayssinet C

更新日期：1983-09-15 00:00:00

abstract：:Previous studies have demonstrated that mice lacking a functional folate binding protein 2 gene (Folbp2-/-) were significantly more sensitive to in utero arsenic exposure than were the wild-type mice similarly exposed. When these mice were fed a folate-deficient diet, the embryotoxic effect of arsenate was further exa...

journal_title：Toxicology and applied pharmacology

authors： Spiegelstein O,Gould A,Wlodarczyk B,Tsie M,Lu X,Le C,Troen A,Selhub J,Piedrahita JA,Salbaum JM,Kappen C,Melnyk S,James J,Finnell RH

更新日期：2005-02-15 00:00:00

abstract：:Approaches for extrapolating in vitro toxicity testing results for prediction of human in vivo outcomes are needed. The purpose of this case study was to employ in vitro toxicokinetics and PBPK modeling to perform in vitro to in vivo extrapolation (IVIVE) of lindane neurotoxicity. Lindane cell and media concentrations...

journal_title：Toxicology and applied pharmacology

authors： Croom EL,Shafer TJ,Evans MV,Mundy WR,Eklund CR,Johnstone AF,Mack CM,Pegram RA

更新日期：2015-02-15 00:00:00

abstract：:Chlorinated dibenzo-p-dioxins (CDDs) are a series of mono- to octa-chlorinated homologous chemicals commonly referred to as polychlorinated dioxins. One of the most potent, well-known, and persistent member of this family is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). As part of translational research to make computer...

journal_title：Toxicology and applied pharmacology

authors： Emond C,Ruiz P,Mumtaz M

更新日期：2017-01-15 00:00:00

abstract：:Triaryl phosphates including tricresyl phosphate (TCP) and butylated triphenyl phosphate (BTP) are organophosphates used in the commercial manufacture of plastics, lubricants, and hydraulic fluids. Rat steroidogenic tissues such as adrenocortical (AC), ovarian interstitial (OI), and Leydig cells use an intracellular p...

journal_title：Toxicology and applied pharmacology

authors： Latendresse JR,Azhar S,Brooks CL,Capen CC

更新日期：1993-10-01 00:00:00

abstract：:Combretastatin A-4 (CA-4) has already entered clinical trials of solid tumors over ten years. However, the limited anticancer activity and dose-dependent toxicity restrict its clinical application. Here, we offered convincing evidence that CA-4 induced autophagy in various cancer cells, which was demonstrated by acrid...

journal_title：Toxicology and applied pharmacology

authors： Li Y,Luo P,Wang J,Dai J,Yang X,Wu H,Yang B,He Q

更新日期：2014-01-15 00:00:00

abstract：:Methyl chloride (MeCl) metabolism and pharmacokinetics were studied in male Fischer 344 rats and male beagle dogs. Apparent steady-state blood MeCl concentrations were proportionate to exposure concentration in rats and dogs exposed to 50 and 1000 ppm. Furthermore, blood MeCl concentrations were similar in both specie...

journal_title：Toxicology and applied pharmacology

authors： Landry TD,Gushow TS,Langvardt PW,Wall JM,McKenna MJ

更新日期：1983-05-01 00:00:00

abstract：:Contact sensitization is caused by low molecular weight compounds which penetrate the skin and bind to protein. In many cases, these compounds are activated to reactive species, either by autoxidation on exposure to air or by metabolic activation in the skin. Geraniol, a widely used fragrance chemical, is considered t...

journal_title：Toxicology and applied pharmacology

authors： Hagvall L,Baron JM,Börje A,Weidolf L,Merk H,Karlberg AT

更新日期：2008-12-01 00:00:00

abstract：:A comparative study was undertaken in order to assess the hematotoxic effects of hydroquinone (HQ), 1,4-benzoquinone (BQ), and doxorubicin (DX) on mouse and human bone marrow (BM) cells. Initial experiments indicated that the inhibitory effects of near-ambient pO2 and HQ on granulocyte/macrophage colony-stimulating fa...

journal_title：Toxicology and applied pharmacology

authors： Colinas RJ,Burkart PT,Lawrence DA

更新日期：1994-11-01 00:00:00

abstract：:Diesel exhaust particles (DEPs) cause many adverse health problems, and reports indicate increased risk of breast cancer in men and women through exposure to gasoline and vehicle exhaust. However, DEPs include vast numbers of compounds, and the specific compound(s) responsible for these actions are not clear. We recen...

journal_title：Toxicology and applied pharmacology

authors： Furuta C,Suzuki AK,Watanabe G,Li C,Taneda S,Taya K

更新日期：2008-08-01 00:00:00

abstract：:The effects of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the reproductive system of male offspring rats were examined. The dams were treated subcutaneously 2 weeks prior to mating and throughout mating, pregnancy, and lactation. They received an initial loading dose of 25, 60, or 300 ng TCDD/kg body w...

journal_title：Toxicology and applied pharmacology

authors： Faqi AS,Dalsenter PR,Merker HJ,Chahoud I

更新日期：1998-06-01 00:00:00

abstract：:Corticosteroids will induce cleft palate in mice. One suggested mechanism for this effect is through inhibition of phospholipase activity. This hypothesis was tested by measuring the effects of dexamethasone, a synthetic corticosteroid, on phospholipase activity in cultures of palate mesenchymal cells. Palate mesenchy...

journal_title：Toxicology and applied pharmacology

authors： Bulleit RF,Zimmerman EF

更新日期：1984-09-15 00:00:00

abstract：:The effect of two concentrations of dietary acid (sulfuric acid) or aluminum (aluminum sulfate) on growth and growth-related hormones was examined in a heavy (broiler) strain of chicken between 4 and 18 days old. Growth (body weight, average daily gain, and tibial length) in chicks receiving either dietary acid or alu...

journal_title：Toxicology and applied pharmacology

authors： Capdevielle MC,Scanes CG

更新日期：1995-07-01 00:00:00

abstract：:The disposition of [3H]diisopropylfluorophosphate (DFP) and its metabolites was studied in mice after iv treatment. In addition, disposition of [3H]DFP in selected tissues was correlated with cholinesterase activity and spontaneous activity following DFP treatment. Within 1 min of administration [3H]DFP had penetrated...

journal_title：Toxicology and applied pharmacology

authors： Martin BR

更新日期：1985-02-01 00:00:00

abstract：:Rodent bioassays indicate that B6C3F1 mice are more sensitive to the carcinogenicity of benzene than are rats. The urinary profile of benzene metabolites is different in rats vs mice. Mice produce higher proportions of hydroquinone conjugates and muconic acid, indicators of metabolism via pathways leading to putative ...

journal_title：Toxicology and applied pharmacology

authors： Sabourin PJ,Muggenburg BA,Couch RC,Lefler D,Lucier G,Birnbaum LS,Henderson RF

更新日期：1992-06-01 00:00:00

abstract：:Chronic inhalation of high concentrations of respirable quartz particles has been implicated in various lung diseases including lung fibrosis and cancer. Generation of reactive oxygen species (ROS) and oxidative stress is considered a major mechanism of quartz toxicity. Curcumin, a yellow pigment from Curcuma longa, h...

journal_title：Toxicology and applied pharmacology

authors： Li H,van Berlo D,Shi T,Speit G,Knaapen AM,Borm PJ,Albrecht C,Schins RP

更新日期：2008-02-15 00:00:00

abstract：:Dasatinib, a multitargeted inhibitor of BCR-ABL and SRC kinases, exhibits antitumor activity and extends the survival of patients with chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). However, some patients suffer from hepatotoxicity, which occurs through an unkno...

journal_title：Toxicology and applied pharmacology

authors： Xue T,Luo P,Zhu H,Zhao Y,Wu H,Gai R,Wu Y,Yang B,Yang X,He Q

更新日期：2012-06-15 00:00:00

abstract：:Exposure to the potent tumor promoter 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) or related agonists of the aryl hydrocarbon receptor (AhR) can result in hepatocarcinogenesis in rodents. Changes in the expression and/or the level of growth factors may be a critical event in TCDD-mediated hepatocarcinogenesis. In this...

journal_title：Toxicology and applied pharmacology

authors： Riebniger D,Schrenk D

更新日期：1998-09-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor which plays a role in the development of multiple tissues and is activated by a large number of ligands, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In order to examine the roles of the AHR in both normal biological development an...

journal_title：Toxicology and applied pharmacology

authors： Harrill JA,Hukkanen RR,Lawson M,Martin G,Gilger B,Soldatow V,Lecluyse EL,Budinsky RA,Rowlands JC,Thomas RS

更新日期：2013-10-15 00:00:00

abstract：:Puerarin is a natural product isolated from Puerarin lobata and has various pharmacological effects, including anti-hyperglycemic and anti-allergic properties. In the present study, we investigated the effect of puerarin against advanced glycation end products (AGEs)-induced inflammation in mouse mesangial cells. Puer...

journal_title：Toxicology and applied pharmacology

authors： Kim KM,Jung DH,Jang DS,Kim YS,Kim JM,Kim HN,Surh YJ,Kim JS

更新日期：2010-04-15 00:00:00