Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression.

abstract：:A number of chemicals cause a nephrotoxic syndrome in male rats, referred to as protein droplet or alpha 2u-globulin (alpha 2u) nephropathy. To evaluate the potential human risk for developing a similar chemically-induced protein-mediated nephrotoxic response, the low-molecular-weight protein fraction (LMWPF) was isol...

journal_title：Toxicology and applied pharmacology

authors： Borghoff SJ,Lagarde WH

更新日期：1993-04-01 00:00:00

abstract：:Toxic cardiovascular effects of allylamine and beta-aminopropionitrile were studied in adult male Sprague-Dawley rats given allylamine alone (AA), 100 mg/kg/day, beta-aminopropionitrile alone (beta APN), 1 g/kg/day, or both chemicals (AA + beta APN) by gavage. Rats were given a total of 10 doses in 11 days. Rats given...

journal_title：Toxicology and applied pharmacology

authors： Kumar D,Hysmith RM,Boor PJ

更新日期：1990-04-01 00:00:00

abstract：:Organophosphorus-ester induced delayed neurotoxicity (OPIDN) is a neurodegenerative disorder characterized by ataxia progressing to paralysis with a concomitant central and peripheral, distal axonapathy. Diisopropylphosphorofluoridate (DFP) produces OPIDN in the chicken that results in mild ataxia in 7-14 days and sev...

journal_title：Toxicology and applied pharmacology

authors： Damodaran TV,Attia MK,Abou-Donia MB

更新日期：2011-11-01 00:00:00

abstract：:With the purpose of assessing the effect of uranyl nitrate (UN) on the rate of erythropoiesis, 1 mg/kg of the compound was injected iv to adult female Wistar rats. The dosing vehicle was injected into control animals. A single injection of UN induced a transient depression of the rate of red cell volume 59Fe uptake, w...

journal_title：Toxicology and applied pharmacology

authors： Giglio MJ,Brandan N,Leal TL,Bozzini CE

更新日期：1989-06-15 00:00:00

abstract：:The Ah locus encodes a cytosolic receptor that regulates the induction of certain drug-metabolizing enzymes by polycyclic aromatic hydrocarbons such as benzo[a]pyrene. Some inbred mouse strains such as C57BL/6N have the high-affinity Ah receptor (Ahb/Ahb), others such as DBA/2N, the poor-affinity receptor (Ahd/Ahd). P...

journal_title：Toxicology and applied pharmacology

authors： Legraverend C,Harrison DE,Ruscetti FW,Nebert DW

更新日期：1983-09-30 00:00:00

abstract：:Based on the observation that congenic haired and hairless mice differ in the hyperkeratinizing/hyperproliferative epidermal response following topical exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in vivo, it has been proposed that this response in mice segregates with the Ah locus (which controls for the Ah...

journal_title：Toxicology and applied pharmacology

authors： Puhvel SM,Sakamoto M

更新日期：1987-06-15 00:00:00

abstract：:Perinatal and juvenile oral treatment of rats with methoxychlor (MXC) only during development reduces testicular size and Sertoli cell number in those animals as adults. The objectives were to determine if MXC administered orally reduces numbers of spermatogonia and daily sperm production that parallel reduction in Se...

journal_title：Toxicology and applied pharmacology

authors： Staub C,Hardy VB,Chapin RE,Harris MW,Johnson L

更新日期：2002-04-15 00:00:00

abstract：:Two members of the cytochrome P450 2A subfamily, CYP2A10 and 2A11, are abundant nasal enzymes previously characterized in rabbit olfactory microsomes. Rabbit CYP2A is active toward a number of nasal toxicants, including the rat nasal procarcinogen hexamethylphosphoramide (HMPA). While P450s immunochemically related to...

journal_title：Toxicology and applied pharmacology

authors： Thornton-Manning JR,Nikula KJ,Hotchkiss JA,Avila KJ,Rohrbacher KD,Ding X,Dahl AR

更新日期：1997-01-01 00:00:00

abstract：:Mechanisms of particulate matter (PM)-induced cardiotoxicity are not fully understood. Direct translocation of PM-associated metals, including zinc, may mediate this effect. We hypothesized that following a single intratracheal instillation (IT), zinc directly translocates outside of the lungs, reaching the heart. To ...

journal_title：Toxicology and applied pharmacology

authors： Wallenborn JG,Kovalcik KD,McGee JK,Landis MS,Kodavanti UP

更新日期：2009-01-01 00:00:00

abstract：:The catalytic activities of glutathione S-transferases (GSTs), particularly the alpha-class isozymes, can provide protection against oxidative stress through GSH-mediated metabolism of reactive products of lipid peroxidation. Lipid peroxidation products from oxidative metabolism in alveolar macrophages play an importa...

journal_title：Toxicology and applied pharmacology

authors： Morrison RJ,Singhal SS,Bidani A,Heming TA,Awasthi S

更新日期：1998-02-01 00:00:00

abstract：:Lactate Dehydrogenase Isoenzymes in Hamster Lung Lavage Fluid after Lung Injury. Beck, B. D., Gerson, B., Feldman, H. A., and Brain, J. D. (1983). Toxicol. Appl. Pharmacol. 71, 59-71. Lactate dehydrogenase (LD) levels and isoenzyme patterns were determined in the cell-free supernatant fractions of lung lavage fluid fr...

journal_title：Toxicology and applied pharmacology

authors： Beck BD,Gerson B,Feldman HA,Brain JD

更新日期：1983-10-01 00:00:00

abstract：:The toxic effects of dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mainly through activation of the aryl hydrocarbon receptor (AhR) are well documented. Fibroblast growth factor (Fgf) 21 plays critical roles in metabolic adaptation to fasting by increasing lipid oxidation and ketogenesis in the liver. T...

journal_title：Toxicology and applied pharmacology

authors： Cheng X,Vispute SG,Liu J,Cheng C,Kharitonenkov A,Klaassen CD

更新日期：2014-07-01 00:00:00

abstract：:The distribution of 14C-labeled clodronate (dichloromethylene bisphosphonate), a new bisphosphonate for the treatment of osteolytic bone metastases and hypercalcemia, was studied in mice by whole-body autoradiography and by measuring the 14C activities in various tissues [14C]Clodronate was administered into the tail ...

journal_title：Toxicology and applied pharmacology

authors： Mönkkönen J,Ylitalo P,Elo HA,Airaksinen MM

更新日期：1987-06-30 00:00:00

abstract：:To evaluate the effect of exposure to an environmentally relevant polychlorinated biphenyl mixture, adult male rats were treated with Aroclor 1260 for 7 days and levels of several cytochrome P450 (CYP) enzymes were measured in liver microsomes prepared 3 days after the last dose. Treatment with Aroclor 1260 at dosages...

journal_title：Toxicology and applied pharmacology

authors： Ngui JS,Bandiera SM

更新日期：1999-12-01 00:00:00

abstract：:Chronic exposure to low lead concentration produces hypertension; however, the underlying mechanisms remain unclear. We analyzed the role of oxidative stress, cyclooxygenase-2-dependent pathways and MAPK in the vascular alterations induced by chronic lead exposure. Aortas from lead-treated Wistar rats (1st dose: 10 μg...

journal_title：Toxicology and applied pharmacology

authors： Simões MR,Aguado A,Fiorim J,Silveira EA,Azevedo BF,Toscano CM,Zhenyukh O,Briones AM,Alonso MJ,Vassallo DV,Salaices M

更新日期：2015-03-01 00:00:00

abstract：:Adult BALB/c mice, which are sensitive to hyperoxia (LT50 = 4.5 days 100% O2), were made tolerant to 100% O2 after treatment with butylated hydroxytoluene (BHT). Following a single ip dose of 400 mg/kg, mice survived longer periods in O2 when exposed to O2 at 7, 14, and 21, but not 2 days, following BHT injection. The...

journal_title：Toxicology and applied pharmacology

authors： Margaretten N,Tryka AF,Witschi H

更新日期：1988-10-01 00:00:00

abstract：:Arsenic-contaminated well water has been shown to increase the risk of atherosclerosis. Because of involving S-adenosylmethionine, homocysteine may modify the risk by interfering with the biomethylation of ingested arsenic. In this study, we assessed the effect of plasma homocysteine level and urinary monomethylarsoni...

journal_title：Toxicology and applied pharmacology

authors： Wu MM,Chiou HY,Hsueh YM,Hong CT,Su CL,Chang SF,Huang WL,Wang HT,Wang YH,Hsieh YC,Chen CJ

更新日期：2006-10-01 00:00:00

abstract：:The present study was undertaken to determine the involvement of calcium-protein kinase C pathway in the mechanism of action of Escherichia coli heat stable enterotoxin (STa) apart from STa-induced activation of guanylate cyclase in human colonic carcinoma cell line COLO-205, which was used as a model cultured cell li...

journal_title：Toxicology and applied pharmacology

authors： Gupta DD,Saha S,Chakrabarti MK

更新日期：2005-08-01 00:00:00

abstract：:Components of the herbicide Agent Orange--2,4-dichlorophenoxyacetic acid (2,4,-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) and their esters, and the contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)--and related chemicals were tested for mutagenicity using Salmonella typhimurium strains TA98, TA100, TA1535...

journal_title：Toxicology and applied pharmacology

authors： Mortelmans K,Haworth S,Speck W,Zeiger E

更新日期：1984-08-01 00:00:00

abstract：:Fibrinogen, a soluble 340kDa plasma glycoprotein, is critical in achieving and maintaining hemostasis. Reduced fibrinogen levels are associated with an increased risk of bleeding and recent research has investigated the efficacy of fibrinogen concentrate for controlling perioperative bleeding. European guidelines on t...

journal_title：Toxicology and applied pharmacology

authors： Beyerle A,Nolte MW,Solomon C,Herzog E,Dickneite G

更新日期：2014-10-01 00:00:00

abstract：:The toxicity of 16 metal salts to Chinese hamster ovary (CHO) cells was determined by measuring the cloning efficiency (CE) of CHO cells after exposure to the metals. CHO cells differed by a factor of 10(5) to 10(6) in their toxic response to these metal salts. While Cd(II) was the most toxic ion, Mg(II) exhibited the...

journal_title：Toxicology and applied pharmacology

authors： Tan EL,Williams MW,Schenley RL,Perdue SW,Hayden TL,Turner JE,Hsie AW

更新日期：1984-07-01 00:00:00

abstract：:Allergic contact dermatitis (ACD) is caused by topical exposure to chemical allergens. Keratinocytes play a key role in innate immunity, as well as in ACD progression. The transmembrane Toll-like receptor 4 (TLR4), strongly implicated in skin inflammation, has the ability to bind Damage Associated Molecular Patterns (...

journal_title：Toxicology and applied pharmacology

authors： Kavasi RM,Berdiaki A,Spyridaki I,Papoutsidakis A,Corsini E,Tsatsakis A,Tzanakakis GN,Nikitovic D

更新日期：2019-08-15 00:00:00

abstract：:This study was designed to evaluate the developmental toxicity of nitrazepam (NZ) in Sprague-Dawley rats and ICR mice and to determine the metabolic factors which modulate susceptibility to the developmental effects of NZ. Rats were treated orally with a single dose of NZ at 300 mg/kg on Day 12 of gestation. Mice rece...

journal_title：Toxicology and applied pharmacology

authors： Takeno S,Hirano Y,Kitamura A,Sakai T

更新日期：1993-08-01 00:00:00

abstract：:The effects of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the reproductive system of male offspring rats were examined. The dams were treated subcutaneously 2 weeks prior to mating and throughout mating, pregnancy, and lactation. They received an initial loading dose of 25, 60, or 300 ng TCDD/kg body w...

journal_title：Toxicology and applied pharmacology

authors： Faqi AS,Dalsenter PR,Merker HJ,Chahoud I

更新日期：1998-06-01 00:00:00

abstract：:Data taken from Aberg et al. ((1969) Arch. Environ. Health 19, 478-484) and Miettinen et al. ((1971) Ann. Clin. Res. 3, 116-122) were analyzed by means of models that describe methyl mercury pharmacokinetics in man in terms of parent compound only (Model I) or in terms of parent compound plus metabolite, inorganic mer...

journal_title：Toxicology and applied pharmacology

authors： Smith JC,Farris FF

更新日期：1996-04-01 00:00:00

abstract：:To understand the effect of thuringiensin on the lungs tissues, male Sprague-Dawley rats were administrated with thuringiensin by intratracheal instillation at doses 0.8, 1.6 and 3.2 mg/kg of body weight, respectively. The rats were sacrificed 4 h after treatment, and lungs were isolated and examined. Subsequently, an...

journal_title：Toxicology and applied pharmacology

authors： Tsai SF,Yang C,Liu BL,Hwang JS,Ho SP

更新日期：2006-10-15 00:00:00

abstract：:The present study was conducted to clarify the acute effect of tris(2-chloroethyl)phosphate (TRCP), an organophosphate flame-retardant, on spontaneous ambulatory activity (AA) in male ICR mice and to examine the neurochemical mechanism of this effect. Single dose administration of 200 mg/kg i.p. of TRCP increased AA i...

journal_title：Toxicology and applied pharmacology

authors： Umezu T,Yonemoto J,Soma Y,Suzuki T

更新日期：1998-01-01 00:00:00

abstract：:The effect of T2-toxin on DNA and protein synthesis was investigated, both in vivo and in vitro. For mice which had been submitted to different treatment schedules (single dose, 3-, or 7-day treatment), the rate of DNA and protein biosynthesis was measured in thymus, bone marrow, liver, and spleen cells. T2-toxin inhi...

journal_title：Toxicology and applied pharmacology

authors： Rosenstein Y,Lafarge-Frayssinet C

更新日期：1983-09-15 00:00:00

abstract：:Bobwhite quail were exposed to 2,4-dinitrophenol (DNP) in a respirometer designed to continuously monitor exchange of O2 and CO2, from which metabolic rates (MR) were estimated. After 14-16 days of acclimation to the system (temperature 22 degrees C, light cycle 8L:14D), hens received feed amended with 0, 625, or 1250...

journal_title：Toxicology and applied pharmacology

authors： Dominguez SE,Menkel JL,Fairbrother A,Williams BA,Tanner RW

更新日期：1993-12-01 00:00:00

abstract：:Nutrient availability is one of the major non-genetic factors determining embryonic growth and larval or fetal size. Due to the high human consumption of blood lipid regulators, fibrates have recently been reported as pollutants in rivers. Our study investigated the developmental toxicity of fibrates in zebrafish. Tre...

journal_title：Toxicology and applied pharmacology

authors： Raldúa D,André M,Babin PJ

更新日期：2008-05-01 00:00:00