Glutathione S-transferases of rabbit lung macrophages.

abstract：:Apoptosis was measured in rat alveolar macrophage NR8383 cells challenged in vitro with respirable quartz or kaolin dust and with the dusts pretreated with dipalmitoyl phosphatidylcholine (DPPC) to model conditioning of respired dusts by interaction with a primary phospholipid component of pulmonary surfactant. Quartz...

journal_title：Toxicology and applied pharmacology

authors： Gao N,Keane MJ,Ong T,Ye J,Miller WE,Wallace WE

更新日期：2001-09-15 00:00:00

abstract：:The effect of non-steroidal anti-inflammatory drugs (NSAIDs) on ion channels has been widely studied in several cell models, but less is known about their modulatory mechanisms. In this report, the effect of mefenamic acid on voltage-activated transient outward K(+) current (I(A)) in cultured rat cerebellar granule ce...

journal_title：Toxicology and applied pharmacology

authors： Zhang M,Shi WJ,Fei XW,Liu YR,Zeng XM,Mei YA

更新日期：2008-02-01 00:00:00

abstract：:Data taken from Aberg et al. ((1969) Arch. Environ. Health 19, 478-484) and Miettinen et al. ((1971) Ann. Clin. Res. 3, 116-122) were analyzed by means of models that describe methyl mercury pharmacokinetics in man in terms of parent compound only (Model I) or in terms of parent compound plus metabolite, inorganic mer...

journal_title：Toxicology and applied pharmacology

authors： Smith JC,Farris FF

更新日期：1996-04-01 00:00:00

abstract：:Organic UV filters including benzophenone-3 (BP-3) are widely used to protect humans and materials from damage by UV irradiation. Despite the environmental occurrence of BP-3 in the aquatic environment, little is known about its effects and modes of action. In the present study we assess molecular and physiological ef...

journal_title：Toxicology and applied pharmacology

authors： Blüthgen N,Zucchi S,Fent K

更新日期：2012-09-01 00:00:00

abstract：:Beryllium (Be+2), a divalent metal ion, is toxic to both man and animal. Although the molecular basis for its toxicity is unknown, it is well established that micromolar concentrations of beryllium specifically inhibit certain enzymes. Previous in vitro studies have shown that the presence of ferritin, an iron-storage...

journal_title：Toxicology and applied pharmacology

authors： Lindenschmidt RC,Sendelbach LE,Witschi HP,Price DJ,Fleming J,Joshi JG

更新日期：1986-02-01 00:00:00

abstract：:Pretreatment of male mice of the inbred strains A2G, BALB/c, C57BL/10, and AKR with iron dextran synergized the action of a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 75 micrograms/kg) in causing hepatic porphyria and necrosis 35 days later. There was no effect in DBA/2 mice. Increased porphyrin levels ...

journal_title：Toxicology and applied pharmacology

authors： Greig JB,Francis JE,Kay SJ,Lovell DP,Smith AG

更新日期：1984-06-15 00:00:00

abstract：:The autoradiographic distribution of the toxic heavy metal nickel (Ni) was studied at 4 and 7 days post-coxsackievirus B3 (CB3) infection in Balb/c mice. The distribution of the iv injected 63Ni was studied 10 min, 4 hr, and 24 hr after administration. Results clearly show that the site of 63Ni accumulation is greatly...

journal_title：Toxicology and applied pharmacology

authors： Ilbäck NG,Fohlman J,Friman G

更新日期：1992-05-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is well known for its immunotoxic effects particularly on the thymus. The exact mechanism by which TCDD induces thymic atrophy is not clear. In the current study, we investigated whether TCDD triggers apoptosis in thymocytes, when administered in vivo, by using the TdT-mediat...

journal_title：Toxicology and applied pharmacology

authors： Kamath AB,Xu H,Nagarkatti PS,Nagarkatti M

更新日期：1997-02-01 00:00:00

abstract：:The concentration of mercury in milk and the distribution pattern in the sucking pup was followed over time after administration of a single iv injection of 0.5 mg/kg body wt of 203Hg-labeled methylmercuric chloride or mercuric chloride to lactating mice on Day 10 of lactation. Mercury concentrations in milk of the da...

journal_title：Toxicology and applied pharmacology

authors： Sundberg J,Jönsson S,Karlsson MO,Oskarsson A

更新日期：1999-01-15 00:00:00

abstract：:The distribution of 14C-labeled clodronate (dichloromethylene bisphosphonate), a new bisphosphonate for the treatment of osteolytic bone metastases and hypercalcemia, was studied in mice by whole-body autoradiography and by measuring the 14C activities in various tissues [14C]Clodronate was administered into the tail ...

journal_title：Toxicology and applied pharmacology

authors： Mönkkönen J,Ylitalo P,Elo HA,Airaksinen MM

更新日期：1987-06-30 00:00:00

abstract：:To assess the relevance of previously identified axonal atrophy to hexanedione neuropathy, the present study quantitated fiber size in peripheral nerve of rats intoxicated with 2,5-hexanedione (HD) by either oral ingestion (0.4% in drinking water) or ip injection (0.4 g/kg/day). Prior to the appearance of neurobehavio...

journal_title：Toxicology and applied pharmacology

authors： Lehning EJ,Dyer KS,Jortner BS,LoPachin RM

更新日期：1995-11-01 00:00:00

abstract：:Tetrandrine, an herbal drug, has been employed in China to treat pulmonary fibrosis. To date, the mechanisms governing the antifibrotic action of tetrandrine are unknown. The present study employs a fibroblast mitogenic assay to determine whether tetrandrine directly inhibits the ability of fibroblasts to respond to s...

journal_title：Toxicology and applied pharmacology

authors： Reist RH,Dey RD,Durham JP,Rojanasakul Y,Castranova V

更新日期：1993-09-01 00:00:00

abstract：:The chemical risk assessment process plays an essential role in the potential human health risk evaluation. Setting priorities for this purpose is critical for better use of the available human and material resources. It has been generally accepted that all new chemicals require safety evaluation before manufacture an...

journal_title：Toxicology and applied pharmacology

authors： Alonzo C,Laborde A

更新日期：2005-09-01 00:00:00

abstract：:We investigated the relative contribution of several cardiorespiratory components to acute lethality produced by N-methylcarbamate cholinesterase (ChE) inhibitors physostigmine, 2-sec-butylphenyl methylcarbamate (BPMC), and 2-isopropoxyphenyl methylcarbamate (PHC) in halothane-anesthetized rabbits. Intravenous injecti...

journal_title：Toxicology and applied pharmacology

authors： Futagawa H,Kakinuma Y,Takahashi H

更新日期：2000-05-15 00:00:00

abstract：:Prescribing appropriate Tacrolimus (Tac) dosing is still a challenge for clinicians due to the interindividual variability in dose requirement and the narrow therapeutic index. Our objective is to identify potential factors that affects Tac exposure in Tunisian Kidney patients and to develop and validate a Tac dose re...

journal_title：Toxicology and applied pharmacology

authors： Ben-Fredj N,Hannachi I,Chadli Z,Ben-Romdhane H,A Boughattas N,Ben-Fadhel N,Aouam K

更新日期：2020-11-15 00:00:00

abstract：:Diabetes is known to potentiate thioacetamide (TA)-induced liver injury via enhanced bioactivation. Little attention has been given to the role of compensatory tissue repair on ultimate outcome of hepatic injury in diabetes. The objective of this study was to investigate the effect of diabetes on TA-induced liver inju...

journal_title：Toxicology and applied pharmacology

authors： Wang T,Fontenot RD,Soni MG,Bucci TJ,Mehendale HM

更新日期：2000-07-15 00:00:00

abstract：:CAsE-PE cells are an arsenic-transformed, human prostate epithelial line containing oncogenic mutations in KRAS compared to immortalized, normal KRAS parent cells, RWPE-1. We previously reported increased copy number of mutated KRAS in CAsE-PE cells, suggesting gene amplification. Here, KRAS flanking genomic and trans...

journal_title：Toxicology and applied pharmacology

authors： Merrick BA,Phadke DP,Bostrom MA,Shah RR,Wright GM,Wang X,Gordon O,Pelch KE,Auerbach SS,Paules RS,DeVito MJ,Waalkes MP,Tokar EJ

更新日期：2020-04-25 00:00:00

abstract：:Diurnal patterns of feeding, drinking, locomotor activity, and rearing in male Fischer-344 rats were examined for 2 weeks after a single oral dose of trimethyltin chloride (TMT) at 0, 3, 5, or 7 mg/kg. Body weights and feeding and drinking efficiency ratios (ratios of amount of food or water consumed per unit effort) ...

journal_title：Toxicology and applied pharmacology

authors： Bushnell PJ,Evans HL

更新日期：1985-06-15 00:00:00

abstract：:Cyanide intoxication in mice can be antagonized by the local anesthetic, procaine HCI, either alone or in combination with sodium nitrite and/or sodium thiosulfate. Antitoxic potency, derived from LD50 values, was compared in groups of mice pretreated with sodium nitrite (43.9 mg/kg i.p.), sodium thiosulfate (1 g/kg i...

journal_title：Toxicology and applied pharmacology

authors： Jiang S,Liu Z,Zhuang X

更新日期：1998-05-01 00:00:00

abstract：:The influence of carbon monoxide (CO) on the development of systemic hypertension was studied in Dahl rats selectively bred for susceptibility (DS) and resistance (DR) to NaCl-induced hypertension. This study was designed to examine the interactions among rat line (DS or DR), NaCl content of diet, and exposure to CO. ...

journal_title：Toxicology and applied pharmacology

authors： Shiotsuka RN,Drew RT,Wehner RW

更新日期：1984-11-01 00:00:00

abstract：:Adult cynomolgus monkeys were administered trimethyltin (TMT) iv in dosages ranging from 0.75 to 4.0 mg TMT/kg and observed for behavioral changes. Animals were subsequently killed for light and electron microscopic examination. TMT showed a dose-related toxicity, with high dose animals (4.0 and 3.0 mg/kg) dying withi...

journal_title：Toxicology and applied pharmacology

authors： Reuhl KR,Gilbert SG,Mackenzie BA,Mallett JE,Rice DC

更新日期：1985-07-01 00:00:00

abstract：:The role of metallothionein or metallothionein-like proteins (MT) in genetic resistance to the testicular and hepatic toxicity of cadmium was examined in inbred strains of mice. Mice of two strains resistant (AJ and C3H/HEJ) or susceptible (129J and DBA/2J) to cadmium-induced testicular necrosis were administered sc 3...

journal_title：Toxicology and applied pharmacology

authors： Nolan CV,Shaikh ZA

更新日期：1986-09-15 00:00:00

abstract：:Previous studies in this laboratory have shown that the well-characterized arginine analogue nitric oxide synthase (NOS) inhibitor, l-nitroarginine methyl ester (l-NAME) is protective against the cytotoxicity of the vesicating agent bis (2-chloroethyl) sulphide (HD). Furthermore, these protective effects were not medi...

journal_title：Toxicology and applied pharmacology

authors： Sawyer TW,Hancock JR,D'Agostino PA

更新日期：1998-08-01 00:00:00

abstract：:Skin is the largest and most accessible drug-metabolizing organ. In mammals, it is the competent barrier that protects against exposure to harmful stimuli in the environment and in the systemic circulation. Skin expresses many cytochromes P450 that have critical roles in exogenous and endogenous substrate metabolism. ...

journal_title：Toxicology and applied pharmacology

authors： Du L,Hoffman SM,Keeney DS

更新日期：2004-03-15 00:00:00

abstract：:This study sought to investigate the effects of environmentally relevant gestational followed by continued chronic exposure to the herbicide, atrazine, on motor function, cognition, and neurochemical indices of nigrostriatal dopamine (DA) activity in male rats. Dams were treated with 100 μg/kg atrazine, 10mg/kg atrazi...

journal_title：Toxicology and applied pharmacology

authors： Walters JL,Lansdell TA,Lookingland KJ,Baker LE

更新日期：2015-12-01 00:00:00

abstract：:In the United States the principal environmental exposure to mercury is through dietary consumption of sea food. Although the mechanism by which low levels of mercury affect the nervous system is not well established, epidemiological studies suggest that low level exposure of pregnant women to dietary mercury can adve...

journal_title：Toxicology and applied pharmacology

authors： Gill R,Lanni L,Jen KL,McCabe MJ Jr,Rosenspire A

更新日期：2015-01-01 00:00:00

abstract：:Heavy metals in the environment originate from both human activities and natural processes. Exposure to these metals can result in important changes to immune activity. Depending on the metal and dose, these changes can result in enhanced immune function, diminished immune responses, or altered responses that produce ...

journal_title：Toxicology and applied pharmacology

authors： Lynes MA,Fontenot AP,Lawrence DA,Rosenspire AJ,Pollard KM

更新日期：2006-01-01 00:00:00

abstract：:Cadmium (Cd(2+)) is a widespread environmental pollutant, which is associated with a wide variety of cytotoxic and metabolic effects. Recent studies showed that intoxication with the heavy metal most importantly targets the integrity of the epithelial barrier. In our study, the lung epithelial cell line, NCI H441, was...

journal_title：Toxicology and applied pharmacology

authors： Papritz M,Pohl C,Wübbeke C,Moisch M,Hofmann H,Hermanns MI,Thiermann H,Kirkpatrick CJ,Kehe K

更新日期：2010-06-15 00:00:00

abstract：:Hexachlorobenzene (HCB) induces hepatic porphyria and liver cancer in female rats, whereas toxicity is minimal in male rats. HCB is biotransformed to sulfur-containing metabolites originating from conjugation to glutathione (GSH). This study aimed to assess differences in GSH conjugation of HCB between male and female...

journal_title：Toxicology and applied pharmacology

authors： D'Amour M,Charbonneau M

更新日期：1992-02-01 00:00:00

abstract：:Although the development of a therapeutic strategy for glioblastoma multiforme (GBM), the most aggressive type of brain tumor in adults, is in progress, the prognosis is still limited. In this study, we evaluated the anti-glioma effects of darapladib, a selective reversible inhibitor of lipoprotein-associated phosphol...

journal_title：Toxicology and applied pharmacology

authors： Wang YJ,Chang SB,Wang CY,Huang HT,Tzeng SF

更新日期：2020-09-01 00:00:00