Mutagenicity testing of agent orange components and related chemicals.

abstract：:Juvenile rat toxicity studies with the direct renin inhibitor aliskiren were initiated to support treatment in the pediatric population. In Study 1, aliskiren was administered orally to juvenile rats at doses of 0, 30, 100 or 300 mg/kg/day with repeated dosing from postpartum day (PPD) 8 to PPD 35/36. In-life, clinica...

journal_title：Toxicology and applied pharmacology

authors： Hoffmann P,Beckman D,McLean LA,Yan JH

更新日期：2014-02-15 00:00:00

abstract：:Rats received one or two consecutive daily ip injections, each 0.5 mg Pb2+/100 g body weight, and the kidneys were studied 48 or 24 hr, respectively, after the injection. Renal brush border preparations from Pb2+-treated rats exhibited significant decreases in the activity of alanine aminopeptidase and gamma-glutamyl ...

journal_title：Toxicology and applied pharmacology

authors： Nicholls DM,Teichert-Kuliszewska K,Kuliszewski MJ

更新日期：1983-02-01 00:00:00

abstract：:The issue of Elongated Mineral Particles (EMP) in building materials has been revealed during roadworks in 2013 in France. In fact, road coating aggregates are made of specific rock gravels that can contain Naturally Occurring Asbestos (NOA), which is mainly actinolite. The legislation refers to six regulatory asbesto...

journal_title：Toxicology and applied pharmacology

authors： Leocat E,Rielland C,Letessier P

更新日期：2018-12-15 00:00:00

abstract：:B200 cells are Ni(II)-transformed mouse BALB/c-3T3 fibroblasts displaying a malignant phenotype and increased resistance to Ni(II) toxicity. In an attempt to find genes whose expression has been altered by the transformation, the Atlas Mouse Stress/Toxicology cDNA Expression Array (Clontech Laboratories, Inc., Palo Al...

journal_title：Toxicology and applied pharmacology

authors： Kowara R,Karaczyn A,Cheng RY,Salnikow K,Kasprzak KS

更新日期：2005-05-15 00:00:00

abstract：:Nutrient availability is one of the major non-genetic factors determining embryonic growth and larval or fetal size. Due to the high human consumption of blood lipid regulators, fibrates have recently been reported as pollutants in rivers. Our study investigated the developmental toxicity of fibrates in zebrafish. Tre...

journal_title：Toxicology and applied pharmacology

authors： Raldúa D,André M,Babin PJ

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tiotropium bromide (TB) is a long acting muscarinic receptor antagonist used to manage chronic obstructive pulmonary disease (COPD). Recent meta-analyses suggest an increased risk of cardiovascular events with TB. Ca2+/calmodulin dependent kinase II (CaMKII) and L-type Ca2+ channels regulate Ca2+...

journal_title：Toxicology and applied pharmacology

authors： Cassambai S,Mee CJ,Renshaw D,Hussain A

更新日期：2019-12-01 00:00:00

abstract：:Accumulation, tissue distribution, and depuration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-derived 3H were examined in fingerling yellow perch fed a diet containing 494 ppt of [3H]TCDD for 13 weeks followed by the same diet without TCDD for 13 weeks. None of the TCDD-exposed perch showed any signs of overt toxici...

journal_title：Toxicology and applied pharmacology

authors： Kleeman JM,Olson JR,Chen SM,Peterson RE

更新日期：1986-05-01 00:00:00

abstract：:Tongue cancer is one of the most common oral malignancies. Quisinostat is a histone deacetylase inhibitor with antitumor activity. The aim of this study was to evaluate the effects of quisinostat on the viability of tongue squamous cell carcinoma (TSCC) cells (CAL-27, TCA-8113) in vitro and in vivo. Cell viability, ce...

journal_title：Toxicology and applied pharmacology

authors： Wang X,Liu K,Gong H,Li D,Chu W,Zhao D,Wang X,Xu D

更新日期：2021-01-01 00:00:00

abstract：:Dietary 2(3)-tert-butyl-4-hydroxyanisole (BHA) treatment has been shown to increase hepatic glutathione (GSH) content in rats and mice. Subsequent studies in our laboratory have demonstrated that hepatic gamma-glutamylcysteine synthetase (GCS) activity is increased in mice treated with dietary BHA. To test whether thi...

journal_title：Toxicology and applied pharmacology

authors： Borroz KI,Buetler TM,Eaton DL

更新日期：1994-05-01 00:00:00

abstract：:Distance learning offers many advantages to students and teachers of almost any scientific discipline. Toxicology is no exception. For example, should Paracelsus be interested in learning more about toxicology at Drexel University, he would have the opportunity to take two courses in this subject utilizing the content...

journal_title：Toxicology and applied pharmacology

authors： Huggins J,Morris J,Peterson CE

更新日期：2005-09-01 00:00:00

abstract：:Glyphosate (GLY) usage for weed control is extensive. To investigate ovarian impacts of chronic GLY exposure, female C57BL6 mice were orally administered saline as vehicle control (CT) or GLY at 0.25 (G0.25), 0.5 (G0.5), 1.0 (G1.0), 1.5 (G1.5), or 2 (G2.0) mg/kg for five days per wk. for 20 wks. Feed intake increased ...

journal_title：Toxicology and applied pharmacology

authors： Ganesan S,Keating AF

更新日期：2020-09-01 00:00:00

abstract：:Previous studies from this laboratory have demonstrated that the addition of methyl groups at the 3 and 4 positions of the 2,5-hexanedione (2,5-HD) molecule results both in more rapid pyrrole formation and in enhanced neurotoxicity. In order to define more clearly the relationship between rates of pyrrole formation an...

journal_title：Toxicology and applied pharmacology

authors： Genter MB,Szakál-Quin G,Anderson CW,Anthony DC,Graham DG

更新日期：1987-02-01 00:00:00

abstract：:In three separate sets of studies, the effects of ureteral ligation and coadministration of cadmium with cysteine or glutathione (GSH) (in either a 4:1 or 2:1 ratio of thiol to cadmium) on the renal disposition of cadmium were assessed in rats 1 h after the administration of cadmium. In all experiments, co-administrat...

journal_title：Toxicology and applied pharmacology

authors： Zalups RK

更新日期：2000-04-01 00:00:00

abstract：:To determine if inhaled nephrotoxic branched and nonnephrotoxic straight chain alkanes differ substantially in their biological fate, male F344 rats were exposed to 14C-labeled isooctane and octane vapors at approximately 1 and 350 ppm by the nose-only mode for 2 hr. Radioactivity in exhalant, urine, and feces was det...

journal_title：Toxicology and applied pharmacology

authors： Dahl AR

更新日期：1989-09-01 00:00:00

abstract：:Radiolabeled 1-naphthyl-beta-D-glucuronide and 1-naphthyl-beta-D-glucoside were synthesized from 1-[14C]naphthol. The fate of the three compounds in male mice was studied. After a po dose of 45 mg/kg of 1-naphthol, 100 mg/kg of 1-naphthyl glucuronide, and 100 mg/kg of 1-naphthyl glucoside, 95, 93, and 81%, respectivel...

journal_title：Toxicology and applied pharmacology

authors： Chern WH,Dauterman WC

更新日期：1983-03-15 00:00:00

abstract：:This study was undertaken to characterize the long-term toxic and carcinogenic potential of a polybrominated biphenyl (PBB) mixture in rats and mice of both sexes. Fischer 344 rats and B6C3F1 mice were given 125 po doses of PBB over a 6-month period at 0 (control), 0.1, 0.3, 1.0, 3.0, and 10.0 mg/kg body weight/day (5...

journal_title：Toxicology and applied pharmacology

authors： Gupta BN,McConnell EE,Moore JA,Haseman JK

更新日期：1983-03-30 00:00:00

abstract：:Traditional predictive tests for dermal sensitization in humans use the albino guinea pig as a model. A number of factors make the prospect of an alternative attractive. Guinea pig designs are labor intensive, require significant animal, caging, and husbandry resources, and are expensive. Extensive development and val...

journal_title：Toxicology and applied pharmacology

authors： Gad SC,Dunn BJ,Dobbs DW,Reilly C,Walsh RD

更新日期：1986-06-15 00:00:00

abstract：:Diesel exhaust particles (DEPs) cause many adverse health problems, and reports indicate increased risk of breast cancer in men and women through exposure to gasoline and vehicle exhaust. However, DEPs include vast numbers of compounds, and the specific compound(s) responsible for these actions are not clear. We recen...

journal_title：Toxicology and applied pharmacology

authors： Furuta C,Suzuki AK,Watanabe G,Li C,Taneda S,Taya K

更新日期：2008-08-01 00:00:00

abstract：:A single, intravenous administration of a low dose of monocrotaline pyrrole (MCTP), a derivative of the pyrrolizidine alkaloid monocrotaline (MCT), induces progressive pulmonary hypertension and right ventricular hypertrophy (RVH) in rats. The temporal relationship between morphologic alterations, biochemical markers ...

journal_title：Toxicology and applied pharmacology

authors： Reindel JF,Ganey PE,Wagner JG,Slocombe RF,Roth RA

更新日期：1990-11-01 00:00:00

abstract：:Tissue factor (TF) is involved not only in the progression of atherosclerosis and other cardiovascular diseases, but is also associated with tumor growth, metastasis, and angiogenesis and hence may be an attractive target for directed cancer therapeutics. Gynostemma pentaphyllum (GP) is widely used in the treatment of...

journal_title：Toxicology and applied pharmacology

authors： Huang TH,Tran VH,Roufogalis BD,Li Y

更新日期：2007-01-01 00:00:00

abstract：:Experiments were conducted to study the acute and subacute effects of intramuscularly injected T-2 toxin in rats and rabbits. The LD50 values of T-2 toxin were 0.85 +/- 0.03 and 1.10 +/- 0.08 mg/kg body wt in rats and rabbits, respectively. The intoxication was characterized by a consistent decrease in serum alkaline ...

journal_title：Toxicology and applied pharmacology

authors： Chan PK,Gentry PA

更新日期：1984-05-01 00:00:00

abstract：:Sibutramine is an inhibitor of norepinephrine and 5-HT reuptake largely used in the management of obesity. Although a fairly safe drug, postmarketing adverse effects of sibutramine were reported including abnormal ejaculation in men. This study investigates the effects of sibutramine on ejaculation and vas deferens an...

journal_title：Toxicology and applied pharmacology

authors： Nojimoto FD,Piffer RC,Kiguti LR,Lameu C,de Camargo AC,Pereira OC,Pupo AS

更新日期：2009-09-15 00:00:00

abstract：:A negative regulatory element (NRE1; position -794 to -774) was previously identified that mediates the downregulation of CYP1A1, including partial suppression of Ah receptor-dependent induction. The CCAAT-box binding protein, nuclear factor-Y (NF-Y), is a component of one of two protein complexes that specifically an...

journal_title：Toxicology and applied pharmacology

authors： Poch MT,Al-Kassim L,Smolinski SM,Hines RN

更新日期：2004-09-15 00:00:00

abstract：:Contamination of animal feed with mycotoxins is a major problem for fish feed mainly due to usage of contaminated ingredients for production and inappropriate storage of feed. The use of cereals for fish food production further increases the risk of a potential contamination. Potential contaminants include the mycotox...

journal_title：Toxicology and applied pharmacology

authors： Pietsch C,Bucheli TD,Wettstein FE,Burkhardt-Holm P

更新日期：2011-10-01 00:00:00

abstract：:Oral administration of dimethylarsinic acid (DMAA), a major metabolite of inorganic arsenics, induces DNA damage in the mouse and rat lung due to both active oxygens and dimethylarsenic peroxyl radical produced in the metabolism of DMAA. Our paper describes the cellular response to DMAA in the mouse lung. In male ICR ...

journal_title：Toxicology and applied pharmacology

authors： Yamanaka K,Hasegawa A,Sawamura R,Okada S

更新日期：1991-04-01 00:00:00

abstract：:Since amitriptyline is a very frequently prescribed antidepressant drug, it is not surprising that amitriptyline toxicity is relatively common. Amitriptyline toxic systemic effects include cardiovascular, autonomous nervous, and central nervous systems. To understand the mechanisms of amitriptyline toxicity we studied...

journal_title：Toxicology and applied pharmacology

authors： Cordero MD,Moreno-Fernández AM,Gomez-Skarmeta JL,de Miguel M,Garrido-Maraver J,Oropesa-Avila M,Rodríguez-Hernández A,Navas P,Sánchez-Alcázar JA

更新日期：2009-03-15 00:00:00

abstract：:In the present study we have examined the effects of hydrocarbons on the formation of reactive oxygen species (ROS) in human neutrophil granulocytes in vitro. We found that hydrocarbons induce ROS formation in a concentration-dependent manner and that the ROS-inducing potency increases with increasing number of carbon...

journal_title：Toxicology and applied pharmacology

authors： Dreiem A,Myhre O,Fonnum F

更新日期：2003-07-15 00:00:00

abstract：:In an earlier study, we exposed nine healthy volunteers to known concentrations of mercury (Hg) vapor in air (median 399; range 365-430 micrograms/m3) for 15 min during light physical exercise (50 W) (Sandborgh-Englund, G., et al., Toxicol. Appl. Pharmacol. 150, 146-153, 1998). Exhaled air, urine, and plasma samples w...

journal_title：Toxicology and applied pharmacology

authors： Jonsson F,Sandborgh-Englund G,Johanson G

更新日期：1999-03-01 00:00:00

abstract：:Celecoxib, an inhibitor of cyclooxygenase-2, is being investigated for enhancement of chemotherapy efficacy in cancer clinical trials. This study investigates the ability of cyclooxygenase-2 inhibitors to sensitize cells from different origins to several chemotherapeutic agents. The effect of the drug's mechanism of a...

journal_title：Toxicology and applied pharmacology

authors： El-Awady RA,Saleh EM,Ezz M,Elsayed AM

更新日期：2011-09-15 00:00:00

abstract：:Endosulfan is an organochlorine pesticide commonly used in agriculture. Endosulfan has affects on vertebrate xenobiotic metabolism pathways that may be mediated, in part, by its ability to activate the pregnane X receptor (PXR) and/or the constitutive androstane receptor (CAR) which can elevate expression of cytochrom...

journal_title：Toxicology and applied pharmacology

authors： Casabar RC,Das PC,Dekrey GK,Gardiner CS,Cao Y,Rose RL,Wallace AD

更新日期：2010-06-15 00:00:00