Abstract：
:The distribution of 14C-labeled clodronate (dichloromethylene bisphosphonate), a new bisphosphonate for the treatment of osteolytic bone metastases and hypercalcemia, was studied in mice by whole-body autoradiography and by measuring the 14C activities in various tissues [14C]Clodronate was administered into the tail vein, and its distribution was followed from 5 min to 90 days after the injection. The drug disappeared promptly from the plasma and accumulated intensively in the bone and moderately in the spleen. In both tissues, relatively high radioactivities were measured as late as 90 days after the [14C]clodronate administration. Small amounts of 14C activity were also detected in the liver for 90 days. The results agree well with the previous observations that bisphosphonates deposit rapidly in the bone. Our findings indicate further that clodronate accumulates in the bone and the spleen for several months.
journal_name
Toxicol Appl Pharmacoljournal_title
Toxicology and applied pharmacologyauthors
Mönkkönen J,Ylitalo P,Elo HA,Airaksinen MMdoi
10.1016/0041-008x(87)90050-0subject
Has Abstractpub_date
1987-06-30 00:00:00pages
287-92issue
2eissn
0041-008Xissn
1096-0333journal_volume
89pub_type
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journal_title：Toxicology and applied pharmacology
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journal_title：Toxicology and applied pharmacology
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