Potentiation of the toxicity of model hepatotoxicants by acetaminophen.

abstract：:In the present study the promoting activity of various PCB and PBB isomers and congeners in rat liver has been studied and compared with a variety of primary xenobiotic-mediated enzymatic changes in this target organ. Female Wistar rats were given diethylnitrosamine (DEN; 10 mg/kg body wt for 10 days) and were subsequ...

journal_title：Toxicology and applied pharmacology

authors： Buchmann A,Ziegler S,Wolf A,Robertson LW,Durham SK,Schwarz M

更新日期：1991-12-01 00:00:00

abstract：:Antrodia camphorata (A. camphorata) is a fungus commonly used for treatment of viral hepatitis and cancer in Chinese folk medicine. Extract of A. camphorate is reported to possess anti-inflammatory, antihepatitis B virus and anticancer activities. In this study, we tested the in vivo effects of polysaccharides derived...

journal_title：Toxicology and applied pharmacology

authors： Cheng PC,Hsu CY,Chen CC,Lee KM

更新日期：2008-03-01 00:00:00

abstract：:Air pollution, especially fine particulate matter (PM2.5, particles <2.5 μm in size), induces adverse health effects on the respiratory system. Uncontrolled proliferation of bronchial epithelial cells, resulting from deregulated cell cycle progression, contributes to pulmonary homeostatic imbalance. Although dysregula...

journal_title：Toxicology and applied pharmacology

authors： Xiao T,Ling M,Xu H,Luo F,Xue J,Chen C,Bai J,Zhang Q,Wang Y,Bian Q,Liu Q

更新日期：2019-08-15 00:00:00

abstract：:Neonatal and adult rats (1, 2, 3, 6, and 12 weeks of age) were given five daily oral doses of di(2-ethylhexyl) phthalate (DEHP) (0, 10, 100, 1000, 2000 mg/kg) and histological changes in the testes were examined 24 hr after the last dose. Relative testis weights were reduced at doses of 1000 mg/kg in 1, 2, 3, and 6-we...

journal_title：Toxicology and applied pharmacology

authors： Dostal LA,Chapin RE,Stefanski SA,Harris MW,Schwetz BA

更新日期：1988-08-01 00:00:00

abstract：:While the effect that TCDD has on humoral immunity has been well documented for the mouse, it has not been for the rat. In this study, the effect that TCDD has on the antibody plaque-forming cell (PFC) response to sheep red blood cells (SRBC) in adult female B6C3F1 mice and F344 rats was compared. The effect that TCDD...

journal_title：Toxicology and applied pharmacology

authors： Smialowicz RJ,Riddle MM,Williams WC,Diliberto JJ

更新日期：1994-02-01 00:00:00

abstract：:Chloroform is a nongenotoxic-cytotoxic liver and kidney carcinogen and nasal toxicant in some strains and sexes of rodents. Substantial evidence indicates that tumor induction is secondary to events associated with cytolethality and regenerative cell proliferation. Therefore, pathways leading to toxicity, such as meta...

journal_title：Toxicology and applied pharmacology

authors： Constan AA,Sprankle CS,Peters JM,Kedderis GL,Everitt JI,Wong BA,Gonzalez FL,Butterworth BE

更新日期：1999-10-15 00:00:00

abstract：:Interleukin-6 (IL-6) is a central mediator of immunotoxicity that is associated with exposure to the trichothecene vomitoxin (VT). The purpose of this investigation was to test the hypothesis that the inducible cyclooxygenase-2 (COX-2) and its metabolites contribute to VT-induced IL-6 upregulation. VT at 100 to 250 ng...

journal_title：Toxicology and applied pharmacology

authors： Moon Y,Pestka JJ

更新日期：2003-03-01 00:00:00

abstract：:Three major enzyme systems have been shown to metabolize epoxidized xenobiotics in vertebrate tissues, and this study demonstrates that these enzyme systems can be differentially induced. The cytosolic epoxide hydrolase activity was routinely monitored with trans-beta-ethylstyrene oxide, the microsomal epoxide hydrola...

journal_title：Toxicology and applied pharmacology

authors： Hammock BD,Ota K

更新日期：1983-11-01 00:00:00

abstract：:Numbers of engineered nanomaterials (ENMs) are steadily increasing. Therefore, alternative testing approaches with reduced costs and high predictivity suitable for high throughput screening and prioritization are urgently needed to ensure a fast and effective development of safe products. In parallel, extensive resear...

journal_title：Toxicology and applied pharmacology

authors： Riebeling C,Wiemann M,Schnekenburger J,Kuhlbusch TA,Wohlleben W,Luch A,Haase A

更新日期：2016-05-15 00:00:00

abstract：:Electrophiles, ubiquitously found in the environment, modify thiol groups of sensor proteins, leading to activation of redox signaling pathways such as the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor E2 related factor 2 (Nrf2) pathway. Nrf2 activation by exposure to single electrophiles has been establi...

journal_title：Toxicology and applied pharmacology

authors： Abiko Y,Aoki H,Kumagai Y

更新日期：2021-01-09 00:00:00

abstract：:Diclofenac, a widely used nonsteroidal anti-inflammatory drug, has been associated with rare but severe cases of clinical hepatotoxicity. Diclofenac causes concentration-dependent cell death in human hepatocytes (after 24-48 h) by mitochondrial permeabilization via poorly defined mechanisms. To explore whether the cyc...

journal_title：Toxicology and applied pharmacology

authors： Siu WP,Pun PB,Latchoumycandane C,Boelsterli UA

更新日期：2008-03-15 00:00:00

abstract：:This study was conducted to evaluate UDP-glucuronosyl-transferase (UDP-GT) activity, UDP-glucuronic acid (UDP-GA) concentration, and UDP-glucose (UDPG) concentration in the rat intestine and liver following oral administration of butylated hydroxyanisole (BHA), benzo[a]pyrene (BaP), 3-methylcholanthrene (3MC), phenoba...

journal_title：Toxicology and applied pharmacology

authors： Goon D,Klaassen CD

更新日期：1992-08-01 00:00:00

abstract：:The neuroblastoma-spinal motor neuron fusion cell line, NSC-34, in its differentiated form, NSC-34D, permits examining the effects of riluzole, a proven treatment for amyotrophic lateral sclerosis (ALS) on cell death induction by staurosporine (STS), thapsigargin (Thaps), hydrogen peroxide (H(2)O(2)) and homocysteine ...

journal_title：Toxicology and applied pharmacology

authors： Hemendinger RA,Armstrong EJ 3rd,Radio N,Brooks BR

更新日期：2012-01-15 00:00:00

abstract：:The immunosuppressive synthetic methylated polycyclic aromatic hydrocarbon (PAH), 7,12-dimethylbenz[a]anthracene (DMBA), has been shown to cause both an immediate and a sustained elevation of free intracellular calcium (Ca2+) in human T cells. In the present studies, a series of anthracene- and pyrene-based PAHs were ...

journal_title：Toxicology and applied pharmacology

authors： Krieger JA,Born JL,Burchiel SW

更新日期：1994-08-01 00:00:00

abstract：:Exposure to excessive manganese (Mn) levels leads to neurotoxicity, referred to as manganism, which resembles Parkinson's disease (PD). Manganism is caused by neuronal injury in both cortical and subcortical regions, particularly in the basal ganglia. The basis for the selective neurotoxicity of Mn is not yet fully un...

journal_title：Toxicology and applied pharmacology

authors： Milatovic D,Gupta RC,Yu Y,Zaja-Milatovic S,Aschner M

更新日期：2011-11-01 00:00:00

abstract：:Arsenic trioxide (ATO) has been reported to inhibit the activity of Ten-eleven translocation methylcytosine dioxygenase (TET). TET modulates FOXP3 expression, while dysregulation of FOXP3 expression promotes the malignant progression of leukemia cells. We examined the role of TET-FOXP3 axis in the cytotoxic effects of...

journal_title：Toxicology and applied pharmacology

authors： Chen YJ,Huang CH,Shi YJ,Lee YC,Wang LJ,Chang LS

更新日期：2018-11-01 00:00:00

abstract：:Apocynin (acetovanillone) is often used as a specific inhibitor of NADPH oxidase. In N11 glial cells, apocynin induced, in a dose-dependent way, a significant increase of both malonyldialdehyde level (index of lipid peroxidation) and lactate dehydrogenase release (index of a cytotoxic effect). Apocynin evoked also, in...

journal_title：Toxicology and applied pharmacology

authors： Riganti C,Costamagna C,Bosia A,Ghigo D

更新日期：2006-05-01 00:00:00

abstract：:We report that there is a time-related change in the phospholipase C (PLC) activities of rat brain cytosol and membrane fractions after iv injection of a soman-like or a sarin-like organophosphorous agent (bis(isopropyl methyl)phosphonate [BIMP] and bis(pinacolyl methyl)phosphonate [BPMP]). PLCgamma was activated in t...

journal_title：Toxicology and applied pharmacology

authors： Niijima H,Nagao M,Nakajima M,Takatori T,Matsuda Y,Iwase H,Kobayashi M

更新日期：1999-04-01 00:00:00

abstract：:Sulfur mustard (SM) is a chemical warfare agent that targets skin where it induces large blisters. DNA alkylation is a critical step to explain SM-induced cutaneous symptoms. We determined the kinetics of formation of main SM-DNA adducts and compare it with the development of the SM-induced pathogenesis in skin. SKH-1...

journal_title：Toxicology and applied pharmacology

authors： Batal M,Boudry I,Mouret S,Wartelle J,Emorine S,Bertoni M,Bérard I,Cléry-Barraud C,Douki T

更新日期：2013-12-15 00:00:00

abstract：:The effect of HgCl2 on kainate (KA)-induced depression of voltage-gated potassium (K+) current in chick embryo telencephalic cells was studied using conventional and nystatin-perforated whole-cell patch-clamp recordings, fluorescence imaging, and flow cytometry techniques. Hg2+ (1 microM) alone did not effect the 4-am...

journal_title：Toxicology and applied pharmacology

authors： Dyatlov VA,Platoshin AV,Lawrence DA,Carpenter DO

更新日期：1996-06-01 00:00:00

abstract：:Aromatase is the only enzyme in vertebrates to catalyze the biosynthesis of estrogens. Although inhibitors of aromatase have been developed for the treatment of estrogen-dependent breast cancer, the whole-body inhibition of aromatase causes severe adverse effects. Thus, tissue-selective aromatase inhibitors are import...

journal_title：Toxicology and applied pharmacology

authors： Guo J,Yuan Y,Lu D,Du B,Xiong L,Shi J,Yang L,Liu W,Yuan X,Zhang G,Wang F

更新日期：2014-08-15 00:00:00

abstract：:High- and low- Se diets received by dams during gestation and lactation are related to insulin resistance in their pups. High-Se diet leads to an increase in serum insulin levels, which does not function properly, and an anabolic process. Low-Se diet is related to very low insulin values and an extreme catabolic energ...

journal_title：Toxicology and applied pharmacology

authors： Ojeda ML,Carreras O,Díaz-Castro J,Murillo ML,Nogales F

更新日期：2019-11-01 00:00:00

abstract：:It has been recently recognized that the gut microbiota, the community of organisms living within the gastrointestinal tract is an integral part of the human body, and that its genoma (the microbiome) interacts with the genes expressed by the cells of the host organism. Several important physiological functions requir...

journal_title：Toxicology and applied pharmacology

authors： Pietroiusti A,Magrini A,Campagnolo L

更新日期：2016-05-15 00:00:00

abstract：:Exposure to the potent tumor promoter 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) or related agonists of the aryl hydrocarbon receptor (AhR) can result in hepatocarcinogenesis in rodents. Changes in the expression and/or the level of growth factors may be a critical event in TCDD-mediated hepatocarcinogenesis. In this...

journal_title：Toxicology and applied pharmacology

authors： Riebniger D,Schrenk D

更新日期：1998-09-01 00:00:00

abstract：:Methyl bromide is used as a disinfectant to fumigate soil and a wide range of stored food commodities in warehouses and mills. Human exposure occurs during the manufacture and use of the chemical. The purpose of this investigation was to determine the disposition and metabolism of [14C]methyl bromide in rats after inh...

journal_title：Toxicology and applied pharmacology

authors： Bond JA,Dutcher JS,Medinsky MA,Henderson RF,Birnbaum LS

更新日期：1985-04-01 00:00:00

abstract：:The present study was undertaken to determine the involvement of calcium-protein kinase C pathway in the mechanism of action of Escherichia coli heat stable enterotoxin (STa) apart from STa-induced activation of guanylate cyclase in human colonic carcinoma cell line COLO-205, which was used as a model cultured cell li...

journal_title：Toxicology and applied pharmacology

authors： Gupta DD,Saha S,Chakrabarti MK

更新日期：2005-08-01 00:00:00

abstract：:Bromocriptine (Bc) produces pituitary tumoral mass regression which induces the cellular death that was classically described as apoptosis. However, recent works have related that other mechanisms of cell death could also be involved in the maintenance of physiological and pathological pituitary homeostasis. The aim o...

journal_title：Toxicology and applied pharmacology

authors： Palmeri CM,Petiti JP,Sosa Ldel V,Gutiérrez S,De Paul AL,Mukdsi JH,Torres AI

更新日期：2009-10-01 00:00:00

abstract：:Luteolin, a flavonoid that exhibits antioxidative properties, exerts myocardial protection effects. However, the underlying molecular mechanisms are not yet fully understood. To investigate the effects of luteolin on myocardial injury protection and its possible mechanisms, a myocardial injury model was established wi...

journal_title：Toxicology and applied pharmacology

authors： Sun GB,Sun X,Wang M,Ye JX,Si JY,Xu HB,Meng XB,Qin M,Sun J,Wang HW,Sun XB

更新日期：2012-12-01 00:00:00

abstract：:The local lymph node assay (LLNA) is a new and promising test in mice used to identify contact allergens by means of dermal exposure. Experimentally this assay, which comprises a sensitizing phase only, is also used to identify respiratory allergens. Another, experimentally used test in mice to identify allergens is a...

journal_title：Toxicology and applied pharmacology

authors： Vandebriel RJ,De Jong WH,Spiekstra SW,Van Dijk M,Fluitman A,Garssen J,Van Loveren H

更新日期：2000-01-15 00:00:00

abstract：:Organic chemicals such as jet fuels and solvents can cause skin irritation after dermal exposure. The molecular responses to these chemicals resulting in acute irritation are not understood well enough to establish safe exposure limits. Male F-344 rats were dermally exposed to JP-8 jet fuel for 1 h using Hill Top Cham...

journal_title：Toxicology and applied pharmacology

authors： Kabbur MB,Rogers JV,Gunasekar PG,Garrett CM,Geiss KT,Brinkley WW,McDougal JN

更新日期：2001-08-15 00:00:00