Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity and lymphocyte subpopulations: differences between mice and rats.

abstract：:The effect of tamoxifen on Ca(2+) signaling and viability in Madin Darby canine kidney (MDCK) cells was investigated by using fura-2 as a Ca(2+) probe. Tamoxifen evoked a rise in cytosolic free Ca(2+) levels ([Ca(2+)](i)) concentration-dependently between 1 and 50 microM with an EC50 of 10 microM. The response was dec...

journal_title：Toxicology and applied pharmacology

authors： Jan CR,Cheng JS,Chou KJ,Wang SP,Lee KC,Tang KY,Tseng LL,Chiang HT

更新日期：2000-10-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor which plays a role in the development of multiple tissues and is activated by a large number of ligands, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In order to examine the roles of the AHR in both normal biological development an...

journal_title：Toxicology and applied pharmacology

authors： Harrill JA,Hukkanen RR,Lawson M,Martin G,Gilger B,Soldatow V,Lecluyse EL,Budinsky RA,Rowlands JC,Thomas RS

更新日期：2013-10-15 00:00:00

abstract：:T-2 toxin, a trichothecene mycotoxin, is a potently cytotoxic and immunosuppressive secondary metabolite produced by Fusarium fungi. Young male white Swiss mice were fed a diet supplemented with T-2 toxin at levels of 5, 10, or 20 ppm, control diet ad libitum, or control diet at a restricted rate for 1, 2, 3, 4, and 6...

journal_title：Toxicology and applied pharmacology

authors： Friend SC,Babiuk LA,Schiefer HB

更新日期：1983-06-30 00:00:00

abstract：:This study assessed the role of aryl hydrocarbon receptor (AHR) affinity, and cytochrome P4501A (CYP1A) protein and activity in polyaromatic hydrocarbon (PAH)-induced oxidative stress. In the 1-100nM concentration range benzo[a]pyrene (BaP) but not benzo[e]pyrene (BeP) competitively displaced 2nM [(3)H]2, 3, 7, 8-tetr...

journal_title：Toxicology and applied pharmacology

authors： Curtis LR,Garzon CB,Arkoosh M,Collier T,Myers MS,Buzitis J,Hahn ME

更新日期：2011-07-01 00:00:00

abstract：:To assess aluminum toxicity to the A1-exposed lactating organism and her suckling offspring, lactating rabbits received 20, sc, A1 lactate injections (0, 25, 100, 400, or 800 mumol A1/kg/inj) between Days 4 and 29 postpartum. Offspring were weaned Day 30 postpartum. Weight gain in the first 12 postnatal weeks was slig...

journal_title：Toxicology and applied pharmacology

authors： Yokel RA

更新日期：1984-08-01 00:00:00

abstract：:Engineered nanomaterials are being developed for a variety of technological applications. However, the increasing use of nanomaterials in society has led to concerns about their potential adverse effects on human health and the environment. During the first decade of nanotoxicological research, the realization has eme...

journal_title：Toxicology and applied pharmacology

authors： Costa PM,Fadeel B

更新日期：2016-05-15 00:00:00

abstract：:It was previously shown that treatment of rats with methyl-n-butyl ketone (MBK) produced an increase in the total level of liver microsomal cytochromes P-450 and an increase in the rate of metabolism of chloroform (CHCl3) to phosgene (COCl2). In the present study it was found that MBK also produced qualitative changes...

journal_title：Toxicology and applied pharmacology

authors： Branchflower RV,Schulick RD,George JW,Pohl LR

更新日期：1983-12-01 00:00:00

abstract：:Technical grade dinitrotoluene (DNT) is hepatocarcinogenic when fed to rats. DNT is oxidatively metabolized by hepatic enzymes and reductively metabolized by rat intestinal microflora in vitro. The objectives of the present studies were to determine the importance of bile as a route of excretion for DNT metabolites an...

journal_title：Toxicology and applied pharmacology

authors： Medinsky MA,Dent JG

更新日期：1983-05-01 00:00:00

abstract：:St. John's wort (SJW, Hypericum perforatum) is one of the popular nutraceuticals for treating depression. Methotrexate (MTX) is an immunosuppressant with narrow therapeutic window. This study investigated the effect of SJW on MTX pharmacokinetics in rats. Rats were orally given MTX alone and coadministered with 300 an...

journal_title：Toxicology and applied pharmacology

authors： Yang SY,Juang SH,Tsai SY,Chao PD,Hou YC

更新日期：2012-08-15 00:00:00

abstract：:We investigated the relative contribution of several cardiorespiratory components to acute lethality produced by N-methylcarbamate cholinesterase (ChE) inhibitors physostigmine, 2-sec-butylphenyl methylcarbamate (BPMC), and 2-isopropoxyphenyl methylcarbamate (PHC) in halothane-anesthetized rabbits. Intravenous injecti...

journal_title：Toxicology and applied pharmacology

authors： Futagawa H,Kakinuma Y,Takahashi H

更新日期：2000-05-15 00:00:00

abstract：:In an earlier study, we exposed nine healthy volunteers to known concentrations of mercury (Hg) vapor in air (median 399; range 365-430 micrograms/m3) for 15 min during light physical exercise (50 W) (Sandborgh-Englund, G., et al., Toxicol. Appl. Pharmacol. 150, 146-153, 1998). Exhaled air, urine, and plasma samples w...

journal_title：Toxicology and applied pharmacology

authors： Jonsson F,Sandborgh-Englund G,Johanson G

更新日期：1999-03-01 00:00:00

abstract：:A comparative test in mice for pulmonary toxicity between butylated hydroxytoluene (2,6-di-tert.-butyl-4-methylphenol, BHT) and 2,6-di-tert.-butyl-4-[alpha, alpha, alpha-2H3]methylphenol (BHT-d3) showed a significantly lower toxic potency of the latter. The rate of in vitro BHT metabolism to 2,6-di-tert.-butyl-4-methy...

journal_title：Toxicology and applied pharmacology

authors： Mizutani T,Yamamoto K,Tajima K

更新日期：1983-06-30 00:00:00

abstract：:Diabetes is known to potentiate thioacetamide (TA)-induced liver injury via enhanced bioactivation. Little attention has been given to the role of compensatory tissue repair on ultimate outcome of hepatic injury in diabetes. The objective of this study was to investigate the effect of diabetes on TA-induced liver inju...

journal_title：Toxicology and applied pharmacology

authors： Wang T,Fontenot RD,Soni MG,Bucci TJ,Mehendale HM

更新日期：2000-07-15 00:00:00

abstract：:The anticancer drug ellipticine exerts its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes. The present study has examined the role of cytochrome P450 oxidoreductase (POR) and cytochrome b5 (Cyb5), electron donors to P450 enzymes, in the CYP-mediated metabolism and disposition of elliptic...

journal_title：Toxicology and applied pharmacology

authors： Reed L,Indra R,Mrizova I,Moserova M,Schmeiser HH,Wolf CR,Henderson CJ,Stiborova M,Phillips DH,Arlt VM

更新日期：2019-03-01 00:00:00

abstract：:To study the interaction of retinoid-induced limb defects and cleft palate on day 11 of gestation, a RXR-selective agonist (AGN191701, an arylpropenyl-thiophene-carboxylic acid derivative, 20 mg/kg orally) was coadministered with a RARalpha-agonist (Am580, an arylcarboxamidobenzoic acid derivative, 5 mg/kg orally) to ...

journal_title：Toxicology and applied pharmacology

authors： Elmazar MM,Rühl R,Nau H

更新日期：2001-01-01 00:00:00

abstract：:A recent report showed that the unfolded protein response (UPR) signaling was activated in the pathogenesis of carbon tetrachloride (CCl(4))-induced hepatic fibrosis. Phenylbutyric acid (PBA) is a well-known chemical chaperone that inhibits endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signalin...

journal_title：Toxicology and applied pharmacology

authors： Wang JQ,Chen X,Zhang C,Tao L,Zhang ZH,Liu XQ,Xu YB,Wang H,Li J,Xu DX

更新日期：2013-01-15 00:00:00

abstract：:The farnesoid X receptor (FXR) is a bile acid-activated transcription factor belonging to the nuclear receptor superfamily. FXR deficiency in mice results in cholestasis, metabolic disorders, and tumorigenesis in liver and intestine. FXR is known to contribute to pathogenesis by regulating gene transcription; however,...

journal_title：Toxicology and applied pharmacology

authors： Zhu Y,Li G,Dong Y,Zhou HH,Kong B,Aleksunes LM,Richardson JR,Li F,Guo GL

更新日期：2013-01-15 00:00:00

abstract：:The mechanisms of action of o,p'-DDD on adrenal steroidogenesis were investigated in vitro in rainbow trout (Oncorhynchus mykiss). Acute exposures to o,p'-DDD inhibited ACTH-stimulated cortisol secretion while cell viability decreased significantly only at the highest concentration tested (200 microM o,p'-DDD). Stimul...

journal_title：Toxicology and applied pharmacology

authors： Lacroix M,Hontela A

更新日期：2003-08-01 00:00:00

abstract：:In transgenic zebrafish (Danio rerio), green fluorescent protein (GFP) is a promising marker for environmental pollutants. In using GFP, one of the obstacles which we faced was how to compare toxicity among different toxicants or among a specific toxicant in different model species with the intensity of GFP expression...

journal_title：Toxicology and applied pharmacology

authors： Seok SH,Baek MW,Lee HY,Kim DJ,Na YR,Noh KJ,Park SH,Lee HK,Lee BH,Ryu DY,Park JH

更新日期：2007-12-01 00:00:00

abstract：:An earlier study indicated that percutaneous absorption of a 40-nmol dose of TCDD decreased with aging in rats, suggesting that the potential for systemic exposure following dermal contact would be decreased in older age groups. In this study, maturational changes in potential for systemic exposure to TCDD following d...

journal_title：Toxicology and applied pharmacology

authors： Anderson YB,Jackson JA,Birnbaum LS

更新日期：1993-04-01 00:00:00

abstract：:Side effects of methotrexate (MTX) especially hepatotoxicity limits clinical applications of this anticancer agent. Carboxypeptidase G2 (CPG2) is administrated for the treatment of elevated plasma concentrations of MTX. In this study, we have investigated the intracellular delivery of CPG2 fused to the transactivator ...

journal_title：Toxicology and applied pharmacology

authors： Sadeghian I,Khalvati B,Ghasemi Y,Hemmati S

更新日期：2018-05-01 00:00:00

abstract：:Hypochlorous acid (HOCl) is potentially an important source of cellular oxidative stress. Human HOCl exposure can occur from chlorine gas inhalation or from endogenous sources of HOCl, such as respiratory burst by phagocytes. Transcription factor Nrf2 is a key regulator of cellular redox status and serves as a primary...

journal_title：Toxicology and applied pharmacology

authors： Woods CG,Fu J,Xue P,Hou Y,Pluta LJ,Yang L,Zhang Q,Thomas RS,Andersen ME,Pi J

更新日期：2009-07-01 00:00:00

abstract：:These studies were initiated to determine (1) if cisplatin (cis-DDP)-induced hyperglucagonemia is related to decreased hormone degradation, (2) the relationship between impaired kidney function associated with cis-DDP nephrotoxicity and hyperglucagonemia, and (3) the contribution of cis-DDP-induced hyperglucagonemia t...

journal_title：Toxicology and applied pharmacology

authors： Goldstein RS,Mayor GH,Gingerich RL,Hook JB,Robinson B,Bond JT

更新日期：1983-04-01 00:00:00

abstract：:Cannabinoid receptor (CB) expression was characterized in immunological cell and tissue preparations. Northern analysis revealed approximately 6-kb transcripts for CB1 (brain-type) in mouse spleen and brain and in rat cerebellum. CB1 was not detected in mouse thymus or rat spleen RNA by Northern analysis. CB2 (periphe...

journal_title：Toxicology and applied pharmacology

authors： Schatz AR,Lee M,Condie RB,Pulaski JT,Kaminski NE

更新日期：1997-02-01 00:00:00

abstract：:Metabolism of tert-butyl hydroperoxide (TBHP, 2.0 mM) by glutathione peroxidase within isolated rat hepatocytes caused a rapid oxidation of intracellular reduced glutathione and ultimately NADPH through glutathione reductase. TBHP also caused the formation of surface blebs in the hepatocyte plasma membrane followed by...

journal_title：Toxicology and applied pharmacology

authors： Rush GF,Yodis LA,Alberts D

更新日期：1986-07-01 00:00:00

abstract：:Interference of exogenous chemicals with the aromatase enzyme can be useful as a tool to identify chemicals that could act either chemopreventive for hormone-dependent cancer or adverse endocrine disruptive. Aromatase is the key enzyme in the biosynthesis of steroids, as it converts androgens to estrogens. Certain fla...

journal_title：Toxicology and applied pharmacology

authors： van Meeuwen JA,Nijmeijer S,Mutarapat T,Ruchirawat S,de Jong PC,Piersma AH,van den Berg M

更新日期：2008-05-01 00:00:00

abstract：:Occupational exposure to nickel (Ni), chromium (Cr), and arsenic (As) containing compounds has been associated with lung cancer and other adverse health effects. Their carcinogenic properties may be attributable in part, to activation and/or repression of gene expression induced by changes in the DNA methylation statu...

journal_title：Toxicology and applied pharmacology

authors： Zhou X,Li Q,Arita A,Sun H,Costa M

更新日期：2009-04-01 00:00:00

abstract：:The length distributions of single fibrils of Coalinga, UICC-B and wet dispersed chrysotile were measured by transmission electron microscopy (TEM). It was found that the distributions significantly diverged above approximately 10 μm (μm) in length, corresponding to differences in published results of animal experimen...

journal_title：Toxicology and applied pharmacology

authors： Chatfield EJ

更新日期：2018-12-15 00:00:00

abstract：:Investigations have characterized addictive drug-induced developmental cardiovascular malformation in human, non-human primate and rodent. However, the underlying mechanism of malformation caused by drugs during pregnancy is still largely unknown, and preventive and therapeutic measures have been lacking. Using 1H NMR...

journal_title：Toxicology and applied pharmacology

authors： Shao X,Hu Z,Hu C,Bu Q,Yan G,Deng P,Lv L,Wu D,Deng Y,Zhao J,Zhu R,Li Y,Li H,Xu Y,Yang H,Zhao Y,Cen X

更新日期：2012-05-01 00:00:00

abstract：:The chemical risk assessment process plays an essential role in the potential human health risk evaluation. Setting priorities for this purpose is critical for better use of the available human and material resources. It has been generally accepted that all new chemicals require safety evaluation before manufacture an...

journal_title：Toxicology and applied pharmacology

authors： Alonzo C,Laborde A

更新日期：2005-09-01 00:00:00