St. John's wort significantly increased the systemic exposure and toxicity of methotrexate in rats.

abstract：:To study the interaction of retinoid-induced limb defects and cleft palate on day 11 of gestation, a RXR-selective agonist (AGN191701, an arylpropenyl-thiophene-carboxylic acid derivative, 20 mg/kg orally) was coadministered with a RARalpha-agonist (Am580, an arylcarboxamidobenzoic acid derivative, 5 mg/kg orally) to ...

journal_title：Toxicology and applied pharmacology

authors： Elmazar MM,Rühl R,Nau H

更新日期：2001-01-01 00:00:00

abstract：:Modified epigenetic programming early in life is proposed to underlie the development of an adverse adult phenotype, known as the Developmental Origins of Health and Disease (DOHaD) concept. Several environmental contaminants have been implicated as modifying factors of the developing epigenome. This underlines the ne...

journal_title：Toxicology and applied pharmacology

authors： Bouwmeester MC,Ruiter S,Lommelaars T,Sippel J,Hodemaekers HM,van den Brandhof EJ,Pennings JL,Kamstra JH,Jelinek J,Issa JP,Legler J,van der Ven LT

更新日期：2016-01-15 00:00:00

abstract：:Poly(amidoamine) (PAMAM) dendrimer nanoparticles have been demonstrated to elicit a well defined cytotoxicological response from mammalian cell lines, the response increasing systematically with dendrimer generation and number of surface amino groups. In this work, using generation G4, G5, and G6 dendrimers, this syst...

journal_title：Toxicology and applied pharmacology

authors： Mukherjee SP,Lyng FM,Garcia A,Davoren M,Byrne HJ

更新日期：2010-11-01 00:00:00

abstract：:The ASCT2 transport system catalyses a sodium-dependent antiport of glutamine and other neutral amino acids which is involved in amino acid metabolism. A library of 1,2,3-dithiazoles was designed, synthesized and evaluated as inhibitors of the glutamine/amino acid ASCT2 transporter in the model system of proteoliposom...

journal_title：Toxicology and applied pharmacology

authors： Oppedisano F,Catto M,Koutentis PA,Nicolotti O,Pochini L,Koyioni M,Introcaso A,Michaelidou SS,Carotti A,Indiveri C

更新日期：2012-11-15 00:00:00

abstract：:Neuropathy target esterase (NTE) is a membrane-bound protein with high esterase catalytic activity. The physiological function of the protein is not known and the catalytic activity is not essential to health of nerve axons. Nevertheless there is overwhelming evidence that modification of the structure of NTE by coval...

journal_title：Toxicology and applied pharmacology

authors： Johnson MK

更新日期：1990-03-01 00:00:00

abstract：:A quantitative assay based on real-time detection polymerase chain reaction (rtdPCR) was applied to analyze basal and metal-induced mRNA levels of two metallothionein (MT) isoforms (Cd-MT and Cu-MT) in organs of the terrestrial gastropod Helix pomatia. The results show that specific Cd-MT mRNA levels increase with Cd ...

journal_title：Toxicology and applied pharmacology

authors： Chabicovsky M,Niederstätter H,Thaler R,Hödl E,Parson W,Rossmanith W,Dallinger R

更新日期：2003-07-01 00:00:00

abstract：:Inflammation induced by chronic exposure to ultraviolet (UV) radiation has been implicated in various skin diseases. We formulated the hypothesis that a high-fat diet may influence the UV-induced inflammatory responses in the skin. C57BL/6 mice were fed a high-fat diet or control diet and exposed to UVB radiation (120...

journal_title：Toxicology and applied pharmacology

authors： Meeran SM,Singh T,Nagy TR,Katiyar SK

更新日期：2009-12-15 00:00:00

abstract：:Tamoxifen is a widely used anti-estrogenic drug for chemotherapy and, more recently, for the chemoprevention of breast cancer. Despite the indisputable benefits of tamoxifen in preventing the occurrence and re-occurrence of breast cancer, the use of tamoxifen has been shown to induce non-alcoholic steatohepatitis, whi...

journal_title：Toxicology and applied pharmacology

authors： Pogribny IP,Bagnyukova TV,Tryndyak VP,Muskhelishvili L,Rodriguez-Juarez R,Kovalchuk O,Han T,Fuscoe JC,Ross SA,Beland FA

更新日期：2007-11-15 00:00:00

abstract：:Previous studies have shown that, in general, young, postnatal animals are more sensitive than adults to the toxic effects of anticholinesterase (antiChE) pesticides. Paradoxically, often fetal brain cholinesterase (ChE) is less inhibited than maternal brain after gestational exposure to an antiChE, presumably due to ...

journal_title：Toxicology and applied pharmacology

authors： Lassiter TL,Padilla S,Mortensen SR,Chanda SM,Moser VC,Barone S Jr

更新日期：1998-09-01 00:00:00

abstract：:Arsenic is a human carcinogen with exposure associated with cancer of the lung, skin, and bladder. Many potential mechanisms have been implicated as playing a role in the process of arsenical-induced malignancy including the perturbation of signaling pathways and aberrant epigenetic regulation. We initiated studies to...

journal_title：Toxicology and applied pharmacology

authors： Jensen TJ,Wozniak RJ,Eblin KE,Wnek SM,Gandolfi AJ,Futscher BW

更新日期：2009-02-15 00:00:00

abstract：:It has been known for many years that administration of androgens or estrogens at critical periods of development in mammals causes severe long-term effects on the endocrine/genital systems. The environmental pollutant p-tert-octylphenol (OP) possesses a weak but clear estrogen agonist activity in in vitro and in vivo...

journal_title：Toxicology and applied pharmacology

authors： Katsuda S,Yoshida M,Watanabe G,Taya K,Maekawa A

更新日期：2000-06-15 00:00:00

abstract：:In the current study C57BL/6J mice were injected intraperitoneally with Hg(2+) in the absence and presence of TCDD. After 6 and 24h the liver was harvested and the expression of Cyps was determined. In vitro, isolated hepatocytes were incubated with TCDD in the presence and absence of Hg(2+). At the in vivo level, Hg(...

journal_title：Toxicology and applied pharmacology

authors： Amara IE,Anwar-Mohamed A,Abdelhamid G,El-Kadi AO

更新日期：2013-02-01 00:00:00

abstract：:High- and low- Se diets received by dams during gestation and lactation are related to insulin resistance in their pups. High-Se diet leads to an increase in serum insulin levels, which does not function properly, and an anabolic process. Low-Se diet is related to very low insulin values and an extreme catabolic energ...

journal_title：Toxicology and applied pharmacology

authors： Ojeda ML,Carreras O,Díaz-Castro J,Murillo ML,Nogales F

更新日期：2019-11-01 00:00:00

abstract：:Melittin is a cationic, hemolytic peptide that is the main toxic component in the venom of the honey bee (Apis mellifera). Melittin has multiple effects, including anti-bacterial, anti-viral and anti-inflammatory, in various cell types. However, the anti-apoptotic mechanisms of melittin have not been fully elucidated ...

journal_title：Toxicology and applied pharmacology

authors： Lee WR,Park JH,Kim KH,Park YY,Han SM,Park KK

更新日期：2011-10-15 00:00:00

abstract：:Mass spectrometry is a unique tool to detect and identify trace levels of organic and bioorganic compounds as well as microorganisms in the environment. The range of potential chemical warfare (CW) and biological warfare (BW) agents is very broad. An important advantage of mass spectrometry over other techniques invol...

journal_title：Toxicology and applied pharmacology

authors： Lebedev AT

更新日期：2005-09-01 00:00:00

abstract：:Trimethyltin (TMT) is a neurotoxicant known to alter auditory function. The present study was designed to compare TMT-induced auditory dysfunction using behavioral, electrophysiological, and anatomical techniques. Adult male Long-Evans hooded rats (n = 9-12/group) were acutely exposed to saline, 3, 5, or 7 mg/kg TMT. ...

journal_title：Toxicology and applied pharmacology

authors： Crofton KM,Dean KF,Ménache MG,Janssen R

更新日期：1990-08-01 00:00:00

abstract：:Propanil, 3,4-dichloropropionanilide, a commonly used herbicide, has been shown to induce effects on the mouse immune system. The aim of this study was to assess the immunotoxicity of propanil in occupationally exposed agricultural workers and to characterize its molecular mechanism of action. Seven agricultural worke...

journal_title：Toxicology and applied pharmacology

authors： Corsini E,Codecà I,Mangiaratti S,Birindelli S,Minoia C,Turci R,Viviani B,Facchi A,Vitelli N,Lucchi L,Galli CL,Marinovich M,Colosio C

更新日期：2007-07-15 00:00:00

abstract：:Vinylcyclohexene (VCH) is an industrial byproduct that is known to cause the destruction of ovarian follicles in mice. Its analog, 4-phenylcyclohexene (4PC), is a volatile product from latex-backed carpeting. These studies were undertaken to assess the structure-activity relationships of these compounds and the potent...

journal_title：Toxicology and applied pharmacology

authors： Hooser SB,Parola LR,Van Ert MD,Sipes IG

更新日期：1993-04-01 00:00:00

abstract：:Luteolin, a flavonoid that exhibits antioxidative properties, exerts myocardial protection effects. However, the underlying molecular mechanisms are not yet fully understood. To investigate the effects of luteolin on myocardial injury protection and its possible mechanisms, a myocardial injury model was established wi...

journal_title：Toxicology and applied pharmacology

authors： Sun GB,Sun X,Wang M,Ye JX,Si JY,Xu HB,Meng XB,Qin M,Sun J,Wang HW,Sun XB

更新日期：2012-12-01 00:00:00

abstract：:Nuclear receptors (NRs) are key regulators of human health and constitute a relevant target for medicinal chemistry applications as well as for toxicological risk assessment. Several open databases dedicated to small molecules that modulate NRs exist; however, depending on their final aim (i.e., adverse effect assessm...

journal_title：Toxicology and applied pharmacology

authors： Valsecchi C,Grisoni F,Motta S,Bonati L,Ballabio D

更新日期：2020-11-15 00:00:00

abstract：:Acrylonitrile (VCN) is a heavily used monomer in plastic and fiber industries. Quantitatively, VCN-induced gastrointestinal hemorrhage is time and dose dependent and is not the result of a direct irritating action of VCN on gastric tissues. The effect of cytochrome P-450 enzymes inducers was studied. Pretreatment with...

journal_title：Toxicology and applied pharmacology

authors： Ghanayem BI,Ahmed AE

更新日期：1983-04-01 00:00:00

abstract：:Morphine may induce cardioprotection by targeting mitochondria, but little is known about the exact mitochondrial events that mediate morphine's protection. We aimed to address the role of the mitochondrial Src tyrosine kinase in morphine's protection. Isolated rat hearts were subjected to 30 min ischemia and 2h of re...

journal_title：Toxicology and applied pharmacology

authors： He H,Huh J,Wang H,Kang Y,Lou J,Xu Z

更新日期：2016-01-01 00:00:00

abstract：:Amphetamine has been shown previously to increase levels of the inducible 70-kDa heat shock protein (hsp70i) in mouse liver. In the present study, the hepatic concentrations of a variety of hsps in livers of mice pretreated with amphetamine (15 mg/kg, i.p.) were evaluated, and the time course of hsp induction was exam...

journal_title：Toxicology and applied pharmacology

authors： Salminen WF Jr,Voellmy R,Roberts SM

更新日期：1997-12-01 00:00:00

abstract：:The effect of cadmium injection on the high-affinity phlorizin binding to renal outer cortical brush-border membranes was studied in rabbits. Animals received subcutaneous injections of CdCl2 at a dose of 3 mg Cd/kg.day for about 3 weeks. Brush-border membranes were isolated from renal outer cortex by Percoll gradient...

journal_title：Toxicology and applied pharmacology

authors： Kim KR,Park YS

更新日期：1995-08-01 00:00:00

abstract：:Peroxynitrite formed by the reaction of superoxide and nitric oxide is a highly reactive species with a role in various pathological processes such as cancer, chronic inflammation, and cardiovascular and neurological diseases. In the present study, the effect of the carotenoids, lycopene and beta-carotene, on peroxyni...

journal_title：Toxicology and applied pharmacology

authors： Muzandu K,Ishizuka M,Sakamoto KQ,Shaban Z,El Bohi K,Kazusaka A,Fujita S

更新日期：2006-09-15 00:00:00

abstract：:Biodistribution of cocaine in female rats before and after delivery of litters was studied in order to provide an explanation for the observed differences in cocaine-induced toxicity in pregnant and postpartum rats. Cocaine (20 mg/kg, ip) given to female rats at 16 days of gestation or 20 days of gestation did not hav...

journal_title：Toxicology and applied pharmacology

authors： Dwivedi C,Engineer FN,Vaughan SL

更新日期：1993-01-01 00:00:00

abstract：:The immunosuppressive effects of polycyclic aromatic hydrocarbons (PAHs) on immune responses in rodents, both in vivo and in vitro, have been widely documented. However, few studies have addressed the immunotoxicity of PAHs in the human system. In this report, we examined the toxic effects of nine different PAHs on hu...

journal_title：Toxicology and applied pharmacology

authors： Davila DR,Romero DL,Burchiel SW

更新日期：1996-08-01 00:00:00

abstract：:T-2 toxin, a trichothecene mycotoxin, is a potently cytotoxic and immunosuppressive secondary metabolite produced by Fusarium fungi. Young male white Swiss mice were fed a diet supplemented with T-2 toxin at levels of 5, 10, or 20 ppm, control diet ad libitum, or control diet at a restricted rate for 1, 2, 3, 4, and 6...

journal_title：Toxicology and applied pharmacology

authors： Friend SC,Babiuk LA,Schiefer HB

更新日期：1983-06-30 00:00:00

abstract：:This study was undertaken to characterize the long-term toxic and carcinogenic potential of a polybrominated biphenyl (PBB) mixture in rats and mice of both sexes. Fischer 344 rats and B6C3F1 mice were given 125 po doses of PBB over a 6-month period at 0 (control), 0.1, 0.3, 1.0, 3.0, and 10.0 mg/kg body weight/day (5...

journal_title：Toxicology and applied pharmacology

authors： Gupta BN,McConnell EE,Moore JA,Haseman JK

更新日期：1983-03-30 00:00:00

abstract：:Chelating agents commonly used in therapy of heavy metal intoxication alter the levels of essential metals in liver, kidneys, and serum. Induction of metallothionein synthesis in liver occurs following exposure to a variety of chemical and environmental insults and, in some cases, has been attributed to enhanced hepat...

journal_title：Toxicology and applied pharmacology

authors： Goering PL,Tandon SK,Klaassen CD

更新日期：1985-09-30 00:00:00