Phlorizin binding to renal outer cortical brush-border membranes of cadmium-injected rabbits.


:The effect of cadmium injection on the high-affinity phlorizin binding to renal outer cortical brush-border membranes was studied in rabbits. Animals received subcutaneous injections of CdCl2 at a dose of 3 mg Cd/ for about 3 weeks. Brush-border membranes were isolated from renal outer cortex by Percoll gradient centrifugation and magnesium precipitation. Cadmium injection resulted in a marked increase in membrane cadmium content and decrease in Na(+)-dependent phlorizin binding. The latter effect was attributed to a reduction in the number of binding sites (N0) and not to changes in the dissociation constant (Kd). Similar results were observed in normal membrane vesicles directly exposed to cadmium in vitro. These results suggest that one mechanism of the cadmium-induced glycosuria is a loss of active Na(+)-glucose cotransport carrier in the proximal tubular brush-border membrane by direct interaction with free cadmium.


Toxicol Appl Pharmacol


Kim KR,Park YS




Has Abstract


1995-08-01 00:00:00














  • Mosla dianthera inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production.

    abstract::In this study, we investigated the effect of the aqueous extract of Mosla dianthera (Maxim.) (AEMD) on the mast cell-mediated allergy model and studied the possible mechanism of action. Mast cell-mediated allergic disease is involved in many diseases such as asthma, sinusitis and rheumatoid arthritis. The discovery of...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Lee DH,Kim SH,Eun JS,Shin TY

    更新日期:2006-11-01 00:00:00

  • Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.

    abstract::The anticancer drug ellipticine exerts its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes. The present study has examined the role of cytochrome P450 oxidoreductase (POR) and cytochrome b5 (Cyb5), electron donors to P450 enzymes, in the CYP-mediated metabolism and disposition of elliptic...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Reed L,Indra R,Mrizova I,Moserova M,Schmeiser HH,Wolf CR,Henderson CJ,Stiborova M,Phillips DH,Arlt VM

    更新日期:2019-03-01 00:00:00

  • Nickel-induced down-regulation of serpin by hypoxic signaling.

    abstract::Nickel (Ni) carcinogenesis is thought to involve gene chip silencing by epigenetic mechanisms. Serpina3g, a member of the mouse serpin family, was among the most down-regulated genes (32-fold) in response to Ni exposure of mouse cells based on the Affymetrix gene chip. Serpina3g down-regulation was controlled by a hyp...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Zhao J,Yan Y,Salnikow K,Kluz T,Costa M

    更新日期:2004-01-01 00:00:00

  • Improving the scientific foundation for mixtures joint toxicity and risk assessment: contributions from the SOT mixtures project--introduction.

    abstract::Risk assessments are enhanced when policy and other decision-makers have access to experimental science designed to specifically inform key policy questions. Currently, our scientific understanding and science policy for environmental mixtures are based largely on extrapolating from and combining data in the observabl...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审


    authors: Mason AM,Borgert CJ,Bus JS,Moiz Mumtaz M,Simmons JE,Sipes IG,SOT Mixtures Task Force.

    更新日期:2007-09-01 00:00:00

  • Oxygen tolerance in mice following exposure to butylated hydroxytoluene.

    abstract::Adult BALB/c mice, which are sensitive to hyperoxia (LT50 = 4.5 days 100% O2), were made tolerant to 100% O2 after treatment with butylated hydroxytoluene (BHT). Following a single ip dose of 400 mg/kg, mice survived longer periods in O2 when exposed to O2 at 7, 14, and 21, but not 2 days, following BHT injection. The...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Margaretten N,Tryka AF,Witschi H

    更新日期:1988-10-01 00:00:00

  • Comparison of two pre-exposure treatment regimens in acute organophosphate (paraoxon) poisoning in rats: tiapride vs. pyridostigmine.

    abstract::Recently, the FDA approved the medical use of oral pyridostigmine as prophylactic treatment of possible nerve agent exposure: the concept is to block the cholinesterase transitorily using the carbamate (pyridostigmine) in order to deny access to the active site of the enzyme to the irreversible inhibitor (nerve agent)...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Petroianu GA,Hasan MY,Nurulain SM,Arafat K,Sheen R,Nagelkerke N

    更新日期:2007-03-01 00:00:00

  • Correlation of suppressed natural killer cell activity with altered host resistance models in B6C3F1 mice.

    abstract::A number of methods have been developed to assess the impact of a xenobiotic on the various components of the immune system. For risk analysis, it is necessary to determine what degree of chemically induced immune perturbation translates into altered host resistance. Natural killer (NK) cells play a pivotal role in th...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Wilson SD,McCay JA,Butterworth LF,Munson AE,White KL Jr

    更新日期:2001-12-15 00:00:00

  • Autometallographic determination of inorganic mercury distribution in the cortex of the calcarine sulcus of the monkey Macaca fascicularis following long-term subclinical exposure to methylmercury and mercuric chloride.

    abstract::The distribution of accumulated inorganic mercury deposits in the cortex of the calcarine sulcus of adult female Macaca fascicularis following long-term subclinical exposure to methyl-mercury (MeHg) and mercuric chloride (inorganic mercury-IHg) has been determined by autometallography. Four groups of monkeys were expo...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Charleston JS,Body RL,Mottet NK,Vahter ME,Burbacher TM

    更新日期:1995-06-01 00:00:00

  • Study of the effect of thiols on the vasodilatory potency of S-nitrosothiols by using a modified aortic ring assay.

    abstract::Both low-molecular-mass thiols (LMM-SH) and protein thiols (P-SH) can modulate the biological activity of S-nitrosothiols (RSNO) via S-transnitrosation reactions. It has been difficult to evaluate the entity of this effect in blood circulation by in vitro assays with isolated aorta rings so far, because media rich in ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Giustarini D,Tsikas D,Rossi R

    更新日期:2011-10-15 00:00:00

  • Comparative study of anti-VEGF Ranibizumab and Interleukin-6 receptor antagonist Tocilizumab in Adjuvant-induced Arthritis.

    abstract::Although the precise etiology of Rheumatoid arthritis (RA) remains obscure, heightened immune response is thought to play a vital role in provoking joint inflammation and bone erosion. This study aims at comparatively evaluating the effects of two monoclonal antibodies Ranibizumab (RANI) as anti-VEGF antibody and Toci...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Abdel-Maged AE,Gad AM,Abdel-Aziz AK,Aboulwafa MM,Azab SS

    更新日期:2018-10-01 00:00:00

  • Phorate-induced oxidative stress, DNA damage and transcriptional activation of p53 and caspase genes in male Wistar rats.

    abstract::Male Wistar rats exposed to a systemic organophosphorus insecticide, phorate [O,O-diethyl S-[(ethylthio) methyl] phosphorothioate] at varying oral doses of 0.046, 0.092 or 0.184mg phorate/kg bw for 14days, exhibited substantial oxidative stress, cellular DNA damage and activation of apoptosis-related p53, caspase 3 an...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Saquib Q,Attia SM,Siddiqui MA,Aboul-Soud MA,Al-Khedhairy AA,Giesy JP,Musarrat J

    更新日期:2012-02-15 00:00:00

  • Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.

    abstract::As a class, the biguanides induce lactic acidosis, a hallmark of mitochondrial impairment. To assess potential mitochondrial impairment, we evaluated the effects of metformin, buformin and phenformin on: 1) viability of HepG2 cells grown in galactose, 2) respiration by isolated mitochondria, 3) metabolic poise of HepG...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Dykens JA,Jamieson J,Marroquin L,Nadanaciva S,Billis PA,Will Y

    更新日期:2008-12-01 00:00:00

  • Physiologically based models for bone-seeking elements. V. Lead absorption and disposition in childhood.

    abstract::A physiologically based model of lead absorption and disposition, previously developed and validated for adults, has been tested and calibrated for children. The model was modified to incorporate additional information on the age dependence of bone formation rate and to take into account increasing localization of bon...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审


    authors: O'Flaherty EJ

    更新日期:1995-04-01 00:00:00

  • In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni.

    abstract::Antrodia camphorata (A. camphorata) is a fungus commonly used for treatment of viral hepatitis and cancer in Chinese folk medicine. Extract of A. camphorate is reported to possess anti-inflammatory, antihepatitis B virus and anticancer activities. In this study, we tested the in vivo effects of polysaccharides derived...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Cheng PC,Hsu CY,Chen CC,Lee KM

    更新日期:2008-03-01 00:00:00

  • Mdr1a, Bcrp and Mrp2 regulate the efficacy and toxicity of mesaconitine and hypaconitine by altering their tissue accumulation and in vivo residence.

    abstract::Mesaconitine (MA) and hypaconitine (HA) are the main bioactive/toxic alkaloids of Aconitum carmichaelii Debx, and MDR1, BCRP and MRP2 are involved in their efflux in vitro. This study aimed to explore the effects of Mdr1a, Bcrp and Mrp2 on the efficacy/toxicity of MA and HA by using efflux transporter gene knockout mo...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Li X,Ou X,Luo G,Ou X,Xie Y,Ying M,Qu W,Zuo H,Qi X,Wang Y,Liu Z,Zhu L

    更新日期:2020-12-15 00:00:00

  • A metabonomic evaluation of the monocrotaline-induced sinusoidal obstruction syndrome (SOS) in rats.

    abstract::The main curative treatment of colorectal cancer remains the surgery. However, when metastases are suspected, surgery is followed by a preventive chemotherapy using oxaliplatin which, unfortunately, may cause liver sinusoidal obstruction syndrome (SOS). Such hepatic damage is barely detected during or after chemothera...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Conotte R,Colet JM

    更新日期:2014-04-15 00:00:00

  • Constitutive androstane receptor mediates PCB-induced disruption of retinoid homeostasis.

    abstract::Environmental exposure to polychlorinated biphenyls (PCBs) is associated with an increased risk of incidence of metabolic disease, however the molecular mechanisms underlying this phenomenon are not fully understood. Our study provides new insights into molecular interactions between PCBs and retinoids (vitamin A and ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Shmarakov IO,Lee YJ,Jiang H,Blaner WS

    更新日期:2019-10-15 00:00:00

  • Phyllanthus orbicularis aqueous extract: cytotoxic, genotoxic, and antimutagenic effects in the CHO cell line.

    abstract::The present work evaluates the cytotoxic, genotoxic, and antimutagenic effects of Phyllanthus orbicularis (plant of genus Phyllantus) aqueous extract in Chinese hamster ovary (CHO) cells. P. orbicularis aqueous extracts are used in Cuban traditional medicine for their antiviral activity against Hepatitis B virus and A...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Sànchez-Lamar A,Fiore M,Cundari E,Ricordy R,Cozzi R,De Salvia R

    更新日期:1999-12-15 00:00:00

  • miR-181b-5p inhibits endothelial-mesenchymal transition in monocrotaline-induced pulmonary arterial hypertension by targeting endocan and TGFBR1.

    abstract::Endothelial-mesenchymal transition (EndMT) is a frequent event in endothelial dysfunction, which is associated with pulmonary arterial hypertension (PAH). MiR-181 family members exert diverse effects in multiple biological processes. However, the relationships between miR-181b-5p (miR-181b) and EndMT in PAH are not we...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Zhao H,Wang Y,Zhang X,Guo Y,Wang X

    更新日期:2020-01-01 00:00:00

  • Transfer of 2,4,5,2',4',5'-hexachlorobiphenyl across the in situ perfused guinea pig placenta.

    abstract::The transplacental crossover of 14C-2,4,5,2',4',5'-hexachlorobiphenyl (6-CB) from the maternal circulation to the fetal side of the placenta was examined in intact fetuses and following the in situ perfusion of the guinea pig placenta. Fetal, late pregnant, and nonpregnant female guinea pig lipoprotein profiles and th...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Ring BJ,Seitz KR,Vodicnik MJ

    更新日期:1988-10-01 00:00:00

  • Organophosphorus compound-induced modification of SH-SY5Y human neuroblastoma mitochondrial transmembrane potential.

    abstract::Organophosphorus (OP) compounds inhibit mitochondrial enzymes, respiration, and ATP generation, in addition to inducing structural changes such as matrix swelling. This implicates mitochondria as primary subcellular targets for these compounds. In this study, the health and function of cellular mitochondria following ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Carlson K,Ehrich M

    更新日期:1999-10-01 00:00:00

  • Selective cytolysis by a protein toxin as a consequence of direct interaction with the lymphocyte plasma membrane.

    abstract::Two lines of evidence support the concept that cardiotoxin from Naja naja siamensis interacts directly with the plasma membrane to produce selective cytolysis of lymphocytes. Toxin adsorbed to the wells of microtiter plates retained the ability to lyse murine T-lymphocytes, but lost the ability to destroy natural kill...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Hinman CL,Jiang XL,Tang HP

    更新日期:1990-06-15 00:00:00

  • The uptake and elimination of 1,1,1-trichloroethane during and following inhalation exposures in rats.

    abstract::The pharmacokinetics of 1,1,1-trichloroethane (TRI) was studied in male Sprague-Dawley rats in order to characterize and quantify TRI uptake and elimination oby direct measurements of the inhaled and exhaled compound. Fifty or 500 ppm TRI was inhaled for 2 hr through a one-way breathing valve by unanesthetized rats of...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Dallas CE,Ramanathan R,Muralidhara S,Gallo JM,Bruckner JV

    更新日期:1989-05-01 00:00:00

  • Response of rats to low levels of sarin.

    abstract::The purpose of this study was to determine whether exposure to levels of sarin causing no overt clinical signs would cause more subtle, adverse health effects that persisted after the exposure ended. Inhalation exposures of male Fischer 344 rats to 0, 0.2, or 0.4 mg/m(3) of sarin for 1 h/day for 1, 5, or 10 days under...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Henderson RF,Barr EB,Blackwell WB,Clark CR,Conn CA,Kalra R,March TH,Sopori ML,Tesfaigzi Y,Ménache MG,Mash DC

    更新日期:2002-10-15 00:00:00

  • Nifedipine and tetrodotoxin delay the onset of methylmercury-induced increase in [Ca2+]i in NG108-15 cells.

    abstract::Methylmercury (MeHg) causes a multiphasic disruption of intraneuronal cation regulation. Release of Ca2+ from internal stores and entry of extracellular Ca2+ (Ca2+e) contribute to the temporally distinct early (first Ca2+ phase) and late (second Ca2+ phase) components of increased intracellular Ca2+ concentration ([Ca...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Hare MF,Atchison WD

    更新日期:1995-12-01 00:00:00

  • Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

    abstract::Methylene chloride (dichloromethane, DCM) is metabolized by two pathways: one dependent on oxidation by mixed function oxidases (MFO) and the other dependent on glutathione S-transferases (GST). A physiologically based pharmacokinetic (PB-PK) model based on knowledge of these pathways was used to describe the metaboli...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Andersen ME,Clewell HJ 3rd,Gargas ML,Smith FA,Reitz RH

    更新日期:1987-02-01 00:00:00

  • Dead or dying: the importance of time in cytotoxicity assays using arsenite as an example.

    abstract::Arsenite is a toxicant and environmental pollutant associated with multisite neoplasias and other health effects. The wide range of doses used and the claims that some high doses are "not toxic" in some assays have confounded studies on its mechanism of action. The purpose of this study is to determine whether the tre...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Komissarova EV,Saha SK,Rossman TG

    更新日期:2005-01-01 00:00:00

  • Measurement of elongate mineral particles: What we should measure and how do we do it?

    abstract::The length distributions of single fibrils of Coalinga, UICC-B and wet dispersed chrysotile were measured by transmission electron microscopy (TEM). It was found that the distributions significantly diverged above approximately 10 μm (μm) in length, corresponding to differences in published results of animal experimen...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Chatfield EJ

    更新日期:2018-12-15 00:00:00

  • The N-methyl-D-aspartate neurotransmitter receptor is a mammalian brain target for the dinoflagellate Pfiesteria piscicida toxin.

    abstract::Blooms of Pfiesteria piscicida, a dinoflagellate in eastern U.S. coastal rivers, are believed to secrete toxins that kill fish and produce short-term memory loss in humans. Only one or two of Pfiesteria's multiple stages secrete the toxin, and only under certain environmental conditions. Thus, neither the presence of ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: El-Nabawi A,Quesenberry M,Saito K,Silbergeld E,Vasta G,Eldefrawi A

    更新日期:2000-11-15 00:00:00

  • Advances in exposure and toxicity assessment of particulate matter: an overview of presentations at the 2009 Toxicology and Risk Assessment Conference.

    abstract::The 2009 Toxicology and Risk Assessment Conference (TRAC) session on "Advances in Exposure and Toxicity Assessment of Particulate Matter" was held in April 2009 in West Chester, OH. The goal of this session was to bring together toxicology, geology and risk assessment experts from the Department of Defense and academi...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审


    authors: Gunasekar PG,Stanek LW

    更新日期:2011-07-15 00:00:00