Phlorizin binding to renal outer cortical brush-border membranes of cadmium-injected rabbits.

abstract：:Dehydroepiandrosterone (DHEA) and its sulfate conjugate are the major circulating steroids in human plasma. Low levels of these adrenal steroids are associated with a number of human diseases including certain cancers. In animal studies, DHEA is chemopreventive toward both spontaneous and chemically induced cancers. A...

journal_title：Toxicology and applied pharmacology

authors： Orner GA,Hendricks JD,Arbogast D,Williams DE

更新日期：1996-12-01 00:00:00

abstract：:Epidemiological studies have shown an association between elevated levels of particulate matter air pollution and increased morbidity and hospital visits in asthmatics. Residual oil fly ash (ROFA) is a primary combustion particle containing sulfate and metals such as vanadium, nickel, and iron. In this study the effec...

journal_title：Toxicology and applied pharmacology

authors： Lambert AL,Dong W,Winsett DW,Selgrade MK,Gilmour MI

更新日期：1999-08-01 00:00:00

abstract：:To study the genotoxicity of valepotriates in vitro, the degree of DNA damage in human endothelial cell line ECV304 treated with 5-60 microg/mL of dichloromethane extracts of valerian (DEV) was analyzed by the Comet assay. No DNA damage was observed in ECV304 cells after culture for 48 h in the presence of 5,10, and 2...

journal_title：Toxicology and applied pharmacology

authors： Hui-lian W,Dong-fang Z,Zhao-feng L,Yang L,Qian-rong Li,Yu-zhen W

更新日期：2003-04-01 00:00:00

abstract：:Previous reports from our laboratory indicated that prophylactic protection against cyanide intoxication in mice can be enhanced by administration of chlorpromazine when it is given with sodium thiosulfate. The mechanism of potentiation of sodium thiosulfate by chlorpromazine was studied alone and in combination with ...

journal_title：Toxicology and applied pharmacology

authors： Kong A,Shen A,Burrows G,Sylvester D,Isom GE,Way JL

更新日期：1983-12-01 00:00:00

abstract：:The current investigation was designed to determine if the pesticide methoxychlor (M) mimicked the effects of estrogen in the brain and on behavior. Running wheel activity (RWA) and sex behaviors were evaluated in this study because the role of estrogen in the regulation of these behaviors has been thoroughly establis...

journal_title：Toxicology and applied pharmacology

authors： Gray LE Jr,Ostby JS,Ferrell JM,Sigmon ER,Goldman JM

更新日期：1988-12-01 00:00:00

abstract：:Bropirimine is an immunomodulator with experimental antiviral and antitumor activities. This pyrimidinone has been found to be embryolethal at doses (200 and 400 mg/kg) that produce only transient maternal toxicity, when administered to pregnant Upj:TUC(SD)spf rats on specific days of gestation. Serum analyses carried...

journal_title：Toxicology and applied pharmacology

authors： Black DL,Marks TA,Branstetter DG,Kirton KT

更新日期：1991-03-15 00:00:00

abstract：:The nicotinic acetylcholine receptor (nAChR) of the electric organ of the electric ray. Torpedo sp., the richest source of nAChR, with similar structure and pharmacology to the mammalian skeletal muscle nAChR, carries several binding sites for different ligands. Incubation of Torpedo membrane-bound nAChRs with the ago...

journal_title：Toxicology and applied pharmacology

authors： Katz EJ,Cortes VI,Eldefrawi ME,Eldefrawi AT

更新日期：1997-10-01 00:00:00

abstract：:Juvenile rats have been reported to be more sensitive to the acute neurotoxic effects of the pyrethroid deltamethrin than adults. While toxicokinetic differences between juveniles and adults are documented, toxicodynamic differences have not been examined. Voltage-gated sodium channels, the primary targets of pyrethro...

journal_title：Toxicology and applied pharmacology

authors： Meacham CA,Brodfuehrer PD,Watkins JA,Shafer TJ

更新日期：2008-09-15 00:00:00

abstract：:As an edible traditional Chinese herb, Fructus psoraleae (FP) has been widely used in Asia for the treatment of vitiligo, bone fracture and osteoporosis. Several cases on markedly elevated bilirubin and acute liver injury following administration of FP and its related proprietary medicine have been reported, but the m...

journal_title：Toxicology and applied pharmacology

authors： Wang XX,Lv X,Li SY,Hou J,Ning J,Wang JY,Cao YF,Ge GB,Guo B,Yang L

更新日期：2015-11-15 00:00:00

abstract：:Organophosphorus-ester induced delayed neurotoxicity (OPIDN) is a neurodegenerative disorder characterized by ataxia progressing to paralysis with a concomitant central and peripheral, distal axonapathy. Diisopropylphosphorofluoridate (DFP) produces OPIDN in the chicken that results in mild ataxia in 7-14 days and sev...

journal_title：Toxicology and applied pharmacology

authors： Damodaran TV,Attia MK,Abou-Donia MB

更新日期：2011-11-01 00:00:00

abstract：:A physiologically based pharmacokinetic (PBPK) model describing transfer of inhaled tetrachloroethylene (PCE) into breast milk with the consequent exposure of the nursing pups was developed and validated in lactating rats. The PBPK model was based on partition coefficients (PCs), which were determined by the equilibra...

journal_title：Toxicology and applied pharmacology

authors： Byczkowski JZ,Kinkead ER,Leahy HF,Randall GM,Fisher JW

更新日期：1994-04-01 00:00:00

abstract：:Glycyrrhetinic acid (GA), the main active ingredient of licorice, reportedly has anti-inflammatory and hepatoprotective properties, but its molecular mechanisms remain be elusive. In the present study, Balb/c mice were pretreated with GA (10, 30, or 100mg/kg) 1h before lipopolysaccharide (LPS)/d-galactosamine (D-GalN)...

journal_title：Toxicology and applied pharmacology

authors： Yin X,Gong X,Zhang L,Jiang R,Kuang G,Wang B,Chen X,Wan J

更新日期：2017-04-01 00:00:00

abstract：:Acute exposure to Cd produces liver injury, whereas chronic exposure results in kidney injury. Tolerance to the hepatotoxicity is observed during chronic exposure to Cd due to the induction of metallothionein (MT). The nephrotoxicity produced by chronic Cd exposure purportedly results from renal uptake of Cd-metalloth...

journal_title：Toxicology and applied pharmacology

authors： Sendelbach LE,Klaassen CD

更新日期：1988-01-01 00:00:00

abstract：:Inorganic arsenicals are clearly toxicants and carcinogens in humans. In mammals, including humans, inorganic arsenic often undergoes methylation, forming compounds such as monomethylarsonic acid (MMAs(V)) and dimethylarsinic acid (DMAs(V)). However, much less information is available on the in vitro toxic potential o...

journal_title：Toxicology and applied pharmacology

authors： Sakurai T,Kojima C,Ochiai M,Ohta T,Sakurai MH,Waalkes MP,Fujiwara K

更新日期：2004-03-01 00:00:00

abstract：:Calcium uptake in cells occurs through specific membrane channels. Since cadmium and mercury inhibit calcium uptake, this study examined whether the calcium channels may also be involved in the uptake of these metals. Primary cultures of rat hepatocytes were incubated with 3 microM CdCl2 or HgCl2 in the absence or pre...

journal_title：Toxicology and applied pharmacology

authors： Blazka ME,Shaikh ZA

更新日期：1991-09-01 00:00:00

abstract：:Bisphenol-A (BPA), a polymer used in plastics manufacturing, and methoxychlor (MXC), a pesticide, are endocrine disrupting compounds with estrogenic and anti-androgenic properties. Prenatal BPA or MXC treatment induces reproductive defects in sheep with BPA causing prepubertal luteinizing hormone (LH) hypersecretion a...

journal_title：Toxicology and applied pharmacology

authors： Abi Salloum B,Steckler TL,Herkimer C,Lee JS,Padmanabhan V

更新日期：2013-05-01 00:00:00

abstract：:Cannabinoid receptor (CB) expression was characterized in immunological cell and tissue preparations. Northern analysis revealed approximately 6-kb transcripts for CB1 (brain-type) in mouse spleen and brain and in rat cerebellum. CB1 was not detected in mouse thymus or rat spleen RNA by Northern analysis. CB2 (periphe...

journal_title：Toxicology and applied pharmacology

authors： Schatz AR,Lee M,Condie RB,Pulaski JT,Kaminski NE

更新日期：1997-02-01 00:00:00

abstract：:In this study, we investigated the effect of the aqueous extract of Mosla dianthera (Maxim.) (AEMD) on the mast cell-mediated allergy model and studied the possible mechanism of action. Mast cell-mediated allergic disease is involved in many diseases such as asthma, sinusitis and rheumatoid arthritis. The discovery of...

journal_title：Toxicology and applied pharmacology

authors： Lee DH,Kim SH,Eun JS,Shin TY

更新日期：2006-11-01 00:00:00

abstract：:Simple alkylating agents induce cell death by activating the apoptotic pathway. In rodent fibroblasts, apoptosis triggered by DNA methylation lesions is executed via the mitochondrial damage pathway. Here, we studied cell death induced by the methylating agents methyl methanesulfonate (MMS) and N-methyl-N'-nitro-N-nit...

journal_title：Toxicology and applied pharmacology

authors： Tomicic MT,Christmann M,Fabian K,Kaina B

更新日期：2005-09-01 00:00:00

abstract：:To characterize modes of action of substances and their cytotoxic effects Bionas GmbH has developed a new screening system to allow the continuous recording of how an active substance can act (Bionas 2500 analyzing system). In the pharmaceutical industry it is important to acquire as much information as possible about...

journal_title：Toxicology and applied pharmacology

authors： Thedinga E,Kob A,Holst H,Keuer A,Drechsler S,Niendorf R,Baumann W,Freund I,Lehmann M,Ehret R

更新日期：2007-04-01 00:00:00

abstract：:A mass-balance study was undertaken to evaluate the accuracy of dose determinations of waterborne 2,5,2',5'-[14C]tetrachlorobiphenyl (TCB) made on transected brook trout (Salvelinus fontinalis) and rainbow trout (Salmo gairdneri) and to determine any pharmacokinetic differences between the two species. The total calcu...

journal_title：Toxicology and applied pharmacology

authors： McKim JM,Heath EM

更新日期：1983-04-01 00:00:00

abstract：:CAsE-PE cells are an arsenic-transformed, human prostate epithelial line containing oncogenic mutations in KRAS compared to immortalized, normal KRAS parent cells, RWPE-1. We previously reported increased copy number of mutated KRAS in CAsE-PE cells, suggesting gene amplification. Here, KRAS flanking genomic and trans...

journal_title：Toxicology and applied pharmacology

authors： Merrick BA,Phadke DP,Bostrom MA,Shah RR,Wright GM,Wang X,Gordon O,Pelch KE,Auerbach SS,Paules RS,DeVito MJ,Waalkes MP,Tokar EJ

更新日期：2020-04-25 00:00:00

abstract：:Female Sprague-Dawley rats were treated with a single ip dose of aflatoxin B1 (AFB1) (3 or 6 mg/kg). Twenty-four hours later and weekly until killed, some of the rats treated with AFB1 were given ethynylestradiol (EE) by gavage at the dose of 13 mg/kg. One, three, six, and nine months following the beginning of the ex...

journal_title：Toxicology and applied pharmacology

authors： Kamdem L,Magdalou J,Siest G,Ban M,Zissu D

更新日期：1983-01-01 00:00:00

abstract：:One proposed mechanism for the development of silica-induced fibrosis is prolonged pulmonary inflammation and lung damage resulting from the secretion of reactive mediators from alveolar macrophages. Metalloporphyrins have antioxidative and antiinflammatory activities. However, the molecular basis for the antiinflamma...

journal_title：Toxicology and applied pharmacology

authors： Kang JL,Pack IS,Hong SM,Lee HS,Hah JS,Nam W,Leonard S,Castranova V

更新日期：2001-04-15 00:00:00

abstract：:Disintegrins and disintegrin-like proteins are molecules found in the venom of four snake families (Atractaspididae, Elapidae, Viperidae, and Colubridae). The disintegrins are nonenzymatic proteins that inhibit cell-cell interactions, cell-matrix interactions, and signal transduction, and may have potential in the tre...

journal_title：Toxicology and applied pharmacology

authors： Sánchez EE,Galán JA,Russell WK,Soto JG,Russell DH,Pérez JC

更新日期：2006-04-01 00:00:00

abstract：:The primary mechanisms proposed for acetaminophen-induced hepatic necrosis should deplete protein thiols, either by covalent binding and thioether formation or by oxidative reactions such as S-thiolations. However, in previous studies we did not detect significant losses of protein thiol contents in response to admini...

journal_title：Toxicology and applied pharmacology

authors： Gupta S,Rogers LK,Taylor SK,Smith CV

更新日期：1997-10-01 00:00:00

abstract：:We developed a fusion toxin consisting of the catalytic and translocation domains of diphtheria toxin linked to human granulocyte-macrophage colony-stimulating factor (GM-CSF) (DTGM) for the treatment of patients with acute myeloid leukemia (AML). Our goal in this study was to determine the toxicity and pharmacokineti...

journal_title：Toxicology and applied pharmacology

authors： Hotchkiss CE,Hall PD,Cline JM,Willingham MC,Kreitman RJ,Gardin J,Latimer A,Ramage J,Feely T,DeLatte S,Tagge EP,Frankel AE

更新日期：1999-07-15 00:00:00

abstract：:Prior consumption of a diet containing the food antioxidant, butylated hydroxyanisole (BHA), by female mice prevented the development of or minimized the acute liver damage caused by monocrotaline, acetaminophen, or bromobenzene. In contrast, neither the incidence nor the severity of carbon tetrachloride-induced hepat...

journal_title：Toxicology and applied pharmacology

authors： Miranda CL,Henderson MC,Schmitz JA,Buhler DR

更新日期：1983-06-15 00:00:00

abstract：:The popularity of hair dyes use has been increasing regularly throughout the world as per the demand of hair coloring fashion trends and other cosmetic products. 2-Amino-3-hydroxypyridine (A132) is widely used as a hair dye ingredient around the world. We are reporting first time the phototoxicity mechanism of A132 un...

journal_title：Toxicology and applied pharmacology

authors： Goyal S,Amar SK,Dwivedi A,Mujtaba SF,Kushwaha HN,Chopra D,Pal MK,Singh D,Chaturvedi RK,Ray RS

更新日期：2016-04-15 00:00:00

abstract：:Nutrient availability is one of the major non-genetic factors determining embryonic growth and larval or fetal size. Due to the high human consumption of blood lipid regulators, fibrates have recently been reported as pollutants in rivers. Our study investigated the developmental toxicity of fibrates in zebrafish. Tre...

journal_title：Toxicology and applied pharmacology

authors： Raldúa D,André M,Babin PJ

更新日期：2008-05-01 00:00:00