Protective role of dietary butylated hydroxyanisole against chemical-induced acute liver damage in mice.

abstract：:Valinomycin and cereulide are bacterial toxins with closely similar chemical structure and properties but different toxic effects. Emetic poisoning is induced by cereulide but not by valinomycin. Both are specific potassium ionophores. Such compounds may affect mitochondrial functions. Both compounds cause a potassium...

journal_title：Toxicology and applied pharmacology

authors： Teplova VV,Mikkola R,Tonshin AA,Saris NE,Salkinoja-Salonen MS

更新日期：2006-01-01 00:00:00

abstract：:Direct additions to culture media of either acetaminophen (APAP) or 7-hydroxy-2-acetylaminofluorene (7-OH-AAF) resulted in abnormal closure of the anterior neuropores of cultured rat embryos in the absence of an exogenous bioactivation system. Concentrations required to produce a 50% incidence of the defect were appro...

journal_title：Toxicology and applied pharmacology

authors： Harris C,Stark KL,Luchtel DL,Juchau MR

更新日期：1989-12-01 00:00:00

abstract：:Studies were conducted to assess the in vitro toxicity of three chloropropanones: monochloropropanone (MCP), 1,1-dichloropropanone (1,1-DCP), and 1,3-dichloropropanone (1,3-DCP). Chloropropanones reacted directly with reduced glutathione (GSH) in sodium phosphate buffer at pH 7.4. All chloropropanones were cytotoxic t...

journal_title：Toxicology and applied pharmacology

authors： Merrick BA,Smallwood CL,Meier JR,McKean DL,Kaylor WH,Condie LW

更新日期：1987-10-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental pollutant that activates the aryl hydrocarbon receptor (AhR) resulting in altered gene expression. In vivo, in vitro, and ex vivo studies have demonstrated that B cells are directly impaired by TCDD, and are a sensitive target as evidenced by sup...

journal_title：Toxicology and applied pharmacology

authors： Kovalova N,Nault R,Crawford R,Zacharewski TR,Kaminski NE

更新日期：2017-02-01 00:00:00

abstract：:Ethambutol, an efficacious antituberculosis agent, can cause irreversible visual loss in a small but significant fraction of patients. However, the mechanism of ocular toxicity remains to be established. We previously reported that ethambutol caused severe vacuole formation in cultured retinal cells, and that the addi...

journal_title：Toxicology and applied pharmacology

authors： Chung H,Yoon YH,Hwang JJ,Cho KS,Koh JY,Kim JG

更新日期：2009-03-01 00:00:00

abstract：:Clofibric acid (CA), a potent peroxisome proliferator (PP), has been shown to cause tumor formation in rat liver. The precise mechanism of action of PPs remains largely unknown. However, it has been proposed that they act by increasing reactive oxygen species (ROS), leading to a cellular oxidative stress. In the prese...

journal_title：Toxicology and applied pharmacology

authors： Bécuwe P,Bianchi A,Dauça M

更新日期：2001-08-01 00:00:00

abstract：:Increased risk of vasospasm, a spontaneous hyperconstriction, is associated with atherosclerosis, cigarette smoking, and hypertension-all conditions involving oxidative stress, lipid peroxidation, and inflammation. To test the role of the lipid peroxidation- and inflammation-derived aldehyde, acrolein, in human vasosp...

journal_title：Toxicology and applied pharmacology

authors： Conklin DJ,Bhatnagar A,Cowley HR,Johnson GH,Wiechmann RJ,Sayre LM,Trent MB,Boor PJ

更新日期：2006-12-15 00:00:00

abstract：:The effects of the chemical species and concentration of selenium (Se) in diets on the concentrations of Se in hair, blood serum, red blood cells (RBCs), and urine were studied to gain an insight into the toxicological and nutritional significance of different chemical forms of Se. Male Wistar rats were fed an Se-defi...

journal_title：Toxicology and applied pharmacology

authors： Shiobara Y,Yoshida T,Suzuki KT

更新日期：1998-10-01 00:00:00

abstract：:1,6-Hexamethylene diisocyanate biuret trimer (HDI-BT) is a nonvolatile isocyanate that is a component of polyurethane spray paints. HDI-BT is a potent irritant that when inhaled stimulates sensory nerves of the respiratory tract. The role of sensory nerves in modulating lung injury following inhalation of HDI-BT was a...

journal_title：Toxicology and applied pharmacology

authors： Lee CT,Poovey HG,Rando RJ,Hoyle GW

更新日期：2007-10-01 00:00:00

abstract：:Previous research has shown that intraperitoneal injection of the solvent pyridine results in a dose- and time-dependent induction of hepatic P450IIE1 in rats, with a twofold increase observed at 6 hr post-treatment. However, inhalation is the primary route of exposure expected for humans exposed to pyridine in labora...

journal_title：Toxicology and applied pharmacology

authors： Hotchkiss JA,Kim SG,Novak RF,Dahl AR

更新日期：1993-01-01 00:00:00

abstract：:The purpose of this study was to determine whether exposure to levels of sarin causing no overt clinical signs would cause more subtle, adverse health effects that persisted after the exposure ended. Inhalation exposures of male Fischer 344 rats to 0, 0.2, or 0.4 mg/m(3) of sarin for 1 h/day for 1, 5, or 10 days under...

journal_title：Toxicology and applied pharmacology

authors： Henderson RF,Barr EB,Blackwell WB,Clark CR,Conn CA,Kalra R,March TH,Sopori ML,Tesfaigzi Y,Ménache MG,Mash DC

更新日期：2002-10-15 00:00:00

abstract：:Besides pathology endpoints, additional immune function endpoints have been included in the Note for Guidance on Repeated Dose Toxicity by the European Union (July 2001), which concern the analysis of antibody responses to a T-cell-dependent antigen. Guidance papers of other regulatory authorities are published as wel...

journal_title：Toxicology and applied pharmacology

authors： van der Laan JW,van Loveren H

更新日期：2005-09-01 00:00:00

abstract：:Anoikis is defined as apoptosis, which is induced by inappropriate cell-matrix interactions. Cancer cells with anoikis resistance tend to undergo metastasis, and this phenomenon has been reported to be associated with integrin and FAK activity. HPW-RX40 is a derivative of 3,4-methylenedioxy-β-nitrostyrene, which is kn...

journal_title：Toxicology and applied pharmacology

authors： Chen IH,Shih HC,Hsieh PW,Chang FR,Wu YC,Wu CC

更新日期：2015-12-01 00:00:00

abstract：:The toxicity of 16 metal salts to Chinese hamster ovary (CHO) cells was determined by measuring the cloning efficiency (CE) of CHO cells after exposure to the metals. CHO cells differed by a factor of 10(5) to 10(6) in their toxic response to these metal salts. While Cd(II) was the most toxic ion, Mg(II) exhibited the...

journal_title：Toxicology and applied pharmacology

authors： Tan EL,Williams MW,Schenley RL,Perdue SW,Hayden TL,Turner JE,Hsie AW

更新日期：1984-07-01 00:00:00

abstract：:A number of methods have been developed to assess the impact of a xenobiotic on the various components of the immune system. For risk analysis, it is necessary to determine what degree of chemically induced immune perturbation translates into altered host resistance. Natural killer (NK) cells play a pivotal role in th...

journal_title：Toxicology and applied pharmacology

authors： Wilson SD,McCay JA,Butterworth LF,Munson AE,White KL Jr

更新日期：2001-12-15 00:00:00

abstract：:Octachlorodibenzo-p-dioxin (OCDD) is a ubiquitous environmental pollutant which has been reported to be nontoxic following acute exposure but has recently been shown to accumulate upon repeated exposure. To determine if this accumulation results in toxic effects, male Fischer 344 rats were treated with 50 micrograms/k...

journal_title：Toxicology and applied pharmacology

authors： Couture LA,Elwell MR,Birnbaum LS

更新日期：1988-03-30 00:00:00

abstract：:Organophosphorus esters (OP) are highly toxic chemicals used as pesticides and nerve agents. Their acute toxicity is attributed to inhibition of acetylcholinesterase (AChE, EC 3.1.1.7) in nerve synapses. Our goal was to find a new therapeutic for protection against OP toxicity. We used a gene therapy vector, adeno-ass...

journal_title：Toxicology and applied pharmacology

authors： Li B,Duysen EG,Poluektova LY,Murrin LC,Lockridge O

更新日期：2006-07-15 00:00:00

abstract：:Occupational exposure to nickel (Ni), chromium (Cr), and arsenic (As) containing compounds has been associated with lung cancer and other adverse health effects. Their carcinogenic properties may be attributable in part, to activation and/or repression of gene expression induced by changes in the DNA methylation statu...

journal_title：Toxicology and applied pharmacology

authors： Zhou X,Li Q,Arita A,Sun H,Costa M

更新日期：2009-04-01 00:00:00

abstract：:Promoting effects of sodium salts of phenobarbital (NaPB) and barbital (NaBB) on the development of bladder tumors were investigated in F344 male rats initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) or N-nitrosobutyl-4-hydroxybutylamine (BBN). To initiate with FANFT, rats were fed 0.2% FANFT mixed ...

journal_title：Toxicology and applied pharmacology

authors： Diwan BA,Hagiwara A,Ward JM,Rice JM

更新日期：1989-04-01 00:00:00

abstract：:Mitochondrial oxidative stress plays important roles in aging and age-related degenerative disorders. The newly identified mitochondrial thioredoxin (mtTrx; Trx2) is a key component of the mitochondrial antioxidant system which is responsible for the clearance of reactive intermediates and repairs proteins with oxidat...

journal_title：Toxicology and applied pharmacology

authors： Chen Y,Yu M,Jones DP,Greenamyre JT,Cai J

更新日期：2006-10-15 00:00:00

abstract：:Reviewing available data shows that most of antipsychotic drugs are associated with arrhythmia and sudden death. Experimental studies have shown a HERG channel blockade, a dose-dependent increase in duration of action potential or of QT interval, with various degrees of indicators of serious arrhythmogenicity. However...

journal_title：Toxicology and applied pharmacology

authors： Titier K,Canal M,Déridet E,Abouelfath A,Gromb S,Molimard M,Moore N

更新日期：2004-08-15 00:00:00

abstract：:Bropirimine is an immunomodulator with experimental antiviral and antitumor activities. This pyrimidinone has been found to be embryolethal at doses (200 and 400 mg/kg) that produce only transient maternal toxicity, when administered to pregnant Upj:TUC(SD)spf rats on specific days of gestation. Serum analyses carried...

journal_title：Toxicology and applied pharmacology

authors： Black DL,Marks TA,Branstetter DG,Kirton KT

更新日期：1991-03-15 00:00:00

abstract：:Arsenic is an environmental toxicant and carcinogen. Exposure to arsenic is associated with development of liver fibrosis and portal hypertension through ill defined mechanisms. We evaluated hepatic fibrogenesis after long term arsenic exposure in a murine model. BALB/c mice were exposed to arsenic by daily gavages of...

journal_title：Toxicology and applied pharmacology

authors： Ghatak S,Biswas A,Dhali GK,Chowdhury A,Boyer JL,Santra A

更新日期：2011-02-15 00:00:00

abstract：:Thiocyanate anions (SCN-) as the end products of tobacco smoke and found in the blood of cigarette smokers have been implicated in atherogenesis and heart diseases. Magnesium deficiency has also been implicated in the etiology of atherogenesis. The contractile responses of rat aorta to SCN- and the modulation of extra...

journal_title：Toxicology and applied pharmacology

authors： Li W,Zheng T,Altura BT,Altura BM

更新日期：1999-05-15 00:00:00

abstract：:Earlier, we reported that chronic cadmium (Cd)-exposure to prostate epithelial (RWPE-1) cells causes defective autophagy, which leads to the transformation of a malignant phenotype in both in vitro and in vivo models. However, the upstream events responsible for defective autophagy are yet to be delineated. The presen...

journal_title：Toxicology and applied pharmacology

authors： Kolluru V,Tyagi A,Chandrasekaran B,Ankem M,Damodaran C

更新日期：2019-06-15 00:00:00

abstract：:The special AT-rich sequence-binding protein 2 (SATB2) is a protein that binds to the nuclear matrix attachment region of the cell and regulates gene expression by altering chromatin structure. In our previous study, we reported that SATB2 gene expression was induced in human bronchial epithelial BEAS-2B cells transfo...

journal_title：Toxicology and applied pharmacology

authors： Wu F,Jordan A,Kluz T,Shen S,Sun H,Cartularo LA,Costa M

更新日期：2016-02-15 00:00:00

abstract：:Liver fibrosis results from chronic tissue damage and excessive regeneration with accumulation of extracellular matrix proteins; it is a precursor of liver cirrhosis and hepatocellular carcinoma. Liver fibrosis treatments are primarily directed at inflammation, with few options to combat fibrogenesis. Pirfenidone is a...

journal_title：Toxicology and applied pharmacology

authors： Seniutkin O,Furuya S,Luo YS,Cichocki JA,Fukushima H,Kato Y,Sugimoto H,Matsumoto T,Uehara T,Rusyn I

更新日期：2018-01-15 00:00:00

abstract：:The developing neuroendocrine brain represents a potential target for endocrine active chemicals. The UV filter 4-methylbenzylidene camphor (4-MBC) exhibits estrogenic activity, but also interferes with the thyroid axis. We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain...

journal_title：Toxicology and applied pharmacology

authors： Maerkel K,Durrer S,Henseler M,Schlumpf M,Lichtensteiger W

更新日期：2007-01-15 00:00:00

abstract：:St. John's wort (SJW, Hypericum perforatum) is one of the popular nutraceuticals for treating depression. Methotrexate (MTX) is an immunosuppressant with narrow therapeutic window. This study investigated the effect of SJW on MTX pharmacokinetics in rats. Rats were orally given MTX alone and coadministered with 300 an...

journal_title：Toxicology and applied pharmacology

authors： Yang SY,Juang SH,Tsai SY,Chao PD,Hou YC

更新日期：2012-08-15 00:00:00

abstract：:The influence of carbon monoxide (CO) on the development of systemic hypertension was studied in Dahl rats selectively bred for susceptibility (DS) and resistance (DR) to NaCl-induced hypertension. This study was designed to examine the interactions among rat line (DS or DR), NaCl content of diet, and exposure to CO. ...

journal_title：Toxicology and applied pharmacology

authors： Shiotsuka RN,Drew RT,Wehner RW

更新日期：1984-11-01 00:00:00