Mosla dianthera inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production.

abstract：:We expressed rat Na(v)1.6 sodium channels in combination with the rat beta(1) and beta(2) auxiliary subunits in Xenopus laevis oocytes and evaluated the effects of the pyrethroid insecticides S-bioallethrin, deltamethrin, and tefluthrin on expressed sodium currents using the two-electrode voltage clamp technique. S-Bi...

journal_title：Toxicology and applied pharmacology

authors： Tan J,Soderlund DM

更新日期：2010-09-15 00:00:00

abstract：:A transformer cooled and insulated with a mixture of 65% Aroclor 1254 and 35% chlorinated benzenes located in the Binghamton State Office Building in Binghamton, New York, was involved in a fire, which produced soot containing polychlorinated biphenyls, biphenylenes, dioxins, and dibenzofurans. A single dose of either...

journal_title：Toxicology and applied pharmacology

authors： Turner JN,Collins DN

更新日期：1983-03-15 00:00:00

abstract：:Oxidative stress is involved in hepatic stellate cells (HSCs) activation and extracellular matrix overproduction. We previously reported the promising effects of dioscin against CCl4-induced liver fibrosis, but its effects and mechanisms on BDL- and DMN-induced liver fibrosis remain unknown. The results in the present...

journal_title：Toxicology and applied pharmacology

authors： Gu L,Tao X,Xu Y,Han X,Qi Y,Xu L,Yin L,Peng J

更新日期：2016-02-01 00:00:00

abstract：:High fetal and neonatal brain levels of methyl mercury (MeHg) have been associated with the abnormal migration of neurons within the cerebellar and cerebral cortices. How MeHg interferes with cellular proliferation, migration, and differentiation is poorly understood. In this study, a cell recognition/cohesion assay b...

journal_title：Toxicology and applied pharmacology

authors： Jacobs AJ,Maniscalco WM,Finkelstein JN

更新日期：1986-12-01 00:00:00

abstract：:The toxicity of 16 metal salts to Chinese hamster ovary (CHO) cells was determined by measuring the cloning efficiency (CE) of CHO cells after exposure to the metals. CHO cells differed by a factor of 10(5) to 10(6) in their toxic response to these metal salts. While Cd(II) was the most toxic ion, Mg(II) exhibited the...

journal_title：Toxicology and applied pharmacology

authors： Tan EL,Williams MW,Schenley RL,Perdue SW,Hayden TL,Turner JE,Hsie AW

更新日期：1984-07-01 00:00:00

abstract：:Numerous studies link arsenic exposure to human cancers in a variety of tissues, including the prostate. Our prior work showed that chronic arsenic exposure of the non-tumorigenic, human prostate epithelial cell line, RWPE-1, to low levels of (5 microM) sodium arsenite for 29 weeks resulted in malignant transformation...

journal_title：Toxicology and applied pharmacology

authors： Benbrahim-Tallaa L,Waterland RA,Styblo M,Achanzar WE,Webber MM,Waalkes MP

更新日期：2005-08-15 00:00:00

abstract：:Previous work from our group indicated that alpha7 nicotinic acetylcholine receptors (alpha7 nAChR) potentially play a role in methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA) neurotoxicity. The aims of the present study were two-fold: (1) to demonstrate the interaction of METH and MDMA with homomer...

journal_title：Toxicology and applied pharmacology

authors： Garcia-Ratés S,Camarasa J,Escubedo E,Pubill D

更新日期：2007-09-15 00:00:00

abstract：:Technical grade dinitrotoluene (DNT) is hepatocarcinogenic when fed to rats. DNT is oxidatively metabolized by hepatic enzymes and reductively metabolized by rat intestinal microflora in vitro. The objectives of the present studies were to determine the importance of bile as a route of excretion for DNT metabolites an...

journal_title：Toxicology and applied pharmacology

authors： Medinsky MA,Dent JG

更新日期：1983-05-01 00:00:00

abstract：:Metabolism of tert-butyl hydroperoxide (TBHP, 2.0 mM) by glutathione peroxidase within isolated rat hepatocytes caused a rapid oxidation of intracellular reduced glutathione and ultimately NADPH through glutathione reductase. TBHP also caused the formation of surface blebs in the hepatocyte plasma membrane followed by...

journal_title：Toxicology and applied pharmacology

authors： Rush GF,Yodis LA,Alberts D

更新日期：1986-07-01 00:00:00

abstract：:Acute lung injury is an acute inflammatory disease with high morbidity rate and high mortality rate. However, there is still no effective clinical treatment to date. Our previous studies found that NLRC5 was significantly increased in acute liver injury model induced by LPS to reduce the secretion of IL-6 and TNF-α. N...

journal_title：Toxicology and applied pharmacology

authors： Wang Y,Huang C,Bian E,Lei T,Lv X,Li J

更新日期：2020-09-15 00:00:00

abstract：:Recent advances have been made in our understanding of the roles played by cutaneous dendritic cells (DCs) in the induction of contact allergy. A number of associated changes in epidermal Langerhans cell phenotype and function required for effective skin sensitization are providing the foundations for the development ...

journal_title：Toxicology and applied pharmacology

authors： Ryan CA,Kimber I,Basketter DA,Pallardy M,Gildea LA,Gerberick GF

更新日期：2007-06-15 00:00:00

abstract：:Learning disabilities (LDs) in children are a serious global problem. Dibutyl phthalate (DBP), a plasticizer widely used in daily life, has been linked to triggering childhood LDs, however the mechanism underlying this remains unclear. Studies have shown that the ERK 1/2 pathway is closely related to apoptosis of hipp...

journal_title：Toxicology and applied pharmacology

authors： Yan B,Sun Y,Zeng J,Chen Y,Li C,Song P,Zhang L,Yang X,Wu Y,Ma P

更新日期：2019-04-01 00:00:00

abstract：:Our recent study demonstrated the increased risk of renal cell carcinoma (RCC) associated with high urinary total arsenic levels among people living in a low arsenic exposure area. Genomic instability is important in arsenic carcinogenesis. This study evaluated the relationship between the polymorphisms of p53, p21, a...

journal_title：Toxicology and applied pharmacology

authors： Huang CY,Su CT,Chu JS,Huang SP,Pu YS,Yang HY,Chung CJ,Wu CC,Hsueh YM

更新日期：2011-12-15 00:00:00

abstract：:Hepatic expression of the proinflammatory cytokine tumor necrosis factor-alpha (TNFalpha) occurs in many acute and chronic liver diseases, as well as following exposure to hepatotoxic chemicals, and is believed to help influence both the damage and repair processes that occur following these insults by regulating addi...

journal_title：Toxicology and applied pharmacology

authors： Simeonova PP,Gallucci RM,Hulderman T,Wilson R,Kommineni C,Rao M,Luster MI

更新日期：2001-12-01 00:00:00

abstract：:Metallothioneins (MTs) are ubiquitous low-molecular-weight proteins that are induced by a variety of inducers, including metals, lipopolysaccharides (LPS), cytokines, oxidative stress, etc., and are thought to play a protective role against various toxic insults. The constitutive level of metallothionein is an importa...

journal_title：Toxicology and applied pharmacology

authors： Choudhuri S,Kramer KK,Berman NE,Dalton TP,Andrews GK,Klaassen CD

更新日期：1995-03-01 00:00:00

abstract：:Previously conducted reproduction and teratology studies in rats (unpublished observations) exposed to fluoxetine have revealed no compound-related adverse effects on fertility and no teratogenic effects. In order to confirm embryonic/fetal exposure to fluoxetine and/or metabolites, dissection and whole-body autoradio...

journal_title：Toxicology and applied pharmacology

authors： Pohland RC,Byrd TK,Hamilton M,Koons JR

更新日期：1989-04-01 00:00:00

abstract：:Occupational exposure to nickel (Ni), chromium (Cr), and arsenic (As) containing compounds has been associated with lung cancer and other adverse health effects. Their carcinogenic properties may be attributable in part, to activation and/or repression of gene expression induced by changes in the DNA methylation statu...

journal_title：Toxicology and applied pharmacology

authors： Zhou X,Li Q,Arita A,Sun H,Costa M

更新日期：2009-04-01 00:00:00

abstract：:The dosage-regimen-dependent teratogenicity as well as plasma and tissue levels of the antiepileptic drug valproic acid (VPA) were studied in the mouse by comparing various injection regimens and infusion of the drug via implanted osmotic minipumps. Concentrations of 225-248 micrograms VPA/ml maternal plasma (about 2X...

journal_title：Toxicology and applied pharmacology

authors： Nau H

更新日期：1985-09-15 00:00:00

abstract：:The inflammasome is a multi-protein complex which when activated regulates caspase-1 activation and IL-1β and IL-18 secretion. The NLRP3 (NACHT, LRR, and pyrin domain-containing protein 3) inflammasome is constitutively assembled and activated in human melanoma cells. We have examined the inhibitory effect of thymoqui...

journal_title：Toxicology and applied pharmacology

authors： Ahmad I,Muneer KM,Tamimi IA,Chang ME,Ata MO,Yusuf N

更新日期：2013-07-01 00:00:00

abstract：:In transgenic zebrafish (Danio rerio), green fluorescent protein (GFP) is a promising marker for environmental pollutants. In using GFP, one of the obstacles which we faced was how to compare toxicity among different toxicants or among a specific toxicant in different model species with the intensity of GFP expression...

journal_title：Toxicology and applied pharmacology

authors： Seok SH,Baek MW,Lee HY,Kim DJ,Na YR,Noh KJ,Park SH,Lee HK,Lee BH,Ryu DY,Park JH

更新日期：2007-12-01 00:00:00

abstract：:The effects of erythropoiesis on cadmium-metallothionein (Cd-MT)2 levels in spleen, a major erythropoietic tissue, was examined following sc injection of 109CdCl2 into mice. As the concentration of Cd in plasma decreased following injection of 109CdCl2 into control mice, the levels in spleen and liver increased rapidl...

journal_title：Toxicology and applied pharmacology

authors： Min KS,Ohyanagi N,Ohta M,Onosaka S,Tanaka K

更新日期：1995-10-01 00:00:00

abstract：:The mechanism of liver cell injury induced by an overdose of the analgesic acetaminophen (AAP) remains controversial. Recently, it was hypothesized that a significant number of hepatocytes die by apoptosis. Since caspases have been implicated as critical signal and effector proteases in apoptosis, we investigated thei...

journal_title：Toxicology and applied pharmacology

authors： Lawson JA,Fisher MA,Simmons CA,Farhood A,Jaeschke H

更新日期：1999-05-01 00:00:00

abstract：:Environmental risk assessment requires models for estimating the bioaccumulation of untested compounds. So far, bioaccumulation models have focused on lipophilic compounds, and only a few have included hydrophilic compounds. Our aim was to extend an existing bioaccumulation model to estimate the oral uptake efficiency...

journal_title：Toxicology and applied pharmacology

authors： O'Connor IA,Huijbregts MA,Ragas AM,Hendriks AJ

更新日期：2013-01-01 00:00:00

abstract：:In the United States the principal environmental exposure to mercury is through dietary consumption of sea food. Although the mechanism by which low levels of mercury affect the nervous system is not well established, epidemiological studies suggest that low level exposure of pregnant women to dietary mercury can adve...

journal_title：Toxicology and applied pharmacology

authors： Gill R,Lanni L,Jen KL,McCabe MJ Jr,Rosenspire A

更新日期：2015-01-01 00:00:00

abstract：:Renal glutathione (GSH) concentrations were reduced approximately 80% at 4 hr after a single injection of buthionine sulfoxime (BSO) (4 mmol/kg body wt) and remained reduced for at least 16 hr in male rats. Following BSO injection, rats were injected with a nephrotoxic dose of cadmium-metallothionein (Cd-MT) (0.3 mg C...

journal_title：Toxicology and applied pharmacology

authors： Suzuki CA,Cherian MG

更新日期：1989-05-01 00:00:00

abstract：:Bobwhite quail were exposed to 2,4-dinitrophenol (DNP) in a respirometer designed to continuously monitor exchange of O2 and CO2, from which metabolic rates (MR) were estimated. After 14-16 days of acclimation to the system (temperature 22 degrees C, light cycle 8L:14D), hens received feed amended with 0, 625, or 1250...

journal_title：Toxicology and applied pharmacology

authors： Dominguez SE,Menkel JL,Fairbrother A,Williams BA,Tanner RW

更新日期：1993-12-01 00:00:00

abstract：:Gene 33 (Mig6, ERRFI1) is an adaptor protein with multiple cellular functions. We recently reported that depletion of this protein promotes lung epithelial cell transformation induced by hexavalent chromium [Cr(VI)]. However, the early molecular events that mediate this process are not clear. In the present study, we ...

journal_title：Toxicology and applied pharmacology

authors： Park S,Zhang X,Li C,Yin C,Li J,Fallon JT,Huang W,Xu D

更新日期：2017-09-01 00:00:00

abstract：:The pharmacokinetics of the industrially important compound triethylamine (TEA) and its metabolite triethylamine-N-oxide (TEAO) were studied in four volunteers after oral and intravenous administration. TEA was efficiently absorbed from the gastrointestinal (GI) tract, rapidly distributed, and in part metabolized into...

journal_title：Toxicology and applied pharmacology

authors： Akesson B,Vinge E,Skerfving S

更新日期：1989-09-15 00:00:00

abstract：:In vitro studies using rat and human hepatic microsomes have shown that the halogenated hydrocarbon 1,2,3-trichloropropane (TCP) is bioactivated to the direct acting mutagen 1,3-dichloroacetone (DCA). The presence of DCA in microsomal incubations was confirmed by gas chromatography-mass spectrometry. DCA formation was...

journal_title：Toxicology and applied pharmacology

authors： Weber GL,Sipes IG

更新日期：1992-03-01 00:00:00

abstract：:Carbon disulfide is present in exposed subjects in free and bound or acid-labile forms. Sensitivities of the blood acid-labile CS2 (AL CS2) concentration and the modified iodine-azide test (IAT) were compared as indicators of CS2 exposure. Rats were exposed to 15 (approximately 5 ppm), 30, 60, or 120 mg/m3 of CS2. Exp...

journal_title：Toxicology and applied pharmacology

authors： Lam CW,DiStefano V

更新日期：1983-09-30 00:00:00