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Effect of chlorpromazine on cyanide intoxication.

Abstract：

:Previous reports from our laboratory indicated that prophylactic protection against cyanide intoxication in mice can be enhanced by administration of chlorpromazine when it is given with sodium thiosulfate. The mechanism of potentiation of sodium thiosulfate by chlorpromazine was studied alone and in combination with sodium nitrite. Although chlorpromazine was found to induce a hypothermic response, the mechanism of enhancement of the antagonism of cyanide by chlorpromazine does not correlate with the hypothermia produced. Various other possible mechanisms were investigated, such as rate of methemoglobin formation, enzymatic activity of rhodanese and cytochrome oxidase, and alpha-adrenergic blockade. The alpha-adrenergic blocking properties of chlorpromazine may provide a basis for its antidotal effect, since this protective effect can be reversed with an alpha-agonist, methoxamine.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Kong A,Shen A,Burrows G,Sylvester D,Isom GE,Way JL

doi

10.1016/0041-008x(83)90028-5

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

407-13

issue

3

eissn

0041-008X

issn

1096-0333

journal_volume

71

pub_type

杂志文章

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