Kidney synthesizes less metallothionein than liver in response to cadmium chloride and cadmium-metallothionein.


:Acute exposure to Cd produces liver injury, whereas chronic exposure results in kidney injury. Tolerance to the hepatotoxicity is observed during chronic exposure to Cd due to the induction of metallothionein (MT). The nephrotoxicity produced by chronic Cd exposure purportedly results from renal uptake of Cd-metallothionein (CdMT) synthesized in liver. The change in target organ from liver to kidney might be due to a lower amount of MT synthesized in the kidney in response to CdMT. Therefore, the purpose of the present study was to quantitate hepatic and renal MT induced by CdCl2 and CdMT. MT levels in mice were quantitated using the Cd-heme assay 24 hr after administration of CdCl2 (0.5-3.0 mg Cd/kg) and CdMT (0.1-0.5 mg Cd/kg). In both liver and kidney, MT reached higher levels following administration of CdCl2 (220 and 60 micrograms/g, respectively) than of CdMT (25 and 35 micrograms/g, respectively), probably because higher dosages of CdCl2 than CdMT are tolerated. CdMT produced 19 and 3 micrograms MT/micrograms Cd in liver and kidney, respectively, while CdCl2 produced 11 and 6 micrograms MT/micrograms Cd, respectively. In conclusion, induction of MT occurs in both the liver and kidney after administration of CdCl2 and CdMT. However, the kidney is less responsive than the liver to the induction of MT by both forms of Cd, which may contribute to making the kidney the target organ of toxicity during chronic Cd exposure.


Toxicol Appl Pharmacol


Sendelbach LE,Klaassen CD




Has Abstract


1988-01-01 00:00:00












  • Disruption of inositol phosphate accumulation in cerebellar granule cells by polychlorinated biphenyls: a consequence of altered Ca2+ homeostasis.

    abstract::The present study examined the activation of protein kinase C (PKC) and disruption of Ca2+ homeostasis as potential mechanisms underlying effects of the polychlorinated biphenyl (PCB) congener 2,2'-dichlorobiphenyl (DCB) on inositol phosphate (IP) signaling in cerebellar granule cells. DCB (100 microM) increased basal...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Shafer TJ,Mundy WR,Tilson HA,Kodavanti PR

    更新日期:1996-12-01 00:00:00

  • Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice.

    abstract::Depression is one of the most common psychiatric disorders in the world. Andrographolide is a natural product that displays evident anti-inflammatory activities. The purpose of the present study was to explore the antidepressant potential of andrographolide in chronic unpredictable mild stress (CUMS)-induced depressiv...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Geng J,Liu J,Yuan X,Liu W,Guo W

    更新日期:2019-09-15 00:00:00

  • The mRNA expression and histological integrity in rat forebrain motor and sensory regions are minimally affected by acrylamide exposure through drinking water.

    abstract::A study was undertaken to determine whether alterations in the gene expression or overt histological signs of neurotoxicity in selected regions of the forebrain might occur from acrylamide exposure via drinking water. Gene expression at the mRNA level was evaluated by cDNA array and/or RT-PCR analysis in the striatum,...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Bowyer JF,Latendresse JR,Delongchamp RR,Warbritton AR,Thomas M,Divine B,Doerge DR

    更新日期:2009-11-01 00:00:00

  • Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice.

    abstract::Nonmelanoma skin cancer is the most common cancer among humans and solar UV radiation, particularly its UVB component (290-320 nm), is its major cause. One way to reduce the occurrence of the cancer is via the use of substances (often antioxidants) termed "photochemopreventive agents". Resveratrol (trans-3,4',5-trihyd...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Afaq F,Adhami VM,Ahmad N

    更新日期:2003-01-01 00:00:00

  • Effects of fasting on cadmium toxicity, glutathione metabolism, and metallothionein synthesis in rats.

    abstract::Acute oral toxicity of Cd (as cadmium chloride) was enhanced in rats fasted 24 hr, as shown by a markedly decreased LD50. To examine the relationship among Cd toxicity, hepatic glutathione (GSH), and metallothionein (MT) during fasting, rats were administered 75 mg Cd/kg orally 24 hr after fasting and euthanized after...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Shimizu M,Morita S

    更新日期:1990-03-15 00:00:00

  • Human and animal health risk assessments of chemicals in the food chain: comparative aspects and future perspectives.

    abstract::Chemicals from anthropogenic and natural origins enter animal feed, human food and water either as undesirable contaminants or as part of the components of a diet. Over the last five decades, considerable efforts and progress to develop methodologies to protect humans and animals against potential risks associated wit...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审


    authors: Dorne JL,Fink-Gremmels J

    更新日期:2013-08-01 00:00:00

  • Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases.

    abstract::The M2 subtype of muscarinic receptor is predominant in heart, and such receptors were reported to be located in muscles as well as in presynaptic cholinergic and adrenergic nerve terminals. Muscarinic receptors of rat heart were identified by the high affinity binding of the agonist (+)-[3H]cis-methyldioxolane ([3H]C...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Silveira CL,Eldefrawi AT,Eldefrawi ME

    更新日期:1990-05-01 00:00:00

  • Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay.

    abstract::Human-based in silico models are emerging as important tools to study the effects of integrating inward and outward ion channel currents to predict clinical proarrhythmic risk. The aims of this study were 2-fold: 1) Evaluate the capacity of an in silico model to predict QTc interval prolongation in the in vivo anesthe...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Morissette P,Polak S,Chain A,Zhai J,Imredy JP,Wildey MJ,Travis J,Fitzgerald K,Fanelli P,Passini E,Rodriguez B,Sannajust F,Regan C

    更新日期:2020-03-01 00:00:00

  • Toxicity of indium arsenide, gallium arsenide, and aluminium gallium arsenide.

    abstract::Gallium arsenide (GaAs), indium arsenide (InAs), and aluminium gallium arsenide (AlGaAs) are semiconductor applications. Although the increased use of these materials has raised concerns about occupational exposure to them, there is little information regarding the adverse health effects to workers arising from exposu...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审


    authors: Tanaka A

    更新日期:2004-08-01 00:00:00

  • Quinone-induced protein handling changes: implications for major protein handling systems in quinone-mediated toxicity.

    abstract::Para-quinones such as 1,4-Benzoquinone (BQ) and menadione (MD) and ortho-quinones including the oxidation products of catecholamines, are derived from xenobiotics as well as endogenous molecules. The effects of quinones on major protein handling systems in cells; the 20/26S proteasome, the ER stress response, autophag...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Xiong R,Siegel D,Ross D

    更新日期:2014-10-15 00:00:00

  • Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats.

    abstract::Doxorubicin (DOX) is a potent anti-neoplastic antibiotic used to treat a variety of malignancies; however, its use is limited by dose-dependent cardiotoxicity. Moreover, there is a strong correlation between cytochrome P450 (CYP)-mediated arachidonic acid metabolites and the pathogenesis of many cardiovascular disease...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Zordoky BN,Anwar-Mohamed A,Aboutabl ME,El-Kadi AO

    更新日期:2010-01-01 00:00:00

  • The anti-cancer agent guttiferone-A permeabilizes mitochondrial membrane: ensuing energetic and oxidative stress implications.

    abstract::Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with cytotoxic action in vitro and anti-tumor action in rodent models. We addressed a potential involvement of mitochondria in GA toxicity (1-25 μM) toward cancer cells by employing both hepatic carcinoma (HepG2) cells and succinate-energized mit...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Pardo-Andreu GL,Nuñez-Figueredo Y,Tudella VG,Cuesta-Rubio O,Rodrigues FP,Pestana CR,Uyemura SA,Leopoldino AM,Alberici LC,Curti C

    更新日期:2011-06-15 00:00:00

  • The NADPH oxidase inhibitor apocynin (acetovanillone) induces oxidative stress.

    abstract::Apocynin (acetovanillone) is often used as a specific inhibitor of NADPH oxidase. In N11 glial cells, apocynin induced, in a dose-dependent way, a significant increase of both malonyldialdehyde level (index of lipid peroxidation) and lactate dehydrogenase release (index of a cytotoxic effect). Apocynin evoked also, in...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Riganti C,Costamagna C,Bosia A,Ghigo D

    更新日期:2006-05-01 00:00:00

  • Hemocompatibility and biocompatibility of antibacterial biomimetic hybrid films.

    abstract::In previous work, we developed novel antibacterial hybrid coatings based on dextran containing dispersed Ag NPs (~5 nm, DEX-Ag) aimed to offer dual protection against two of the most common complications associated with implant surgery, infections and rejection of the implant. However, their blood-material interaction...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Coll Ferrer MC,Eckmann UN,Composto RJ,Eckmann DM

    更新日期:2013-11-01 00:00:00

  • A mechanistic study of cigarette smoke and cyclooxygenase-2 on proliferation of gastric cancer cells.

    abstract::Cigarette smoke has been shown to cause gastric cancer. Overexpression of cyclooxygenase-2 (COX-2) is a common characteristic in gastric malignancy. The present study aimed to explore the correlation between cigarette smoke and COX-2 in the promotion of tumorigenesis in human gastric cancer cells (AGS). We further stu...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Shin VY,Liu ES,Ye YN,Koo MW,Chu KM,Cho CH

    更新日期:2004-02-15 00:00:00

  • Blood-bound carbon disulfide: an indicator of carbon disulfide exposure, and its accumulation in repeatedly exposed rats.

    abstract::Carbon disulfide is present in exposed subjects in free and bound or acid-labile forms. Sensitivities of the blood acid-labile CS2 (AL CS2) concentration and the modified iodine-azide test (IAT) were compared as indicators of CS2 exposure. Rats were exposed to 15 (approximately 5 ppm), 30, 60, or 120 mg/m3 of CS2. Exp...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Lam CW,DiStefano V

    更新日期:1983-09-30 00:00:00

  • Effect of chlorpromazine on cyanide intoxication.

    abstract::Previous reports from our laboratory indicated that prophylactic protection against cyanide intoxication in mice can be enhanced by administration of chlorpromazine when it is given with sodium thiosulfate. The mechanism of potentiation of sodium thiosulfate by chlorpromazine was studied alone and in combination with ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Kong A,Shen A,Burrows G,Sylvester D,Isom GE,Way JL

    更新日期:1983-12-01 00:00:00

  • Experimental and mathematical modeling methods for the investigation of toxicological interactions.

    abstract::While procedures have been developed and used for many years to assess risk and determine acceptable exposure levels to individual chemicals, most cases of environmental contamination can result in concurrent or sequential exposure to more than one chemical. Toxicological predictions of such combinations must be based...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审


    authors: El-Masri HA

    更新日期:2007-09-01 00:00:00

  • A chimeric aryl hydrocarbon receptor knockout mouse model indicates that aryl hydrocarbon receptor activation in hematopoietic cells contributes to the hepatic lesions induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin.

    abstract::Pathologic changes associated with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) exposure have been reported in the livers of a wide range of species. While these changes have been extensively described, the mechanisms of toxic interaction(s) that produce these lesions remain unclear. Using an aryl hydrocarbon receptor ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Thurmond TS,Silverstone AE,Baggs RB,Quimby FW,Staples JE,Gasiewicz TA

    更新日期:1999-07-01 00:00:00

  • Activation of ERK and JNK signaling pathways by mycotoxin citrinin in human cells.

    abstract::Mycotoxin citrinin (CTN) is commonly found in foods and feeds that are contaminated/inoculated with Penicillium, Aspergillus and Monascus species. The exposure of human embryonic kidney (HEK293) and HeLa cells to CTN resulted in a dose-dependent increase in the phosphorylation of two major mitogen-activated protein ki...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Chang CH,Yu FY,Wang LT,Lin YS,Liu BH

    更新日期:2009-06-15 00:00:00

  • Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.

    abstract::Tabun represents the phosphoramidate class of organophosphates that are covalent inhibitors of acetylcholinesterase (AChE), an essential enzyme in neurotransmission. Currently used therapy in counteracting excessive cholinergic stimulation consists of a muscarinic antagonist (atropine) and an oxime reactivator of inhi...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Kovarik Z,Maček Hrvat N,Kalisiak J,Katalinić M,Sit RK,Zorbaz T,Radić Z,Fokin VV,Sharpless KB,Taylor P

    更新日期:2019-06-01 00:00:00

  • Mdr1a, Bcrp and Mrp2 regulate the efficacy and toxicity of mesaconitine and hypaconitine by altering their tissue accumulation and in vivo residence.

    abstract::Mesaconitine (MA) and hypaconitine (HA) are the main bioactive/toxic alkaloids of Aconitum carmichaelii Debx, and MDR1, BCRP and MRP2 are involved in their efflux in vitro. This study aimed to explore the effects of Mdr1a, Bcrp and Mrp2 on the efficacy/toxicity of MA and HA by using efflux transporter gene knockout mo...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Li X,Ou X,Luo G,Ou X,Xie Y,Ying M,Qu W,Zuo H,Qi X,Wang Y,Liu Z,Zhu L

    更新日期:2020-12-15 00:00:00

  • Characterization of phenotypic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocytes in vivo and its effect on apoptosis.

    abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly toxic environmental pollutant and is well known for inducing thymic atrophy in mice, although the exact mechanism of its action remains unclear. Recent studies from our laboratory demonstrated that TCDD induces apoptosis in thymocytes and that Fas- mice (lpr/lpr) ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Kamath AB,Nagarkatti PS,Nagarkatti M

    更新日期:1998-05-01 00:00:00

  • Nuclear penetration of surface functionalized gold nanoparticles.

    abstract::Free gold nanoparticles easily aggregate when the environment conditions change. Here, gold nanoparticles (AuNPs) with average diameter of 3.7 nm were prepared and then modified with poly(ethylene glycol) (PEG) to improve stability. The gold nanoparticles were first surface-modified with 3-mercaptopropionic acid (MPA)...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Gu YJ,Cheng J,Lin CC,Lam YW,Cheng SH,Wong WT

    更新日期:2009-06-01 00:00:00

  • Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity.

    abstract::Polycyclic aromatic hydrocarbons (PAHs) (50 mg/kg, i.p.) selectively deplete mouse bone marrow (BM) hematopoietic cells through a process that is dependent on CYP1B1. 7,12-dimethylbenz(a)anthracene (DMBA), which forms greater amounts of dihydrodiol-epoxide-DNA adducts in BM, is much more effective in depleting BM cell...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Galván N,Teske DE,Zhou G,Moorthy B,MacWilliams PS,Czuprynski CJ,Jefcoate CR

    更新日期:2005-02-01 00:00:00

  • Ovarian mitochondrial and oxidative stress proteins are altered by glyphosate exposure in mice.

    abstract::Glyphosate (GLY) usage for weed control is extensive. To investigate ovarian impacts of chronic GLY exposure, female C57BL6 mice were orally administered saline as vehicle control (CT) or GLY at 0.25 (G0.25), 0.5 (G0.5), 1.0 (G1.0), 1.5 (G1.5), or 2 (G2.0) mg/kg for five days per wk. for 20 wks. Feed intake increased ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Ganesan S,Keating AF

    更新日期:2020-09-01 00:00:00

  • In vitro effects of benzene metabolites on mouse bone marrow stromal cells.

    abstract::Benzene exposure can result in bone marrow myelotoxicity. We examined the effects of benzene metabolites on bone marrow stromal cells of the hemopoietic microenvironment. Male B6C3F1 mouse bone marrow adherent stromal cells were plated at 4 X 10(6) cells per 2 ml of DMEM medium in 35-mm tissue culture dishes. The grow...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Gaido K,Wierda D

    更新日期:1984-10-01 00:00:00

  • Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor.

    abstract::The topobiological behaviour of Nrf1 dictates its post-translational modification and its ability to transactivate target genes. Here, we have elucidated that topovectorial mechanisms control the juxtamembrane processing of Nrf1 on the cyto/nucleoplasmic side of endoplasmic reticulum (ER), whereupon it is cleaved and ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Xiang Y,Halin J,Fan Z,Hu S,Wang M,Qiu L,Zhang Z,Mattjus P,Zhang Y

    更新日期:2018-12-01 00:00:00

  • Oxygen tension, insulin, and glucagon affect the preservation and induction of cytochrome P450 isoforms in cultured rat hepatocytes.

    abstract::The role of oxygen tension, insulin, and glucagon on the preservation and induction of cytochrome P450 isoenzyme activities and contents was investigated in rat hepatocytes cultured for 4 days on crude liver membrane fractions at 4 or 13% O2. At 13% O2, three out of six immunochemically analyzed P450 isoenzymes were s...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Saad B,Thomas H,Schawalder H,Waechter F,Maier P

    更新日期:1994-06-01 00:00:00

  • Influence of iron and zinc status on cadmium accumulation in Bangladeshi women.

    abstract::Cadmium is a widespread environmental contaminant present in food. The absorption in the intestine increases in individuals with low iron stores, but the effect of zinc deficiency is not clear. The aim of the present study was to assess the influence of iron and zinc status on cadmium accumulation in pregnant Banglade...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Kippler M,Ekström EC,Lönnerdal B,Goessler W,Akesson A,El Arifeen S,Persson LA,Vahter M

    更新日期:2007-07-15 00:00:00