当前位置： SCI文献检索 > TOXICOLOGY AND APPLIED PHARMACOLOGY期刊下所有文献 > The synergistic upregulation of phase II detoxification enzymes by glucosinolate breakdown products in cruciferous vegetables.

The synergistic upregulation of phase II detoxification enzymes by glucosinolate breakdown products in cruciferous vegetables.

Abstract：

:Cruciferous vegetables contain secondary metabolites termed glucosinolates that break down to products that upregulate hepatic detoxification enzymes. We have previously shown that a mixture of four major glucosinolate breakdown products from Brussels sprouts interact to produce synergistic induction of phase II detoxification enzymes. Here we tested the hypothesis that this synergism is at the level of transcription and is due to the interaction between the oral bifunctional inducer, indole-3-carbinol (I3C), and monofunctional inducer, crambene (1-cyano 2-hydroxy 3-butene). Adult male rats were treated by gavage with either corn oil (vehicle); crambene (50 mg/kg), I3C (56 mg/kg), or a mix of crambene and I3C at the doses shown. Given orally, I3C alone and crambene with I3C caused significant induction of CYP1A activity and CYP1A1 mRNA levels, whereas crambene alone had no significant effect on CYP1A activity or mRNA levels. Crambene and I3C individually caused induction of glutathione S-transferase (GST) and quinone reductase (QR) activity. The mixture of crambene and I3C caused induction of GST and QR that was significantly greater than the sum of the induction by individual treatments. Upregulation of total GST activity was not as great as that of QR, possibly because some subunits did not show this effect. GST Ya2 mRNA showed a synergistic upregulation by crambene and I3C, while Yc1 and Yc2 showed only an additive response. We speculate that this different regulation is partly due to differences in gene sequences within the antioxidant response element and xenobiotic response element in the regulatory region of GST Ya2 compared to those within the regulatory region of the Yc1/Yc2 subunits.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Nho CW,Jeffery E

doi

10.1006/taap.2001.9207

subject

Has Abstract

pub_date

2001-07-15 00:00:00

pages

146-52

issue

2

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(01)99207-5

journal_volume

174

pub_type

杂志文章

相关文献

TOXICOLOGY AND APPLIED PHARMACOLOGY文献大全
  • Kisspeptin-52 partially rescues the activity of the hypothalamus-pituitary-gonadal axis in underweight male rats dosed with an anti-obesity compound.

    abstract：:Energy metabolism and reproduction are closely linked and reciprocally regulated. The detrimental effect of underweight on reproduction complicates the safety evaluation of anti-obesity drugs, making it challenging to distinguish pathological changes mediated through the intended drug-induced weight loss from direct d...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2020.115152

    authors： Bolze F,Williams H,Bhuwania R,Egecioglu E,Bloem E,Paulsson JF,Pedersen MØ,Broadmeadow A,Chesher CJ,Moore EL,Skydsgaard M,Galle PS,Dalgaard M,Wulff BS,Tena-Sempere M,Andersen LW

    更新日期：2020-10-01 00:00:00

  • Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis.

    abstract：:Tamoxifen is a widely used anti-estrogenic drug for chemotherapy and, more recently, for the chemoprevention of breast cancer. Despite the indisputable benefits of tamoxifen in preventing the occurrence and re-occurrence of breast cancer, the use of tamoxifen has been shown to induce non-alcoholic steatohepatitis, whi...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2007.07.001

    authors： Pogribny IP,Bagnyukova TV,Tryndyak VP,Muskhelishvili L,Rodriguez-Juarez R,Kovalchuk O,Han T,Fuscoe JC,Ross SA,Beland FA

    更新日期：2007-11-15 00:00:00

  • Verapamil stereoisomers induce antiproliferative effects in vascular smooth muscle cells via autophagy.

    abstract：:Calcium channel blockers (CCBs) are important in the management of hypertension and limit restenosis. Although CCB efficacy could derive from decreased blood pressure, other mechanisms independent of CCB activity also can contribute to antiproliferative action. To understand mechanisms of CCB-mediated antiproliferatio...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.04.036

    authors： Salabei JK,Balakumaran A,Frey JC,Boor PJ,Treinen-Moslen M,Conklin DJ

    更新日期：2012-08-01 00:00:00

  • Identification of potential endocrine disrupting chemicals using gene expression biomarkers.

    abstract：:Recent technological advances have moved the field of toxicogenomics from reliance on microarray platforms to high-throughput transcriptomic (HTTr) technologies that measure global gene expression. Gene expression biomarkers are emerging as useful tools for interpreting gene expression profiles to identify perturbatio...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2019.114683

    authors： Corton JC,Kleinstreuer NC,Judson RS

    更新日期：2019-10-01 00:00:00

  • Naringenin protects against oxido-inflammatory aberrations and altered tryptophan metabolism in olfactory bulbectomized-mice model of depression.

    abstract：:Oxido-inflammatory aberrations play a substantial role in the pathophysiology of depression. Oxido-inflammatory stress increases catabolism of tryptophan into kynurenine which leads to imbalance in kynurenine and serotonin levels in the brain. Naringenin a flavonoid, has been reported to possess antidepressant propert...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2018.07.010

    authors： Bansal Y,Singh R,Saroj P,Sodhi RK,Kuhad A

    更新日期：2018-09-15 00:00:00

  • Cellular glutathione prevents cytolethality of monomethylarsonic acid.

    abstract：:Inorganic arsenicals are clearly toxicants and carcinogens in humans. In mammals, including humans, inorganic arsenic often undergoes methylation, forming compounds such as monomethylarsonic acid (MMAs(V)) and dimethylarsinic acid (DMAs(V)). However, much less information is available on the in vitro toxic potential o...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2003.11.022

    authors： Sakurai T,Kojima C,Ochiai M,Ohta T,Sakurai MH,Waalkes MP,Fujiwara K

    更新日期：2004-03-01 00:00:00

  • The benzene metabolite trans,trans-muconaldehyde blocks gap junction intercellular communication by cross-linking connexin43.

    abstract：:Benzene is used at large volumes in many different human activities. Hematotoxicity and cancer-causation as a result of benzene exposure was recognized many years ago, but the mechanisms involved remain unclear. Aberrant regulation of gap junction intercellular communication (GJIC) has been linked to both cancer induc...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2008.07.022

    authors： Rivedal E,Leithe E

    更新日期：2008-11-01 00:00:00

  • The inhibitory effect of CIL-102 on the growth of human astrocytoma cells is mediated by the generation of reactive oxygen species and induction of ERK1/2 MAPK.

    abstract：:CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is the major active agent of the alkaloid derivative of Camptotheca acuminata, with multiple pharmacological activities, including anticancer effects and promotion of apoptosis. The mechanism by which CIL-102 inhibits growth remains poorly understood in hum...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.05.025

    authors： Teng CC,Kuo HC,Cheng HC,Wang TC,Sze CI

    更新日期：2012-08-15 00:00:00

  • Disruption of inositol phosphate accumulation in cerebellar granule cells by polychlorinated biphenyls: a consequence of altered Ca2+ homeostasis.

    abstract：:The present study examined the activation of protein kinase C (PKC) and disruption of Ca2+ homeostasis as potential mechanisms underlying effects of the polychlorinated biphenyl (PCB) congener 2,2'-dichlorobiphenyl (DCB) on inositol phosphate (IP) signaling in cerebellar granule cells. DCB (100 microM) increased basal...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.0311

    authors： Shafer TJ,Mundy WR,Tilson HA,Kodavanti PR

    更新日期：1996-12-01 00:00:00

  • Use of genomic data in risk assessment case study: I. Evaluation of the dibutyl phthalate male reproductive development toxicity data set.

    abstract：:A case study was conducted, using dibutyl phthalate (DBP), to explore an approach to using toxicogenomic data in risk assessment. The toxicity and toxicogenomic data sets relative to DBP-related male reproductive developmental outcomes were considered conjointly to derive information about mode and mechanism of action...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2010.09.006

    authors： Makris SL,Euling SY,Gray LE Jr,Benson R,Foster P

    更新日期：2013-09-15 00:00:00

  • Quantitative analysis of enzyme-altered liver foci in rats initiated with diethylnitrosamine and promoted with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin.

    abstract：:A quantitative method based upon a stochastic model was used to estimate rates of initiation (alteration to express the ATPase-deficient phenotype) and of clonal growth of altered cells in an initiation promotion experiment in the livers of female Wistar rats. Diethylnitrosamine (DEN) was used as the initiating agent ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.0094

    authors： Moolgavkar SH,Luebeck EG,Buchmann A,Bock KW

    更新日期：1996-05-01 00:00:00

  • Pharmacokinetics of triethylamine and triethylamine-N-oxide in man.

    abstract：:The pharmacokinetics of the industrially important compound triethylamine (TEA) and its metabolite triethylamine-N-oxide (TEAO) were studied in four volunteers after oral and intravenous administration. TEA was efficiently absorbed from the gastrointestinal (GI) tract, rapidly distributed, and in part metabolized into...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(89)90300-1

    authors： Akesson B,Vinge E,Skerfving S

    更新日期：1989-09-15 00:00:00

  • Decrease in 4-aminobiphenyl-induced methemoglobinemia in Cyp1a2(-/-) knockout mice.

    abstract：:Methemoglobin formation, as well as hemoglobin or DNA adducts, are useful biomarkers of occupational exposure to certain arylamines. It has been suggested that, in liver from animals not treated with a cytochrome P450 (CYP) inducer, hepatic CYP1A2 is the major P450 involved in N-hydroxylation. This is the first step i...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.2002.9398

    authors： Shertzer HG,Dalton TP,Talaska G,Nebert DW

    更新日期：2002-05-15 00:00:00

  • Low concentrations of lead decrease the sperm fertilization ability by altering the acrosome reaction in mice.

    abstract：:Lead (Pb) exposure at high concentrations is associated with poor sperm quality, acrosome alterations, and low fertilization rate. Sperm capacitation and the acrosome reaction (AR) are required for successful fertilization. Actin polymerization is crucial for correct capacitation, and small GTPases, such as RhoA, Rac1...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2019.114694

    authors： Godínez-Solís Y,Solís-Heredia MJ,Roa-Espitia A,Parra-Forero LY,Hernández-González EO,Hernández-Ochoa I,Quintanilla-Vega B

    更新日期：2019-10-01 00:00:00

  • The effect of piperonyl butoxide on hepatic cytochrome P-450-dependent monooxygenase activities in rainbow trout (Salmo gairdneri).

    abstract：:Although piperonyl butoxide (PBO) is commonly used both in vivo and in vitro as an inhibitor of cytochrome P-450-dependent monooxygenase (MO) activity in a wide variety of species, the effect of PBO on the hepatic MO of fishes has never been characterized. The MO activity in hepatic microsomes from rainbow trout expos...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(88)90331-6

    authors： Erickson DA,Goodrich MS,Lech JJ

    更新日期：1988-06-15 00:00:00

  • Moving into advanced nanomaterials. Toxicity of rutile TiO2 nanoparticles immobilized in nanokaolin nanocomposites on HepG2 cell line.

    abstract：:Immobilization of nanoparticles on inorganic supports has been recently developed, resulting in the creation of nanocomposites. Concerning titanium dioxide nanoparticles (TiO2 NPs1), these have already been developed in conjugation with clays, but so far there are no available toxicological studies on these nanocompos...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2016.12.018

    authors： Bessa MJ,Costa C,Reinosa J,Pereira C,Fraga S,Fernández J,Bañares MA,Teixeira JP

    更新日期：2017-02-01 00:00:00

  • Acute lung injury induced by a commercial leather conditioner.

    abstract：:Following a formulation change, a leather conditioner was involved in a 1992 nationwide outbreak of respiratory illness. We investigated the composition and toxicity of the conditioner produced before (previous product) and after (new product) the disease outbreak. The new product induced tachypnea, pulmonary edema, p...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.8053

    authors： Hubbs AF,Castranova V,Ma JY,Frazer DG,Siegel PD,Ducatman BS,Grote A,Schwegler-Berry D,Robinson VA,Van Dyke C,Barger M,Xiang J,Parker J

    更新日期：1997-03-01 00:00:00

  • Impaired regulation of surfactant phospholipid metabolism in the isolated rat lung after nitrogen dioxide inhalation.

    abstract：:Various drugs have been shown to stimulate surfactant phospholipid metabolism. Particularly beta-adrenergic agonists play an important role under physiologic conditions. For the first time we have studied whether nitrogen dioxide (NO2) inhalation alters beta-adrenergic regulation of surfactant phospholipid metabolism ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1993.1105

    authors： Mengel RG,Bernhard W,Barth P,von Wichert P,Müller B

    更新日期：1993-06-01 00:00:00

  • Glutathione S-transferases of rabbit lung macrophages.

    abstract：:The catalytic activities of glutathione S-transferases (GSTs), particularly the alpha-class isozymes, can provide protection against oxidative stress through GSH-mediated metabolism of reactive products of lipid peroxidation. Lipid peroxidation products from oxidative metabolism in alveolar macrophages play an importa...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1997.8339

    authors： Morrison RJ,Singhal SS,Bidani A,Heming TA,Awasthi S

    更新日期：1998-02-01 00:00:00

  • High doses of baicalin induces kidney injury and fibrosis through regulating TGF-β/Smad signaling pathway.

    abstract：:Baicalin is a major flavonoid compound purified from Scutellariae radix, which has been described as an herb in the Chinese Pharmacopoeia. Previous studies have suggested baicalin possessed extensive anti-inflammatory, anti-cancer, anti-viral properties. However, up to known, there have been no reports of safety and t...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2017.08.003

    authors： Cai Y,Ma W,Xiao Y,Wu B,Li X,Liu F,Qiu J,Zhang G

    更新日期：2017-10-15 00:00:00

  • Effects of subchronic inhalation of low concentrations of nitrogen dioxide. I. The proximal alveolar region of juvenile and adult rats.

    abstract：:Inhalation of nitrogen dioxide (NO2) produces injury to the epithelium of terminal airways and the alveoli proximal to the airways. Techniques were devised to isolate alveolar tissue from this region for morphometric studies to define the extent of alveolar septal injury caused by NO2. One-day-old and six-week-old rat...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(86)90321-2

    authors： Chang LY,Graham JA,Miller FJ,Ospital JJ,Crapo JD

    更新日期：1986-03-30 00:00:00

  • JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats.

    abstract：:We investigated the effects of JBP485 (an anti-inflammatory dipeptide and a substrate of OAT) on regulation of the expression and function of renal Oat1 and Oat3, which can accelerate the excretion of accumulated uremic toxins (e.g. indoxyl sulfate) in the kidney to improve gentamicin-induced ARF in rats. JBP485 cause...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2013.04.029

    authors： Guo X,Meng Q,Liu Q,Wang C,Sun H,Peng J,Ma X,Kaku T,Liu K

    更新日期：2013-09-01 00:00:00

  • Effects of fasting on cadmium toxicity, glutathione metabolism, and metallothionein synthesis in rats.

    abstract：:Acute oral toxicity of Cd (as cadmium chloride) was enhanced in rats fasted 24 hr, as shown by a markedly decreased LD50. To examine the relationship among Cd toxicity, hepatic glutathione (GSH), and metallothionein (MT) during fasting, rats were administered 75 mg Cd/kg orally 24 hr after fasting and euthanized after...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(90)90259-w

    authors： Shimizu M,Morita S

    更新日期：1990-03-15 00:00:00

  • Study on the toxic effects induced by different arsenicals in primary cultured rat astroglia.

    abstract：:Arsenic toxicity is a global health problem affecting millions of people. The objectives of this study were to determine if the toxic effects on primary cultured rat astroglia would be induced by different arsenicals. Based on alamarBlue assay and the single cell gel electrophoresis (SCGE, comet assay), the cell viabi...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2004.01.015

    authors： Jin Y,Sun G,Li X,Li G,Lu C,Qu L

    更新日期：2004-05-01 00:00:00

  • Balance between the toxicity and anticancer activity of arsenic trioxide in treatment of acute promyelocytic leukemia.

    abstract：:Arsenic trioxide (ATO) has a long history and it is recognized as both poison and drug for more than two thousand years. Since the establishment of ATO as a frontline therapeutic agent for acute promyelocytic leukemia (APL), the survival of APL patients have been greatly improved and APL is turned from highly fatal to...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2020.115299

    authors： Wang QQ,Hua HY,Naranmandura H,Zhu HH

    更新日期：2020-12-15 00:00:00

  • Metallothionein-I and -II knock-out mice are sensitive to cadmium-induced liver mRNA expression of c-jun and p53.

    abstract：:Zinc pretreatment has been shown in vitro (rat myoblasts) to induce metallothionein (MT) and inhibit cadmium (Cd)-induced protooncogenes c-myc and c-jun mRNA levels. therefore, the purpose of this study was to determine whether the mRNA expression of the protooncogene c-jun as well as the tumor suppressor gene p53 is ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.0029

    authors： Zheng H,Liu J,Choo KH,Michalska AE,Klaassen CD

    更新日期：1996-02-01 00:00:00

  • Physiologically based models for bone-seeking elements. V. Lead absorption and disposition in childhood.

    abstract：:A physiologically based model of lead absorption and disposition, previously developed and validated for adults, has been tested and calibrated for children. The model was modified to incorporate additional information on the age dependence of bone formation rate and to take into account increasing localization of bon...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1006/taap.1995.1072

    authors： O'Flaherty EJ

    更新日期：1995-04-01 00:00:00

  • Comparative neurotoxicity of tubulin-binding drugs: inhibition of goldfish optic nerve regeneration.

    abstract：:Intraperitoneal or intraocular (io) injection of tubulin-binding drugs in goldfish, Carassius auratus L., inhibited axonal regeneration or restoration of functional synapses in optic axons following optic nerve crush. One eye was used to detect effects on regeneration and the other was kept intact to detect effects on...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(85)90088-2

    authors： Davis RE,Schlumpf BE,Klinger PD

    更新日期：1985-09-15 00:00:00

  • Mdr1a, Bcrp and Mrp2 regulate the efficacy and toxicity of mesaconitine and hypaconitine by altering their tissue accumulation and in vivo residence.

    abstract：:Mesaconitine (MA) and hypaconitine (HA) are the main bioactive/toxic alkaloids of Aconitum carmichaelii Debx, and MDR1, BCRP and MRP2 are involved in their efflux in vitro. This study aimed to explore the effects of Mdr1a, Bcrp and Mrp2 on the efficacy/toxicity of MA and HA by using efflux transporter gene knockout mo...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2020.115332

    authors： Li X,Ou X,Luo G,Ou X,Xie Y,Ying M,Qu W,Zuo H,Qi X,Wang Y,Liu Z,Zhu L

    更新日期：2020-12-15 00:00:00

  • Comparative analysis of lung and blood transcriptomes in mice exposed to multi-walled carbon nanotubes.

    abstract：:Pulmonary exposure to multi-walled carbon nanotubes (MWCNT) causes inflammation, fibroproliferation, immunotoxicity, and systemic responses in rodents. However, the search for representative biomarkers of exposure is an ongoing endeavor. Whole blood gene expression profiling is a promising new approach for the identif...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2020.114898

    authors： Khaliullin TO,Yanamala N,Newman MS,Kisin ER,Fatkhutdinova LM,Shvedova AA

    更新日期：2020-03-01 00:00:00