Toxicity and cardiac effects of acute exposure to tryptophan metabolites on the kynurenine pathway in early developing zebrafish (Danio rerio) embryos.

abstract：:Accumulation, tissue distribution, and depuration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-derived 3H were examined in fingerling yellow perch fed a diet containing 494 ppt of [3H]TCDD for 13 weeks followed by the same diet without TCDD for 13 weeks. None of the TCDD-exposed perch showed any signs of overt toxici...

journal_title：Toxicology and applied pharmacology

authors： Kleeman JM,Olson JR,Chen SM,Peterson RE

更新日期：1986-05-01 00:00:00

abstract：:The effect of N-benzyl-D-glucamine dithiocarbamate (BGD) on the renal toxicity produced by subacute exposure to cadmium in rats was studied. Rats were injected sc with CdCl2 (1.5 mg Cd/kg) daily for 26 days and thereafter they received 13 injections of BGD (400 mumol/kg) every other day. Urinary protein concentration ...

journal_title：Toxicology and applied pharmacology

authors： Kojima S,Ono H,Kiyozumi M,Honda T,Takadate A

更新日期：1989-03-15 00:00:00

abstract：:Halogenated aromatic hydrocarbons (HAHs) are ubiquitous environment contaminants that produce many of their toxic effects by binding to the aryl hydrocarbon receptor (AhR). However, several investigations have demonstrated that certain polychlorinated biphenyl (PCB) congeners, principally di-ortho-chlorinated PCB cong...

journal_title：Toxicology and applied pharmacology

authors： Suh J,Kang JS,Yang KH,Kaminski NE

更新日期：2003-02-15 00:00:00

abstract：:Previous studies have shown that fumonisin B1 (FB1) inhibits ceramide synthase, resulting in accumulation of free sphinganine and sphingosine. Tumor necrosis factor-alpha (TNFalpha) plays an important role in FB1 toxicity and the expression of TNFalpha mRNA in liver and kidney is increased following FB1 exposure in mi...

journal_title：Toxicology and applied pharmacology

authors： He Q,Riley RT,Sharma RP

更新日期：2001-07-01 00:00:00

abstract：:The correlation among hyperammonemia, brain neutral amino acid, and encephalopathy induced by cyanide was investigated in mice. Subcutaneous injection of 10 mg/kg of potassium cyanide increased the levels of blood ammonia by 2.5-fold as compared to those of the corresponding controls and caused loss of consciousness i...

journal_title：Toxicology and applied pharmacology

authors： Yamamoto H

更新日期：1989-07-01 00:00:00

abstract：:The present study investigates the effects of nicotine treatment on exocrine pancreatic function. Adult male, Sprague-Dawley rats received nicotine via a time-release pellet, at a rate of 1.65 micrograms/min for 3 weeks. At the end of the experimental period, it was observed that although nicotine did not affect final...

journal_title：Toxicology and applied pharmacology

authors： Dubick MA,Palmer R,Lau PP,Morrill PR,Geokas MC

更新日期：1988-10-01 00:00:00

abstract：:Catechol estrogens have been postulated to mediate estradiol-induced kidney tumorigenesis in Syrian hamsters. As part of an examination of this postulate, we studied the influence of quercetin, a polyphenolic flavonoid, on the incidence and severity of estrogen-induced kidney tumors, on the metabolic activation of est...

journal_title：Toxicology and applied pharmacology

authors： Zhu BT,Liehr JG

更新日期：1994-03-01 00:00:00

abstract：:Nitrogen mustard (NM) is a toxic vesicant known to cause damage to the respiratory tract. Injury is associated with increased expression of inducible nitric oxide synthase (iNOS). In these studies we analyzed the effects of transient inhibition of iNOS using aminoguanidine (AG) on NM-induced pulmonary toxicity. Rats w...

journal_title：Toxicology and applied pharmacology

authors： Malaviya R,Venosa A,Hall L,Gow AJ,Sinko PJ,Laskin JD,Laskin DL

更新日期：2012-12-15 00:00:00

abstract：:Metallothioneins (MTs) are ubiquitous low-molecular-weight proteins that are induced by a variety of inducers, including metals, lipopolysaccharides (LPS), cytokines, oxidative stress, etc., and are thought to play a protective role against various toxic insults. The constitutive level of metallothionein is an importa...

journal_title：Toxicology and applied pharmacology

authors： Choudhuri S,Kramer KK,Berman NE,Dalton TP,Andrews GK,Klaassen CD

更新日期：1995-03-01 00:00:00

abstract：:The radioprotective effect of extracellular melanin, a naturally occurring pigment, isolated from the fungus Gliocephalotrichum simplex was examined in BALB/C mice, and the probable mechanism of action was established. At an effective dose of 50mg/kg body weight, melanin exhibited both prophylactic and mitigative acti...

journal_title：Toxicology and applied pharmacology

authors： Kunwar A,Adhikary B,Jayakumar S,Barik A,Chattopadhyay S,Raghukumar S,Priyadarsini KI

更新日期：2012-10-15 00:00:00

abstract：:The dermal sensitizing potencies of four diisocyanates were investigated using the mouse ear-swelling test (MEST) with BALB/cBy mice. Mice were administered topical doses of diisocyanates to the abdomen and were challenged on the ear 4 days later with a nonirritating dose of chemical. The increase in ear thickness at ...

journal_title：Toxicology and applied pharmacology

authors： Thorne PS,Hillebrand JA,Lewis GR,Karol MH

更新日期：1987-01-01 00:00:00

abstract：:A number of chemicals cause a nephrotoxic syndrome in male rats, referred to as protein droplet or alpha 2u-globulin (alpha 2u) nephropathy. To evaluate the potential human risk for developing a similar chemically-induced protein-mediated nephrotoxic response, the low-molecular-weight protein fraction (LMWPF) was isol...

journal_title：Toxicology and applied pharmacology

authors： Borghoff SJ,Lagarde WH

更新日期：1993-04-01 00:00:00

abstract：:This study investigated the in vivo metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP) in rats after multiple dosing, the metabolism of MEHP in primary rat hepatocyte cultures for periods of up to 3 days, and the biotransformation of some major metabolites of MEHP. Rats were orally...

journal_title：Toxicology and applied pharmacology

authors： Lhuguenot JC,Mitchell AM,Milner G,Lock EA,Elcombe CR

更新日期：1985-08-01 00:00:00

abstract：:A great number of people are suffering from allergic inflammatory disease such as asthma, atopic dermatitis, and sinusitis. Therefore discovery of drugs for the treatment of these diseases is an important subject in human health. Putranjivain A (PJA), member of ellagitannin, is known to possess beneficial effects incl...

journal_title：Toxicology and applied pharmacology

authors： Kim HH,Park SB,Lee S,Kwon TK,Shin TY,Park PH,Lee SH,Kim SH

更新日期：2014-02-01 00:00:00

abstract：:Intraperitoneal or intraocular (io) injection of tubulin-binding drugs in goldfish, Carassius auratus L., inhibited axonal regeneration or restoration of functional synapses in optic axons following optic nerve crush. One eye was used to detect effects on regeneration and the other was kept intact to detect effects on...

journal_title：Toxicology and applied pharmacology

authors： Davis RE,Schlumpf BE,Klinger PD

更新日期：1985-09-15 00:00:00

abstract：:The dosage-regimen-dependent teratogenicity as well as plasma and tissue levels of the antiepileptic drug valproic acid (VPA) were studied in the mouse by comparing various injection regimens and infusion of the drug via implanted osmotic minipumps. Concentrations of 225-248 micrograms VPA/ml maternal plasma (about 2X...

journal_title：Toxicology and applied pharmacology

authors： Nau H

更新日期：1985-09-15 00:00:00

abstract：:Acetaminophen (APAP) and 7-hydroxy-2-acetylaminofluorene (7-OH-AAF) each produced a similar incidence of, as well as a qualitatively similar, abnormal closure of the anterior neuropore at similar concentrations when added to the medium of cultured rat embryos. At concentrations producing a 50-65% incidence of abnormal...

journal_title：Toxicology and applied pharmacology

authors： Stark KL,Harris C,Juchau MR

更新日期：1989-03-01 00:00:00

abstract：:For many decades it has been thought that oxygen analogs (oxons) of organophosphorus insecticides phosphorylate the catalytic site of acetylcholinesterase by a mechanism that follows simple Michaelis-Menten kinetics. More recently, the interactions of at least some oxons have been shown to be far more complex and like...

journal_title：Toxicology and applied pharmacology

authors： Kaushik R,Rosenfeld CA,Sultatos LG

更新日期：2007-06-01 00:00:00

abstract：:Recent literature reports of myocardial infarction in athletes who self-administer anabolic-androgenic steroid (AAS) and previous animal studies of the effects of AASs on the heart suggest that these drugs may be directly injurious to the myocardium. We have previously demonstrated that 100 microM testosterone cypiona...

journal_title：Toxicology and applied pharmacology

authors： Welder AA,Robertson JW,Fugate RD,Melchert RB

更新日期：1995-08-01 00:00:00

abstract：:The catalytic activities of glutathione S-transferases (GSTs), particularly the alpha-class isozymes, can provide protection against oxidative stress through GSH-mediated metabolism of reactive products of lipid peroxidation. Lipid peroxidation products from oxidative metabolism in alveolar macrophages play an importa...

journal_title：Toxicology and applied pharmacology

authors： Morrison RJ,Singhal SS,Bidani A,Heming TA,Awasthi S

更新日期：1998-02-01 00:00:00

abstract：:There is concern that P-glycoprotein mediated efflux contributes to steroid resistance. Therefore, this study examined bidirectional corticosteroid transport and induction capabilities for P-glycoprotein (P-gp) to understand which of the systemic and inhaled corticosteroids interacted with P-gp to the greatest extent....

journal_title：Toxicology and applied pharmacology

authors： Crowe A,Tan AM

更新日期：2012-05-01 00:00:00

abstract：:Speciation of arsenicals in biological samples is an essential tool to gain insight into its distribution in tissues and its species-specific toxicity to target organs. Biological samples (urine, hair, fingernail) examined in the present study were collected from 41 people of West Bengal, India, who were drinking arse...

journal_title：Toxicology and applied pharmacology

authors： Mandal BK,Ogra Y,Anzai K,Suzuki KT

更新日期：2004-08-01 00:00:00

abstract：:Treatment of cancer patients with the antitumor antibiotic bleomycin (BLM) is associated with lung damage which can progress to pulmonary fibrosis. Shortly after intratracheal (it) administration of BLM to experimental animals there is an influx of inflammatory cells into the lung. These inflammatory cells, consisting...

journal_title：Toxicology and applied pharmacology

authors： Janick-Buckner D,Ranges GE,Hacker MP

更新日期：1989-09-15 00:00:00

abstract：:Dietary phytochemicals are excellent ROS-modulating agents and have been shown to effectively enhance ROS levels beyond toxic threshold in cancer cells to ensure their selective killing while leaving normal cells unscathed. Here we demonstrate that hydroxychavicol (HC), extracted and purified from Piper betel leaves, ...

journal_title：Toxicology and applied pharmacology

authors： Gundala SR,Yang C,Mukkavilli R,Paranjpe R,Brahmbhatt M,Pannu V,Cheng A,Reid MD,Aneja R

更新日期：2014-10-01 00:00:00

abstract：:Over half of T cell acute lymphoblastic leukemia (T-ALL) patients have activating mutations in the Notch gene. Moreover, the contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) is a known carcinogen that mediates its toxicity through the aryl hydrocarbon receptor (AHR), and crosstalk between activated AHR and Notch...

journal_title：Toxicology and applied pharmacology

authors： Ahrenhoerster LS,Leuthner TC,Tate ER,Lakatos PA,Laiosa MD

更新日期：2015-03-01 00:00:00

abstract：UNLABELLED:In the heart, cardiac fibroblasts (CF) and cardiac myofibroblasts (CMF) are the main cells responsible for wound healing after cardiac insult. Exchange protein activated by cAMP (EPAC) is a downstream effector of cAMP, and it has been not completely studied on CF. Moreover, in CMF, which are the main cells r...

journal_title：Toxicology and applied pharmacology

authors： Olmedo I,Muñoz C,Guzmán N,Catalán M,Vivar R,Ayala P,Humeres C,Aránguiz P,García L,Velarde V,Díaz-Araya G

更新日期：2013-10-15 00:00:00

abstract：:The toxic effects of dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mainly through activation of the aryl hydrocarbon receptor (AhR) are well documented. Fibroblast growth factor (Fgf) 21 plays critical roles in metabolic adaptation to fasting by increasing lipid oxidation and ketogenesis in the liver. T...

journal_title：Toxicology and applied pharmacology

authors： Cheng X,Vispute SG,Liu J,Cheng C,Kharitonenkov A,Klaassen CD

更新日期：2014-07-01 00:00:00

abstract：:Although carbon tetrachloride (CCl4) is of concern as a drinking water contaminant, it has been necessary in most oral toxicity studies to give CCl4 in an oil vehicle due to its limited water solubility. The primary objective of our study was to assess the influence of dosing vehicles on the acute hepatotoxicity of CC...

journal_title：Toxicology and applied pharmacology

authors： Kim HJ,Odend'hal S,Bruckner JV

更新日期：1990-01-01 00:00:00

abstract：:Endothelial-mesenchymal transition (EndMT) is a frequent event in endothelial dysfunction, which is associated with pulmonary arterial hypertension (PAH). MiR-181 family members exert diverse effects in multiple biological processes. However, the relationships between miR-181b-5p (miR-181b) and EndMT in PAH are not we...

journal_title：Toxicology and applied pharmacology

authors： Zhao H,Wang Y,Zhang X,Guo Y,Wang X

更新日期：2020-01-01 00:00:00

abstract：:We developed a fusion toxin consisting of the catalytic and translocation domains of diphtheria toxin linked to human granulocyte-macrophage colony-stimulating factor (GM-CSF) (DTGM) for the treatment of patients with acute myeloid leukemia (AML). Our goal in this study was to determine the toxicity and pharmacokineti...

journal_title：Toxicology and applied pharmacology

authors： Hotchkiss CE,Hall PD,Cline JM,Willingham MC,Kreitman RJ,Gardin J,Latimer A,Ramage J,Feely T,DeLatte S,Tagge EP,Frankel AE

更新日期：1999-07-15 00:00:00