Hyperammonemia, increased brain neutral and aromatic amino acid levels, and encephalopathy induced by cyanide in mice.

abstract：:Steatosis is the characteristic type of VPA-induced hepatotoxicity and may result in life-threatening hepatic lesion. Approximately 61% of patients treated with VPA have been diagnosed with hepatic steatosis through ultrasound examination. However, the mechanisms underlying VPA-induced intracellular fat accumulation a...

journal_title：Toxicology and applied pharmacology

authors： Bai X,Hong W,Cai P,Chen Y,Xu C,Cao D,Yu W,Zhao Z,Huang M,Jin J

更新日期：2017-06-01 00:00:00

abstract：:The esters of the general structure, [CH(SH)COOR]2, i.e., Di-BDMS, R = CH2CH(CH3)2; Ds-BDMS, R = CH(CH3)CH2CH3; Di-ADMS, R = CH2CH2CH(CH3)2; and D3-ADMS, R = CH(CH2CH3)2 from the reaction of meso-2,3-dimercaptosuccinic acid with isobutyl, sec-butyl, isoamyl, and 3-amyl alcohols, respectively, have been prepared, chara...

journal_title：Toxicology and applied pharmacology

authors： Singh PK,Jones MM,Gale GR,Atkins LM,Smith AB

更新日期：1989-03-01 00:00:00

abstract：:The disposition and metabolism of 2,3,7,8-tetrachlorodibenzofuran (TCDF) was investigated in rainbow trout (Oncorhynchus mykiss) in order to better understand the metabolic and physiological factors that modulate the fate of this extremely toxic compound in rainbow trout compared to other species. The fish were dosed ...

journal_title：Toxicology and applied pharmacology

authors： Steward AR,Maslanka R,Pangrekar J,Kumar S,Sikka HC

更新日期：1996-08-01 00:00:00

abstract：:gamma-Hexachlorocyclohexane (gamma-HCH), the active ingredient of the insecticide lindane, has been shown to be a seizure-inducing agent in mammals. gamma-HCH and two non-convulsant isomers of HCH (alpha and delta) were compared as to their CNS-related pharmacological and biochemical effects. gamma-HCH was a potent se...

journal_title：Toxicology and applied pharmacology

authors： Fishman BE,Gianutsos G

更新日期：1988-03-30 00:00:00

abstract：:The immunosuppressive synthetic methylated polycyclic aromatic hydrocarbon (PAH), 7,12-dimethylbenz[a]anthracene (DMBA), has been shown to cause both an immediate and a sustained elevation of free intracellular calcium (Ca2+) in human T cells. In the present studies, a series of anthracene- and pyrene-based PAHs were ...

journal_title：Toxicology and applied pharmacology

authors： Krieger JA,Born JL,Burchiel SW

更新日期：1994-08-01 00:00:00

abstract：:The special AT-rich sequence-binding protein 2 (SATB2) is a protein that binds to the nuclear matrix attachment region of the cell and regulates gene expression by altering chromatin structure. In our previous study, we reported that SATB2 gene expression was induced in human bronchial epithelial BEAS-2B cells transfo...

journal_title：Toxicology and applied pharmacology

authors： Wu F,Jordan A,Kluz T,Shen S,Sun H,Cartularo LA,Costa M

更新日期：2016-02-15 00:00:00

abstract：:Diurnal patterns of feeding, drinking, locomotor activity, and rearing in male Fischer-344 rats were examined for 2 weeks after a single oral dose of trimethyltin chloride (TMT) at 0, 3, 5, or 7 mg/kg. Body weights and feeding and drinking efficiency ratios (ratios of amount of food or water consumed per unit effort) ...

journal_title：Toxicology and applied pharmacology

authors： Bushnell PJ,Evans HL

更新日期：1985-06-15 00:00:00

abstract：:Hepatic expression of the proinflammatory cytokine tumor necrosis factor-alpha (TNFalpha) occurs in many acute and chronic liver diseases, as well as following exposure to hepatotoxic chemicals, and is believed to help influence both the damage and repair processes that occur following these insults by regulating addi...

journal_title：Toxicology and applied pharmacology

authors： Simeonova PP,Gallucci RM,Hulderman T,Wilson R,Kommineni C,Rao M,Luster MI

更新日期：2001-12-01 00:00:00

abstract：:In previous work, we developed novel antibacterial hybrid coatings based on dextran containing dispersed Ag NPs (~5 nm, DEX-Ag) aimed to offer dual protection against two of the most common complications associated with implant surgery, infections and rejection of the implant. However, their blood-material interaction...

journal_title：Toxicology and applied pharmacology

authors： Coll Ferrer MC,Eckmann UN,Composto RJ,Eckmann DM

更新日期：2013-11-01 00:00:00

abstract：:The mechanisms of action of o,p'-DDD on adrenal steroidogenesis were investigated in vitro in rainbow trout (Oncorhynchus mykiss). Acute exposures to o,p'-DDD inhibited ACTH-stimulated cortisol secretion while cell viability decreased significantly only at the highest concentration tested (200 microM o,p'-DDD). Stimul...

journal_title：Toxicology and applied pharmacology

authors： Lacroix M,Hontela A

更新日期：2003-08-01 00:00:00

abstract：:The embryotoxic and teratogenic potential of inhaled monochlorobenzene (MCB) was evaluated in rats and rabbits. Bred Fischer 344 rats and inseminated New Zealand White rabbits were exposed to 0, 75, 210, or 590 ppm of MCB via inhalation for 6 hr/day during the period of major organogenesis. Exposure to 590 ppm caused ...

journal_title：Toxicology and applied pharmacology

authors： John JA,Hayes WC,Hanley TR Jr,Johnson KA,Gushow TS,Rao KS

更新日期：1984-11-01 00:00:00

abstract：:Ochratoxin A (OTA) is a mycotoxin that is found in various food and feed products. The molecular mechanisms that are associated with OTA hepatotoxicity and teratogenicity have not been extensively elucidated in a developing organism. In this study, the transcriptomic profile of zebrafish embryos indicates that hemosta...

journal_title：Toxicology and applied pharmacology

authors： Wu TS,Lin YT,Huang YT,Cheng YC,Yu FY,Liu BH

更新日期：2018-02-01 00:00:00

abstract：:DNA double-stranded breaks are the most detrimental form of DNA damage and, if not repaired properly, may lead to an accumulation of chromosomal aberrations and eventually tumorigenesis. Proteins of the Rad51/Rad52 epitasis group are crucial for the recombinational repair of DNA double-stranded breaks, whereas the Rad...

journal_title：Toxicology and applied pharmacology

authors： Yuan SS,Yang YK,Chen HW,Chung YF,Chang HL,Su JH

更新日期：2003-11-01 00:00:00

abstract：:Nucleoside analog reverse transcriptase inhibitors (NRTIs) are known to directly inhibit mitochondrial complex I activity as well as various mitochondrial kinases. Recent observations that complex I activity and superoxide production are modulated through cAMP-dependent phosphorylation suggests a mechanism through whi...

journal_title：Toxicology and applied pharmacology

authors： Lund KC,Wallace KB

更新日期：2008-01-01 00:00:00

abstract：:Fibrinogen, a soluble 340kDa plasma glycoprotein, is critical in achieving and maintaining hemostasis. Reduced fibrinogen levels are associated with an increased risk of bleeding and recent research has investigated the efficacy of fibrinogen concentrate for controlling perioperative bleeding. European guidelines on t...

journal_title：Toxicology and applied pharmacology

authors： Beyerle A,Nolte MW,Solomon C,Herzog E,Dickneite G

更新日期：2014-10-01 00:00:00

abstract：:Erionite, a naturally occurring fibrous zeolite, is associated with the development of nonmalignant and malignant lung diseases and is more carcinogenic than asbestos fibers in man and rodent inhalation models of disease. To investigate the possible molecular mechanisms of erionite-induced toxicity and carcinogenesis ...

journal_title：Toxicology and applied pharmacology

authors： Timblin CR,Guthrie GD,Janssen YW,Walsh ES,Vacek P,Mossman BT

更新日期：1998-07-01 00:00:00

abstract：:Two hours after a four-hour exposure to hexamethylene diisocyanate trimer (HDIt) aerosol between 2.5 and 39 mg/m3, mice were injected iv with 51Cr-EDTA (chromium ethylenediaminetetraacetate). Ten minutes later the lung was lavaged. A larger amount of 51Cr-EDTA was detected in the lung lavage of HDIt mice than of contr...

journal_title：Toxicology and applied pharmacology

authors： Valentini JE,Wong KL,Alarie Y

更新日期：1983-07-01 00:00:00

abstract：:We previously found downregulation of ubiquitin-conjugating enzyme E2E 2 (UBE2E2) in GST-P-positive (+) proliferative lesions produced by tumor promotion from early hepatocarcinogenesis stages in rats. Here we investigated the role of UBE2E2 downregulation in preneoplastic lesions of the liver and other target organs ...

journal_title：Toxicology and applied pharmacology

authors： Mizukami S,Watanabe Y,Saegusa Y,Nakajima K,Ito Y,Masubuchi Y,Yoshida T,Shibutani M

更新日期：2017-11-01 00:00:00

abstract：:Endothelial apoptosis is a driving force in atherosclerosis development. Oxidized low-density lipoprotein (oxLDL) promotes inflammatory and thrombotic processes and is highly atherogenic, as it stimulates macrophage cholesterol accumulation and foam cell formation. Previous studies have shown that the phosphatidylinos...

journal_title：Toxicology and applied pharmacology

authors： Ou HC,Lee WJ,Lee SD,Huang CY,Chiu TH,Tsai KL,Hsu WC,Sheu WH

更新日期：2010-10-15 00:00:00

abstract：:Chemotherapy is one of the major strategies for cancer treatment. Several antineoplastic drugs including vinorelbine (VRB) are commonly intravenously infused and liable to cause serious phlebitis. The therapeutic drugs for preventing this complication are limited. In this study, the mechanism of baicalein (BCN) was in...

journal_title：Toxicology and applied pharmacology

authors： Ge GF,Shi WW,Yu CH,Jin XY,Zhang HH,Zhang WY,Wang LC,Yu B

更新日期：2017-03-01 00:00:00

abstract：:Inhibition of intercellular communication, as measured by metabolic cooperation between 6-thioguanine-sensitive and 6-thioguanine-resistant Chinese hamster V79 cells, has been previously shown to be correlated with a large variety of known tumor promoters, including some of the organochlorine pesticides. Since further...

journal_title：Toxicology and applied pharmacology

authors： Lin ZX,Kavanagh T,Trosko JE,Chang CC

更新日期：1986-03-30 00:00:00

abstract：:The popularity of hair dyes use has been increasing regularly throughout the world as per the demand of hair coloring fashion trends and other cosmetic products. 2-Amino-3-hydroxypyridine (A132) is widely used as a hair dye ingredient around the world. We are reporting first time the phototoxicity mechanism of A132 un...

journal_title：Toxicology and applied pharmacology

authors： Goyal S,Amar SK,Dwivedi A,Mujtaba SF,Kushwaha HN,Chopra D,Pal MK,Singh D,Chaturvedi RK,Ray RS

更新日期：2016-04-15 00:00:00

abstract：:Diarrhea is a common dose-limiting toxicity associated with cancer chemotherapy, in particular for drugs such as irinotecan (CPT-11), 5-fluouracil, oxaliplatin, capecitabine and raltitrexed. St. John's wort (Hypericum perforatum, SJW) has anti-inflammatory activity, and our preliminary study in the rat and a pilot stu...

journal_title：Toxicology and applied pharmacology

authors： Hu ZP,Yang XX,Chan SY,Xu AL,Duan W,Zhu YZ,Sheu FS,Boelsterli UA,Chan E,Zhang Q,Wang JC,Ee PL,Koh HL,Huang M,Zhou SF

更新日期：2006-10-15 00:00:00

abstract：:A subchronic oral toxicity study of disobutamide, a piperidine ring compound with antiarrhythmic activity, was conducted at doses of 30, 100, and 250 mg/kg in rats, 45 mg/kg in dogs, and 90 mg/kg in monkeys. Numerous vacuoles were observed in various organs such as the liver, kidneys, heart, lungs, spleen, thymus, sto...

journal_title：Toxicology and applied pharmacology

authors： Koizumi H,Watanabe M,Numata H,Sakai T,Morishita H

更新日期：1986-06-15 00:00:00

abstract：:Although the tricyclic antidepressant drugs imipramine and doxepin exert similar direct electrophysiological effects on cardiac cells, toxic cardiac arrhythmias and conduction disturbances are much more commonly associated with imipramine than doxepin in clinical use. To ascertain if this discrepancy could be due to d...

journal_title：Toxicology and applied pharmacology

authors： Brennan FJ

更新日期：1984-06-30 00:00:00

abstract：:Lipid rafts are microdomains of the plasma membrane enriched in cholesterol and sphingolipids, and play an important role in the initiation of many pharmacological agent-induced signaling pathways and toxicological effects. The structure of lipid rafts is dynamic, resulting in an ever-changing content of both lipids a...

journal_title：Toxicology and applied pharmacology

authors： George KS,Wu S

更新日期：2012-03-15 00:00:00

abstract：:Organic UV filters including benzophenone-3 (BP-3) are widely used to protect humans and materials from damage by UV irradiation. Despite the environmental occurrence of BP-3 in the aquatic environment, little is known about its effects and modes of action. In the present study we assess molecular and physiological ef...

journal_title：Toxicology and applied pharmacology

authors： Blüthgen N,Zucchi S,Fent K

更新日期：2012-09-01 00:00:00

abstract：:In order to assess the effects of long-term exposure to cadmium (Cd) on the renal metabolism of eicosanoids, the urinary excretion of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), prostaglandin E2 (PGE2), prostaglandin F2 alpha (PGF2 alpha), and thromboxane B2 (TXB2) was determined in 37 workers exposed to Cd and...

journal_title：Toxicology and applied pharmacology

authors： Cárdenas A,Ramis I,Hotter G,Roselló J,Gelpí E,Roels H,Bernard A,Lauwerys R

更新日期：1992-10-01 00:00:00

abstract：:The multidrug resistance (MDR) transporter is a phosphorylated glycoprotein (P-gp) that has been implicated in the efflux of a large variety of xenobiotics, thereby protecting vital organs. This study examines the hypothesis that the multidrug resistance transporter is involved in restricting the entry of polychlorina...

journal_title：Toxicology and applied pharmacology

authors： Tampal NM,Robertson LW,Srinivasan C,Ludewig G

更新日期：2003-03-15 00:00:00

abstract：:Morphine has been shown to reduce renal and hepatic clearance of several xenobiotics in rodents. After iv administration of gentamicin, 10 to 30 mg/kg, its plasma levels were elevated in mice given morphine, 20 mg/kg sc. Plasma clearance of gentamicin was nearly halved by morphine, due primarily to lowering of the eli...

journal_title：Toxicology and applied pharmacology

authors： Hurwitz A,Garty M,Ben-Zvi Z

更新日期：1988-05-01 00:00:00